Fourth National Report on Human Exposure to Environmental Chemicals Update

Transcript

1 201 8 Fourth National Report on Human Exposure to Environmental Chemicals U pdated Tables, March 2018 , Volume One

2 Complete Table of Contents - Volumes One and Two Volume One General Information 1 Introduction and Public Health Uses What’s New and Different? 4 Data Sources and Data Analysis 6 Interpretation of Report and Updated Tables Data: Important Factors 12 Calculation of Urinary Inorganic-related Arsenic Species 14 Calculation of PFOS and PFOA as the Sum of the Isomers 15 Chemical and Toxicological Information 17 Adducts of Hemoglobin Acrylamide 19 CAS No. 79-06-1 Glycidamide 20 CAS No. 486-56-6 Tobacco Smoke Cotinine 21 CAS No. 486-56-6 Hydroxycotinine 24 25 NNAL CAS No. 76014-81-8 Disinfection By-Products 29 Bromodichloromethane CAS No. 75-27-4 Dibromochloromethane (Chlorodibromomethane) 31 CAS No. 124-48-1 Tribromomethane (Bromoform) 33 CAS No. 75-25-2 Trichloromethane (Chloroform) 35 CAS No. 67-66-3 Personal Care and Consumer Product Chemicals and Metabolites Benzophenone-3 37 CAS No. 131-57-7 Bisphenol A 41 CAS No. 80-05-7 Bisphenol F 45 Bisphenol S 47 4-tert-Octylphenol 49 CAS No. 140-66-9 Triclocarban 51 CAS No. 101-20-2 Triclosan 53 CAS No. 3380-34-5 Butyl paraben 57 CAS No. 94-26-8 _________________________________________________________________________________________________ i Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018

3 61 Ethyl paraben CAS No. 120-47-8 Methyl paraben 65 CAS No. 99-76-3 69 n-Propyl paraben CAS No. 94-13-3 73 2,4-Dichlorophenol CAS No. 120-83-2 77 2,5-Dichlorophenol CAS No. 583-78-8 Flame Retardant Metabolites Bis(1-chloro-2-propyl) phosphate (BCPP) 81 83 Bis(2-chloroethyl) phosphate (BCEtP) 85 Bis(1,3-dichloro-2-propyl) phosphate (BDCPP) 87 Dibenzyl phosphate (DBzP) 89 Dibutyl phosphate (DBuP) 91 Di-o-cresylphosphate (DoCP) 93 Di-p-cresylphosphate (DpCP) 95 Diphenyl phosphate (DPhP) 97 2,3,4,5-Tetrabromobenzoic acid (TBBA) Fungicides and Metabolites 99 ortho-Phenylphenol CAS No. 90-43-7 Ethylene thiourea 101 CAS No. 96-45-7 Pentachlorophenol 103 CAS No. 87-86-5 Propylene thiourea 105 CAS No. 2122-19-2 Herbicides and Metabolites Atrazine 107 CAS No. 1912-24-9 Atrazine mercapturate 109 CAS No. 138722-96-0 Desethyl atrazine 111 CAS No. 6190-65-4 113 Desisopropyl atrazine CAS No. 1007-28-9 Desisopropyl atrazine mercapturate 115 CAS No. 1007-28-9 Diaminochlorotriazine 117 119 2,4-Dichlorophenoxyacetic acid CAS No. 94-75-7 123 2,4,5-Trichlorophenoxyacetic acid CAS No. 93-76-5 Sulfonyl Urea Herbicides Bensulfuron-methyl 127 CAS No. 83055-99-6 _________________________________________________________________________________________________ ii Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018

4 129 Chlorsulfuron CAS No. 64902-72-3 131 Ethametsulfuron-methyl CAS No. 97780-06-8 Foramsulfuron 133 CAS No. 173159-57-4 135 Halosulfuron CAS No. 135397-30-7 137 Mesosulfuron-methyl CAS No. 208465-21-8 139 Metsulfuron-methyl CAS No. 74223-64-6 Nicosulfuron 141 CAS No. 111991-09-4 143 Oxasulfuron CAS No. 144651-06-9 145 Primisulfuron-methyl CAS No. 86209-51-0 147 Prosulfuron CAS No. 94125-34-5 Rimsulfuron 149 CAS No. 122931-48-0 151 Sulfometuron-methyl CAS No. 74222-97-2 153 Sulfosulfuron CAS No. 141776-32-1 Thifensulfuron-methyl 155 CAS No. 79277-27-3 157 Triasulfuron CAS No. 82097-50-5 159 Triflusulfuron-methyl CAS No. 126535-15-7 Insect Repellent and Metabolites N,N-Diethyl-meta-toluamide (DEET) 161 CAS No. 134-62-3 165 3-(Diethylcarbamoyl) benzoic acid (DCBA) CAS No. 858981-15-4 N,N-Diethyl-3-(hydroxymethyl) benzamide (DHMB) 169 CAS No. 72236-22-7 Carbamate Pesticide Metabolites Carbofuranphenol 173 CAS No. 1563-38-8 175 2-Isopropoxyphenol CAS No. 4812-20-8 Organochlorine Pesticide Metabolites 177 2,4,5-Trichlorophenol CAS No. 95-95-4 2,4,6-Trichlorophenol 179 CAS No. 88-06-2 _________________________________________________________________________________________________ iii Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018

5 Organophosphorus Insecticides: Specific Metabolites 181 Acephate CAS No. 30560-19-1 Dimethoate 183 CAS No. 60-51-5 185 Methamidophos CAS No. 10265-92-6 Omethoate 187 CAS No. 1113-02-6 189 Malathion dicarboxylic acid CAS No. 1190-28-9 191 2-Isopropyl-4-methyl-pyrimidinol CAS No. 2814-20-2 193 para-Nitrophenol CAS No. 100-02-7 195 3,5,6-Trichlor-2-pyridinol CAS No. 6515-38-4 Organophosphorus Insecticides: Dialkyl Phosphate Metabolites Diethylphosphate (DEP) 197 CAS No. 598-02-7 201 Dimethylphosphate (DMP) CAS No. 813-78-5 Diethylthiophosphate (DETP) 205 CAS No. 5871-17-0 Dimethylthiophosphate (DMTP) 209 CAS No. 59401-04-6 Diethyldithiophosphate (DEDTP) 213 CAS No. 298-06-6 217 Dimethyldithiophosphate (DMDTP) CAS No. 756-80-9 Pyrethroid Metabolites trans-3-(2,2-Dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid 221 CAS No. 55701-05-8 225 cis-3-(2,2-Dibromovinyl)-2,2dimethylcyclopropane carboxylic acid 227 4-Fluoro-3-phenoxybenzoic acid CAS No. 77279-89-1 229 3-Phenoxybenzoic acid CAS No. 3739-38-6 Metals and Metalloids 231 Antimony CAS No. 7440-36-0 237 Arsenic, Total CAS No. 7440-38-2 Inorganic-related Arsenic Species 241 245 Arsenic (V) acid 249 Arsenobetaine CAS No. 64436-13-1 Arsenocholine 253 CAS No. 96055-45-7 Arsenous (III) acid 257 CAS No. 13464-58-9 _________________________________________________________________________________________________ iv Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018

6 261 Dimethylarsinic acid CAS No. 917-76-0 265 Monomethylarsonic acid CAS No. 65513-69-1 Trimethylarsine oxide 269 CAS No. 4964-14-1 273 Barium CAS No. 81-25-4 279 Beryllium CAS No. 7440-41-7 Cadmium 283 CAS No. 81271-94-5 292 Cesium CAS No. 7440-46-2 298 Chromium 299 Cobalt Copper 306 CAS No. 7440-50-8 307 Lead CAS No. 7439-92-1 Manganese 316 CAS No. 8075-39-6 319 Mercury CAS No. 92786-62-4 330 Molybdenum CAS No. 7439-98-7 336 Platinum CAS No. 7740-l06-4 340 Selenium CAS No. 7782-49-2 342 Strontium CAS No. 7440-24-6 344 Thallium CAS No. 7440-28-0 Tin 350 CAS No. 7440-31-5 352 Tungsten CAS No. 7440-33-7 358 Uranium CAS No. 7440-61-1 364 Zinc CAS No. 7440-66-6 Perchlorate and Other Anions Nitrate 365 CAS No. 84145-82-4 369 Perchlorate CAS No. 14797-73-0 375 Thiocyanate CAS No. 302-04-5 Perfluoroalkyl and Polyfluoroalkyl Substances: Surfactants Perfluorobutane sulfonic acid (PFBS) 379 CAS No. 375-73-5 _________________________________________________________________________________________________ v Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018

7 383 Perfluorodecanoic acid (PFDA) CAS No. 335-76-2 Perfluorododecanoic acid (PFDoA) 387 CAS No. 307-55-1 391 Perfluoroheptanoic acid (PFHpA) CAS No. 375-85-9 395 Perfluorohexane sulfonic acid (PFHxS) CAS No. 355-46-4 399 Perfluorononanoic acid (PFNA) CAS No. 375-95-1 Perfluorooctanoic acid (PFOA) 403 CAS No. 335-67-1 n-Perfluorooctanoic acid (n-PFOA) 407 Branched Perfluorooctanoic isomers (Sb-PFOA) 409 Perfluorooctane sulfonic acid (PFOS) 411 CAS No. 1763-23-1 n-Perfluorooctane sulfonic acid (n-PFOS) 415 Perfluoromethylheptane sulfonic acid isomers (Sm-PFOS) 417 419 Perfluorooctane sulfonamide (PFOSA or FOSA) CAS No. 754-91-6 423 2-(N-Ethyl-perfluorooctane sulfonamido) acetic acid (EtFOSAA) CAS No. 2991-50-6 2-(N-Methyl-perfluorooctane sulfonamido) acetic acid (MeFOSAA) 427 CAS No. 2355-31-9 431 Perfluoroundecanoic acid (PFUnDA) CAS No. 2058-94-8 Phthalate and Phthalate Alternative Metabolites Mono-benzyl phthalate (MBzP) 435 CAS No. 2528-16-7 441 Mono-3-hydroxybutyl phthalate (MHBP) 443 Mono-n-butyl phthalate (MnBP) CAS No. 131-70-4 Mono-isobutyl phthalate (MiBP) 449 CAS No. 30833-53-5 455 Mono-2-methyl-2-hydroxypropyl phthalate (MHiBP) 457 Mono-cyclohexyl phthalate (MCHP) CAS No. 7517-36-4 Mono-ethyl phthalate (MEP) 461 CAS No. 863029-89-4 467 Mono-2-ethylhexyl phthalate (MEHP) CAS No. 4376-20-9 Mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) 473 CAS No. 40321-99-1 479 Mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) CAS No. 40321-98-0 485 Mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP) CAS No. 40809-41-4 489 Mono-(carboxynonyl) phthalate (MCNP) CAS No. 1373125-93-9 Mono-isononyl phthalate (MiNP) 493 CAS No. 297182-83-3 _________________________________________________________________________________________________ vi Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018

8 499 Mono-(carboxyoctyl) phthalate (MCOP) CAS No. Di-isononyl phthalate (DNP) 503 Mono-methyl phthalate (MMP) CAS No. 4376-18-5 Mono-(3-carboxypropyl) phthalate (MCPP) 509 CAS No. 66851-46-5 515 Mono-n-octyl phthalate (MOP) CAS No. 5393-19-1 519 Cyclohexane-1,2-dicarboxylic acid mono(hydroxy-isononyl ester) (MHNCH) Phytoestrogens and Metabolites Daidzein 521 CAS No. 486-66-8 Enterodiol 525 CAS No. 80226-00-2 529 Enterolactone CAS No. 77756-20-8 Equol 533 CAS No. 531-95-3 537 Genistein CAS No. 446-72-0 O-Desmethylangolensin 541 CAS No. 21255-69-6 Polycyclic Aromatic Hydrocarbon Metabolites 2-Hydroxyfluorene 545 CAS No. 2443-58-5 551 3-Hydroxyfluorene CAS No. 6344-67-8 557 9-Hydroxyfluorene CAS No. 1689-64-1 1-Hydroxyphenanthrene 563 CAS No. 2433-56-9 569 2-Hydroxyphenanthrene CAS No. 605-55-0 3-Hydroxyphenanthrene 575 CAS No. 605-87-8 581 2 + 3-Hydroxyphenanthrene 4-Hydroxyphenanthrene 583 CAS No. 7657-86-7 1-Hydroxypyrene 587 CAS No. 5315-79-7 593 1-Hydroxynaphthalene (1-Naphthol) CAS No. 90-15-3 2-Hydroxynaphthalene (2-Naphthol) 599 CAS No. 135-19-3 Heterocyclic Amines 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) 605 607 2-Amino-3-methyl-9H-pyriodo[2,3-b]indole (MeA-α-C) 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (Ph1P) 609 2-Amino-9H-pyrido[2,3-b]indole (A-α-C) 611 _________________________________________________________________________________________________ vii Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018

9 613 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) 2-Amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P1) 615 2-Aminodipyrido[1,2-a:3',2'-d] imidazole (GLU-P2) 617 619 1-Methyl-9H-pyrido[3,4-]indole (Harman) 1-Methyl-3-amino-5H-pyrido[4,3-b]indole (Trp-P-2) 621 623 9H-Pyrido[3,4-]indole (Norharman) Volatile Organic Compounds (VOCs) 1,1,1-Trichloroethane (Methyl chloroform) 625 CAS No. 71-55-6 1,1,1,2-Tetrachloroethane 627 CAS No. 79-34-5 629 1,1,2,2-Tetrachloroethane CAS No. 79-34-5 631 1,1,2-Trichloroethane CAS No. 79-00-5 1,2,3-Trichloropropane 633 CAS No. 96-18-4 635 1,1-Dichloroethane CAS No. 75-34-3 1,1-Dichloroethene (Vinylidene chloride) 637 CAS No. 75-34-3 1,2-Dibromo-3-chloropropane (DBCP) 639 CAS No. 96-12-8 1,2-Dibromoethane 640 CAS No. 106-93-4 642 1,2-Dichlorobenzene (o-Dichlorobenzene) CAS No. 95-50-1 1,2-Dichloroethane (Ethylene dichloride) 644 CAS No. 107-06-2 646 cis-1,2-Dichloroethene CAS No. 156-59-2 trans-1,2-Dichloroethene 648 CAS No. 156-60-5 650 1,2-Dichloropropane CAS No. 78-87-5 652 1,3-Dichlorobenzene (m-Dichlorobenzene) CAS No. 95-50-1 1,4-Dichlorobenzene (Paradichlorobenzene) 654 CAS No. 106-46-7 656 1,4-Dioxane 658 2,5-Dimethylfuran . ‎ 625-86-5 CAS No Benzene 660 CAS No. 71-43-2 662 Chlorobenzene (Monochlorobenzene) CAS No. 108-90-7 664 Chloroethane Cyclohexane 665 666 Dibromomethane CAS No. 74-95-3 _________________________________________________________________________________________________ viii Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018

10 668 Dichloromethane (Methylene chloride) CAS No. 75-09-2 670 Ethyl acetate 671 Diethylether 672 Ethylbenzene CAS No. 100-41-4 674 Furan CAS No. 110-00-9 676 Heptane Hexachloroethane 677 CAS No. 67-72-1 679 Hexane 681 Isopropylbenzene (Cumene) CAS No. 98-82-8 Methyl-tert-butyl ether (MTBE) 683 CAS No. 1634-04-4 685 Methylcyclopentane 686 Nitrobenzene CAS No. 98-95-3 688 Nitromethane CAS No. 75-52-5 Octane 689 690 Styrene CAS No. 100-42-5 691 Tetrachloroethene (Perchloroethylene) CAS No. 127-18-4 693 Tetrachloromethane (Carbon tetrachloride) CAS No. 56-23-5 695 Tetrahydrofuran 696 Toluene CAS No. 108-88-3 Trichloroethene (Trichloroethylene) 698 CAS No. 79-01-6 ααα-Trifluorotoluene 700 Vinyl bromide 701 m-/p-Xylene 702 CAS No. 108-38-3/106-42-3 704 o-Xylene CAS No. 95-47-6 Volatile Organic Compound (VOC) Metabolites N-Acetyl-S-(2-carboxyethyl)-L-cysteine 706 CAS No. 51868-61-2 710 N-Acetyl-S-(3-hydroxypropyl)-L-cysteine CAS No. 23127-40-4 714 N-Acetyl-S-(2-carbamoylethyl)-L-cysteine CAS No. 81690-92-8 718 N-Acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine N-Acetyl-S-(2-cyanoethyl)-L-cysteine 722 CAS No. 74514-75-3 726 N-Acetyl-S-(2-hydroxyethyl)-L-cysteine CAS No. 15060-26-1 _________________________________________________________________________________________________ ix Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018

11 730 N-Acetyl-S-(phenyl)-L-cysteine CAS No. 4775-80-8 734 N-Acetyl-S-(n-propyl)-L-cysteine 738 N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine CAS No. 144889-50-9 N-Acetyl-S-(1-hydroxymethyl-2-propenyl)-L-cysteine 742 746 N-Acetyl-S-(2-hydroxy-3-butenyl)-L-cysteine CAS No. 159092-64-5 750 N-Acetyl-S-(4-hydroxy-2-butenyl)-L-cysteine CAS No. 159092-65-6 754 2-Thioxothiazolidine-4-carboxylic acid CAS No. 20933-67-9 758 N-Acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine CAS No. 33164-70-4 2-Aminothiazoline-4-carboxylic acid 762 CAS No. 40283-41-8 766 N-Acetyl-S-(N-methylcarbamoyl)-L-cysteine CAS No. 103974-29-4 Phenylglyoxylic acid 770 CAS No. 611-73-4 774 N-Acetyl-S-(2-hydroxypropyl)-L-cysteine CAS No. 923-43-3 778 N-Acetyl-S-(phenyl-2-hydroxyethyl)-L-cysteine 782 Mandelic acid CAS No. 90-64-2, 611-71-2 (R), 17199-29-0 (S) 786 N-Acetyl-S-(trichlorovinyl)-L-cysteine CAS No. 111348-61-9 790 N-Acetyl-S-(benzyl)-L-cysteine CAS No. 19542-77-9 794 N-Acetyl-S-(1,2-dichlorovinyl)-L-cysteine CAS No. 2148-31-4 798 N-Acetyl-S-(2,2-dichlorovinyl)-L-cysteine CAS No. 126543-43-9 802 N-Acetyl-S-(dimethylphenyl)-L-cysteine 806 2-Methylhippuric acid CAS No. 42013-20-7 810 3- and 4-Methylhippuric acid CAS No. 27115-49-7, 27115-50-0 Appendices 814 Appendix A 818 Appendix C Appendix D 833 Volume Two Special Analysis of Pooled Samples for Select Chemicals Special Analysis of Pooled Samples for Select Chemicals 1 _________________________________________________________________________________________________ x Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018

12 Organochlorine Pesticides and Metabolites (Pooled Samples after 2004) Aldrin 3 CAS No. 309-00-2 Dieldrin 5 CAS No. 60-57-1 Endrin 7 CAS No. 72-20-8 Heptachlor epoxide 9 CAS No. 1024-57-3 11 Oxychlordane CAS No. 27304-13-8 19 trans-Nonachlor CAS No. 39765-80-5 27 p,p'-DDT CAS No. 50-29-3 35 p,p'-DDE CAS No. 72-55-9 o,p'-DDT 43 45 Hexachlorobenzene CAS No. 118-74-1 beta-Hexachlorocyclohexane 53 CAS No. 319-85-7 61 gamma-Hexachlorocyclohexane 69 Mirex CAS No. 2385-85-5 Polybrominated Diphenyl Ethers and PBB 153 (Pooled Samples after 2004) 77 2,2',4’-Tribromodiphenyl ether (BDE 17) CAS No. 147217-75-2 81 2,4,4’-Tribromodiphenyl ether (BDE 28) CAS No. 41318-75-6 2,2’,4,4’-Tetrabromodiphenyl ether (BDE 47) 85 CAS No. 5436-43-1 89 2,3',4,4'-Tetrabromodiphenyl ether (BDE 66) CAS No. 189084-61-5 2,2’,3,4,4’-Pentabromodiphenyl ether (BDE 85) 93 CAS No. 182346-21-0 97 2,2’,4,4’,5-Pentabromodiphenyl ether (BDE 99) CAS No. 60328-60-9 101 2,2’,4,4’,6-Pentabromodiphenyl ether (BDE 100) CAS No. 189084-64-8 105 2,2’,4,4’,5,5’-Hexabromodiphenyl ether (BDE 153) CAS No. 68631-49-2 109 2,2’,4,4’,5,6’-Hexabromodiphenyl ether (BDE 154) CAS No. 207122-15-4 2,2’,3,4,4’,5’,6-Heptabromodiphenyl ether (BDE 183) 113 CAS No. 207122-16-5 2,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl ether (BDE 209) 117 CAS No. 1163-19-5 2,2’,4,4’,5,5’-Hexabromobiphenyl (PBB 153) 120 CAS No. 59080-40-9 Polychlorinated Dibenzo-p-dioxins (Pooled Samples after 2004) 1,2,3,4,6,7,8-Heptachlorodibenzo-p-dioxin (HpCDD) 124 _________________________________________________________________________________________________ xi Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018

13 132 1,2,3,4,7,8-Hexachlorodibenzo-p-dioxin (HxCDD) CAS No. 39227-28-6 140 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin (HxCDD) CAS No. 57653-85-7 1,2,3,7,8,9-Hexachlorodibenzo-p-dioxin (HxCDD) 148 CAS No. 19408-74-3 156 1,2,3,4,6,7,8,9-Octachlorodibenzo-p-dioxin (OCDD) CAS No. 3268-87-9 1,2,3,7,8-Pentachlorodibenzo-p-dioxin (PeCDD) 164 CAS No. 40321-76-4 172 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) CAS No. 1746-01-6 Polychlorinated Dibenzofurans (Pooled Samples after 2004) 180 1,2,3,4,6,7,8-Heptachlorodibenzofuran (HpCDF) CAS No. 67562-39-4 188 1,2,3,4,7,8,9-Heptachlorodibenzofuran (HpCDF) CAS No. 55673-89-7 1,2,3,4,7,8-Hexachlorodibenzofuran (HxCDF) 196 CAS No. 70648-26-9 204 1,2,3,6,7,8-Hexachlorodibenzofuran (HxCDF) CAS No. 57117-44-9 212 1,2,3,7,8,9-Hexachlorodibenzofuran (HxCDF) CAS No. 72918-21-9 2,3,4,6,7,8-Hexachlorodibenzofuran (HxCDF) 220 CAS No. 60851-34-5 228 1,2,3,4,6,7,8,9-Octachlorodibenzofuran (OCDF) CAS No. 39001-02-0 1,2,3,7,8-Pentachlorodibenzofuran (PeCDF) 236 CAS No. 57117-41-6 244 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) CAS No. 57117-31-4 252 2,3,7,8-Tetrachlorodibenzofuran (TCDF) CAS No. 51207-31-9 Dioxin-like Polychlorinated Biphenyls: coplanar PCBs (Pooled Samples after 2004) 260 3,4,4',5-Tetrachlorobiphenyl (PCB 81) CAS No. 70362-50-4 268 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) CAS No. 57465-28-8 3,3',4,4',5,5'-Hexachlorobiphenyl (PCB 169) 276 CAS No. 32774-16-6 Dioxin-like Polychlorinated Biphenyls: mono-ortho-substituted PCBs (Pooled Samples after 2004) 284 2,3,3',4,4'-Pentachlorobiphenyl (PCB 105) CAS No. 32598-14-4 2,3,3',4,4'-Pentachlorobiphenyl (PCB 114) 292 CAS No. 74472-37-0 2,3',4,4',5-Pentachlorobiphenyl (PCB 118) 298 CAS No. 31508-00-6 2',3,4,4',5-Pentachlorobiphenyl (PCB 123) 306 CAS No. 65510-44-3 310 2,3,3',4,4',5-Hexachlorobiphenyl (PCB 156) CAS No. 38380-08-4 _________________________________________________________________________________________________ xii Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018

