Microsoft Word STROBE checklist cross sectional.doc

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1 STROBE Statement—Checklist of items th at should be included in reports of cross-sectional studies Item No Recommendation ( ) Indicate the study’s design with a commonly used term in the title or the abstract a 1 Title and abstract ( ) Provide in the abstract an informative and balanced summary of what was done b and what was found Introduction 2 Background/rationale Explain the scientific background and rationale for the investigation being reported ecified hypotheses including any presp Objectives 3 State specific objectives, Methods Study design 4 Present key elements of study design early in the paper 5 Describe the setting, locations, and relevant dates, including periods of recruitment, Setting exposure, follow-up, and data collection Participants 6 ( a ) Give the eligibility criteria, and the sources and methods of selection of participants 7 Variables predictors, potential co nfounders, and effect Clearly define all outcomes, exposures, modifiers. Give diagnostic criteria, if applicable 8* Data sources/ For each variable of interest, give sources of data and details of methods of assessment (measurement). Describe comparab ility of assessment methods if there is measurement more than one group 9 Describe any efforts to address potential sources of bias Bias 10 Explain how the study size was arrived at Study size Quantitative variables 11 Explain how quantitative variables were handled in the analyses. If applicable, describe which groupings were chosen and why ( ) Describe all statistical methods, including those used to control for confounding 12 a Statistical methods ) Describe any methods used to examine subgroups and interactions ( b ) Explain how missing data were addressed c ( ( ) If applicable, describe analytical methods taking account of sampling strategy d e ( ) Describe any sensitivity analyses Results (a) Report numbers of individuals at each stage of study—eg numbers potentially Participants 13* eligible, examined for eligibility, confirmed eligible, included in the study, completing follow-up, and analysed (b) Give reasons for non-participation at each stage (c) Consider use of a flow diagram (a) Give characteristics of study participan ts (eg demographic, clinical, social) and 14* Descriptive data information on exposures and potential confounders ing data for each variable of interest (b) Indicate number of participants with miss Outcome data 15* Report numbers of outcome events or summary measures Main results ) Give unadjusted estimates and, if app licable, confounder-adjusted estimates and ( 16 a ear which confounders were their precision (eg, 95% conf idence interval). Make cl adjusted for and why they were included b ) Report category boundaries when c ontinuous variables were categorized ( ( c ) If relevant, consider translating estimates of relative risk into absolute risk for a meaningful time period 17 Other analyses Report other analyses done—eg analyses of subgroups and interactions, and sensitivity analyses 1

2 Discussion Key results Summarise key results with reference to study objectives 18 19 Discuss limitations of the study, taking into account sources of potential bias or Limitations imprecision. Discuss both direction and magnitude of any potential bias Interpretation 20 Give a cautious overall interpreta tion of results considering objectives, limitations, multiplicity of analyses, results from similar studies, and other relevant evidence Generalisability 21 Discuss the generalisability (external validity) of the study results Other information 22 Give the source of funding and the role of the funders for the present study and, if Funding applicable, for the original study on which the present article is based *Give information separately for exposed and unexposed groups. Note: An Explanation and Elaboration article discusses each checklist item and gives methodological background and published examples of transparent reporting. The STROBE check list is best used in conjunction with this article (freely available on the Web sites of PLoS Medicine at http:// www.plosmedicine.org/, Annals of Internal Medicine at http://www.annals.org/, and Epidemiology at http://www.e pidem.com/). Information on the STROBE Initiative is available at www.strobe-statement.org. 2

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