14 318 2,3,3',4,4',5'-Hexachlorobiphenyl (PCB 157) CAS No. 69782-90-7 326 2,3',4,4',5,5'-Hexachlorobiphenyl (PCB 167) CAS No. 52663-72-6 334 2,3,3’,4,4’,5,5’-Heptachlorobiphenyl (PCB 189) CAS No. 39635-31-9 Polychlorinated Biphenyls: Non-Dioxin-Like (Pooled Samples after 2004) 342 2,4,4'-Trichlorobiphenyl (PCB 28) CAS No. 7012-37-5 350 2,2'3,5'-Tetrachloro biphenyl (PCB 44) CAS No. 41464-39-5 2,2',4,5'-Tetrachloro biphenyl (PCB 49) 356 CAS No. 41464-40-8 2,2',5,5'-Tetrachlorobiphenyl (PCB 52) 362 CAS No. 35693-99-3 368 2,3',4,4'-Tetrachlorobiphenyl (PCB 66) CAS No. 33025-41-1 2,4,4',5-Tetrachlorobiphenyl (PCB 74) 376 CAS No. 32690-93-0 384 2,2',3,4,5'-Pentachlorobiphenyl (PCB 87) CAS No. 41464-51-1 2,2',4,4',5-Pentachlorobiphenyl (PCB 99) 390 CAS No. 38380-02-8 398 2,2',4,5,5'-Pentachlorobiphenyl (PCB 101) CAS No. 37680-73-2 404 2,3,3’,4’,6-Pentachlorobiphenyl (PCB 110) CAS No. 74472-35-8 410 2,2',3,3',4,4'-Hexachlorobiphenyl (PCB 128) CAS No. 38380-07-3 2,2',3,4,4',5' and 2,3,3’,4,4’,6-Hexachlorobiphenyl (PCB 138 & 158) 416 CAS No. 52712-04-6 and 74472-42-7 2,2',3,4',5,5'-Hexachlorobiphenyl (PCB 146) 424 CAS No. 51908-16-8 432 2,2’,3,4’,5’,6-Hexachlorobiphenyl (PCB 149) CAS No. 38380-04-0 438 2,2’,3,5,5’,6-Hexachlorobiphenyl (PCB 151) CAS No. 52663-63-5 444 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) CAS No. 35065-27-1 452 2,2',3,3',4,4',5-Heptachlorobiphenyl (PCB 170) CAS No. 35065-30-6 460 2,2',3,3',4,5,5'-Heptachlorobiphenyl (PCB 172) CAS No. 52663-74-8 2,2',3,3',4,5',6'-Heptachlorobiphenyl (PCB 177) 466 CAS No. 40186-70-7 472 2,2',3,3',5,5',6-Heptachlorobiphenyl (PCB 178) CAS No. 52663-67-9 480 2,2',3,4,4',5,5'-Heptachlorobiphenyl (PCB 180) CAS No. 35065-29-3 2,2',3,4,4',5',6-Heptachlorobiphenyl (PCB 183) 488 CAS No. 52663-69-1 496 2,2',3,4',5,5',6-Heptachlorobiphenyl (PCB 187) CAS No. 52663-68-0 _________________________________________________________________________________________________ xiii Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018

15 504 2,2’,3,3’,4,4’,5,5’-Octachlorobiphenyl (PCB 194) CAS No. 35694-08-7 512 2,2’,3,3’,4,4’,5,6-Octachlorobiphenyl (PCB 195) CAS No. 52663-78-2 2,2’,3,3’,4,4’,5,6’ and 2,2’,3,4,4’,5,5’,6-Octachlorobiphenyl (PCB 196 & 203) 518 CAS No. 42740-50-1 and 52663-76-0 526 2,2’,3,3’,4,5,5’,6-Octachlorobiphenyl (PCB 199) CAS No. 52663-73-7 2,2’,3,3’,4,4’,5,5’,6-Nonachlorobiphenyl (PCB 206) 534 CAS No. 40186-72-9 542 2,2',3,3',4,4',5,5',6,6'-Decachlorobiphenyl (PCB 209) CAS No. 2051-24-3 Exposure to Chemicals Found in Cigarette Smoke in U.S. Adults Exposure to Chemicals Found in Cigarette Smoke in U.S. Adults: Analysis of Select Chemicals in a Special Sample 549 Metals and Metalloids (Special Sample: Adult Smokers & Nonsmokers) 550 Antimony CAS No. 7440-36-0 552 Arsenic, Total CAS No. 7440-38-2 554 Arsenic (V) acid 556 Arsenobetaine CAS No. 64436-13-1 Arsenocholine 558 CAS No. 96055-45-7 Arsenous (III) acid 560 CAS No. 13464-58-9 562 Dimethylarsinic acid CAS No. 917-76-0 564 Monomethylarsonic acid CAS No. 65513-69-1 Trimethylarsine oxide 566 CAS No. 4964-14-1 568 Barium CAS No. 81-25-4 Cadmium 570 CAS No. 81271-94-5 572 Cesium CAS No. 7440-46-2 574 Cobalt CAS No. 7440-48-4 576 Lead CAS No. 7439-92-1 578 Manganese CAS No. 8075-39-6 Molybdenum 580 CAS No. 7439-98-7 582 Strontium CAS No. 7440-24-6 584 Thallium CAS No. 7440-28-0 586 Tin CAS No. 7440-31-5 _________________________________________________________________________________________________ xiv Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018

16 588 Tungsten CAS No. 7440-33-7 590 Uranium CAS No. 7440-61-1 Perchlorate and Other Anions (Special Sample: Adult Smokers & Nonsmokers) Nitrate 592 CAS No. 84145-82-4 Perchlorate 594 CAS No. 14797-73-0 Thiocyanate 596 CAS No. 302-04-5 Polycyclic Aromatic Hydrocarbon Metabolites (Adult Cigarette Smokers & Nonsmokers: Special Sample) 598 2-Hydroxyfluorene CAS No. 2443-58-5 600 3-Hydroxyfluorene CAS No. 6344-67-8 9-Hydroxyfluorene 602 CAS No. 1689-64-1 1-Hydroxyphenanthrene 604 CAS No. 2433-56-9 2-Hydroxyphenanthrene 606 CAS No. 605-55-0 3-Hydroxyphenanthrene 608 CAS No. 605-87-8 610 4-Hydroxyphenanthrene CAS No. 7657-86-7 612 1-Hydroxypyrene CAS No. 5315-79-7 614 1-Hydroxynaphthalene (1-Naphthol) CAS No. 90-15-3 2-Hydroxynaphthalene (2-Naphthol) 616 CAS No. 135-19-3 Heterocyclic Amines 618 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) 620 2-Amino-3-methyl-9H-pyriodo[2,3-b]indole (MeA-α-C) 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (Ph1P) 622 624 2-Amino-9H-pyrido[2,3-b]indole (A-α-C) 626 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) 2-Amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P1) 628 2-Aminodipyrido[1,2-a:3',2'-d] imidazole (GLU-P2) Harman 630 632 1-Methyl-3-amino-5H-pyrido[4,3-b]indole (Trp-P-2) Norharman 634 Volatile Organic Compounds (VOC) 638 1,1,1-Trichloroethane (Methyl chloroform) CAS No. 71-55-6 639 1,1,1,2-Tetrachloroethane CAS No. 79-34-5 1,2,3-Trichloropropane 640 CAS No. 96-18-4 _________________________________________________________________________________________________ xv Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018

17 641 1,2-Dibromoethane CAS No. 106-93-4 642 1,2-Dichlorobenzene (o-Dichlorobenzene) CAS No. 95-50-1 1,2-Dichloroethane (Ethylene dichloride) 643 CAS No. 107-06-2 644 1,3-Dichlorobenzene (m-Dichlorobenzene) CAS No. 95-50-1 645 1,4-Dichlorobenzene (Paradichlorobenzene) CAS No. 106-46-7 646 1,4-Dioxane 647 2,5-Dimethylfuran CAS No . ‎ 625-86-5 648 Benzene CAS No. 71-43-2 Bromodichloromethane 649 Chlorobenzene (Monochlorobenzene) 650 CAS No. 108-90-7 651 Chloroethane Cyclohexane 652 Dibromochloromethane 653 654 Dichloromethane (Methylene chloride) CAS No. 75-09-2 655 Diethylether 656 Ethyl acetate 657 Ethylbenzene CAS No. 100-41-4 658 Furan CAS No. 110-00-9 659 Heptane 660 Hexane 661 Isopropylbenzene (Cumene) CAS No. 98-82-8 Methyl-tert-butyl ether (MTBE) 662 CAS No. 1634-04-4 663 Methylcyclopentane 664 Nitrobenzene CAS No. 98-95-3 665 Octane 666 Tetrachloroethene (Perchloroethylene) CAS No. 127-18-4 Tetrachloromethane (Carbon tetrachloride) 667 CAS No. 56-23-5 668 Tetrahydrofuran 669 Toluene CAS No. 108-88-3 670 Tribromomethane (Bromoform) Trichloroethene (Trichloroethylene) 671 CAS No. 79-01-6 Trichloromethane (Chloroform) 672 _________________________________________________________________________________________________ xvi Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018

18 ααα-Trifluorotoluene 673 Vinyl bromide 674 675 m-/p-Xylene CAS No. 108-38-3/106-42-3 676 o-Xylene CAS No. 95-47-6 Volatile Organic Compound (VOC) Metabolites (Special Sample: Adult Smokers & Nonsmokers) 677 N-Acetyl-S-(2-carboxyethyl)-L-cysteine CAS No. 51868-61-2 679 N-Acetyl-S-(3-hydroxypropyl)-L-cysteine CAS No. 23127-40-4 N-Acetyl-S-(2-carbamoylethyl)-L-cysteine 681 CAS No. 81690-92-8 683 N-Acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine 685 N-Acetyl-S-(2-cyanoethyl)-L-cysteine CAS No. 74514-75-3 N-Acetyl-S-(2-hydroxyethyl)-L-cysteine 687 CAS No. 15060-26-1 689 N-Acetyl-S-(phenyl)-L-cysteine CAS No. 4775-80-8 N-Acetyl-S-(n-propyl)-L-cysteine 691 N-Acetyl-S-(3,4-dihydroxybutyl)-L-cysteine 693 CAS No. 144889-50-9 695 N-Acetyl-S-(1-hydroxymethyl-2-propenyl)-L-cysteine 697 N-Acetyl-S-(2-hydroxy-3-butenyl)-L-cysteine CAS No. 159092-64-5 N-Acetyl-S-(4-hydroxy-2-butenyl)-L-cysteine 699 CAS No. 159092-65-6 701 2-Thioxothiazolidine-4 carboxylic acid CAS No. 20933-67-9 N-Acetyl-S-(3-hydroxypropyl-1-methyl)-L-cysteine 703 CAS No. 33164-70-4 705 2-Aminothiazoline-4-carboxylic acid CAS No. 40283-41-8 707 N-Acetyl-S-(N-methylcarbamoyl)-L-cysteine CAS No. 103974-29-4 Phenylglyoxylic acid 709 CAS No. 611-73-4 711 N-Acetyl-S-(2-hydroxypropyl)-L-cysteine CAS No. 923-43-3 N-Acetyl-S-(phenyl-2-hydroxyethyl)-L-cysteine 713 Mandelic acid 715 CAS No. 90-64-2, 611-71-2 (R), 17199-29-0 (S) 717 N-Acetyl-S-(trichlorovinyl)-L-cysteine CAS No. 111348-61-9 719 N-Acetyl-S-(benzyl)-L-cysteine CAS No. 19542-77-9 N-Acetyl-S-(1,2-dichlorovinyl)-L-cysteine 721 CAS No. 2148-31-4 723 N-Acetyl-S-(2,2-dichlorovinyl)-L-cysteine CAS No. 126543-43-9 _________________________________________________________________________________________________ xvii Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018

19 725 N-Acetyl-S-(dimethylphenyl)-L-cysteine 727 2-Methylhippuric acid CAS No. 42013-20-7 729 3- & 4-Methylhippuric acid CAS No. 27115-49-7, 27115-50-0 Appendices Appendix A 731 Appendix C 735 750 Appendix D _________________________________________________________________________________________________ xviii Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018

20 Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, 2018 March The Fourth Report on Human Exposure to Environmental Chemicals, Updated Tables, March (the presents nationally representative, cumulative 2018) 2018 Updated Tables, March biomonitoring data gathered from 1999– 2000 through 2015-2016. It includes all the data from each of the previous National Reports on Human Exposure to Environmental Chemicals and Updated Tables (collectively, the Report each of the previous Updated Tables ). and In each survey period, the reported chemicals or their metabolites were measured in blood, serum, and urine samples from random subsamples of the National Health and Nutrition Survey (NHANES). These subsamples typically consisted of about 2,500 participants – exact numbers are included in the tables. Survey data and samples are collected by the Centers for Disease Control and Prevention (CDC’s) National Center for Health Statistics. CDC’s Environmental Health Laboratory (Division of Laboratory Sciences (DLS), National Center for Environmental Health) used mass spectrometry methods to obtain the blood, serum, and urine exposure measurements presented in the and Updated Tables . Report The data tables for most chemicals from the1999-2000 to 2009-2010 survey periods are located in one table. A second table includes data from the 2011-2012 survey period. For example, blood lead data for 1999 -2010 are shown in one table, followed by a second table showing -2014. Of note, not all chemicals have data for all survey cycles. Most blood lead data for 2011 of the table titles include the survey periods for which data are displayed in that table. For chemicals measured in pooled samples after 2003-2004, the first tables for a chemical presents results measured prior to 2005 in individual samples. The second table gives results for the pooled measurements. The term environmental chemical refers to a chemical compound or chemical element present in air, water, food, soil, dust, or other environmental media (e.g., consumer products). Biomonitoring is the assessment of human exposure to chemicals by measuring the chemicals or their metabolites in human specimens such as blood or urine. A metabolite is a chemical alteration of the original compound produced by body tissues. Blood, serum, and urine levels reflect the amount of the chemical that actually gets into the body by all routes of exposure, including ingestion, inhalation, and dermal absorption. The measurement of an environmental chemical in a person’s blood or urine is a measure of exposure; it does not by itself mean that the chemical causes disease or an adverse effect. Research studies, separate from these data, are required to determine which blood or urine levels are safe and which are associated with disease or an adverse effect. For blood, serum, and urine levels, the and Updated Tables provide geometric means Report and percentiles of environmental chemicals by age group, gender and race/ethnicity. More in- depth statistical analysis, including multivariate analysis incorporating health endpoints and other predictive variables, is beyond the scope of this document. We encourage scientists to examine the data further through analysis of the raw data available at . http://www.cdc.gov/nchs/nhanes.htm _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 1

21 Recently, the Updated Tables expanded into two volumes: Volume One • provides data on the general U.S. population. It includes recently released 2008, 2009– 2014, and 2006, 2007– 2010, 2011-2012, 2013– data from NHANES 2005– 2015-2016. Volume One also includes updated introductory sections from the Fourth Report on Human Exposure to Environmental Chemicals, 2009. These sections are the and Data Sources and Data Analysis, Interpretation of Data, and Report Updated Tables Chemical and Toxicological Information. • Volume Two provides data for chemicals measured in pooled samples. Some of these chemicals were previously measured in individual samples. This volume includes recently released data from NHANES 2009– 2010. Volume Two also provides data for the special sample of adult cigarette smokers and nonsmokers, including recently released data from NHANES 2013– 2014. Of note, the age for eligibility in the special 2012 to 18 years and sample decreased from 20 years and older in NHANES 2011– older in NHANES 2013 –2014 (NHANES lowered the age for asking the smoking questions in 2013). Updated Tables, March 2018 The data for 346 chemicals, of which 38 are new and provides 176 have data updated since the Updated Tables, January 2017 . Many of the data tables include a link at the bottom to a biomonitoring summary that has information about a specific chemical or chemical group. Several listings also have a link to a factsheet about the chemical or chemical group. Two appendices are updated to include information pertinent to these Updated Tables (Appendix C. Limit of chemicals and the other chemicals included in the Detection Table; Appendix D. References for Biomonitoring Methods ). On the Report website, “Chemicals in the Fourth Report and Updated Tables” is a complete list of the chemicals in Updated Tables March 2018. The Updated Tables, March 2018 provides data updated for 203 chemicals since the publication of the with new data for 135 Fourth Report chemicals. website is the best The National Report on Human Exposure to Environmental Chemicals resource for updates of available data. The Fourth National Report on Human Exposure to , can also be downloaded from this website. Environmental Chemicals, 2009 Public Health Uses of the Report and Updated Tables is to provide specific information to all purpose of the Report and Updated Tables The over scientists, physicians, and health officials to help prevent exposure to environmental chemicals. Report and Updated Tables Some public health uses of the exposure information in the include the following: • To determine which chemicals are getting into U.S. residents and at what concentrations. • To determine the prevalence of people with levels of chemicals above known toxicity levels (e.g., blood lead level greater than or equal to a specific concentration). To determine the prevalence of people with levels of chemicals that put them at • increased risk for toxicity. • To establish reference ranges that physicians and scientists can use to determine whether a person or group has an unusually high exposure. (This information is especially helpful to identify population groups that merit further assessment of exposure sources or health effects.) _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 2

22 • To assess the effectiveness of public health efforts to reduce exposure of U.S. residents to specific chemicals. • To determine whether exposure levels are higher among potentially vulnerable groups, such as minorities and children. • To track trends in levels of exposure of the population. • To set priorities for research on human health effects. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 3

23 What’s New and Different? The include chemicals that have results available from the Updated Tables, March 2018, NHANES survey periods 1999-2000 through 2015-2016. New chemicals measured for the first F (BPF), bisphenol S (BPS), nine urinary time include serum hydroxycotinine, urinary bisphenol flame retardant metabolites, blood cobalt and chromium, and two phthalate urinary metabolites -2-hydroxypropyl phthalate). Serum per - (mono-3-hydroxybutyl phthalate and mono-2-methyl and polyfluoroalkyl substances (PFAS) were measured in a special sample of children ages 3 to 11 years in NHANES 2013-2014 to provide data for younger children who are not included in the regular NHANES sample for the PFAS chemicals. Ten blood VOCs were measured for the NES 2013 -2014: chloroethane; cyclohexane; diethylether; ethyl acetate; first time in NHA heptane; methylcyclopentane; octane; tetrahydrofuran; ααα-trifluorotoluene; and vinyl bromide. Also in NHANES 2013-2014, 10 urinary heterocyclic aromatic amines were measured in the U.S . general population and in the special sample of adult cigarette smokers and nonsmokers. Chemicals with updated data in this release are • serum cotinine; • blood cadmium, lead, manganese, total mercury, and selenium; • urinary DEET metabolites; • urinary phthalate metabolites; • urinary polycyclic aromatic hydrocarbon (PAH) metabolites ; • blood VOCs, including disinfection by -products; • urinary VOC metabolites; serum PBDEs and PBB 153 (pooled); • serum organochlorine pesticides and metabolites (pooled); • • serum PCBs and mono-ortho-substituted PCBs (pooled); • serum polychlorinated dibenzo-p-dioxins (pooled); • serum polychlorinated dibenzofurans (pooled); • serum dioxin-like polychlorinated biphenyls: coplanar PCBs (pooled). Updated Tables in Two Volumes Continuing with thi Updated Tables to two volumes, each as a s release, we have expanded the separate PDF. This change was made because the file size of the single PDF had become so large that it could not easily be shared or sent as an attachment. Volume One contains data tables for most of the chemicals measured in the U.S. general population. Volume Two contains data tables for the persistent organic pollutants and pesticides previously measured in individual samples and are currently measured in pooled samples. Volume Two also contains data tables for the special sample of adult cigarette smokers and nonsmokers, including recently released data from NHANES 2013-2014. We anticipate that future Updated Tables will continue to be presented in two volumes. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 4

24 PFOS and PFOA HANES 2013-2 014 Results for N and branched isomers FOA Starting in 2013, we began measuring linear of both PFOS and P and no longer m easuring total P FOS or P FOA . The isomers of each chemical represent more hat was previously reported as P FOS and PFOA. PFOS a than 95% of w ere nd PFOA w calculated b y s umming the linear an d branched isomers for eac h participant before applying the appropri ate sample weight. Becaus e the 2013-2 014 values are a calculated sum, there is no limit of detection (LOD) for PFOS and PFOA. Data tables for each of the four isomers also are presented. and PFOA as the Sum of the Isomers for more details. See Calculation of PFOS The calculated PFOS and PFOA results can be used to compare with previous measurements and to examine trends in the general U.S. population. The “What’s N ew and Different” s ections i n previous releases of Updated Tables is available in . the Archives from Updated Tables at: http://www.cdc.gov/exposurereport/ _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 5

25 Data Sources and Data Analysis Blood, serum, and urine samples from NHANES National Report on Human Exposure to Environmental Biomonitoring measurements for CDC’s Updated Tables (referred to as the Report and Updated Tables Chemicals and , respectively) are made using samples from participants in the National Health and Nutrition Examination Survey (NHANES), conducted by CDC’s National Center for Health Statistics (NCHS). NHANES is designed to collect data on the health and nutritional status of the U.S. population. NHANES collects information about a wide range of health-related behaviors, performs physical examinations, and collects clinical samples for laboratory tests. Beginning in 1999, NHANES became a continuous survey, sampling the U.S. population annually and releasing the data in 2- -cluster year cycles. The sampling plan follows a complex, stratified, multistage, probability design to select a representative sample of the civilian, noninstitutionalized population in the United States based on age, gender, and race/ethnicity. The NHANES protocol includes a home interview, followed by a standardized physical examination in a mobile examination center. As part of the examination, blood is obtained by venipuncture from participants aged 1 year and older, and urine specimens are collected from participants aged 6 years and older. Starting with the 2015– 2016 survey, urine specimens were collected from children ages 3– 5 years. Additional detailed information on the design and . conduct of the NHANES survey is available at http://www.cdc.gov/nchs/nhanes.htm NHANES measures environmental chemicals in blood, serum, or urine specimens. Most of the environmental chemicals are measured in randomly selected subsamples within specific age groups. Randomization of subsample selection is built into the NHANES design before sample collection begins. Different random subsamples include different participants. Subsampling is needed to ensure an adequate quantity of sample for analysis and the mass spectrometry analytical methods. • Data tables in the and Updated Tables specify age groups and sample sizes for Report each exposure measurement. • Blood measurements in children younger than 12 years are limited by the amount of blood that can be collected. Blood metals are measured in participants aged 1 year and older. • Beginning in 2011, the blood mercury species methyl mercury and ethyl mercury were • . added • Serum cotinine and hemoglobin adducts of acrylamide and glycidamide are measured in the entire NHANES sample for participants ages 3 years and older. • Cotinine data are shown only in nonsmokers in the Report and Updated Tables . • Most measurements of chemicals in serum are made in samples from participant ages 12 years and older. • Urine was collected from participants ages 6 years and older until 2015, when it became possible to collect urine from children as young as 3 years. • Mos t urine chemicals are measured in a representative one-third subsample, but a full sample is used for participants ages 3– 5 years. If a particular chemical or an entire chemical group has no detectable results for three survey periods, it is usually not measured in subsequent survey periods. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 6

26 • The sulfonyl urea herbicide group was measured in NHANES 2003– 2006, 2004, 2005– 2008 with no detections, even at the 95th percentile, so this group is no and 2007– longer measured in the ongoing survey. n • -octyl phthalate (MOP), a phthalate urinary metabolite, was not detected above Mono- the 95th percentile for more than three survey cycles, so it was no longer reported after 2010. • Several banned organophosphate and organochlorine pesticides have become largely undetectable and are no longer measured. Some chemicals are widely detected but have had unchanging levels in the population • (e.g., phytoestrogens) and are no longer measured. - By discontinuing measurements of chemicals that are rarely or not detectable, or well characterized chemicals for which the source of exposure is consistent, CDC’s Environmental Health Laboratory can better allocate and optimize its limited resources. It can use those continue to measure resources to develop methods to measure new chemicals of concern and population exposure to chemicals of concern. Beginning with NHANES 2005– 2006, CDC used a weighted pooled-sample design to measure serum concentrations of dioxins, furans, polychlorinated biphenyls (PCBs), organochlorine pesticides and metabolites, and brominated flame retardants (polybrominated diphenyl ethers and polybrominated biphenyl [PBB] 153). Pooled samples are used when larger sample volumes are needed to improve the sensitivity of the measurements and to reduce the number of samples being analyzed, balancing the cost of the analysis against a low frequency of detectable results. The following considerations guided the selection of chemicals in the Report and Updated Tables : Scientific data suggested exposure in the U.S. popul • ation. • Health effects known or suspected to result from some levels of exposure were serious enough to cause concern. • Data were needed to assess the effectiveness of public health actions to reduce exposure to a chemical. Biomonitoring analytical methods could provide results with adequate accuracy, • precision, sensitivity, specificity, and throughput. • Adequate blood or urine samples were available. • Incremental analytical costs to perform the biomonitoring analysis for the chemical were reasonable. The availability of biomonitoring methods with adequate performance and acceptable cost was a major consideration. Details on the prioritization process for scoring nominated chemicals and the resulting scores are available at: . https://www.cdc.gov/exposurereport/chemical_selection.html Laboratory Analysis CDC’s Environmental Health Laboratory (Division of Laboratory Sciences, National Center for Environmental Health) made the blood, serum, and urine exposure measurements in the Report and Updated Tables . The following analytical techniques were used for measuring the environmental chemicals or their metabolites in blood, serum, and urine: _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 7

27 • Isotope dilution mass spectrometry Inductively coupled plasma mass spectrometry • • Graphite furnace atomic absorption spectrometry Laboratory measurements underwent extensive quality control and quality assurance review: • Tolerance limits for operational parameters were maintained. Quality control samples were measured in each analytical run to detect unacceptable • performance in accuracy or precision. • Traceable calibration materials were verified. Appendix D lists references for the analytical methods used to measure the different chemicals. Data Analysis NHANES is a complex, stratified, multistage, probability -cluster design survey. Because of that, sample weights must be used to adjust for the unequal probability of selection into the survey. Sample weights also are used to adjust for possible bias resulting from nonresponse and are post-stratified to U.S. Census Bureau estimates of the U.S. population. Data were analyzed using Statistical Analysis System (SAS) (SAS Institute Inc., 2002) and the SUDAAN (RTI International, NC) statistical software packages. SUDAAN uses sample weights and calculates variance estimates that account for the complex survey design. The design does not permit straightforward analysis of exposure levels by non-targeted strata such as locality, state, or region; seasons of the year; proximity to sources of exposure; or by use of particular products. NCHS g uidelines for analysis of NHANES data are available at . https://wwwn.cdc.gov/nchs/nhanes/analyticguidelines.aspx The and Updated Tables present descriptive statistics on the blood, serum, or urine Report levels for each environmental chemical reported. Statistics include unadjusted geometric means and percentiles with confidence intervals. In each table, results are given for the total population and by age group, gender, and race/ethnicity, as defined in NHANES. For these analyses, based on the sample design, race/ethnicity is categorized as Mexican American, non- Hispanic black, and non-Hispanic white. Beginning in 2011 –2012, two additional categories were added: all Hispanic and non-Hispanic Asian (referred to as Asian in the tables). Other racial/ethnic groups are sampled, but the proportion of the total U.S. population represented by other racial/ethnic groups is not large enough to produce valid estimates. Other racial/ethnic groups are included in estimates that are based on the entire population sample. Age groups are as described for each chemical in each data table. Gender is coded as male or female. Units For chemicals measured in urine, levels are presented per volume of urine and per gram of creatinine. Urinary levels are expressed both ways in the literature and used for different purposes. Levels per gram of creatinine (i.e., creatinine corrected) adjust for urine dilution. For example, a person who drinks more fluids than another person will likely have a higher, but more dilute, urine output. Interpretation of creatinine-corrected results should also recognize that creatinine correction can partially adjust for differences in lean body mass or renal function among persons. Children and young adolescents typically have less muscle mass than adults. Because muscle is an important source of creatinine in urine, children have lower urinary creatinine concentrations than do adults. The lower urine creatinine concentration can result in higher creatinine-corrected results in children in comparison with adults. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 8

28 For dioxins, furans, PCBs, and organochlorine pesticides, serum levels are presented per gram of total lipid and per whole weight of serum. These compounds are lipophilic and concentrate in the body’s lipid stores, including the lipid in serum. Serum levels reported per gram of total lipid reflect the amount of these compounds stored in body fat. Serum levels per whole weight of serum are also included for easier comparison with studies investigating exposure to these chemicals and reported levels in these units. Other mostly non-lipophilic chemicals measured in serum are expressed per liter of serum (e.g., micrograms per liter). Acrylamide and glycidamide adducts are expressed in picomoles per gram of blood hemoglobin. Results are reported in standard units, generally conforming to those most commonly used in biomonitoring measurements. Table 2 shows some useful unit conversions. Table 2. Units of measurements and abbreviations Abbrev i Unit Value ation iter L l 1 - dL 10 eciliter d liters - 3 illiliter L 10 m liters m ram g g - 3 m g 10 illigram grams m 6 - μ g 10 microgram grams - 9 anogram g 10 grams n n - 12 p g 10 p ic grams ogram 15 - f 10 emtogram f grams g Geometric means A geometric mean gives a better estimate of central tendency for data that are distributed with a long tail at the upper end of the distribution. This type of distribution is common when measuring environmental chemicals in blood or urine. The geometric mean is influenced less by high values than is the arithmetic mean. In the and Updated Tables , geometric means are Report calculated by taking the log of each concentration and then using SUDAAN software to compute the weighted mean of those log-transformed values. Ninety -five percent confidence intervals around the weighted mean are calculated by adding and subtracting an amount equal to the product of a Student’s t -statistic and the standard error of the weighted mean estimate. The degrees of freedom of the -statistic was determined by subtracting the number of strata from t the number of primary sampling units, according to the data available from the complex survey design. The standard error was computed with SUDAAN’s PROC DESCRIPT procedure and “with replacement” design option (design = WR), with Taylor series linearization used for varia nce estimation. The weighted geometric mean and its confidence limits were obtained by taking the antilog of this weighted mean and its upper and lower confidence limits. The measured value for a pooled sample is comparable to an arithmetic average of measurements in individuals. Consequently, the pooled sample result is expected to be higher than the geometric mean of multiple individual results. In addition, direct calculation of the design effects required for accurate standard error and confidence interval estimation is not possible because samples are pooled across the design cells of the original survey. For these reasons, data tables showing the pooled sample results present only weighted arithmetic means and unadjusted standard errors for each category. The standard errors are unadjusted and _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 9

29 therefore, do not reflect the design effects of the survey. In many cases, the standard errors are based on very few pooled sample measurements and cannot be expected to accurately reflect the true imprecision of the weighted arithmetic mean estimates. Therefore, when the unadjusted standard error was more than 30% of the weighted arithmetic mean, this is noted with a double asterisk (**) and footnoted. Limit of detection The limit of detection (LOD) is the level at which the measurement has a 95% probability of , the LODs for each chemical and being greater than zero (Taylor 1987). In the Updated Tables survey period are provided in a footnote to each data table and collectively in Appendix C. Concentrations less than the LOD are assigned a value equal to the LOD divided by the square root of two for calculation of geometric means. Assigning a value of the LOD divided by two made little difference in geometric mean estimates. If the proportion of results below the LOD was greater than 40%, geometric means were not calculated. For the same chemical, LOD values sometimes change over time as a result of improvements to analytical methods. One 2000 possible consequence is that results reported as “< LOD” in the 1999– data might be 2002 or 2003– reported as a concentration value above the LOD in 2001– 2004 because the analytical method had improved. Thus, for proper interpretation of LODs in the data tables, care must be taken to use the LOD that applies to the survey period. Percentile estimates (see below) that are less than the LOD for the chemical analysis were reported as “< LOD.” For most chemicals, the LOD is constant for each specimen analyzed. Dioxins, furans, PCBs, organochlorine pesticides, and a few other pesticides are different: these have an individual LOD for each sample, mostly because the sample volume used for each analysis was different. A higher sample volume results in a lower LOD (i.e., a better ability to detect low levels).The maximum LOD values are given in each data table and in Appendix C. The maximum LOD was the highest LOD among all samples analyzed. Typically, the mean LOD is about 40% –50% of the maximum LOD. The same procedure for imputing values below the LOD in calculations of geometric means was used for chemicals with individual LODs for each sample. Concentrations less than the individual LOD were assigned a value equal to the individual LOD divided by the square root of two. When reporting percentiles for chemicals with individual sample LODs, if any sample LOD in the demographic group was above the percentile estimate, then the percentile estimate was not reported. For chemicals measured in urine, separate tables are presented for the chemical concentration expressed per volume of urine (uncorrected table) and the chemical concentration expressed per gram of creatinine (creatinine corrected table). Geometric mean and percentile calculations were performed separately for each of these concentrations. LOD calculations were performed using the chemical concentration expressed per volume of urine, because this concentration determines the analytical sensitivity. For this reason, LOD results for urine measurements in each data table and in Appendix C are in units of weight per volume of urine. In the creatinine corrected tables, a result for a geometric mean or percentile was reported as < LOD if the corresponding geometric mean or percentile was < LOD in the table using weight per volume of urine. For example, if the 50th percentile for males was < LOD in the table using weight per volume of urine, it would also be < LOD in the creatinine corrected table. For chemicals measured in serum lipid, separate tables are presented for the chemical concentration expressed per volume of serum (lipid unadjusted table) and the chemical concentration expressed per amount of lipid (lipid adjusted table). Geometric mean and percentile calculations were performed separately for each of these concentrations. LOD _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 10

30 calculations were performed using the chemical concentration expressed per amount of lipid, because this concentration determines the analytical sensitivity. For this reason, LOD results for chemicals measured in each data table and in Appendix C are in weight per amount of lipid. In the lipid unadjusted tables, a result for a geometric mean or percentile was reported as < LOD if the corresponding geometric mean or percentile was < LOD in the lipid adjusted table. Percentiles Percentiles (50th, 75th, 90th, and 95th) provide additional information about the shape of the distribution. Percentile estimates and 95% confidence interval estimates that are less than the limit of detection are indicated as

31 Interpretation of Report Updated Tables Data: Important Factors and Research studies, separ ate from the Report and Updated Tables, are required to determine whether blood or urine levels are safe or are associated with disease or adverse effects. The measurement of an environmental chemical in a person’s blood or urine does not mean, by itself, that the chemical causes disease. Advances in analytical methods allow us to measure low levels of environmental chemicals in people, but separate studies of varying exposure levels and health effects are needed to determine whether blood or urine levels result in disease. These studies must also consider other factors such as duration of exposure. The Report and do not present new data on health risks from different exposures. Updated Tables For some environmental chemicals, such as lead, research studies have given us a good understanding of the health risks associated with different blood levels. However, for many environmental chemicals, we need more research to assess health risks from different blood or Report and Updated Tables should help prioritize and urine levels. The results shown in the foster research on human health risks that result from exposure to environmental chemicals. For more information about exposure to environmental chemicals, see the section later in this document titled “Chemical and Toxicological Information”, which includes Internet reference sites. Persistent and non-persistent chemicals; Use of percentiles; Comparison of levels between groups In the Report and Updated Tables , most measurements in urine quantify chemical metabolites of non-persistent chemicals (those that do not stay in the body a long time). Metals and some tobacco biomarkers (e.g., heterocyclic amines) measured in urine are exceptions for they are not metabolites. Persistent chemicals (those that stay in the body for a long time) are usually measured in serum as the parent chemical. th th th , 90 , 95 ) provided for each chemical convey useful information The higher percentiles (75 th percentile is helpful about the upper distribution and range of levels in the population. The 95 when determining whether levels observed in separate public health investigations or other studies are unusual. Levels of chemicals are provided for the demographic groups as stratified by age, gender, and race/ethnicity. Demographic groups may not be equal in their composition with respect to other variables. Chemicals measured in pooled serum samples are stratified by combined demographic groups (e.g., non-Hispanic black females, ages 12-19 years). CDC scientists publish separate scientific papers that make detailed comparisons of levels of chemicals in for a list of peer - different demographic groups. See http://www.cdc.gov/exposurereport/ reviewed biomonitoring papers. Not all the c hemicals in the Report and Updated Tables are measured in the same individuals. Therefore, it is not possible to determine the fraction of all measured chemicals that were found at detectable levels in a given person. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 12

32 Blood, serum, and urine levels of a chemical should not be confused with levels of the chemical in air, water, food, soil, or dust. Concentrations of environmental chemicals in blood or urine are not the same as those in air, water, food, soil, or dust. For example, a chemical concentration of 10 μg/L in water does not produce a level of 10 μg/L in blood or urine. Blood or urine levels may reflect exposure from one or more sources, including air, water, food, soil, and dust. Levels of a chemical in blood, serum, and urine are determined by how much of the chemical has entered the body through all routes of exposure, including ingestion, inhalation, and dermal absorption, and how the chemical is distributed in body tissues, transformed into metabolites, and eliminated from the body. Although the levels in the blood, serum and urine are measures of the amount of a chemical that has entered the body by all routes of exposure, the blood or urine level alone does not determine which exposure source or which route of exposure has occurred. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 13

33 Calculation of Urinary Inorganic -related Arsenic Species We present data for the urinary inorganic -related arsenic species. The values are calculated using results for each NHANES survey period for the following four arsenic species: arsenic (V) acid, arsenous (III) acid, dimethylarsinic acid (DMA), and monomethylarsonic acid (MMA). The sum of the four species is calculated for each individual NHANES participant. If the value of a species is less than the limit of detection (LOD), then the imputed value is used. The imputed value is calculated as the LOD divided by the square root of 2 (Hornung and Reed, 1990) and imputed values are provided in the NHANES public release file. If all four arsenic species are reported as less than the LOD, then the sum will be the sum of the four imputed values. The geometric means, selected percentiles, and confidence intervals are calculated using sums with detectable values of 60 percent or higher. If the detection frequency for a category is less than 60 percent, this is indicated by an asterisk (*). There is no LOD for the inorganic -related arsenic species because the values are calculated, rather than measured. Reference: Hornung RW, Reed LD. 1990. Estimation of average concentration in the presence of nondetectable values. Appl Occup Environ Hyg 5(1):46-51. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 14

34 Calculation of PFOS and PFOA as the Sum of the Isomers Beginning w ith NHANES 2013-2014, we report results for both serum PFOS and PFOA as the sum of their respective isomers. This is because in 2013 we began measuring separately linear and branched isomers of both PFOS and PFOA and no longer measure total PFOS or PFOA. This calculated sum of PFOS (or PFOA) isomers is comparable to the total PFOS (or PFOA) reported before. Production of PFOS and PFOA employed electrochemical fluorination (ECF) or fluorotelomerization. ECF used from the 1950s until the early 2000s yielded branched and linear isomers. In contrast, fluorotelomerization produced almost exclusively linear compounds. Measurement of the two types of isomers may be informative because branched isomers may be eliminated from the body more rapidly than linear isomers (Benskin et al, 2009a). In addition, separate measurements may provide information that is helpful for evaluating exposure source contributions (Benskin et al, 2010, 2009b). The value of PFOS is calculated as the sum of branched PFOS isomers n -PFOS). PFOA (perfluoromethylheptane sulfonate isomers, Sm-PFOS) plus the linear isomer ( n is calculated as the sum of branched PFOA isomers (Sb-PFOA) plus the linear isomer ( - ers is PFOA). For each chemical (PFOS and PFOA), the sum of the branched and linear isom calculated for each individual NHANES participant. If the value for any isomer is below the limit of detection (LOD), then the imputed value is used. The imputed value is calculated as the LOD and imputed values are provided in divided by the square root of 2 (Hornung and Reed, 1990) the NHANES public release file. If both isomers for calculating either PFOS or PFOA are reported as less than the LOD, then two imputed values are summed. These calculated PFOA and PFOS results can be used to compare with previous measurements and examine trends in the U.S. population. The geometric means, selected percentiles, and confidence intervals are calculated using sums with detectable values of 60 percent or higher. If the detection frequency for a category is l ess than 60 percent, this is indicated by an asterisk (*). Beginning with 2013-2014, values for PFOA and PFOS are a calculated sum so there is no limit of detection (LOD) for either of these two chemicals. -PFOS) and PFOA (Sb-PFOA) are a mixture of isomers. The branched isomers of PFOS (Sm The isomers known to be included in Sm-PFOS are perfluoro-3-methylheptane sulfonate, perfluoro-4-methylheptane sulfonate, perfluoro-5-methylheptane sulfonate, and perfluoro-6- be included in Sb-PFOA are perfluoro-3- methylheptane sulfonate. The isomers known to methylheptanoic acid, perfluoro-4-methyheptanoic acid, perfluoro-5-methyheptanoic acid, perfluoro-6-methyheptanoic acid, perfluoro-4,4-dimethylhexanoic acid, perfluoro-5,5 - dimethylhexanoic acid, perfluoro-3,5 -dimethy lhexanoic acid, and perfluoro-4,5-dimethylhexanoic acid. The linear isomers of PFOS ( -PFOS) and PFOA ( n -PFOA) are single chemicals. Data n tables are also presented for each of the four isomers that were measured. References: Benskin JP, Hold A, Martin JW. 2009a. Isomer -specific biotransformation rates of a perfluorooctane sulfonate 9PFOS) precursor by cytochrome P450 isozymes and human liver microsomes. Environ Sci Technol 43:8566-8572. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 15

35 Benskin JP, DeSilver AO, Martin LJ, Arsenault G, McCrindle R, Riddell N, et al. 2009b.Disposition of perfluorinated acid isomers in Sprague-Dawley rats: part 1: single dose. Environ Toxicol Chem 28:542-554. Benskin JP, DeSilver AG, Martin JW. 2010. Isomer profiling of perfluorinated substances as a tool for source tracking: a review of early findings and future applications. Rev Environ Contamin Toxicol 208:111-160. Hornung RW, Reed LD. 1990. Estimation of average concentration in the presence of nondetectable values. Appl Occup Environ Hyg 5(1):46-51. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 16

36 Chemical and Toxicological Information National R The Updated Tables eport on Human Exposure to Environmental Chemicals and Report ) Updated Tables , respectively referred to as the presents biomonitoring data on the ( and exposure of the U.S. population to environmental chemicals. The measurement of an environmental chemical in a person’s blood or urine does not mean, by itself, that the chemical causes disease or adverse effects. Advances in analytical methods allow us to measure lower and lower levels of environmental chemicals in people. Separate studies of varying exposure levels and health effects associated with these levels are required to determine whether blood, serum, and urine levels result in disease or adverse effects. The data and information in the and Updated Tables Report do not establish health effects nor do they create guidelines. Where can I find more information? web links are provided below. Links to For more information about environmental chemicals, nonfederal organizations are provided solely as a service to our readers. These links do not constitute an endorsement of these organizations or their programs by CDC or the federal government. CDC is not responsible for the content of an individual organization’s Web pages found at these links. U.S. Governmental Sources Centers for Disease Control and Prevention (CDC) ) • National Center for Health Statistics (NCHS) (http://www.cdc.gov/nchs • National Health and Nutrition Examination Survey (NHANES) (http://www.cdc.gov/nchs/nhanes.htm ) • National Institute for Occupational Safety and Health (NIOSH) (http://www.cdc.gov/niosh/data/ ) o Registry of Toxic Effects of Chemical Substances (RTECS) (http://www.cdc.gov/niosh/rtecs ) National Center for Environmental Health (NCEH) ( https://www.cdc.gov/nceh/ ) • National Biomonitoring Program ( https://www.cdc.gov/biomonitoring/ ) • Agency for Toxic Substances and Disease Registry (ATSDR) • Toxicological Profiles and ToxFAQs o ToxFAQs https://www.atsdr.cdc.gov/toxfaqs/Index.asp o Toxicological Profiles https://www.atsdr.cdc.gov/ToxProfiles/index.asp • Toxic Substances Portal (http://www.atsdr.cdc.gov/substances/index.asp ) U.S. Food and Dr ug Administration (FDA) • ed Nutrition Center for Food Safety and Appli o https://www.fda.gov/AboutFDA/CentersOffices/OfficeofFoods/CFSAN/default. htm • National Center for Toxicological Research o https://www.fda.gov/AboutFDA/CentersOffices/OC/OfficeofScientificandMedic alPrograms/NCTR/default.htm _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 17

37 U.S. Environmental Protection Agency (EPA) ) Integrated Risk http://www.epa.gov/iris • -Inform ation System (IRIS) ( Office of Chemical Safety and Pollution Prevention (OCSPP) • https://www.epa.gov/aboutepa/about -safety -and -pollution- prevention- -office-chemical ocspp Office of Drinking Water (https://www.epa.gov/ground-water ) • -and-drinking-water U.S. Geol ogical Survey (USGS) (https://www.usgs.gov/ ) U.S. Depar tment of Agriculture (USDA) • Food Safety and Inspection Service https://www.fsis.usda.gov/wps/portal/fsis/home National Ins titutes of Health (NIH) • National Institute for Environmental Health Sciences (NIEHS) ) (http://www.niehs.nih.gov th • National Toxicology Program (NTP) ( ), 14 Report on http://ntp.niehs.nih.gov Carcinogens ( ) https://ntp.niehs.nih.gov/pubhealth/roc/index-1.html • National Library of Medicine (NLM), Toxicology Data Network (http://toxnet.nlm.nih.gov ) • Environmental Health Concerns and National Library of Medicine (NLM), Tox Town ( Toxic Chemicals Where You Live, Work, and Play) ( https://toxtown.nlm.nih.gov/ ) • National Library of Medicine (NLM), Environmental Health and Toxicology, online Toxicology Tutorial https://toxtutor.nlm.nih.gov/index.html Professional and Academic Organizations • Ameri can Conference of Governmental Industrial Hygienists http://www.acgih.org/home Association of Public Health Laboratories ( http://www.aphl.org ) • Pediatric Environmental Health Specialty Units (PEHSUs) ( • ) http://www.PEHSU.net • International Occupational Safety and Health Information Center International Chemical Safety Cards o http://www.ilo.org/safework/info/publications/WCMS_113134/lang-- en/index.htm • The EXtension TOXicology NETwork (EXTOXNET) o Pesticide Information Profiles ( http://extoxnet.orst.edu/pips/ghindex.html ) World Health Organization International P rogramme on Chemical Safety (IPCS) ( http://www.who.int/pcs ) • Monographs of the Joint FAO/WHO Meeting on Pesticide Residues (http://www.inchem.org/pages/jmpr.html ) • Environmental Health Criteria documents (http://www.who.int/ipcs/publications/ehc/en/ ) International A gency for Research on Cancer (IARC) ( www.iarc.fr ) • Monographs on the Evaluation of Carcinogenic Risks to Humans http://monographs.iarc.fr/index.php _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 18

38 Acrylamide (2003 – 2006) om the Geometric mean and selected percentiles of hemoglobin adduct concentrations (in pmol/g hemoglobin) for the U.S. population fr National Health and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 61.2 (58.1 - 64.4) 54.8 (52.8 Total 57.7) 79.1 (73.5 - 85.6) 141 (124 - 155) 192 (168 - 217) 7101 03 - - 06 61.6 (58.1 - 65.4) 54.8 (52.8 - 56.8) 79.1 (75.1 - 86.1) 165 (151 - 178) (204 - 246) 7857 05 221 Age group 5 years - 03 - 04 59.4 (53.6 - 65.7) 58.6 (51.7 - 64.9) 75.7 (63.4 - 83.6) 90.6 (81.9 - 105) 108 (86.2 - 118) 350 3 - - 59.1 (55.8 - 62.6) 63.6 (58.6 - 66.4) 74.4 (73.2 06 76.3) 90.3 (80.8 - 100) 102 (87.3 - 121) 483 05 - 11 years 03 - 04 58.6 (56.1 - 61.2) 57.3 (55.2 - 59.7) 71.0 (67.4 - 76.3) 86.8 (81.2 - 91.4) 98.8 (91.0 - 104) 6 769 - 06 56.1 (53.9 - 58.5) 57.1 (54.8 - 59.9) 67.8 (65.3 - 69.8) 78.8 (74.9 - 86.8) 93.8 (81.1 - 103) 924 05 - 19 years 03 - 04 57.4 (54.4 - 60.5) 54.5 (52.1 - 57.4) 70.7 (65.6 - 75.7) 100 (89.2 - 114) 132 (115 - 151) 1889 12 - - 56.4 (52.5 - 60.6) 53.1 (50.7 - 55.8) 69.5 (66.2 06 73.1) 112 (98.0 - 127) 162 (131 - 221) 1977 05 - 59 years 03 - 04 66.2 (62.2 - 70.6) 57.9 (54.6 - 61.1) 20 (83.6 - 108) 163 (147 - 191) 223 (194 - 243) 2570 96.1 - 06 66.8 (62.1 - 71.9) 56.4 (53.7 - 59.8) 101 (87.1 - 118) 196 (177 - 210) 257 (222 - 298) 3066 05 (57.6 60 years and older - 04 50.1 (47.9 - 52.3) 46.5 (44.0 - 49.2) 61.0 03 - 66.0) 96.1 (88.0 - 108) 141 (120 - 152) 1523 05 - 06 52.5 (49.4 - 55.7) 47.8 (45.0 - 49.6) 65.9 (60.2 - 71.6) 136 (112 - 156) 184 (167 - 198) 1407 Gender 03 04 63.9 (60.2 - 67.9) 57.0 (53.7 - 60.1) 85.5 (79.2 - 93.7) 152 (139 - 175) 220 (189 - 237) 3509 Males - - - 65.7 (61.5 - 70.1) 57.5 (55.1 - 60.4) 91.5 (80.9 06 101) 183 (163 - 208) 246 (213 - 277) 3826 05 03 - 04 58.7 (55.9 - 61.5) 53.4 (51.8 - 55.9) 73.9 (69.5 - 80.6) Females (111 - 142) 164 (147 - 191) 3592 126 - 06 58.1 (54.6 - 61.7) 52.8 (50.9 - 54.7) 73.1 (68.3 - 78.2) 146 (131 - 160) 199 (182 - 211) 4031 05 Race/ethnicity (69.2 - 04 61.7 (58.7 - 64.9) 57.4 (54.4 Mexican Americans 60.4) 73.0 03 - 77.3) 101 (95.0 - 115) 149 (125 - 179) 1792 - 05 - 06 57.2 (54.0 - 60.7) 54.8 (51.4 - 58.2) 70.2 (67.2 - 73.7) 94.0 (86.2 - 104) 130 (110 - 148) 2035 Non 03 - 04 63.8 (57.3 - 71.1) 57.1 (52.1 - 64.1) 86.5 (74.6 - 104) 156 (120 - 203) 218 (172 - 271) 1874 Hispanic blacks - - 06 58.1 (53.5 - 63.2) 54.2 (52.4 - 55.7) 82.3 05 - 95.4) 170 (147 - 189) 226 (198 - 259) 2061 (74.0 Non - Hispanic whites 03 - 04 62.4 (59.0 - 66.0) 55.3 (53.0 - 58.6) 82.2 (75.4 - 89.1) 146 (129 - 163) 197 (172 - 223) 2994 (76.5 06 63.9 (59.8 - 68.3) 55.4 (53.0 - 58.5) 83.8 - - 94.9) 177 (160 - 194) 228 (208 - 258) 3153 05 Limit of detection (LOD, see Data Analysis section) for Survey year 03 - 04 and 05 - 06 are 3.0 and 0.11, respectively. Biomonitoring Summary http://www.cdc.gov/biom onitoring/Acrylamide_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Acrylamide_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 19

39 Glycidamide (2003 – 2006) om the Geometric mean and selected percentiles of hemoglobin adduct concentrations (in pmol/g hemoglobin) for the U.S. population fr National Health and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 59.3 (56.7 - 62.1) 59.9 (57.6 Total 62.5) 85.9 (81.6 - 90.5) 130 (120 - 141) 167 (153 - 181) 7278 03 - - 06 50.4 (46.9 - 54.1) 49.4 (46.5 - 52.4) 71.3 (67.1 - 75.6) 109 (98.4 - 120) (130 - 151) 7740 05 142 Age group 5 years - 03 - 04 71.6 (66.9 - 76.7) 71.1 (66.9 - 78.9) 94.7 (87.3 - 101) 118 (103 - 126) 126 (119 - 135) 411 3 - - 66.7 (61.5 - 72.2) 72.9 (65.9 - 76.3) 89.4 (82.8 06 96.8) 107 (104 - 113) 120 (109 - 129) 482 05 - 11 years 03 - 04 74.1 (70.3 - 78.2) 75.0 (70.9 - 77.9) 95.6 (90.4 - 103) 121 (112 - 134) 141 (126 - 157) 6 784 - 06 58.2 (55.4 - 61.2) 59.6 (57.3 - 61.8) 73.7 (70.0 - 77.5) 90.8 (81.3 - 99.8) 106 (93.8 - 113) 907 05 - 19 years 03 - 04 55.4 (51.1 - 60.1) 59.2 (56.1 - 62.1) 79.2 (72.7 - 86.7) 113 (94.9 - 138) 146 (123 - 169) 1931 12 - - 48.2 (45.1 - 51.6) 47.3 (44.8 - 49.3) 64.1 (60.5 06 67.9) 92.0 (82.8 - 103) 123 (103 - 149) 1944 05 - 59 years 03 - 04 62.5 (59.4 - 65.8) 60.9 (58.7 - 64.4) 20 (84.4 - 98.2) 143 (130 - 159) 187 (169 - 204) 2623 90.7 - 06 52.3 (47.9 - 57.1) 50.1 (46.3 - 54.2) 74.5 (69.5 - 80.9) 121 (107 - 134) 154 (140 - 179) 3025 05 (63.5 60 years and older - 04 45.5 (42.8 - 48.3) 46.8 (44.8 - 49.3) 65.2 03 - 66.9) 96.4 (90.0 - 103) 129 (111 - 141) 1529 05 - 06 40.9 (38.1 - 44.0) 39.5 (37.4 - 42.7) 56.7 (51.1 - 63.8) 88.7 (75.7 - 103) 118 (103 - 133) 1382 Gender 03 04 59.5 (56.9 - 62.3) 59.4 (56.8 - 61.8) 87.1 (82.5 - 92.3) 136 (123 - 148) 174 (157 - 197) 3604 Males - - - 50.8 (46.9 - 55.0) 49.4 (46.1 - 53.2) 74.5 (70.2 06 78.8) 113 (102 - 127) 148 (131 - 165) 3761 05 03 - 04 59.1 (56.0 - 62.5) 60.4 (57.5 - 64.0) 85.0 (80.2 - 90.0) Females (116 - 135) 159 (143 - 175) 3674 125 - 06 50.0 (46.7 - 53.6) 49.2 (46.5 - 52.3) 68.3 (63.9 - 73.2) 101 (93.8 - 114) 136 (125 - 145) 3979 05 Race/ethnicity (81.5 - 04 64.7 (61.2 - 68.4) 65.4 (61.1 Mexican Americans 70.1) 87.4 03 - 94.4) 118 (110 - 129) 152 (135 - 170) 1841 - 05 - 06 50.3 (46.5 - 54.4) 50.7 (46.8 - 54.8) 66.1 (61.6 - 70.5) 86.6 (80.6 - 95.8) 106 (98.1 - 114) 2022 Non 03 - 04 53.8 (51.1 - 56.7) 56.0 (52.4 - 59.7) 83.0 (75.2 - 91.5) 121 (108 - 140) 159 (129 - 204) 1954 Hispanic blacks - - 06 42.3 (38.9 - 46.0) 44.1 (41.7 - 45.9) 64.0 05 - 67.8) 99.9 (87.2 - 109) 129 (117 - 140) 2008 (60.3 Non - Hispanic whites 03 - 04 61.1 (57.6 - 64.9) 60.7 (57.9 - 64.2) 87.5 (83.0 - 93.5) 136 (124 - 149) 172 (157 - 194) 3044 (69.9 06 52.5 (48.5 - 56.9) 50.7 (46.8 - 55.0) 74.5 - - 80.1) 115 (102 - 129) 147 (134 - 160) 3110 05 Limit of detection (LOD, see Data Analysis section) for Survey year 03 - 04 and 05 - 06 are 4.0 and 0.66, respectively. Biomonitoring Summary http://www.cdc.gov/biom onitoring/Acrylamide_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Acrylamide_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 20

40 Serum Cotinine (1999 – 2010) Metabolite of nicotine (component of tobacco smoke) smoking U.S. population from the National Geometric mean and selected percentiles of serum concentrations (in ng/mL) for the ***non - Health and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size 00 * .060 (

41 Serum Cotinine (1999 2010) – Metabolite of nicotine (component of tobacco smoke) smoking U.S. population from the National Geometric mean and selected percentiles of serum concentrations (in ng/mL) for the ***non - Health and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity (.370 - 99 < LOD .140 (.110 - .180) .506 00 - .726) 1.21 (.900 - 1.70) 2241 Mexican Americans * - 02 ** .060 (

42 Serum Cotinine (2011 – 20 14) Metabolite of nicotine (component of tobacco smoke) smoking U.S. population from the National Geometric mean and selected percentiles of serum concentrations (in ng/mL) for the ***non - Health and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 12 * .020 (.018 - .023) .059 (.049 - .072) .356 (.263 - .500) 1.30 (.882 - 1.60) 6108 Total 11 14 * .017 (

43 Serum Hydroxycotinine (2013 – 2014) Metabolite of nicotine (component of tobacco smoke) smoking U.S. population from the National Geometric mean and selected percentiles of serum concentrations (in ng/mL) for the ***non - Health and Nutrition Examination Survey. Sample Survey Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 * < LOD .023 (.018 - .032) .121 (.086 - .232) Total .553 (.425 - .782) 6561 Age group .314 11 years 13 - 14 * < LOD .044 - (.028 - .070) (.161 - .531) .667 (.462 - .984) 1445 3 - 19 years 13 - 14 * < LOD .038 (.020 - .073) 12 .407 (.181 - .662) .848 (.447 - 1.39) 1129 20 years and older 13 - 14 * < LOD .020 (.016 - .025) .088 (.063 - .140) .437 (.260 - .744) 3987 Gender 13 - 14 * < LOD .024 (.018 - .034) .168 (.099 - .286) .673 (.489 - .978) 3063 Males .188) Females - 14 * < LOD .022 (.017 - .030) .095 (.070 - 13 .447 (.308 - .677) 3498 Race/ethnicity Mexican Americans 13 - 14 * < LOD < LOD .058 (.038 - .105) .224 (.118 - .437) 1261 Non - 13 - 14 * .015 (

44 Urinary NNAL (4 - - 1 - (3 - pyridyl) - 1 - butanol) (2007 – 2010) (methylnitrosamino) - (methylnitrosamino) 1 - (3 - pyridyl) - 1 - butanone) (NNK) Metabolite of (4 - smoking U.S. population from the National Geometric mean and selected percentiles of urine concentrations (in pg/mL) for the **non - Health and Nutri tion Examination Survey. Sample Survey 50th Percentile 95th Percentile 75th Percentile Geometric mean 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 07 - 08 * < LOD 2.80 (2.20 - 3.70) 11.1 (8.80 - 14.4) 24.5 (18.0 - 30.4) 5212 Total - * 09 < LOD 1.90 (1.60 - 2.40) 7.30 (6.40 - 8.50) 16.7 (13.9 - 19.6) 6067 10 Age group 11 years 07 - 08 * 1.30 (.600 - 2.60) 6 8.50 (4.70 - 13.8) 31.4 (17.5 - 49.8) 60.6 (37.1 - 75.7) 875 - 09 - 10 * .600 (

45 Urinary NNAL (4 - - 1 - (3 - pyridyl) - 1 - butanol) (2011 – 2012) (methylnitrosamino) - (methylnitrosamino) 1 - (3 - pyridyl) - 1 - butanone) (NNK) Metabolite of (4 - smoking U.S. population Geometric mean and selected percentiles of urine concentrations (in pg/mL) for the **non - from the National Health and Nutrition Examination Survey. Sample Survey 50th Percentile 75th Percentile Geometric mean 90th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 11 12 * .800 (.700 - .900) 2.30 (2.00 - 2.60) 7.40 (6.10 - 8.90) 15.7 (11.7 - 21.0) 5486 Total Age group - 11 years 11 - 12 1.91 (1.57 - 2.32) 1.30 (1.10 - 1.70) 5.10 (3.80 - 7.30) 21.1 (11.5 - 31.9) 36.7 6 - 60.2) 955 (20.1 12 19 years 11 - 12 1.53 (1.35 - 1.73) 1.30 (1.10 - 1.40) 3.10 (2.20 - 4.30) 10.8 (7.60 - 14.4) 19.3 (13.2 - 27.0) 949 - - 12 * .700 (.600 - .900) 2.00 (1.80 - 2.20) 5.70 20 years and older (4.80 - 6.80) 11.7 (10.0 - 14.9) 3582 11 Gender (2.40 - 12 1.32 (1.23 - 1.41) 1.00 (.900 Males 1.10) 2.80 11 - 3.10) 9.80 (7.60 - 11.2) 19.5 (13.5 - 26.4) 2616 - Females 11 - 12 * .700 (.600 - .800) 1.90 (1.70 - 2.20) 5.70 (4.60 - 7.20) 12.4 (9.00 - 18.5) 2870 Race/ethnicity - 12 1.12 (.956 - 1.30) .900 (.700 - 1.20) 1.90 (1.50 - 2.50) 5.30 (3.70 - 7.40) 9.50 (7.70 - 15.0) 775 Mexican Americans 11 - Hispanic blacks 11 - 12 1.98 (1.57 - 2.48) 1.60 (1.30 - 2.10) Non (3.30 - 8.70) 15.9 (9.40 - 28.8) 30.4 (18.5 - 46.7) 1393 5.10 Non Hispanic whites 11 - 12 * .800 (.600 - .900) 2.10 - - 2.40) 6.70 (5.30 - 8.50) 14.4 (11.4 - 20.4) 1679 (1.80 Asians 11 - 12 * .600 (

46 Urinary NNAL (4 - - 1 - (3 - pyridyl) - 1 - butanol) (creat inine corrected) (2007 – 2010) (methylnitrosamino) - (methylnitrosamino) 1 - (3 - pyridyl) - 1 - butanone) (NN K) Metabolite of (4 - smoking U.S. population from Geometric mean and selected percentiles of urine concentrations (in pg/mg of creatinine) for the **non - the National Health and Nutrition Examination Survey. Sample Survey 50th Percentile 95th Percentile 75th Percentile Geometric mean 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 07 - 08 * < LOD 2.79 (2.31 - 3.50) 10.3 (7.36 - 14.0) 20.5 (16.4 - 27.5) 5210 Total - * 09 < LOD 2.05 (1.88 - 2.28) 6.40 (5.71 - 7.41) 14.6 (11.5 - 17.3) 6066 10 Age group 11 years 07 - 08 * 2.15 (1.38 - 3.22) 6 10.7 (5.95 - 17.9) 38.3 (21.2 - 57.1) 60.9 (46.4 - 72.1) 875 - 09 - 10 * 1.19 (

47 U rinary NNAL (4 (methylnitrosamino) - 1 - (3 - pyridyl) - 1 - butanol) (creatinine corrected) (2011 – 2012) - - (methylnitrosamino) 1 - (3 - pyridyl) - 1 - butanone) (NNK) Metabolite of (4 - smoking U.S. population from Geometric mean and selected percentiles of urine concentrations (in pg/mg of creatinine) for the **non - the National Health and Nutrition Examination Survey. Sample Survey 50th Percentile 95th Percentile 75th Percentile Geometric mean 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 11 12 1.06 (1.00 - 1.14) 2.47 (2.14 - 2.72) 6.57 (5.24 - 8.25) 14.3 (11.7 - 18.4) 5483 Total * Age group - 11 years 11 - 12 2.57 (2.13 - 3.10) 1.91 (1.60 - 2.47) 5.93 (4.21 - 8.49) 23.5 (13.7 - 31.6) 39.1 (23.5 6 59.0) 954 - 12 19 years 11 - 12 1.45 (1.31 - 1.60) 1.14 (1.05 - 1.25) 3.40 (2.50 - 3.99) 9.14 (5.71 - 13.4) 18.4 (12.2 - 22.2) 949 - - 12 * 1.00 (.938 - 1.08) 2.12 (1.91 - 2.42) 5.00 20 years and older (4.26 - 6.18) 10.5 (8.56 - 13.0) 3580 11 Gender (2.08 - 12 1.19 (1.10 - 1.29) .984 (.909 Males 1.05) 2.38 11 - 2.68) 7.36 (5.60 - 9.33) 15.2 (11.5 - 21.4) 2615 - Females 11 - 12 * 1.18 (1.04 - 1.30) 2.48 (2.17 - 2.86) 5.67 (4.69 - 8.21) 13.5 (10.3 - 18.0) 2868 Race/ethnicity - 12 1.15 (.985 - 1.35) 1.03 (.860 - 1.22) 1.94 (1.67 - 2.35) 4.72 (3.51 - 6.74) 9.93 (6.46 - 15.9) 775 Mexican Americans 11 - Hispanic blacks 11 - 12 1.50 (1.18 - 1.91) 1.31 (1.02 - 1.63) Non (2.36 - 6.09) 11.5 (6.69 - 19.0) 19.7 (11.5 - 33.7) 1392 3.70 Non Hispanic whites 11 - 12 * 1.04 (.984 - 1.14) 2.47 - - 2.79) 5.94 (5.14 - 7.72) 16.1 (11.5 - 18.9) 1677 (2.06 Asians 11 - 12 * .972 (

48 Blood Bromodichloromethane (2001 – 2008) alth and Geometric mean and selected percentiles of whole blood concentrations (in pg/mL) for the U.S. population from the National He Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 02 2.21 (1.65 - 2.97) 2.30 (1.56 - 3.21) 4.63 (3.24 - 6.20) 8.45 (5.86 - 12.0) 12.0 (7.68 Total 19.2) 785 01 - - 1.50 (1.20 - 1.86) 1.40 (1.10 - 1.90) 3.40 (2.60 - 04 6.20 (5.30 - 7.00) 9.50 (7.00 - 12.0) 1322 03 4.20) - 06 1.41 (1.09 - 1.83) 1.30 (.880 - 1.80) 3.00 (2.10 - 4.40) 6.30 (4.30 - 9.70) (6.80 - 14.0) 3139 05 10.0 07 08 1.52 (1.24 - 1.86) 1.42 (1.05 - 1.90) 3.13 (2.50 - 4.20) 6.42 (4.70 - 8.30) 9.59 (7.05 - 14.6) 2982 - Age group 19 years 05 - 06 1.23 (.954 - 1.58) 1.00 (.620 - 1.60) 2.80 (1.70 - 4.10) 5.50 (4.10 - 7.20) 8.20 (6.20 - 12 932 - 12.0) 07 08 1.49 (1.19 - 1.86) 1.26 (.910 - 1.88) 3.10 (2.42 - 4.05) 6.20 (4.13 - 8.52) 9.02 (6.20 - 15.0) 482 - - 59 years 01 - 02 2.21 (1.65 - 2.97) 2.30 (1.56 - 3.21) 4.63 (3.24 - 6.20) 8.45 (5.86 - 12.0) 12.0 (7.68 - 19.2) 785 20 03 04 1.50 (1.20 - 1.86) 1.40 (1.10 - 1.90) 3.40 (2.60 - 4.20) 6.20 (5.30 - 7.00) 9.50 (7.00 - 12.0) 1322 - 05 - 1.45 (1.11 - 1.89) 1.30 (.900 - 1.90) 3.10 (2.10 - 4.60) 6.40 (4.30 - 10.0) 11.0 (6.90 - 14.0) 1537 06 - 4.43) 1.60 (1.28 - 2.01) 1.56 (1.13 - 2.04) 3.33 (2.61 - 07 6.90 (4.94 - 9.29) 11.0 (7.39 - 15.6) 1607 08 - 06 1.43 (.996 - 2.05) 1.40 (.850 - 2.00) 3.20 (1.60 - 5.90) 6.50 (3.20 - 15.0) 9.70 (5.00 - 18.0) 670 60 years and older 05 07 - 08 1.28 (1.07 - 1.53) 1.20 (.870 - 1.59) 2.60 (1.90 - 3.41) 4.88 (3.67 - 6.50) 7.39 (5.70 - 8.80) 893 Gender - 02 2.19 (1.60 - 3.00) 2.31 (1.63 - 3.21) 4.64 (3.21 - 6.08) 7.96 (5.74 - 15.3) 13.0 (6.93 - 20.5) 382 Males 01 03 - 04 1.48 (1.18 - 1.85) 1.40 (.940 - 2.00) 3.40 - 4.30) 6.60 (5.40 - 7.20) 11.0 (7.20 - 14.0) 650 (2.60 - 06 1.39 (1.07 - 1.80) 1.20 (.830 - 1.70) 3.00 05 - 4.30) 6.50 (4.30 - 10.0) 11.0 (6.80 - 16.0) 1489 (2.00 07 - 08 1.52 (1.24 - 1.87) 1.50 (1.03 - 1.95) 3.23 (2.59 - 4.20) 6.72 (4.80 - 9.02) 11.0 (7.31 - 15.9) 1487 Females - 02 2.24 (1.66 - 3.01) 2.28 (1.49 - 3.24) 4.63 (3.09 - 7.01) 8.62 (5.26 - 12.9) 11.1 (7.68 - 25.0) 403 01 03 - 1.51 (1.21 - 1.90) 1.50 (1.10 - 1.90) 3.30 (2.50 - 4.20) 6.10 (4.69 - 7.30) 7.80 (6.40 - 12.0) 672 04 - (4.20 1.44 (1.10 - 1.88) 1.30 (.900 - 1.90) 3.10 (2.10 - 4.60) 6.20 05 - 9.40) 9.40 (6.30 - 13.0) 1650 06 (4.60 - 1.51 07 (1.22 - 1.87) 1.40 (1.01 - 1.92) 3.03 (2.42 - 4.10) 6.20 08 - 7.82) 8.31 (6.80 - 12.9) 1495 Race/ethnicity 01 - 02 3.28 (2.29 - 4.68) 3.32 (2.19 - 4.70) 6.81 (3.71 - 10.4) 10.8 (8.24 - 14.7) 14.7 (11.1 - 20.5) Mexican Americans 227 - 04 1.65 (1.15 - 2.38) 1.60 (.820 - 2.80) 3.50 (2.60 - 4.90) 7.30 (4.50 - 10.0) 10.0 (7.30 - 11.0) 244 03 - 05 1.95 (1.19 - 3.18) 1.90 (1.00 - 3.70) 4.40 (2.10 06 9.10) 9.10 (4.80 - 17.0) 14.0 (7.50 - 22.0) 771 - 07 - 08 1.61 (1.27 - 2.03) 1.57 (1.08 - 2.20) 3.44 (2.42 - 5.93 (4.70 - 8.15) 8.90 (6.80 - 13.2) 574 4.50) Non Hispanic blacks 01 - 02 2.32 (1.82 - 2.94) 2.50 (1.56 - 3.55) - (3.60 - 5.56) 8.69 (5.63 - 9.49) 10.0 (5.89 - 13.5) 130 4.57 03 - 04 1.56 (1.15 - 2.13) 1.70 (1.10 - 2.20) 2.90 (2.15 - 3.80) 5.10 (3.80 - 6.60) 6.60 (4.90 - 13.0) 290 05 06 1.74 (1.27 - 2.37) 1.70 (1.00 - 2.70) 3.80 (2.70 - 4.80) 6.40 (4.50 - 8.90) 8.70 (6.60 - 11.0) 817 - - 07 1.72 (1.42 - 2.08) 1.70 (1.30 - 2.21) 3.29 (2.80 08 4.01) 5.78 (4.70 - 7.30) 7.49 (6.03 - 9.70) 593 - - Hispanic whites 01 - 02 2.02 (1.42 - 2.87) 2.16 (1.36 - 3.09) 4.34 Non (2.92 - 6.01) 7.33 (4.72 - 15.3) 11.1 (6.01 - 26.1) 365 - 04 1.42 (1.11 - 1.81) 1.30 (.850 - 1.90) 3.30 03 - 4.40) 6.20 (5.20 - 7.20) 9.80 (6.70 - 13.0) 684 (2.30 05 - 06 1.29 (.989 - 1.67) 1.10 (.710 - 1.70) 2.70 (1.80 - 4.10) 5.80 (4.00 - 8.60) 9.40 (6.20 - 14.0) 1318 (2.23 08 1.45 (1.11 - 1.87) 1.32 (.917 - 1.90) 3.03 - - 4.30) 6.50 (4.20 - 9.29) 9.59 (6.30 - 15.3) 1347 07 Limit of detection (LOD, see Data Analysis section) for Survey years 01 - 02, 03 - 04, 05 - 06, and 07 - 08 are 0.233, 0.62, 0.62, and 0.62, respectively. some < LOD means less than the limit of detection, which may vary for chemicals by year and by individual sample. Biomonitoring Summary http://www.cdc.gov/biomonitoring/THM - DBP_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 29

49 Blood Bromodichloromethane (2013 – 2 014) alth and Geometric mean and selected percentiles of whole blood concentrations (in pg/mL) for the U.S. population from the National He Nutrition Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 * < LOD < LOD 7.00 (

50 Blood Dibromochloromethane (Chlorodibromomethane) (2001 – 2008) alth and Geometric mean and selected percentiles of whole blood concentrations (in pg/mL) for the U.S. population from the National He Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 02 .867 (.521 - 1.44) .780 (.340 - 1.90) 2.61 (1.22 - 4.38) 5.46 (3.53 - 9.71) 8.96 (5.04 - 12.9) 781 Total 01 04 * - < LOD 1.30 (1.00 - 1.80) 3.60 (2.70 - 4.80) 7.20 (4.80 - 8.60) 1333 03 (2.40 - * < LOD 1.40 (.870 - 2.40) 4.30 - 7.40) 7.80 (4.60 - 13.0) 3122 05 06 - 08 * .775 (

51 Blood Dibromochloromethane ( Chlorodibromomethane) (2013 2014) – alth and Geometric mean and selected percentiles of whole blood concentrations (in pg/mL) for the U.S. population from the National He Nutrition Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 * < LOD < LOD Total 7.00 (6.00 - 10.0) 3195 < LOD Age group < LOD 19 years 13 - 14 - * < LOD < LOD < LOD 598 12 13 - 14 * < LOD < LOD < LOD 20 years and older 7.00 (6.00 - 10.0) 2597 Gender 14 * < LOD < LOD < LOD - 7.00 (5.00 - 12.0) 1543 Males 13 13 - 14 * < LOD < LOD < LOD 7.00 (5.00 - Females 1652 9.00) Race/ethnicity (

52 Blood Tribromomethane (Bromoform) (2001 – 2008) alth and Geometric mean and selected percentiles of whole blood concentrations (in pg/mL) for the U.S. population from the National He Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 02 1.57 (1.07 - 2.31) 1.39 (.960 - 2.02) 2.78 (1.76 - 4.63) 6.05 (2.92 - 29.2) 15.5 (3.68 - 85.4) 774 Total 01 04 * - < LOD 1.80 (

53 Blood Tribromomethane (Bromoform) (2013 – 2014) alth and Geometric mean and selected percentiles of whole blood concentrations (in pg/mL) for the U.S. population from the National He Nutrition Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 * < LOD < LOD Total 8.00 (

54 Blood Trichloromethane (Chloroform) (2001 – 2008) alth and Geometric mean and selected percentiles of whole blood concentrations (in pg/mL) for the U.S. population from the National He Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 02 16.6 (13.0 - 21.1) 16.1 (11.9 - 22.2) 31.7 (23.9 - 40.4) 55.5 (44.5 - 68.6) 72.1 (57.3 Total 105) 744 01 - - 10.2 (8.56 - 12.2) 10.0 (8.50 - 13.0) 20.0 (17.0 - 04 35.0 (29.0 - 40.0) 50.0 (37.0 - 65.0) 1222 03 24.0) - 06 10.1 (9.09 - 11.3) 9.90 (8.90 - 11.0) 19.0 (17.0 - 21.0) 36.0 (31.0 - 41.0) (46.0 - 64.0) 3111 05 54.0 07 08 6.63 (5.30 - 8.30) 6.56 (4.87 - 8.83) 14.6 (11.0 - 19.4) 27.7 (22.0 - 37.0) 41.8 (33.0 - 54.1) 2754 - Age group 19 years 05 - 06 9.22 (8.20 - 10.4) 9.10 (8.10 - 10.0) 17.0 (14.0 - 20.0) 33.0 (27.0 - 40.0) 46.0 (36.0 - 12 913 - 64.0) 07 08 5.95 (4.69 - 7.53) 5.33 (3.92 - 7.98) 12.5 (8.56 - 19.0) 25.5 (17.6 - 48.3) 47.6 (26.0 - 56.8) 440 - - 59 years 01 - 02 16.6 (13.0 - 21.1) 16.1 (11.9 - 22.2) 31.7 (23.9 - 40.4) 55.5 (44.5 - 68.6) 72.1 (57.3 - 105) 744 20 03 04 10.2 (8.56 - 12.2) 10.0 (8.50 - 13.0) 20.0 (17.0 - 24.0) 35.0 (29.0 - 40.0) 50.0 (37.0 - 65.0) 1222 - 05 - 10.5 (9.29 - 11.8) 10.0 (8.90 - 12.0) 20.0 (18.0 - 22.0) 37.0 (31.0 - 44.0) 55.0 (46.0 - 71.0) 1529 06 - 20.8) 6.89 (5.37 - 8.83) 6.78 (5.00 - 9.53) 15.1 (11.2 - 07 29.0 (23.3 - 38.3) 42.0 (34.2 - 55.8) 1503 08 - 06 9.71 (8.25 - 11.4) 9.60 (8.20 - 11.0) 19.0 (14.0 - 22.0) 35.0 (27.0 - 40.0) 46.0 (39.0 - 59.0) 669 60 years and older 05 07 - 08 6.25 (5.24 - 7.46) 6.34 (4.64 - 8.30) 14.0 (11.0 - 17.2) 24.8 (19.5 - 33.0) 36.0 (25.4 - 48.6) 811 Gender - 02 16.8 (12.0 - 23.5) 16.1 (11.0 - 24.8) 34.3 (22.4 - 48.7) 57.0 (39.9 - 76.4) 75.2 (54.5 - 156) 358 Males 01 03 - 04 10.1 (8.43 - 12.1) 10.0 (7.90 - 14.0) 20.0 - 25.0) 36.8 (29.0 - 49.0) 53.0 (36.8 - 69.0) 599 (17.0 - 06 9.94 (8.80 - 11.2) 9.80 (8.50 - 11.0) 19.0 05 - 22.0) 38.0 (33.0 - 44.0) 54.0 (46.0 - 67.0) 1483 (17.0 07 - 08 6.54 (5.25 - 8.14) 6.32 (4.85 - 8.43) 14.2 (11.0 - 19.1) 29.0 (21.9 - 37.6) 41.8 (31.8 - 59.2) 1376 Females - 02 16.4 (13.4 - 20.1) 16.6 (12.0 - 21.5) 29.2 (24.0 - 36.5) 53.5 (38.4 - 68.9) 69.5 (53.3 - 104) 386 01 03 - 10.4 (8.41 - 12.7) 10.0 (8.40 - 13.0) 20.0 (16.0 - 23.9) 33.0 (26.0 - 40.0) 46.0 (35.0 - 65.0) 623 04 - (29.0 10.4 (9.24 - 11.6) 10.0 (9.10 - 11.0) 19.0 (17.0 - 21.0) 32.0 05 - 39.0) 52.0 (41.0 - 67.0) 1628 06 (21.5 - 6.73 07 (5.29 - 8.55) 6.73 (4.80 - 9.35) 15.0 (11.0 - 19.7) 26.9 08 - 37.7) 42.0 (31.4 - 54.0) 1378 Race/ethnicity 01 - 02 17.0 (10.5 - 27.6) 14.5 (10.0 - 32.7) 35.1 (18.6 - 57.6) 60.7 (41.5 - 100) 93.0 (49.7 - 243) Mexican Americans 223 - 04 9.17 (7.45 - 11.3) 9.30 (7.60 - 11.0) 19.0 (15.0 - 24.0) 34.0 (24.0 - 44.4) 44.4 (30.0 - 59.0) 225 03 - 05 10.3 (8.59 - 12.5) 10.0 (7.60 - 14.0) 20.0 (17.0 06 22.0) 36.0 (30.0 - 41.0) 47.0 (41.0 - 64.0) 740 - 07 - 08 5.87 (4.20 - 8.19) 5.23 (3.50 - 7.80) 13.0 (7.76 - 30.3 (15.8 - 49.2) 45.9 (23.4 - 89.7) 504 20.0) Non Hispanic blacks 01 - 02 19.1 (12.9 - 28.1) 20.9 (9.28 - 37.4) - (27.7 - 46.0) 55.9 (45.5 - 69.8) 68.9 (51.9 - 74.0) 116 38.4 03 - 04 11.8 (9.54 - 14.6) 12.0 (8.90 - 15.0) 20.0 (15.0 - 30.0) 35.0 (28.0 - 59.0) 61.0 (34.0 - 100) 272 05 06 11.9 (9.78 - 14.4) 12.0 (9.10 - 15.0) 22.0 (19.0 - 26.0) 39.0 (31.0 - 47.0) 55.0 (46.0 - 70.0) 822 - - 07 8.00 (6.22 - 10.3) 8.60 (6.20 - 11.0) 15.7 (12.0 08 20.0) 28.0 (22.3 - 37.0) 39.6 (34.5 - 46.6) 585 - - Hispanic whites 01 - 02 15.6 (12.0 - 20.2) 15.2 (11.2 - 20.5) 26.8 Non (20.4 - 39.5) 53.5 (35.3 - 72.1) 69.5 (53.5 - 105) 348 - 04 9.84 (8.09 - 12.0) 10.0 (8.10 - 13.0) 20.0 03 - 23.0) 33.8 (27.0 - 40.0) 47.0 (35.0 - 67.0) 630 (16.0 05 - 06 9.87 (8.79 - 11.1) 9.70 (8.80 - 11.0) 19.0 (16.0 - 21.0) 34.0 (29.0 - 43.0) 53.0 (45.0 - 67.0) 1318 (10.1 08 6.45 (4.95 - 8.40) 6.30 (4.16 - 9.23) 14.9 - - 21.0) 27.7 (21.0 - 40.0) 41.8 (31.0 - 58.9) 1226 07 Limit of detection (LOD, see Data Analysis section) for Survey years 01 - 02, 03 - 04, 05 - 06, and 07 - 08 are 2.37, 2.11, 2.1, and 2.1, respectively. some < LOD means less than the limit of detection, which may vary for chemicals by year and by individual sample. Biomonitoring Summary http://www.cdc.gov/biomonitoring/THM - DBP_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 35

55 Blood Trichloromethane (Chloroform) (2013 – 2014) alth and Geometric mean and selected percentiles of whole blood concentrations (in pg/mL) for the U.S. population from the National He Nutrition Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 * 8.00 (

56 Urinary Benzophenone - – 2010) 3 (2003 d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 22.9 (18.1 - 28.9) 18.1 (15.5 - Total 94.0 (67.5 123) 370 (225 - 570) 1040 (698 - 1390) 2517 03 - 04 23.2) 06 19.4 (16.5 - 22.8) 14.1 (12.5 17.5) 68.8 (54.5 - 87.2) 433 (294 - 597) 1150 (936 - 1510) 2548 05 - - - 18.3 (13.7 - 24.3) 14.3 (10.7 - 19.8) 64.1 (42.8 - 08 365 (223 - 524) 801 (471 - 2080) 2604 07 116) - 10 22.3 (18.0 - 27.7) 16.4 (12.7 - 20.5) 81.2 (55.0 - 126) 493 (320 - 742) (931 - 3120) 2749 09 1750 Age group - 11 years - 04 21.2 (16.4 - 27.3) 17.2 (14.9 - 25.9) 66.7 (38.7 03 102) 158 (106 - 246) 246 (154 - 618) 314 - 6 - 06 21.2 (14.3 - 31.3) 19.4 (11.7 - 26.1) 58.8 (40.5 - 102) 259 (115 - 433) 852 (355 - 2200) 356 05 - 24.1 (15.0 - 38.7) 17.2 (11.8 - 25.0) 79.9 (32.9 - 168) 392 (129 - 1610) 1410 (165 - 43600) 389 07 08 - 09 21.7 (15.6 - 30.2) 14.6 (12.0 - 19.7) 52.7 (27.2 10 119) 470 (80.7 - 1900) 1570 (153 - 6440) 415 - - 19 years 03 - 04 22.9 (18.0 - 29.3) 20.1 (16.1 - 25.1) 67.1 (45.2 - 93.8) 170 (137 - 240) 407 (183 - 717) 715 12 05 06 21.2 (15.8 - 28.4) 14.9 (12.1 - 21.4) 64.3 (39.7 - 95.3) 227 (130 - 382) 633 (252 - 1260) 702 - 07 - 21.5 (16.0 - 28.8) 15.0 (11.9 - 21.3) 59.3 (36.7 - 111) 214 (113 - 613) 613 (206 - 1350) 401 08 129) - 23.3 (16.6 - 32.5) 16.6 (13.1 - 19.7) 62.3 (35.1 - 423 (184 - 843) 988 (550 - 2670) 420 09 10 03 - 04 23.1 (18.0 - 29.6) 18.1 (14.7 - 23.3) 109 (72.1 20 years and older 140) 450 (315 - 733) 1220 (769 - 1750) 1488 - 05 06 19.0 (16.5 - 21.8) 13.5 (12.0 - 16.3) 70.9 (55.2 - 87.2) 543 (390 - 638) 1200 (954 - 1690) 1490 - 07 - 08 17.3 (13.0 - 23.0) 13.7 (10.0 - 19.5) 64.1 (41.5 - 117) 371 (240 - 516) 801 (516 - 1790) 1814 - 10 22.3 (17.9 - 27.7) 16.5 (12.3 - 22.5) 86.7 (63.1 - 129) 505 (339 - 760) 1890 (1240 - 3170) 1914 09 Gender 03 - 04 16.8 (13.2 - 21.3) 13.7 (11.4 - 16.8) 55.3 (33.2 - 86.6) 178 (134 - 324) 567 (238 - 1350) 1229 Males 05 - 06 14.6 (10.8 - 19.7) 11.8 (8.80 15.9) 43.4 (31.0 - 68.8) 227 (103 - 552) 909 (479 - 1190) 1270 - (22.6 08 11.9 (8.84 - 16.0) 9.40 (7.70 - 12.3) 37.6 - - 54.7) 172 (79.9 - 376) 471 (208 - 1410) 1294 07 09 - 10 15.3 (12.7 - 18.6) 12.2 (10.0 - 15.2) 52.8 (33.9 - 72.6) 223 (129 - 332) 610 (318 - 1270) 1399 Females - 04 30.7 (23.7 - 39.8) 26.0 (20.2 - 34.1) 137 (106 - 172) 596 (403 - 769) 1340 (776 - 1790) 1288 03 05 - 25.5 (21.7 - 29.9) 17.9 (14.3 - 23.1) 129 (82.9 - 166) 638 (478 - 900) 1410 (945 - 2620) 1278 06 - - 27.6 (20.4 - 37.3) 25.6 (17.5 - 33.9) 117 (72.6 07 211) 535 (361 - 757) 1260 (643 - 2280) 1310 08 - 09 32.0 (23.7 - 43.3) 23.0 (16.4 - 29.8) 148 (73.3 10 260) 1020 (540 - 1800) 3200 (1760 - 4400) 1350 - Race/ethnicity - - 04 16.5 (10.9 - 25.1) 11.9 (8.50 Mexican Americans 18.3) 45.5 (25.9 - 78.2) 178 (76.4 - 412) 412 (178 - 2180) 613 03 - 05 14.3 (10.7 - 19.1) 10.2 (7.40 - 14.1) 45.6 (24.1 06 75.7) 214 (166 - 313) 635 (337 - 1090) 637 - 07 - 08 12.1 (9.49 - 15.3) 9.90 (7.70 - 12.4) 32.6 - 48.3) 142 (85.0 - 268) 409 (214 - 778) 531 (25.0 - 10 17.2 (13.7 - 21.6) 12.5 (10.5 - 14.5) 41.9 09 - 57.4) 351 (248 - 546) 1130 (493 - 2140) 566 (30.2 Non - Hispanic blacks 03 - 04 12.8 (9.38 - 17.4) 10.2 (7.40 - 14.4) 34.3 (22.8 - 50.6) 127 (90.8 - 176) 247 (143 - 499) 652 05 06 12.4 (9.77 - 15.6) 9.40 (7.30 - 11.8) 33.0 (22.3 - 46.5) 208 (115 - 291) 556 (269 - 1060) 678 - - 07 8.55 (6.75 - 10.8) 7.40 (5.00 - 9.70) 25.5 (17.5 08 34.5) 117 (66.8 - 217) 422 (195 - 786) 597 - 09 - 10 14.0 (10.9 - 18.1) 8.90 (7.30 - 10.5) 30.9 (21.9 - 276 (143 - 437) 705 (320 - 3000) 516 50.5) Non Hispanic whites 03 - 04 27.7 (20.3 - 37.8) 24.4 (16.8 - 32.0) - (83.6 - 162) 507 (316 - 769) 1340 (733 - 2070) 1092 121 05 - 06 21.6 (18.5 - 25.2) 16.0 (13.5 - 19.0) 82.4 (64.2 - 114) 552 (392 - 754) 1370 (945 - 2050) 1038 (47.4 08 23.1 (15.0 - 35.5) 18.7 (11.0 - 33.7) 101 - - 206) 459 (241 - 749) 1160 (487 - 2620) 1077 07 09 - 10 26.1 (19.0 - 35.9) 21.1 (14.6 - 29.7) 94.9 (59.8 - 186) 610 (325 - 1240) 2130 (934 - 3820) 1206 Limit of detection (LOD, see Data Analysis section) for Survey years 03 - 04, 05 - 06, 07 - 08 and 09 - 10 are 0.3, 0.4, 0.4, and 0.4 respectively. Biomonitoring S ummary http://www.cdc.gov/biomonitoring/Benzophenone - 3_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Benzophenone - 3_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 37

57 Urinary Benzophenone - – 2014) 3 (2011 urine concentrations (in μg/L) for the U.S. population from the National Health and Geometric mean and selected percentiles of Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 23.2 (17.2 - 31.3) 18.7 (13.6 Total 27.0) 83.8 (50.8 - 142) 461 (290 - 861) 1200 (861 - 1610) 2489 11 - - 14 25.2 (20.4 - 31.2) 21.0 (16.8 - 25.3) 87.9 (72.7 - 102) 417 (269 - 642) (853 - 1760) 2686 13 1210 Age group 11 years - 11 - 12 18.7 (12.3 - 28.2) 13.2 (8.20 - 20.8) 55.4 (28.0 - 108) 336 (134 - 653) 657 (236 - 1270) 396 6 - - 26.0 (16.5 - 40.9) 19.2 (14.4 - 30.0) 77.6 (39.0 14 206) 363 (171 - 720) 824 (271 - 1840) 409 13 - 19 years 11 - 12 27.8 (15.4 - 50.2) 21.6 (10.8 - 42.1) 109 (34.0 - 255) 433 (159 - 1160) 1120 (261 - 1990) 388 12 13 14 29.2 (23.3 - 36.4) 26.2 (19.7 - 36.4) 87.2 (57.8 - 137) 261 (167 - 504) 537 (269 - 1340) 462 - 11 12 23.1 (17.8 - 30.0) 19.2 (14.4 - 27.0) 83.8 (52.8 - 137) 482 (305 - 805) 1250 (975 - 1640) 1705 20 years and older - - - 24.6 (19.7 - 30.6) 20.1 (16.0 - 24.7) 90.6 (73.4 14 102) 482 (294 - 801) 1360 (875 - 2740) 1815 13 Gender - - 12 17.2 (12.1 - 24.5) 16.0 (9.40 Males 23.6) 50.2 (40.1 - 78.7) 295 (141 - 448) 594 (301 - 1360) 1259 11 13 (46.4 14 19.0 (15.8 - 22.9) 16.8 (14.4 - 19.8) 55.0 - 63.1) 231 (176 - 259) 576 (340 - 864) 1285 - (79.9 Females - 12 31.0 (22.7 - 42.2) 22.2 (16.0 - 34.1) 137 11 - 243) 781 (467 - 1220) 1720 (1260 - 2290) 1230 13 - 14 32.9 (24.9 - 43.5) 26.2 (19.4 - 37.2) 120 (94.9 - 195) 733 (447 - 1230) 1950 (1200 - 3460) 1401 Race/ethnicity 11 12 16.8 (10.5 - 26.8) 13.4 (7.20 - 25.2) 46.1 (25.2 - 115) 305 (111 - 644) 885 (305 - 1740) 316 Mexican Americans - - - 25.9 (20.5 - 32.7) 19.0 (15.0 - 24.2) 69.3 (44.1 14 86.6) 256 (204 - 538) 893 (518 - 1230) 438 13 - Hispanic blacks 11 - 12 14.5 (11.4 - 18.5) 10.9 (8.00 - 14.1) 41.4 Non - 59.5) 316 (192 - 433) 895 (475 - 1270) 665 (28.8 - 14 10.9 (7.48 - 15.8) 9.60 (6.60 - 13.1) 26.9 (19.6 - 39.9) 104 (60.3 - 205) 448 (118 - 1070) 609 13 - 11 - 12 26.8 (17.8 - 40.5) 22.2 (14.8 - 36.5) 101 Non (52.8 - 216) 512 (255 - 1130) 1230 (805 - 1830) 813 Hispanic whites 13 - 14 29.7 (22.7 - 38.8) 24.9 (19.5 - 32.9) 108 (94.0 - 131) 523 (340 - 853) 1470 (1150 - 2860) 988 All Hispanics - 12 21.2 (15.2 - 29.4) 16.3 (10.6 - 22.7) 57.9 (38.2 - 126) 408 (261 - 684) 1020 (527 - 1610) 571 11 (64.7 13 14 28.2 (23.8 - 33.4) 20.1 (16.5 - 23.9) 81.5 - - 98.3) 415 (219 - 824) 1120 (738 - 1780) 690 Asians 11 - 12 16.7 (10.5 - 26.5) 11.9 (7.30 - 21.1) 66.4 (37.6 - 122) 486 (157 - 1350) 1640 (770 - 2780) 352 (36.1 14 18.6 (12.4 - 28.0) 17.0 (8.30 - 26.8) 64.2 - - 107) 254 (114 - 532) 532 (283 - 1770) 289 13 Limit of detection (LOD, see Data Analysis section) for Survey years 11 - 12 and 13 - 14 are 0.4 and 0.4, respectively. Biomonitoring Summary http://www. cdc.gov/biomonitoring/Benzophenone - 3_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Benzophenone - 3_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 38

58 Urinary Benzophenone - – 2010) 3 (creatinine corrected) (2003 onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 22.2 (17.6 - 28.0) 16.2 (12.7 - 21.6) 82.0 (58.7 - 108) 415 (283 - 577) 1080 (686 Total 1600) 2514 03 - - 18.9 (15.8 - 22.6) 13.5 (11.2 - 16.8) 60.4 (47.6 - 06 445 (346 - 553) 1210 (794 - 1970) 2548 05 81.4) - 08 18.4 (13.9 - 24.4) 13.5 (10.2 - 17.8) 67.9 (45.2 - 117) 338 (215 - 584) (525 - 1800) 2604 07 935 09 10 23.3 (18.7 - 29.1) 16.1 (12.8 - 19.8) 79.1 (52.2 - 124) 579 (355 - 1040) 2340 (1380 - 3010) 2749 - Age group 11 years 03 - 04 25.8 (19.5 - 34.1) 22.4 (14.4 - 33.7) 84.6 (41.0 - 131) 171 (132 - 365) 427 (171 - 6 314 - 710) 05 06 23.3 (15.9 - 34.1) 17.5 (11.6 - 28.3) 67.7 (39.7 - 105) 249 (106 - 631) 868 (264 - 2080) 356 - 07 - 08 29.7 (19.0 - 46.6) 19.3 (12.4 - 32.3) 103 (51.1 - 159) 442 (133 - 1550) 1430 (187 - 29100) 389 - 10 28.3 (20.4 - 39.4) 18.8 (14.7 - 21.1) 53.9 (33.2 - 132) 565 (104 - 3410) 1780 (253 - 8230) 415 09 - 19 years 03 - 04 17.2 (13.7 - 21.5) 12.9 (10.4 - 16.5) 43.6 (29.5 - 57.7) 136 (91.7 - 239) 350 (173 - 646) 713 12 - - 15.8 (11.6 - 21.6) 12.1 (9.16 - 17.0) 42.5 (28.6 06 58.7) 164 (101 - 438) 625 (225 - 956) 702 05 07 - 08 16.7 (12.4 - 22.4) 12.1 (8.57 - 17.6) 55.7 (30.4 - 74.8) 211 (88.2 - 505) 505 (163 - 902) 401 09 10 18.7 (13.4 - 26.1) 13.6 (10.1 - 19.7) 39.9 (25.5 - 91.6) 412 (89.8 - 750) 1240 (629 - 2540) 420 - - 04 22.8 (17.8 - 29.1) 16.2 (12.7 - 21.9) 93.2 (66.0 - 130) 491 (361 - 700) 1330 (880 - 1880) 1487 20 years and older 03 05 - 06 19.0 (16.3 - 22.2) 13.4 (11.2 - 16.2) 64.2 - 87.0) 509 (406 - 628) 1480 (816 - 2200) 1490 (49.3 - 08 17.7 (13.3 - 23.6) 12.6 (9.93 - 17.5) 67.7 07 - 127) 362 (249 - 584) 960 (581 - 1970) 1814 (44.1 09 - 10 23.6 (18.8 - 29.5) 16.3 (12.7 - 20.2) 83.6 (58.3 - 146) 602 (364 - 1230) 2470 (1350 - 3080) 1914 Gender 03 04 13.6 (10.8 - 17.1) 10.3 (8.36 - 12.9) 40.0 (24.9 - 62.5) 169 (93.3 - 316) 381 (229 - 685) 1228 Males - 49.4) - 11.7 (8.74 - 15.8) 9.43 (6.72 - 12.5) 31.9 (19.7 - 176 (77.1 - 406) 553 (317 - 948) 1270 05 06 - 08 10.0 (7.37 - 13.7) 7.50 (5.74 - 10.0) 28.7 (18.5 - 47.3) 142 (65.8 - 225) 332 (181 - 960) 1294 07 09 - 13.7 (11.4 - 16.6) 10.7 (8.53 - 12.7) 44.6 (29.7 - 57.4) 186 (123 - 287) 420 (287 - 1230) 1399 10 - 04 35.5 (27.1 - 46.4) 28.2 (20.2 - 37.0) 144 (101 - 224) 686 (491 - 1130) 1850 (1220 - 2580) 1286 Females 03 05 - 06 (25.3 - 35.6) 20.9 (17.0 - 29.0) 129 (88.0 - 175) 707 (527 - 912) 1880 (1150 - 2770) 1278 30.0 - 08 33.0 (25.0 - 43.7) 26.2 (19.1 - 41.1) 156 (90.2 - 235) 617 (385 - 935) 1500 (746 - 2710) 1310 07 - 09 38.6 (28.1 - 53.0) 25.7 (17.5 - 35.2) 161 (76.3 10 378) 1580 (955 - 2410) 3250 (2540 - 4640) 1350 - Race/ethnicity - - 04 15.1 (9.44 - 24.0) 11.1 (6.95 Mexican Americans 16.0) 40.7 (18.3 - 85.8) 158 (87.4 - 362) 595 (118 - 1860) 612 03 (23.1 05 06 12.9 (10.2 - 16.2) 8.63 (6.16 - 12.5) 32.1 - - 51.8) 216 (135 - 408) 948 (441 - 1220) 637 07 - 08 11.8 (8.87 - 15.6) 8.97 (7.00 - 12.4) 33.6 (26.0 - 43.2) 154 (93.4 - 249) 413 (217 - 932) 531 09 10 17.1 (13.4 - 21.7) 12.2 (9.64 - 14.5) 40.4 (26.4 - 60.3) 288 (155 - 603) 1310 (441 - 2180) 566 - - 03 - 04 8.78 (6.49 - 11.9) 6.80 (5.27 - 9.00) 19.7 (13.5 - 33.4) 79.8 (46.8 - 139) 185 (79.8 - 536) 651 Non Hispanic blacks 05 06 8.69 (7.02 - 10.8) 6.29 (5.52 - 7.78) 21.2 (14.5 - 34.5) 118 (74.9 - 245) 448 (208 - 876) 678 - (13.2 08 6.65 (5.24 - 8.42) 5.09 (4.15 - 6.10) 17.8 - - 24.2) 86.6 (57.5 - 122) 297 (113 - 903) 597 07 09 - 10 10.2 (8.12 - 12.7) 6.46 (5.40 - 7.67) 23.1 (15.5 - 38.2) 160 (79.9 - 396) 653 (305 - 1580) 516 Non 03 - 04 28.3 (20.6 - 38.8) 22.0 (14.6 - 32.7) 116 (73.5 - 175) 510 (380 - 760) 1330 (852 - 2410) 1091 Hispanic whites - - 06 22.7 (19.4 - 26.7) 16.2 (13.0 - 19.7) 77.3 05 - 106) 538 (406 - 679) 1500 (828 - 2430) 1038 (56.5 07 - 08 24.1 (15.6 - 37.2) 18.1 (11.0 - 30.0) 103 (53.6 - 198) 494 (227 - 960) 1170 (522 - 2710) 1077 1550) - 10 29.3 (20.7 - 41.5) 22.1 (14.6 - 33.1) 99.2 (54.3 - 241) 767 (412 - 09 2590 (1510 - 3250) 1206 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Benzophenone - 3_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Benzophenone - 3_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 39

59 Urinary Benzophenone - – 2014) 3 (creatinine corrected) (2011 onal H ealth Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 12 26.4 (19.3 - 36.2) 18.8 (13.3 Total 27.3) 102 (57.8 - 162) 613 (330 - 1020) 1680 (1010 - 2500) 2487 11 - - 14 25.2 (20.5 - 31.0) 19.8 (15.7 - 24.7) 79.8 (66.2 - 103) 467 (299 - 603) 1190 (847 - 1810) 2684 13 Age group 11 years - 11 - 12 26.9 (17.9 - 40.2) 18.8 (13.0 - 28.6) 67.8 (37.8 - 135) 552 (138 - 1010) 1010 (297 - 1670) 395 6 - - 32.8 (21.5 - 50.1) 28.8 (16.7 - 45.7) 90.0 (46.9 14 189) 401 (152 - 868) 868 (432 - 1700) 409 13 - 19 years 11 - 12 27.1 (14.2 - 51.8) 16.7 (8.69 - 44.3) 102 12 (29.9 - 331) 631 (117 - 3050) 1720 (331 - 3900) 388 - 14 23.7 (17.8 - 31.4) 21.6 (15.8 - 28.7) 63.0 (49.1 - 86.2) 221 (116 - 440) 506 (221 - 647) 462 13 - 12 26.3 (19.8 - 34.8) 19.8 (13.9 - 26.6) 107 (68.1 - 156) 640 (371 - 957) 1890 (1080 - 2500) 1704 20 years and older 11 13 - 14 24.7 (20.3 - 30.0) 18.8 (15.2 - 23.1) 82.3 (69.5 - 102) 529 (317 - 790) 1420 (915 - 2660) 1813 Gender 1030) - 12 16.1 (11.3 - 22.8) 11.9 (8.77 - 18.1) 48.8 (31.6 - 84.5) 237 (120 - 442) 716 (267 - Males 1258 11 (33.1 13 14 15.9 (13.2 - 19.3) 13.8 (10.9 - 17.5) 44.0 - - 58.5) 181 (146 - 229) 432 (299 - 532) 1284 Females 11 - 12 42.7 (30.6 - 59.5) 30.1 (19.7 - 49.4) 186 (107 - 374) 1150 (771 - 1910) 2720 (1660 - 4230) 1229 13 14 38.9 (29.2 - 51.8) 29.7 (21.3 - 39.9) 153 (83.6 - 242) 905 (603 - 1250) 2550 (1440 - 3500) 1400 - Race/ethnicity - 11 12 18.9 (12.4 - 29.0) 13.8 (8.75 - 45.3 (23.5 - 132) 369 (132 - 820) 1030 (371 - 2330) 316 Mexican Americans 22.0) 13 - 14 26.4 (20.2 - 34.4) 18.2 (15.6 - 23.2) 59.1 (40.6 - 82.7) 296 (122 - 1090) 1180 (473 - 2130) 438 Non Hispanic blacks 11 - 12 11.3 (8.82 - 14.5) 7.48 (6.04 - 9.49) 27.6 (18.0 - 42.1) 269 (159 - 376) 747 (376 - 1010) 665 - - 14 8.02 (5.57 - 11.5) 6.43 (4.68 - 8.60) 16.9 13 - 24.7) 93.5 (51.1 - 204) 332 (144 - 818) 609 (11.6 Non - Hispanic whites 11 - 12 32.6 (21.1 - 50.4) 25.5 (15.3 - 41.1) 128 (70.8 - 248) 793 (334 - 1320) 1970 (1030 - 3500) 811 13 14 31.2 (24.5 - 39.6) 25.3 (20.1 - 31.5) 115 (77.3 - 159) 569 (432 - 765) 1270 (871 - 2550) 987 - (38.6 All Hispanics - 12 23.7 (17.6 - 32.0) 15.9 (11.4 - 21.7) 65.0 11 - 132) 425 (265 - 916) 1850 (784 - 2330) 571 13 - 14 28.0 (23.2 - 33.7) 18.8 (16.3 - 22.5) 66.8 (50.9 - 84.5) 338 (190 - 1020) 1380 (974 - 2740) 690 (41.6 Asians - 12 22.3 (14.3 - 34.9) 14.2 (8.24 - 27.8) 73.1 11 - 153) 624 (282 - 1640) 1860 (641 - 4410) 352 13 - 14 23.1 (16.3 - 32.8) 20.2 (12.9 - 34.4) 67.5 (48.4 - 102) 253 (131 - 537) 657 (287 - 1900) 288 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Benzophenone - 3_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Benzophenone - 3_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 40

60 Urinary Bisphenol A (2003 – 2010) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 2.64 (2.38 - 2.94) 2.80 (2.50 - Total 5.50 (5.00 6.20) 10.6 (9.40 - 12.0) 16.0 (14.4 - 17.2) 2517 03 - 04 3.10) 06 1.90 (1.79 - 2.02) 2.00 (1.90 - 2.00) 3.70 (3.50 - 3.90) 7.00 (6.40 - 7.60) 11.5 (10.0 - 13.6) 2548 05 - 08 2.08 (1.92 - 2.26) 2.10 (1.90 - 2.30) 4.10 (3.60 - 4.60) 7.70 (6.80 - 8.70) 13.0 (10.0 - 15.6) 2604 07 - - 10 1.83 - - 1.94) 1.90 (1.70 - 2.00) 3.50 (3.30 - 3.80) 6.60 (6.00 7.20) 9.60 (8.50 - 11.3) 2749 09 (1.72 Age group 11 years 6 03 - 04 3.55 (2.95 - 4.29) 3.80 (2.70 - 5.00) 6.90 (6.00 - 8.30) 12.6 (9.50 - 15.1) 16.0 (11.5 - 23.3) 314 - 05 06 2.86 (2.52 - 3.24) 2.70 (2.30 - 2.90) 5.00 (4.40 - 5.80) 13.5 (9.30 - 16.8) 22.8 (13.6 - 34.6) 356 - 5.50) - 2.48 (2.21 - 2.77) 2.40 (1.90 - 3.00) 4.50 (3.70 - 7.60 (6.30 - 9.50) 13.4 (8.80 - 17.8) 389 07 08 - 10 1.81 (1.55 - 2.10) 1.70 (1.50 - 2.00) 3.40 (3.00 - 4.00) 6.50 (4.30 - 9.70) 9.20 (6.50 - 15.1) 415 09 - 03 - 04 3.74 (3.31 - 4.22) 4.30 (3.60 - 4.60) 7.80 19 years (6.50 - 9.00) 13.5 (11.8 - 15.2) 16.5 (15.2 - 20.9) 715 12 05 - 06 2.42 (2.18 - 2.68) 2.40 (2.10 - 2.70) 4.30 (3.90 - 5.20) 8.40 (6.50 - 10.8) 11.9 (10.7 - 14.8) 702 - 08 2.45 (2.14 - 2.80) 2.40 (2.10 - 2.60) 4.40 (3.60 - 5.50) 9.70 (7.30 - 11.9) 12.2 (9.70 - 19.0) 401 07 09 - 2.11 (1.86 - 2.40) 2.20 (1.90 - 2.40) 3.80 (3.20 - 4.50) 6.90 (4.70 - 10.8) 11.1 (6.90 - 21.0) 420 10 5.70) 03 2.41 (2.15 - 2.72) 2.60 (2.30 - 2.80) 5.10 (4.50 - 04 9.50 (8.10 - 11.3) 15.2 (12.4 - 18.1) 1488 - 20 years and older - 06 1.75 (1.62 - 1.89) 1.80 (1.70 - 2.00) 3.40 (3.10 3.70) 6.40 (5.80 - 7.50) 10.7 (8.80 - 12.1) 1490 05 - 07 08 1.99 (1.82 - 2.18) 2.00 (1.80 - 2.30) 3.90 (3.40 - 4.60) 7.40 (6.60 - 8.50) 13.2 (9.10 - 15.7) 1814 - 09 - 10 1.79 (1.67 - 1.93) 1.80 (1.60 - 2.00) 3.50 (3.30 - 3.70) 6.50 (6.00 - 7.20) 9.60 (8.30 - 11.3) 1914 Gender - 04 2.92 (2.63 - 3.24) 3.20 (2.70 - 3.60) 6.10 (5.40 - 6.60) 10.4 (9.50 - 11.6) 16.0 (12.7 - 17.6) 1229 Males 03 05 - 06 2.09 (1.92 - 2.28) 2.10 (2.00 - 2.30) 3.70 (3.40 - 4.20) 7.70 (6.80 - 9.30) 12.8 (10.1 - 15.8) 1270 07 08 2.20 (2.01 - 2.41) 2.10 (1.90 - 2.40) 4.00 (3.60 - 4.70) 8.10 (6.70 - 9.70) 14.0 (8.70 - 20.8) 1294 - (3.40 10 1.94 (1.82 - 2.07) 1.90 (1.70 - 2.00) 3.70 - - 4.10) 6.90 (5.90 - 7.90) 10.9 (8.40 - 13.5) 1399 09 Females 03 - 04 2.41 (2.11 - 2.75) 2.50 (2.20 - 2.80) 5.00 (4.20 - 6.20) 10.6 (8.70 - 12.5) 15.9 (13.5 - 20.1) 1288 05 06 1.74 (1.55 - 1.95) 1.80 (1.60 - 2.00) 3.70 (3.10 - 4.00) 6.20 (5.80 - 7.60) 10.4 (7.70 - 14.7) 1278 - 07 - 1.97 (1.80 - 2.16) 2.00 (1.80 - 2.20) 4.10 (3.60 - 4.60) 7.40 (6.80 - 8.20) 12.0 (9.60 - 14.1) 1310 08 (5.60 - 1.73 09 (1.60 - 1.87) 1.80 (1.60 - 2.00) 3.40 (3.20 - 3.70) 6.50 10 - 7.10) 9.20 (8.00 - 11.2) 1350 Race/ethnicity 03 - 04 2.58 (2.15 - 3.08) 2.60 (2.10 - 3.20) 5.20 (4.40 - 6.50) 9.90 (7.30 - 13.9) 15.4 (10.2 - 19.7) 613 Mexican Americans 05 06 2.05 (1.75 - 2.40) 2.00 (1.70 - 2.40) 3.60 (3.00 - 4.20) 6.90 (5.40 - 10.1) 12.2 (8.00 - 15.6) 637 - - 07 2.09 (1.94 - 2.26) 2.00 (1.80 - 2.30) 3.80 (3.30 08 4.30) 7.10 (6.10 - 8.60) 11.7 (7.70 - 14.6) 531 - 09 - 10 1.92 (1.69 - 2.19) 2.10 (1.80 - 2.30) 3.50 (3.10 - 6.50 (5.20 - 7.50) 9.00 (6.90 - 16.2) 566 4.10) Non Hispanic blacks 03 - 04 4.24 (3.73 - 4.82) 4.30 (3.80 - 5.10) - (7.10 - 9.80) 14.2 (11.7 - 16.9) 20.6 (14.9 - 25.2) 652 8.20 05 - 06 2.50 (2.25 - 2.77) 2.70 (2.30 - 3.00) 4.60 (4.00 - 5.00) 8.00 (6.80 - 9.30) 11.3 (8.90 - 14.2) 678 07 08 2.66 (2.38 - 2.97) 2.80 (2.60 - 3.10) 5.40 (4.40 - 6.40) 9.10 (7.50 - 10.4) 13.3 (10.0 - 15.1) 597 - 09 5.00) 10 2.51 (2.22 - 2.83) 2.60 (2.30 - 3.00) 4.40 (3.80 - 7.30 (6.10 - 8.80) 10.3 (7.90 - 13.6) 516 - - 03 - 04 2.51 (2.26 - 2.79) 2.70 (2.50 - 3.00) 5.20 Non (4.70 - 5.80) 9.60 (8.30 - 10.9) 15.1 (12.6 - 16.7) 1092 Hispanic whites 05 - 06 1.76 (1.62 - 1.91) 1.80 (1.60 - 2.00) 3.50 (3.20 - 3.80) 6.80 (5.90 - 7.60) 11.0 (8.80 - 13.7) 1038 (3.40 08 2.06 (1.87 - 2.27) 2.00 (1.80 - 2.30) 4.00 - - 4.70) 7.80 (6.70 - 8.90) 13.7 (9.80 - 16.1) 1077 07 09 - 10 1.73 (1.60 - 1.87) 1.70 (1.60 - 1.90) 3.40 (3.10 - 3.70) 6.40 (5.40 - 7.60) 9.20 (8.20 - 11.2) 1206 Limit of detection (LOD, see Data Analysis section) for Survey years 03 - 04, 05 - 06, 07 - 08 and 09 - 10 are 0.4, 0.4, 0.4, and 0.4 respectively. Biomonitoring S ummary http://www.cdc.gov/biomonitoring/BisphenolA_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/BisphenolA_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 41

61 Urinary Bisphenol A (2011 – 2014) ine concentrations (in μg/L) for the U.S. population from the National Health and Geometric mean and selected percentiles of ur Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 1.51 (1.41 - 1.62) 1.40 (1.30 Total 1.60) 3.00 (2.70 - 3.30) 5.60 (4.90 - 6.50) 9.40 (7.70 - 11.2) 2489 11 - - 14 1.28 (1.20 - 1.36) 1.30 (1.20 - 1.40) 2.50 (2.40 - 2.70) 4.90 (4.10 - 5.60) (6.80 - 8.30) 2686 13 7.70 Age group 11 years - 11 - 12 1.58 (1.41 - 1.78) 1.50 (1.30 - 1.70) 3.10 (2.60 - 3.50) 6.70 (5.10 - 8.00) 8.70 (6.20 - 21.4) 396 6 - - 1.43 (1.30 - 1.59) 1.40 (1.30 - 1.60) 2.90 (2.30 14 3.40) 4.40 (4.10 - 5.20) 8.00 (5.20 - 10.2) 409 13 - 19 years 11 - 12 1.69 (1.42 - 2.00) 1.70 (1.30 - 2.10) 3.30 (2.80 - 4.00) 6.90 (4.80 - 7.90) 10.0 (7.10 - 13.0) 388 12 13 14 1.28 (1.16 - 1.41) 1.20 (1.10 - 1.40) 2.40 (1.90 - 2.70) 4.60 (3.30 - 5.20) 6.80 (5.20 - 8.10) 462 - 11 12 1.48 (1.35 - 1.61) 1.40 (1.20 - 1.60) 2.90 (2.50 - 3.30) 5.40 (4.70 - 6.30) 9.30 (7.30 - 12.2) 1705 20 years and older - - - 1.26 (1.18 - 1.35) 1.30 (1.20 - 1.40) 2.50 (2.40 14 2.80) 4.90 (4.10 - 6.00) 7.80 (6.80 - 8.60) 1815 13 Gender - - 12 1.64 (1.49 - 1.81) 1.50 (1.40 Males 1.70) 3.20 (2.70 - 3.70) 6.00 (5.00 - 7.70) 9.50 (7.80 - 11.2) 1259 11 13 (2.40 14 1.43 (1.30 - 1.58) 1.40 (1.30 - 1.60) 2.80 - 3.20) 5.30 (4.30 - 6.60) 8.30 (6.80 - 10.3) 1285 - (2.40 Females - 12 1.39 (1.25 - 1.55) 1.30 (1.20 - 1.50) 2.80 11 - 3.20) 5.20 (4.30 - 6.30) 8.50 (6.50 - 13.4) 1230 13 - 14 1.15 (1.05 - 1.26) 1.20 (1.10 - 1.30) 2.30 (2.00 - 2.60) 4.20 (3.80 - 5.20) 7.20 (5.60 - 8.10) 1401 Race/ethnicity 11 12 1.45 (1.30 - 1.63) 1.40 (1.20 - 1.60) 2.80 (2.30 - 3.10) 5.00 (4.20 - 6.50) 7.70 (5.90 - 9.70) 316 Mexican Americans - - - 1.28 (1.06 - 1.53) 1.30 (1.00 - 1.70) 2.50 (2.10 14 2.80) 4.10 (3.50 - 4.90) 5.60 (4.60 - 7.30) 438 13 - Hispanic blacks 11 - 12 2.12 (1.88 - 2.38) 2.00 (1.80 - 2.40) 4.10 Non - 4.60) 7.10 (5.70 - 8.10) 11.4 (8.10 - 14.3) 665 (3.40 - 14 1.83 (1.62 - 2.07) 1.90 (1.50 - 2.20) 3.60 (3.20 - 4.10) 6.80 (5.70 - 7.80) 9.80 (7.70 - 12.9) 609 13 - 11 - 12 1.46 (1.34 - 1.58) 1.30 (1.20 - 1.50) 2.90 Non (2.50 - 3.20) 5.40 (4.60 - 6.60) 8.90 (6.90 - 13.4) 813 Hispanic whites 13 - 14 1.22 (1.13 - 1.31) 1.30 (1.10 - 1.40) 2.40 (2.20 - 2.70) 4.40 (3.90 - 5.90) 7.40 (6.40 - 8.30) 988 All Hispanics - 12 1.48 (1.25 - 1.74) 1.40 (1.20 - 1.70) 2.80 (2.20 - 3.40) 5.70 (4.20 - 7.30) 9.10 (6.50 - 14.1) 571 11 (2.20 13 14 1.31 (1.18 - 1.46) 1.30 (1.10 - 1.50) 2.60 - - 2.80) 4.10 (3.70 - 4.70) 6.10 (4.90 - 7.50) 690 Asians 11 - 12 1.03 (.863 - 1.23) .900 (.800 - 1.10) 1.80 (1.50 - 2.20) 4.00 (2.40 - 6.40) 7.30 (3.90 - 11.9) 352 (1.00 14 .782 (.646 - .948) .800 (.700 - .900) 1.40 - - 1.80) 2.40 (1.80 - 3.30) 3.60 (2.40 - 12.1) 289 13 Limit of detection (LOD, see Data Analysis section) for Survey years 11 - 12 and 13 - 14 are 0.4 and 0.2, respectively. Biomonitoring Summary http://www.cdc.gov/biom onitoring/BisphenolA_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/BisphenolA_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 42

62 Urinary Bisphenol A (creatinine corrected) (2003 – 2010) onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 2.58 (2.36 - 2.82) 2.50 (2.31 - 2.80) 4.29 (3.88 - 4.75) 7.67 (6.62 - 8.66) 11.2 (9.78 Total 12.4) 2514 03 - - 1.86 (1.79 - 1.92) 1.71 (1.64 - 1.79) 3.01 (2.86 - 06 5.73 (5.29 - 6.36) 9.70 (8.31 - 10.9) 2548 05 3.20) - 08 2.10 (1.95 - 2.25) 1.95 (1.84 - 2.03) 3.45 (3.02 - 3.83) 6.09 (5.10 - 7.45) (7.48 - 13.2) 2604 07 10.0 09 10 1.91 (1.79 - 2.04) 1.76 (1.67 - 1.84) 3.06 (2.80 - 3.33) 5.33 (4.68 - 6.06) 8.03 (6.94 - 10.0) 2749 - Age group 11 years 03 - 04 4.32 (3.63 - 5.14) 4.29 (3.63 - 5.23) 7.14 (5.83 - 9.56) 12.2 (9.84 - 14.8) 15.7 (12.2 - 6 314 - 23.2) 05 06 3.14 (2.79 - 3.54) 2.80 (2.55 - 3.06) 5.04 (4.46 - 5.71) 15.6 (8.15 - 22.4) 24.6 (19.9 - 48.5) 356 - 07 - 08 3.05 (2.73 - 3.41) 2.69 (2.38 - 3.12) 5.06 (4.33 - 5.60) 11.9 (6.30 - 17.4) 20.8 (12.7 - 26.3) 389 - 10 2.36 (2.09 - 2.65) 2.18 (2.00 - 2.53) 3.70 (3.14 - 4.29) 5.97 (4.57 - 9.15) 9.57 (6.52 - 13.7) 415 09 - 19 years 03 - 04 2.80 (2.52 - 3.11) 2.74 (2.35 - 3.22) 4.74 (4.21 - 5.09) 7.79 (6.41 - 8.87) 11.8 (8.05 - 14.2) 713 12 - - 1.80 (1.67 - 1.95) 1.65 (1.50 - 1.76) 2.73 (2.41 06 2.98) 5.71 (4.07 - 7.50) 8.52 (6.94 - 12.2) 702 05 07 - 08 1.90 (1.72 - 2.10) 1.69 (1.50 - 2.00) 2.94 (2.38 - 3.60) 5.10 (4.17 - 6.82) 7.72 (5.32 - 13.9) 401 09 10 1.70 (1.47 - 1.95) 1.60 (1.34 - 1.88) 2.63 (2.11 - 3.58) 4.47 (3.76 - 6.19) 6.71 (4.40 - 17.8) 420 - - 04 2.39 (2.17 - 2.64) 2.36 (2.15 - 2.59) 3.93 (3.44 - 4.33) 6.64 (5.97 - 7.74) 10.0 (9.01 - 11.4) 1487 20 years and older 03 05 - 06 1.75 (1.67 - 1.84) 1.64 (1.56 - 1.75) 2.84 - 3.08) 5.38 (4.89 - 5.87) 8.54 (7.58 - 9.77) 1490 (2.67 - 08 2.04 (1.90 - 2.20) 1.92 (1.79 - 2.03) 3.36 07 - 3.78) 6.02 (4.88 - 7.48) 9.32 (7.48 - 12.1) 1814 (2.91 09 - 10 1.90 (1.76 - 2.05) 1.76 (1.66 - 1.84) 3.04 (2.76 - 3.24) 5.33 (4.67 - 6.11) 8.00 (6.97 - 10.0) 1914 Gender 03 04 2.38 (2.15 - 2.63) 2.31 (2.08 - 2.70) 4.19 (3.81 - 4.64) 7.10 (6.41 - 8.28) 9.94 (9.06 - 11.7) 1228 Males - 3.14) - 1.68 (1.57 - 1.80) 1.56 (1.45 - 1.64) 2.73 (2.43 - 5.27 (4.64 - 6.04) 8.40 (6.81 - 11.4) 1270 05 06 - 08 1.85 (1.71 - 2.01) 1.77 (1.57 - 1.91) 2.97 (2.59 3.33) 5.41 (4.47 - 7.51) 9.52 (6.29 - 13.4) 1294 07 - 09 10 1.74 (1.62 - 1.87) 1.60 (1.48 - 1.72) 2.76 (2.53 - 2.96) 5.00 (4.16 - 5.86) 7.50 (6.22 - 9.00) 1399 - 03 - 04 2.78 (2.50 - 3.08) 2.68 (2.40 - 2.94) 4.41 (3.81 - 5.15) Females (6.48 - 10.2) 12.4 (9.29 - 18.2) 1286 7.93 - 06 2.04 (1.95 - 2.14) 1.85 (1.76 - 2.02) 3.21 (2.98 - 3.39) 6.47 (5.51 - 7.50) 9.86 (8.62 - 11.8) 1278 05 - 07 2.36 (2.17 - 2.57) 2.14 (1.98 - 2.33) 3.77 (3.43 08 4.31) 6.67 (5.41 - 7.83) 10.5 (7.45 - 15.2) 1310 - 09 - 10 2.09 (1.92 - 2.27) 1.93 (1.80 - 2.15) 3.33 (2.94 - 3.84) 5.49 (4.87 - 6.74) 8.80 (6.47 - 12.5) 1350 Race/ethnicity (3.24 - 04 2.34 (2.02 - 2.71) 2.38 (2.00 Mexican Americans 2.65) 3.85 03 - 4.55) 7.09 (5.00 - 9.04) 10.9 (8.50 - 14.3) 612 - 05 - 06 1.84 (1.66 - 2.04) 1.62 (1.45 - 1.84) 2.99 (2.56 - 3.60) 6.00 (4.51 - 8.00) 10.3 (6.84 - 14.9) 637 07 08 2.04 (1.86 - 2.24) 1.88 (1.72 - 2.11) 3.33 (2.96 - 3.95) 5.68 (5.05 - 6.59) 8.90 (6.30 - 11.8) 531 - - 09 1.91 (1.71 - 2.13) 1.76 (1.67 - 1.87) 3.13 (2.63 10 3.57) 5.51 (4.72 - 6.97) 8.71 (5.86 - 14.4) 566 - - Hispanic blacks 03 - 04 2.92 (2.58 - 3.32) 2.95 (2.51 - 3.27) 4.90 (4.07 - 6.13) 8.64 (7.53 - 9.63) 11.9 (10.2 - 13.3) 651 Non - 06 1.76 (1.62 - 1.90) 1.68 (1.53 - 1.92) 2.82 (2.67 - 3.04) 4.56 (3.85 - 5.43) 6.81 (5.00 - 9.27) 678 05 (2.86 07 08 2.06 (1.91 - 2.23) 2.03 (1.83 - 2.25) 3.24 - - 3.78) 5.71 (5.15 - 6.54) 8.59 (6.54 - 10.9) 597 09 - 10 1.82 (1.65 - 2.01) 1.70 (1.56 - 1.89) 2.90 (2.39 - 3.17) 4.94 (4.02 - 6.03) 6.74 (5.95 - 8.09) 516 Non 03 - 04 2.58 (2.37 - 2.81) 2.55 (2.32 - 2.80) 4.30 (3.93 - 4.67) 7.58 (6.32 - 8.87) 11.0 (9.34 - 12.4) 1091 Hispanic whites - - 06 1.85 (1.75 - 1.96) 1.70 (1.60 - 1.82) 3.08 05 - 3.31) 5.80 (5.13 - 6.72) 9.77 (7.87 - 11.5) 1038 (2.78 07 - 08 2.15 (1.97 - 2.35) 1.97 (1.84 - 2.11) 3.50 (3.04 - 3.95) 6.44 (5.04 - 8.00) 10.9 (7.47 - 14.5) 1077 (4.67 - 10 1.94 (1.79 - 2.10) 1.78 (1.67 - 1.92) 3.16 (2.80 - 3.59) 5.45 09 - 6.94) 8.55 (6.73 - 10.0) 1206 Biomonitoring Summary http://www.cdc.gov/biomonitoring/BisphenolA_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/BisphenolA_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 43

63 Urinary Bisphenol A (creatinine corrected) (2011 – 2014) onal Hea lth Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 12 1.72 (1.61 - 1.84) 1.58 (1.46 Total 1.71) 2.86 (2.62 - 3.01) 4.62 (4.12 - 5.65) 8.24 (6.47 - 11.0) 2487 11 - - 14 1.28 (1.18 - 1.39) 1.21 (1.11 - 1.32) 2.12 (1.92 - 2.33) 3.88 (3.46 - 4.24) 5.09 (4.65 - 5.96) 2684 13 Age group 11 years - 11 - 12 2.27 (1.97 - 2.62) 2.00 (1.78 - 2.16) 3.33 (2.93 - 3.75) 7.94 (4.71 - 12.4) 14.0 (6.45 - 47.5) 395 6 - - 1.81 (1.68 - 1.96) 1.80 (1.52 - 2.03) 3.10 (2.63 14 3.46) 4.48 (4.00 - 4.96) 7.03 (5.00 - 9.92) 409 13 - 19 years 11 - 12 1.64 (1.44 - 1.87) 1.48 (1.13 - 1.98) 2.88 12 (2.21 - 3.23) 4.50 (3.37 - 8.16) 8.74 (3.57 - 18.4) 388 - 14 1.04 (.887 - 1.21) .932 (.809 - 1.19) 1.71 (1.33 - 2.03) 2.69 (2.28 - 3.33) 3.99 (3.29 - 4.67) 462 13 - 12 1.68 (1.57 - 1.80) 1.55 (1.43 - 1.68) 2.75 (2.54 - 3.00) 4.55 (4.00 - 5.39) 7.73 (5.73 - 10.0) 1704 20 years and older 11 13 - 14 1.27 (1.16 - 1.39) 1.21 (1.11 - 1.30) 2.09 (1.90 - 2.31) 3.88 (3.33 - 4.37) 5.09 (4.58 - 5.97) 1813 Gender 11.0) - 12 1.54 (1.40 - 1.69) 1.37 (1.20 - 1.59) 2.55 (2.21 - 2.94) 4.38 (3.75 - 6.00) 8.24 (6.01 - Males 1258 11 (1.78 13 14 1.20 (1.11 - 1.31) 1.12 (.988 - 1.25) 1.95 - - 2.24) 3.75 (3.25 - 4.29) 4.91 (4.42 - 7.02) 1284 Females 11 - 12 1.91 (1.76 - 2.08) 1.75 (1.57 - 1.97) 2.93 (2.73 - 3.24) 4.94 (4.27 - 6.24) 8.13 (6.00 - 11.1) 1229 13 14 1.36 (1.23 - 1.51) 1.28 (1.17 - 1.43) 2.25 (2.03 - 2.48) 3.94 (3.27 - 4.48) 5.18 (4.50 - 6.07) 1400 - Race/ethnicity - 11 12 1.64 (1.49 - 1.80) 1.46 (1.32 - 2.70 (2.34 - 3.01) 4.50 (3.45 - 7.00) 7.37 (4.76 - 11.4) 316 Mexican Americans 1.64) 13 - 14 1.30 (1.16 - 1.45) 1.27 (1.05 - 1.57) 2.25 (1.97 - 2.50) 3.57 (3.04 - 3.98) 4.25 (3.93 - 4.83) 438 Non Hispanic blacks 11 - 12 1.65 (1.48 - 1.84) 1.50 (1.30 - 1.71) 2.63 (2.11 - 3.17) 4.82 (3.82 - 6.24) 7.23 (5.98 - 10.7) 665 - - 14 1.35 (1.25 - 1.46) 1.32 (1.13 - 1.46) 2.17 13 - 2.35) 3.89 (3.24 - 4.27) 5.00 (4.40 - 6.01) 609 (1.96 Non - Hispanic whites 11 - 12 1.77 (1.64 - 1.92) 1.64 (1.49 - 1.78) 2.90 (2.65 - 3.08) 4.60 (4.05 - 6.00) 9.00 (6.11 - 12.3) 811 13 14 1.28 (1.14 - 1.44) 1.21 (1.06 - 1.38) 2.13 (1.85 - 2.42) 3.94 (3.33 - 4.56) 5.60 (4.65 - 6.53) 987 - (2.39 All Hispanics - 12 1.66 (1.44 - 1.90) 1.47 (1.28 - 1.70) 2.80 11 - 3.14) 4.82 (3.67 - 7.00) 7.69 (5.76 - 9.62) 571 13 - 14 1.30 (1.19 - 1.43) 1.25 (1.09 - 1.42) 2.20 (1.92 - 2.47) 3.61 (3.13 - 3.98) 4.54 (4.03 - 4.89) 690 (1.84 Asians - 12 1.38 (1.25 - 1.52) 1.32 (1.16 - 1.40) 2.11 11 - 2.50) 4.04 (2.80 - 6.25) 7.42 (4.38 - 12.1) 352 13 - 14 .990 (.847 - 1.16) .918 (.778 - 1.05) 1.62 (1.39 - 1.97) 2.71 (2.09 - 4.00) 4.44 (2.71 - 10.0) 288 Biomonitoring Summary http://www.cdc.gov/biomonitoring/BisphenolA_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/BisphenolA_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 44

64 Urinary Bisphenol F (2013 – 2014) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 .532 (.460 - .616) .400 (.300 - .500) 1.10 (.900 - 1.40) 4.00 (2.80 - 5.30) Total (6.50 - 16.1) 2682 9.80 Age group (.600 11 years 13 - 14 .421 (.343 - .516) .300 (.200 - .400) .900 - 1.30) 2.30 (1.50 - 3.30) 3.90 (3.00 - 6.10) 409 6 - - 19 years 13 - 14 .567 (.458 - .701) .400 (.300 - .600) 1.20 12 - 1.50) 5.30 (2.50 - 8.40) 8.80 (6.50 - 18.7) 461 (1.00 20 years and older 13 - 14 .541 (.457 - .641) .400 (.300 - .500) 1.20 (.900 - 1.50) 4.20 (2.60 - 6.30) 12.2 (6.00 - 21.4) 1812 Gender 13 - 14 .582 (.505 - .671) .400 (.400 - .500) 1.20 (1.10 - 1.40) 5.10 (3.00 - 6.50) 12.4 (7.00 - Males 1284 17.7) Females 13 - 14 .489 (.401 - .596) .300 (.300 - .500) 1.00 (.700 - 1.50) 3.30 (2.40 - 4.60) 8.90 (4.50 - 21.4) 1398 Race/ethnicity Mexican Americans - 14 * .300 (

65 Urinary Bisphenol F (creatinine corrected) (2013 – 2014) onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 .534 (.471 - .606) .444 (.385 - .515) 1.07 (.899 - 1.21) 3.33 (2.39 - 4.76) Total (5.90 - 12.0) 2680 8.39 Age group (.798 11 years 13 - 14 .532 (.431 - .656) .452 (.360 - .636) 1.19 - 1.74) 2.44 (1.91 - 3.49) 4.76 (3.48 - 10.0) 409 6 - - 19 years 12 13 - 14 .460 (.365 - .580) .388 (.287 - .474) 1.06 (.680 - 1.46) 3.23 (1.85 - 5.17) 8.80 (3.31 - 14.4) 461 20 years and older 13 - 14 .546 (.479 - .622) .464 (.395 - .526) 1.06 (.875 - 1.21) 3.40 (2.29 - 5.03) 8.75 (5.70 - 13.8) 1810 Gender (.783 - 14 .489 (.426 - .563) .398 (.311 Males .492) .994 13 - 1.16) 3.98 (2.63 - 5.17) 9.47 (6.81 - 13.8) 1283 - Females 13 - 14 .581 (.497 - .678) .494 (.421 - .583) 1.11 (.896 - 1.40) 3.09 (2.11 - 4.10) 6.97 (3.89 - 14.1) 1397 Race/ethnicity 14 * .308 (

66 Urinary Bisphenol S (2013 – 2014) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 .427 (.375 - .487) .400 (.300 - .500) .900 (.700 - 1.10) 2.10 (1.70 - 2.40) Total (2.50 - 4.70) 2682 3.60 Age group (.500 11 years 13 - 14 .351 (.306 - .404) .300 (.300 - .400) .700 - .800) 1.40 (1.00 - 1.60) 2.10 (1.50 - 4.90) 409 6 - - 19 years 12 13 - 14 .400 (.332 - .482) .400 (.300 - .500) .800 (.600 - 1.10) 1.80 (1.20 - 2.40) 3.20 (1.80 - 8.30) 461 20 years and older 13 - 14 .441 (.381 - .510) .400 (.400 - .500) .900 (.800 - 1.10) 2.10 (1.80 - 2.50) 3.80 (2.60 - 4.60) 1812 Gender (.700 - 14 .455 (.393 - .527) .400 (.400 Males .500) .900 13 - 1.10) 2.30 (1.60 - 2.60) 3.90 (2.40 - 6.40) 1284 - Females 13 - 14 .403 (.343 - .473) .400 (.300 - .500) .900 (.700 - 1.10) 2.00 (1.50 - 2.30) 3.40 (2.40 - 4.60) 1398 Race/ethnicity - 14 .498 (.381 - .650) .500 (.400 - .600) 1.00 (.800 - 1.40) 2.10 (1.60 - 4.30) 4.90 (2.20 - 10.8) Mexican Americans 438 13 - 13 - 14 .636 (.537 - .754) .600 (.500 - .700) 1.40 Non (1.20 - 1.70) 3.20 (2.10 - 4.80) 6.00 (3.50 - 9.50) 608 Hispanic blacks Non - Hispanic whites 13 - 14 .383 (.334 - .440) .400 (.300 - .400) .800 (.600 - .900) 1.90 (1.40 - 2.40) 3.00 (2.40 - 4.00) 987 (.800 All Hispanics - 14 .507 (.424 - .606) .500 (.400 - .600) 1.00 13 - 1.30) 2.10 (1.70 - 3.30) 4.10 (2.60 - 6.40) 690 Asians 13 - 14 .327 (.270 - .397) .300 (.300 - .300) .600 (.500 - .900) 1.40 (1.00 - 2.70) 2.80 (1.60 - 6.50) 287 Survey Limit of detection (LOD, see Data Analysis section) for year 13 - 14 is 0.1. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 47

67 Urinary Bisphenol S (creatinine corrected) (2013 – 2014) onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 .428 (.387 - Total .380 (.352 - .411) .797 (.690 - .903) 1.80 (1.49 - 2.10) 3.33 (2.60 - 4.68) 2680 .474) Age group - 11 years 13 - 14 .444 (.390 - .505) .405 (.345 - .457) .778 (.652 - 6 1.59 (1.14 - 2.27) 2.63 (2.05 - 4.93) 409 .938) 12 19 years 13 - 14 .325 (.287 - .368) .294 (.256 - .331) .588 (.500 - .674) 1.31 (.886 - 1.88) 2.27 (1.33 - 4.58) 461 - 1.88 - 20 years and older .444 (.396 - .498) .389 (.357 - .426) .839 (.714 - .960) 13 (1.56 - 2.22) 3.49 (2.71 - 4.91) 1810 14 Gender Males 13 - 14 .383 (.335 - .437) .333 (.299 - .370) .741 (.630 - .851) 1.56 (1.33 - 1.93) 2.81 (1.88 - 4.76) 1283 Females - 14 .477 (.431 - .529) .417 (.385 - .455) .848 (.729 - .986) 2.03 (1.67 - 2.60) 3.64 (2.97 - 5.20) 1397 13 Race/ethnicity (.722 - 14 .507 (.410 - .627) .458 (.370 Mexican Americans .549) .962 13 - 1.25) 2.22 (1.30 - 5.42) 5.57 (2.26 - 14.9) 438 - Non - Hispanic blacks 13 - 14 .471 (.398 - .557) .414 (.336 - .519) .943 (.792 - 1.11) 2.10 (1.50 - 3.67) 4.11 (2.58 - 6.69) 608 Non 13 - 14 .402 (.354 - .457) .357 (.316 - .390) .714 Hispanic whites (.596 - .864) 1.68 (1.38 - 1.95) 3.02 (2.20 - 4.58) 986 - All Hispanics 13 - 14 .503 (.435 - .581) .487 (.411 - .538) .909 (.756 - 1.09) 2.03 (1.53 - 2.78) 3.90 (2.80 - 5.75) 690 .938) Asians 13 - 14 .420 (.359 - .492) .389 (.357 - .459) .720 (.546 - 1.68 (.964 - 2.76) 2.76 (1.75 - 8.04) 286 _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 48

68 Urinary 4 - - Octylphenol (2005 – 2010)‡ tert les of urine concentrations (in μg/L) for the U.S. population from the National Health and Geometric mean and selected percenti Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 06 * < LOD < LOD < LOD .200 (

69 Urinary 4 - - Octyl phenol (creatinine corrected) (2005 – 2010)‡ tert onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 06 * < LOD < LOD < LOD .560 (

70 Urinary Triclocarban (2013 – 2014) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 * < LOD .200 (.200 - .200) 2.20 (1.20 - Total 13.4 (8.00 - 24.5) 2686 4.10) Age group (.200 11 years 13 - 14 * < LOD - < LOD .300 - .500) .900 (.400 - 5.50) 409 6 - 19 years 13 - 14 * < LOD .200 (.100 - .200) .900 12 - 1.90) 2.60 (1.40 - 9.40) 462 (.400 20 years and older 13 - 14 * < LOD .200 (.200 - .300) 3.40 (1.80 - 7.00) 17.9 (10.0 - 30.8) 1815 Gender 13 - 14 * < LOD .200 (.200 - .400) 3.50 (1.60 - 9.90) 31.9 (13.9 - 47.6) 1285 Males 3.50) Females - 14 * < LOD .200 (.100 - .200) 1.70 (.600 - 13 7.50 (3.50 - 12.9) 1401 Race/ethnicity Mexican Americans 13 - 14 * < LOD .100 (

71 Urinary Triclocarban (creatinine corrected) (2013 – 2014) onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Surve y. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 * < LOD .275 (.248 - .306) 1.96 (1.00 - Total 14.6 (8.93 - 21.3) 2684 4.17) Age group (.323 11 years 13 - 14 * < LOD - < LOD .413 - .725) .778 (.389 - 7.77) 409 6 - 19 years 13 - 14 * < LOD .200 (.146 12 .248) .559 (.380 - .888) 1.97 (.769 - 8.70) 462 - 20 years and older 13 - 14 * < LOD .292 (.261 - .333) 3.20 (1.67 - 7.07) 17.6 (10.7 - 22.9) 1813 Gender 13 - 14 * < LOD .250 (.185 - .306) 3.00 (1.07 - 9.86) 21.3 (13.7 - Males 1284 28.3) Females 13 - 14 * < LOD .292 (.250 - .357) 1.65 (.700 - 4.17) 9.33 (4.17 - 14.9) 1400 Race/ethnicity Mexican Americans - 14 * < LOD .200 (

72 Urinary Triclosan (2003 – 2010) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 13.0 (11.6 - 14.6) 9.20 (7.90 - Total 47.4 (38.2 58.4) 249 (188 - 304) 461 (383 - 522) 2517 03 - 04 10.9) 06 18.5 (16.1 - 21.3) 15.1 (11.8 - 18.5) 76.2 (57.9 - 97.6) 334 (279 - 402) 655 (573 - 739) 2548 05 - 08 15.3 (13.5 - 17.4) 12.1 (10.2 - 13.8) 57.2 (46.1 - 65.9) 225 (176 - 288) 494 (371 - 615) 2604 07 - - 10 14.5 - - 16.6) 10.7 (8.80 - 12.6) 51.2 (39.4 - 67.7) 238 (200 284) 483 (398 - 569) 2749 09 (12.6 Age group 11 years 6 03 - 04 8.16 (6.20 - 10.8) 6.00 (4.00 - 8.50) 20.7 (14.3 - 31.6) 123 (36.4 - 163) 157 (113 - 380) 314 - 05 06 12.8 (9.89 - 16.7) 10.3 (8.30 - 17.2) 35.4 (23.9 - 65.8) 97.6 (67.4 - 181) 246 (99.5 - 462) 356 - 52.2) - 11.8 (7.57 - 18.2) 9.80 (6.70 - 13.9) 27.7 (14.8 - 98.5 (40.5 - 364) 296 (67.4 - 826) 389 07 08 - 10 10.9 (9.35 - 12.8) 9.90 (7.10 - 11.9) 28.3 (22.1 - 35.5) 95.5 (71.5 - 117) 200 (114 - 474) 415 09 - 03 - 04 14.5 (11.0 - 19.1) 10.3 (8.20 - 13.1) 39.0 19 years (26.5 - 86.4) 304 (134 - 566) 655 (310 - 890) 715 12 05 - 06 18.8 (14.9 - 23.8) 15.4 (11.0 - 21.0) 67.5 (45.3 - 100) 330 (174 - 461) 566 (389 - 707) 702 - 08 18.2 (13.8 - 23.8) 13.8 (9.40 - 20.1) 63.2 (38.7 - 110) 296 (144 - 395) 401 (308 - 853) 401 07 09 - 11.7 (9.89 - 13.8) 8.80 (7.30 - 10.9) 30.2 (24.3 - 40.6) 165 (56.7 - 289) 301 (220 - 431) 420 10 65.7) 03 13.6 (12.0 - 15.3) 9.60 (8.20 - 11.5) 51.7 (39.6 - 04 261 (198 - 317) 472 (406 - 522) 1488 - 20 years and older - 06 19.3 (16.4 - 22.6) 15.5 (11.8 - 19.4) 84.3 (61.0 114) 366 (289 - 462) 738 (583 - 864) 1490 05 - 07 08 15.4 (13.7 - 17.3) 12.3 (10.1 - 14.4) 60.1 (48.5 - 69.0) 225 (185 - 286) 504 (378 - 573) 1814 - 09 - 10 15.5 (12.9 - 18.5) 11.1 (8.60 - 14.2) 61.8 (41.8 - 86.0) 262 (214 - 327) 544 (415 - 621) 1914 Gender - 04 16.2 (13.4 - 19.6) 11.7 (9.30 - 14.8) 84.9 (50.6 - 111) 317 (231 - 433) 574 (461 - 716) 1229 Males 03 05 - 06 21.3 (17.6 - 25.7) 17.6 (11.9 - 23.2) 103 (69.9 - 143) 446 (366 - 488) 738 (601 - 873) 1270 07 08 15.2 (12.9 - 17.9) 12.3 (9.50 - 15.3) 60.6 (45.8 - 72.8) 236 (159 - 338) 467 (367 - 636) 1294 - (40.4 10 14.8 (12.7 - 17.4) 10.9 (8.60 - 13.3) 55.1 - - 77.5) 243 (214 - 295) 455 (327 - 600) 1399 09 Females 03 - 04 10.6 (9.29 - 12.1) 7.60 (6.10 - 9.10) 33.2 (27.1 - 39.4) 144 (96.5 - 250) 380 (258 - 430) 1288 05 06 16.2 (13.9 - 18.8) 12.6 (10.1 - 15.6) 58.7 (41.5 - 81.9) 226 (169 - 304) 513 (310 - 773) 1278 - 07 - 15.5 (12.6 - 18.9) 12.0 (9.90 - 14.1) 52.1 (37.1 - 74.4) 210 (133 - 367) 504 (285 - 648) 1310 08 (149 - 14.2 09 (12.0 - 16.8) 10.5 (8.70 - 12.6) 50.0 (34.4 - 63.8) 235 10 - 302) 488 (332 - 661) 1350 Race/ethnicity 03 - 04 14.6 (10.6 - 20.1) 8.80 (5.40 - 17.5) 65.4 (32.8 - 127) 357 (225 - 456) 597 (372 - 992) 613 Mexican Americans 05 06 26.7 (21.2 - 33.7) 18.7 (13.5 - 25.5) 196 (99.4 - 269) 668 (475 - 759) 866 (750 - 1180) 637 - - 07 17.1 (12.9 - 22.6) 11.8 (8.40 - 17.8) 67.4 (42.5 08 106) 358 (208 - 474) 556 (363 - 856) 531 - 09 - 10 14.9 (12.2 - 18.3) 10.2 (8.20 - 12.8) 54.7 (33.3 - 345 (260 - 494) 691 (443 - 1180) 566 86.5) Non Hispanic blacks 03 - 04 14.4 (11.4 - 18.2) 11.1 (8.70 - 16.1) - (30.2 - 58.0) 203 (87.5 - 341) 450 (254 - 750) 652 37.6 05 - 06 17.3 (13.3 - 22.4) 14.0 (10.4 - 19.0) 59.2 (37.7 - 98.3) 258 (138 - 460) 541 (273 - 1190) 678 07 08 13.7 (11.7 - 16.1) 11.3 (8.80 - 13.9) 41.4 (28.9 - 49.6) 150 (93.5 - 265) 480 (190 - 757) 597 - 09 44.6) 10 12.8 (10.8 - 15.0) 9.30 (7.70 - 11.7) 34.3 (24.0 - 168 (88.4 - 263) 451 (202 - 959) 516 - - 03 - 04 12.9 (11.2 - 14.9) 9.20 (7.40 - 11.0) 49.2 Non (37.8 - 63.4) 245 (163 - 334) 461 (383 - 527) 1092 Hispanic whites 05 - 06 17.5 (14.9 - 20.6) 15.1 (10.9 - 19.0) 74.3 (54.1 - 90.3) 288 (231 - 366) 569 (462 - 693) 1038 (41.9 08 15.0 (12.6 - 17.7) 12.3 (9.80 - 14.5) 59.6 - - 73.4) 197 (147 - 266) 408 (296 - 537) 1077 07 09 - 10 14.0 (11.8 - 16.7) 10.5 (8.30 - 12.9) 51.7 (33.1 - 79.2) 216 (174 - 266) 431 (301 - 565) 1206 Limit of detection (LOD, see Data Analysis section) for Survey years 03 - 04, 05 - 06, 07 - 08 and 09 - 10 are 2.3, 2.3, 2.3, and 2.3 respectively. Biomonitoring S ummary http://www.cdc.gov/biomonitoring/Triclosan_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Triclosan_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 53

73 Urinary Triclosan (2011 – 2014) concentrations (in μg/L) for the U.S. population from the National Health and Geometric mean and selected percentiles of urine Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 12 11.8 (10.6 - 13.1) 7.10 (6.10 Total 7.90) 41.6 (30.2 - 59.5) 267 (207 - 332) 553 (429 - 722) 2489 11 - - 14 9.78 (9.01 - 10.6) 6.30 (5.70 - 7.20) 33.9 (29.1 - 39.1) 172 (138 - 208) 379 (324 - 431) 2686 13 Age group 11 years - 11 - 12 7.18 (5.73 - 9.01) 5.00 (3.40 - 7.30) 17.2 (10.4 - 21.8) 77.6 (28.9 - 184) 184 (78.7 - 393) 396 6 - - 8.24 (6.70 - 10.1) 6.10 (4.80 - 8.00) 22.9 (15.3 14 33.5) 73.8 (52.7 - 96.0) 124 (91.2 - 204) 409 13 - 19 years 11 - 12 10.1 (7.70 - 13.3) 5.80 (4.70 - 7.50) 25.5 (15.1 - 38.9) 156 (73.5 - 286) 489 (171 - 1550) 388 12 13 14 7.96 (6.81 - 9.31) 6.00 (4.80 - 7.40) 19.7 (15.4 - 25.3) 85.7 (37.2 - 183) 224 (122 - 325) 462 - 11 12 12.7 (11.2 - 14.4) 7.60 (6.40 - 8.50) 57.4 (37.0 - 75.8) 298 (243 - 388) 594 (437 - 845) 1705 20 years and older - - - 10.3 (9.32 - 11.3) 6.40 (5.60 - 7.50) 39.3 (32.4 14 48.5) 203 (147 - 270) 420 (350 - 529) 1815 13 Gender - - 12 11.6 (10.1 - 13.1) 6.40 (5.30 Males 7.50) 41.6 (28.1 - 58.7) 320 (211 - 388) 566 (392 - 722) 1259 11 13 (29.3 14 9.95 (8.75 - 11.3) 6.40 (5.20 - 8.50) 34.7 - 40.6) 172 (126 - 215) 372 (297 - 479) 1285 - (25.7 Females - 12 12.0 (10.2 - 14.0) 7.60 (6.20 - 8.60) 42.2 11 - 75.8) 242 (188 - 286) 545 (380 - 855) 1230 13 - 14 9.63 (8.41 - 11.0) 6.20 (5.60 - 7.10) 31.7 (24.9 - 42.5) 173 (112 - 240) 384 (302 - 528) 1401 Race/ethnicity 11 12 12.6 (8.98 - 17.8) 7.20 (4.70 - 11.7) 47.6 (21.9 - 82.7) 411 (151 - 628) 628 (393 - 1250) 316 Mexican Americans - - - 8.65 (5.55 - 13.5) 5.20 (2.60 - 12.2) 31.9 (15.4 14 68.0) 191 (79.5 - 346) 488 (180 - 822) 438 13 - Hispanic blacks 11 - 12 10.5 (9.08 - 12.2) 6.70 (5.70 - 8.40) 29.9 Non - 40.0) 169 (106 - 278) 475 (278 - 718) 665 (22.4 - 14 8.34 (7.54 - 9.23) 5.50 (4.40 - 6.60) 24.9 (18.9 - 32.6) 145 (68.6 - 209) 304 (204 - 509) 609 13 - 11 - 12 11.7 (10.0 - 13.7) 7.00 (5.60 - 8.00) 44.6 Non (24.4 - 75.8) 248 (184 - 392) 552 (365 - 759) 813 Hispanic whites 13 - 14 10.0 (8.95 - 11.3) 6.40 (5.60 - 8.00) 34.7 (29.2 - 43.1) 148 (122 - 210) 350 (253 - 438) 988 All Hispanics - 12 13.4 (11.6 - 15.5) 7.50 (6.40 - 9.30) 48.3 (33.2 - 75.5) 411 (264 - 518) 861 (536 - 1040) 571 11 (17.9 13 14 9.14 (6.95 - 12.0) 6.00 (3.70 - 9.50) 29.6 - - 44.3) 208 (131 - 325) 583 (325 - 737) 690 Asians 11 - 12 11.7 (7.75 - 17.8) 7.30 (3.80 - 15.1) 42.9 (18.6 - 125) 274 (117 - 433) 453 (235 - 636) 352 (25.2 14 11.5 (9.24 - 14.3) 6.20 (4.30 - 9.10) 71.5 - - 121) 294 (212 - 428) 594 (384 - 740) 289 13 Limit of detection (LOD, see Data Analysis section) for Survey years 11 - 12 and 13 - 14 are 2.3 and 1.7, respectively. Biomonitoring Summary http://www.cdc.gov/biomonit oring/Triclosan_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Triclosan_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 54

74 Urinary Triclosan (creatinine corrected) (2003 – 2010) onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 12.7 (11.5 - 14.1) 9.48 (8.22 - 10.4) 43.9 (33.8 - 60.6) 212 (172 - 241) 368 (294 Total 463) 2514 03 - - 18.0 (16.0 - 20.3) 13.0 (11.5 - 16.1) 73.2 (57.3 - 06 304 (240 - 364) 532 (434 - 674) 2548 05 91.6) - 08 15.5 (13.7 - 17.5) 12.4 (10.6 - 14.2) 50.4 (40.2 - 59.8) 233 (171 - 300) (330 - 559) 2604 07 443 09 10 15.1 (13.2 - 17.4) 10.9 (9.41 - 12.4) 49.4 (37.0 - 67.3) 256 (191 - 322) 454 (352 - 557) 2749 - Age group 11 years 03 - 04 9.93 (7.43 - 13.3) 7.55 (4.72 - 13.4) 25.1 (15.3 - 35.6) 116 (39.9 - 236) 236 (115 - 6 314 - 336) 05 06 14.1 (10.8 - 18.5) 13.5 (7.97 - 18.5) 38.6 (26.0 - 54.1) 108 (62.4 - 169) 241 (108 - 598) 356 - 07 - 08 14.5 (9.47 - 22.1) 13.0 (8.00 - 17.5) 33.1 (17.5 - 72.4) 132 (52.7 - 331) 331 (131 - 599) 389 - 10 14.2 (12.4 - 16.4) 12.0 (8.84 - 15.0) 37.1 (27.0 - 47.3) 129 (89.1 - 155) 300 (148 - 469) 415 09 - 19 years 03 - 04 10.9 (8.32 - 14.2) 7.45 (5.48 - 10.7) 31.8 (21.9 - 61.1) 193 (90.7 - 318) 356 (169 - 580) 713 12 - - 14.0 (11.0 - 17.8) 11.1 (8.68 - 13.6) 51.0 (33.0 06 73.4) 193 (125 - 306) 385 (203 - 739) 702 05 07 - 08 14.1 (11.0 - 18.1) 11.0 (7.87 - 14.4) 50.2 (27.1 - 78.8) 206 (95.3 - 293) 378 (238 - 571) 401 09 10 9.38 (7.86 - 11.2) 7.71 (5.71 - 9.21) 23.2 (17.3 - 29.3) 153 (63.0 - 201) 247 (166 - 379) 420 - - 04 13.4 (12.0 - 15.1) 10.0 (8.89 - 11.4) 50.0 (36.0 - 73.8) 224 (186 - 272) 385 (308 - 506) 1487 20 years and older 03 05 - 06 19.3 (16.9 - 22.0) 13.7 (11.6 - 17.0) 86.1 - 109) 343 (262 - 411) 581 (440 - 718) 1490 (64.0 - 08 15.8 (14.0 - 17.8) 12.6 (10.7 - 14.5) 52.3 07 - 64.6) 244 (186 - 309) 484 (336 - 568) 1814 (43.8 09 - 10 16.4 (13.7 - 19.6) 11.5 (9.63 - 14.8) 57.1 (38.4 - 80.2) 279 (202 - 364) 504 (372 - 601) 1914 Gender 03 04 13.2 (11.3 - 15.6) 9.21 (6.86 - 12.1) 73.1 (45.8 - 85.9) 237 (175 - 294) 384 (294 - 506) 1228 Males - 109) - 17.1 (14.1 - 20.7) 12.4 (10.0 - 18.5) 82.6 (58.2 - 308 (232 - 368) 472 (355 - 721) 1270 05 06 - 08 12.8 (10.9 - 15.0) 10.0 (8.12 - 13.0) 45.7 (32.1 57.3) 191 (132 - 241) 330 (253 - 456) 1294 07 - 09 10 13.3 (11.3 - 15.7) 9.21 (7.40 - 11.7) 43.9 (33.5 - 67.4) 230 (178 - 276) 345 (276 - 429) 1399 - 03 - 04 12.2 (10.6 - 14.2) 9.54 (8.45 - 10.4) 32.3 (26.2 - 46.6) Females (138 - 217) 336 (225 - 480) 1286 182 - 06 19.0 (16.1 - 22.6) 13.8 (11.7 - 16.7) 64.0 (47.6 - 89.8) 301 (209 - 434) 619 (418 - 898) 1278 05 - 07 18.5 (15.6 - 22.0) 14.4 (12.4 - 16.8) 55.3 (38.5 08 77.0) 300 (182 - 435) 571 (359 - 729) 1310 - 09 - 10 17.1 (14.6 - 20.1) 12.3 (10.7 - 14.8) 50.6 (37.0 - 71.3) 300 (187 - 422) 556 (422 - 668) 1350 Race/ethnicity (28.8 - 04 13.3 (9.38 - 18.8) 9.18 (5.45 Mexican Americans 13.9) 66.7 03 - 112) 292 (151 - 432) 453 (263 - 1150) 612 - 05 - 06 24.1 (19.3 - 29.9) 17.6 (13.3 - 22.8) 154 (96.4 - 242) 440 (379 - 601) 736 (601 - 818) 637 07 08 16.6 (12.2 - 22.6) 12.6 (8.51 - 16.5) 60.1 (39.6 - 80.3) 325 (182 - 475) 637 (368 - 828) 531 - - 09 14.8 (12.1 - 18.2) 9.38 (7.63 - 12.4) 45.4 (32.2 10 110) 352 (244 - 458) 578 (402 - 737) 566 - - Hispanic blacks 03 - 04 9.94 (7.92 - 12.5) 7.74 (5.50 - 10.0) 30.2 (25.6 - 37.3) 132 (78.0 - 213) 260 (127 - 513) 651 Non - 06 12.2 (9.47 - 15.6) 9.50 (7.64 - 11.8) 41.0 (23.3 - 77.4) 179 (106 - 243) 352 (203 - 674) 678 05 (22.3 07 08 10.6 (8.91 - 12.7) 8.34 (6.47 - 10.1) 28.6 - - 36.7) 120 (71.0 - 203) 266 (151 - 407) 597 09 - 10 9.23 (7.62 - 11.2) 6.62 (5.63 - 8.18) 22.7 (16.9 - 29.1) 136 (63.6 - 240) 356 (180 - 689) 516 Non 03 - 04 13.3 (11.6 - 15.1) 9.82 (8.11 - 11.5) 47.0 (34.3 - 67.7) 213 (160 - 272) 358 (276 - 480) 1091 Hispanic whites - - 06 18.4 (16.0 - 21.2) 13.5 (11.6 - 17.0) 73.4 05 - 97.0) 282 (231 - 343) 472 (367 - 699) 1038 (56.8 07 - 08 15.6 (13.1 - 18.7) 13.0 (10.7 - 14.8) 50.4 (35.9 - 65.9) 222 (129 - 303) 418 (262 - 586) 1077 (159 - 10 15.8 (13.1 - 19.0) 11.4 (9.41 - 14.8) 52.0 (37.0 - 71.3) 242 09 - 323) 410 (317 - 547) 1206 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Triclosan_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Triclosan_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 55

75 Urinary Triclosan (creatinine corrected) (2011 – 2014) onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 12 13.4 (11.8 - 15.1) 8.39 (6.79 Total 10.0) 49.3 (37.4 - 57.5) 309 (229 - 404) 642 (508 - 788) 2487 11 - - 14 9.83 (9.00 - 10.7) 6.90 (6.27 - 7.65) 29.9 (25.1 - 34.4) 173 (138 - 207) 358 (292 - 425) 2684 13 Age group 11 years - 11 - 12 10.3 (8.18 - 12.9) 6.70 (5.62 - 9.06) 22.4 (16.3 - 31.7) 103 (54.5 - 153) 235 (113 - 333) 395 6 - - 10.4 (8.61 - 12.6) 8.97 (6.62 - 11.5) 23.4 (18.4 14 36.1) 78.1 (57.0 - 125) 184 (81.2 - 268) 409 13 - 19 years 11 - 12 9.84 (7.85 - 12.4) 5.83 (4.95 - 7.23) 26.3 12 (19.0 - 37.8) 182 (65.0 - 399) 421 (182 - 647) 388 - 14 6.46 (5.24 - 7.96) 5.11 (4.39 - 5.93) 15.7 (10.0 - 21.8) 53.6 (33.2 - 105) 153 (102 - 289) 462 13 - 12 14.4 (12.4 - 16.7) 9.06 (7.41 - 11.2) 54.3 (43.9 - 75.0) 364 (246 - 514) 660 (536 - 817) 1704 20 years and older 11 13 - 14 10.4 (9.44 - 11.4) 7.17 (6.32 - 8.26) 34.4 (29.3 - 41.6) 202 (162 - 234) 408 (296 - 531) 1813 Gender 656) - 12 10.8 (9.49 - 12.2) 6.40 (5.24 - 8.53) 37.4 (26.8 - 49.4) 226 (153 - 309) 536 (311 - Males 1258 11 (22.6 13 14 8.36 (7.44 - 9.41) 5.74 (4.80 - 6.67) 26.7 - - 31.8) 143 (111 - 195) 296 (216 - 426) 1284 Females 11 - 12 16.5 (13.8 - 19.6) 10.8 (8.44 - 12.7) 53.3 (44.2 - 75.0) 381 (273 - 539) 746 (614 - 900) 1229 13 14 11.5 (10.0 - 13.1) 8.08 (6.70 - 9.23) 34.4 (25.1 - 42.2) 205 (150 - 253) 419 (294 - 573) 1400 - Race/ethnicity - 11 12 14.2 (10.4 - 19.5) 8.29 (6.10 - 62.5 (31.8 - 111) 399 (163 - 536) 536 (271 - 900) 316 Mexican Americans 12.4) 13 - 14 8.82 (5.50 - 14.1) 6.08 (3.08 - 13.4) 25.5 (15.9 - 61.3) 147 (68.8 - 340) 425 (142 - 659) 438 Non Hispanic blacks 11 - 12 8.18 (7.09 - 9.44) 5.52 (4.66 - 6.27) 21.5 (16.7 - 29.9) 130 (74.3 - 222) 365 (229 - 461) 665 - - 14 6.16 (5.30 - 7.15) 4.27 (3.52 - 4.93) 16.7 13 - 21.3) 107 (66.1 - 125) 218 (116 - 284) 609 (12.7 Non - Hispanic whites 11 - 12 14.2 (12.1 - 16.7) 8.95 (6.79 - 11.7) 51.9 (39.1 - 69.1) 311 (180 - 569) 675 (508 - 817) 811 13 14 10.6 (9.78 - 11.5) 7.78 (6.67 - 9.09) 33.0 (26.4 - 40.2) 178 (128 - 215) 339 (247 - 420) 987 - (40.8 All Hispanics - 12 15.0 (13.0 - 17.3) 8.58 (6.52 - 11.4) 70.8 11 - 98.6) 449 (320 - 514) 647 (506 - 913) 571 13 - 14 9.07 (6.64 - 12.4) 6.08 (3.75 - 11.0) 24.7 (17.0 - 55.6) 197 (114 - 322) 462 (322 - 619) 690 (23.6 Asians - 12 15.7 (10.2 - 24.2) 10.5 (6.05 - 17.4) 51.8 11 - 142) 333 (127 - 609) 575 (381 - 719) 352 13 - 14 14.6 (11.5 - 18.6) 8.00 (5.74 - 13.3) 100 (39.3 - 151) 406 (247 - 528) 659 (419 - 917) 288 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Triclosan_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Triclosan_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 56

76 Urinary Butyl paraben (2005 – 2010) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 06 * < LOD 1.30 (.800 - 1.80) 6.60 (4.80 - 10.7) 19.6 (16.4 Total 26.7) 2548 05 - - * < LOD 1.10 (.900 - 1.50) 9.00 08 - 11.4) 20.9 (15.2 - 30.1) 2604 07 (6.20 - 10 * .600 (.500 - .800) 5.10 (3.40 - 8.10) 17.1 (10.5 - 29.4) 2749 09 < LOD Age group 11 years - 05 - 06 * < LOD .400 (.200 - .600) 1.90 (.800 - 5.80) 7.50 (1.70 - 18.5) 356 6 - * < LOD .300 (.200 - .500) 1.30 08 (.900 - 1.70) 3.80 (1.00 - 114) 389 07 09 - 10 * < LOD .300 (

77 Urinary Butyl paraben (2011 – 2014) U.S. population from the National Health and Geometric mean and selected percentiles of urine concentrations (in μg/L) for the Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 * < LOD .300 (.200 - .400) 2.50 (1.60 - 3.40) 7.70 (4.50 Total 11.4) 2489 11 - - * < LOD .200 (.100 - .200) 1.30 14 - 1.70) 4.40 (2.70 - 6.10) 2686 13 (.800 Age group - 11 - 12 * < LOD < LOD .700 (.300 - 1.00) 1.50 (1.00 - 1.90) 396 6 11 years - * < LOD < LOD .300 (.200 - .500) 13 .600 (.300 - 1.30) 409 14 .900 19 years 11 - 12 * < LOD .300 (

78 Urinary Butyl paraben (creatinine corrected) (2005 – 2010) onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 06 * < LOD 1.16 (.910 - 1.62) 7.82 (6.26 - 11.2) 21.2 (16.8 Total 27.3) 2548 05 - - * < LOD 1.16 (.880 - 1.59) 9.83 08 - 13.5) 23.1 (18.1 - 30.4) 2604 07 (6.51 - 10 * < LOD .710 (.610 - .930) 5.58 (3.55 - 10.0) (10.2 - 27.6) 2749 09 18.0 Age group 11 years - 06 * < LOD .440 (.370 - .660) 1.65 05 (1.00 - 5.29) 7.92 (1.64 - 30.5) 356 - 6 - 08 * < LOD .540 (.410 - .720) (.920 - 2.80) 5.91 (.930 - 76.0) 389 07 1.24 09 10 * < LOD .530 (

79 Urinary Butyl par aben (creatinine corrected) (2011 2014) – onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 * < LOD .560 Total (.476 - .667) 3.50 (2.00 - 4.55) 10.0 (6.26 - 13.5) 2487 11 - 14 * < LOD .250 (.202 - .318) 1.54 - 2.22) 4.39 (3.25 - 6.96) 2684 13 (.952 Age group 11 years - 11 - 12 * < LOD < LOD .825 (.737 - 1.12) 1.56 (.825 - 2.44) 395 6 - - * < LOD < LOD .411 (.326 14 .538) .714 (.467 - .984) 409 13 - 19 years 11 - 12 * < LOD .378 (

80 Urinary Ethyl paraben (2005 – 2010) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 06 * < LOD 4.80 (3.40 - 6.00) 26.2 (19.4 - 31.9) 57.2 (40.3 Total 83.4) 2548 05 - - * < LOD 5.40 (3.80 - 6.90) 29.3 08 - 42.4) 72.1 (54.6 - 91.8) 2604 07 (21.9 - 10 * (

81 Urinary Ethyl paraben (2011 – 2014) U.S. population from the National Health and Geometric mean and selected percentiles of urine concentrations (in μg/L) for the Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 * < LOD 5.10 (4.00 - 7.10) 33.6 (24.6 - 42.9) 68.8 (52.1 Total 106) 2489 11 - - * < LOD 5.30 (4.50 - 6.50) 33.5 14 - 46.4) 77.0 (66.4 - 97.9) 2686 13 (25.5 Age group - 11 - 12 * < LOD < LOD 3.40 (1.70 - 6.90) 6.90 (3.40 - 17.4) 396 6 11 years - - * < LOD 1.30 (1.00 - 1.70) 5.60 (2.90 13 8.40) 10.7 (6.60 - 17.3) 409 14 9.60 19 years 11 - 12 * < LOD 2.00 (1.10 - 3.10) - (5.50 - 14.0) 21.5 (9.60 - 69.2) 388 12 13 - 14 * < LOD 2.40 (1.60 - 3.40) 15.6 (6.60 - 29.3) 48.7 - 83.4) 462 (19.4 20 years and older 11 - 12 * < LOD 7.20 (5.50 - 10.0) 41.1 (33.4 - 51.0) 86.5 (58.0 - 140) 1705 13 - * 1.10 (

82 Urinary Ethyl paraben (creatinine corrected) (2005 – 2010) onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 06 * < LOD 4.61 (3.39 - 6.30) 27.1 (19.1 - 34.0) 66.5 (46.5 Total 84.2) 2548 05 - - * < LOD 5.56 (4.31 - 7.56) 32.7 08 - 50.2) 80.0 (53.2 - 117) 2604 07 (22.5 - 10 * 1.65 (

83 Urinary Ethyl par aben (creatinine corrected) (2011 2014) – onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 * < LOD 6.57 Total (5.32 - 8.80) 39.5 (28.4 - 50.6) 87.7 (63.6 - 121) 2487 11 - 14 * < LOD 5.41 (4.31 - 6.33) 36.6 (26.5 - 99.3 (69.5 - 129) 2684 13 47.5) Age group 11 years 11 - 12 * < LOD < LOD 5.92 (3.74 - 7.50) 7.95 (6.51 - 17.8) - 395 6 13 * < LOD 2.45 (2.03 - 2.96) 6.30 14 (3.94 - 9.44) 12.4 (7.02 - 26.6) 409 - - 19 years 11 - 12 * < LOD 2.53 (1.81 - 3.83) 11.1 (6.70 - 14.5) 20.5 (11.9 - 44.1) 388 12 13 - 14 * < LOD 2.24 (1.83 - 2.81) 11.8 (4.44 - 15.7) 36.1 (13.2 - 73.2) 462 11 12 * < LOD 9.17 (6.69 - 12.5) 46.4 (34.7 - 64.8) 110 (71.5 - 146) 1704 20 years and older - - * 1.57 (

84 Urinary Methyl paraben (2005 – 2010) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 06 56.4 (46.9 - 67.9) 63.5 (47.9 - 74.5) 216 (168 - 282) 560 (432 - 777) 974 (827 Total 1110) 2548 05 - - 60.1 (49.6 - 72.8) 59.8 (47.5 - 73.3) 204 (171 - 08 544 (444 - 675) 902 (746 - 1100) 2604 07 253) - 10 57.1 (51.0 - 63.9) 55.1 (46.7 - 62.6) 213 (179 - 259) 621 (546 - 716) (919 - 1170) 2749 09 1010 Age group - 11 years - 06 33.5 (25.6 - 43.8) 25.0 (19.4 - 35.3) 86.7 (61.5 05 153) 289 (238 - 868) 1560 (389 - 2090) 356 - 6 - 08 35.2 (25.0 - 49.6) 30.1 (19.6 - 38.5) 94.0 - 214) 340 (218 - 527) 651 (430 - 995) 389 07 (46.6 09 10 33.9 (27.4 - 41.9) 26.5 (20.4 - 33.3) 79.4 (59.0 - 126) 415 (163 - 849) 873 (477 - 1230) 415 - - 19 years 05 - 06 53.8 (43.9 - 66.0) 53.5 (39.4 - 65.7) 192 (163 - 264) 491 (380 - 720) 901 (571 - 1210) 702 12 07 08 64.9 (50.3 - 83.8) 66.3 (48.0 - 96.7) 221 (180 - 276) 521 (424 - 789) 971 (574 - 1390) 401 - 09 - 53.9 (40.9 - 70.9) 56.5 (39.4 - 75.6) 176 (122 - 291) 716 (399 - 934) 984 (805 - 1210) 420 10 05 - 06 60.3 (48.7 - 74.7) 70.0 (57.1 - 85.3) 225 (177 322) 602 (439 - 814) 974 (827 - 1110) 1490 20 years and older - - - 63.0 (51.8 - 76.7) 64.0 (51.4 - 79.8) 210 (172 08 267) 558 (447 - 678) 916 (743 - 1190) 1814 07 09 - 10 61.0 (53.5 - 69.6) 59.1 (50.6 - 72.6) 239 (188 - 276) 625 (566 - 711) 1010 (909 - 1270) 1914 Gender - 06 29.8 (24.8 - 35.8) 23.7 (19.5 - 29.4) 97.6 (78.1 - 121) 299 (229 - 355) 491 (385 - 743) 1270 Males 05 07 - 08 33.6 (27.3 - 41.3) 27.4 (20.8 - 39.9) 93.5 - 137) 312 (260 - 407) 598 (460 - 734) 1294 (71.0 - 10 31.7 (27.6 - 36.4) 25.3 (20.6 - 30.6) 94.0 09 - 122) 366 (275 - 482) 727 (569 - 919) 1399 (76.8 Females 05 - 06 104 (80.8 - 135) 137 (93.0 - 168) 356 (279 - 427) 842 (660 - 974) 1110 (956 - 1330) 1278 07 08 105 (90.2 - 123) 116 (95.2 - 139) 315 (248 - 424) 683 (558 - 901) 1140 (917 - 1420) 1310 - (696 09 100 (87.9 - 114) 106 (90.9 - 125) 349 (271 - 405) 812 10 - 931) 1230 (1010 - 1550) 1350 - Race/ethnicity 05 - 06 78.2 (61.0 - 100) 86.3 (64.7 - 121) 301 (233 - 349) 742 (474 - 896) 1100 (896 - 1170) 637 Mexican Americans 07 08 80.5 (66.0 - 98.2) 87.0 (63.4 - 117) 283 (222 - 348) 630 (533 - 791) 1030 (773 - 1240) 531 - 09 385) 10 82.9 (68.6 - 100) 85.5 (73.0 - 99.8) 293 (231 - 821 (536 - 1120) 1580 (855 - 2360) 566 - - 05 - 06 174 (133 - 229) 216 (150 - 306) 616 Non (465 - 789) 1180 (1010 - 1480) 1690 (1210 - 2880) 678 Hispanic blacks 07 - 08 152 (135 - 171) 159 (135 - 194) 483 (421 - 552) 1080 (938 - 1350) 1720 (1210 - 2700) 597 09 10 191 (171 - 213) 223 (170 - 288) 678 (533 - 849) 1470 (1220 - 2010) 2340 (1650 - 2750) 516 - - 05 - 06 43.8 (36.7 - 52.3) 44.3 (36.7 - 58.2) 165 Non (132 - 209) 412 (320 - 520) 806 (485 - 974) 1038 Hispanic whites 07 - 08 48.9 (39.9 - 59.9) 47.6 (37.8 - 62.0) 158 (129 - 198) 430 (301 - 557) 671 (524 - 921) 1077 (127 10 43.5 (39.4 - 48.1) 41.3 (33.5 - 47.7) 150 - - 176) 463 (361 - 557) 757 (619 - 888) 1206 09 Limit of detection (LOD, see Data Analysis section) for Survey years 05 - 06, 07 - 08, and 09 - 10 are 1.0, 1.0, and 1.0 respectively. Biomonitoring Summary http: //www.cdc.gov/biomonitoring/Parabens_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Parabens_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 65

85 Urinary Methyl paraben (2011 – 2014) urine concentrations (in μg/L) for the U.S. population from the National Health and Geometric mean and selected percentiles of Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 12 40.3 (35.4 - 46.0) 39.0 (32.4 Total 47.8) 172 (149 - 198) 471 (401 - 593) 841 (692 - 975) 2489 11 - - 14 48.1 (43.0 - 53.8) 41.7 (34.5 - 50.4) 167 (151 - 186) 445 (404 - 509) 819 (663 - 918) 2686 13 Age group 11 years - 11 - 12 18.5 (15.7 - 21.9) 13.8 (11.2 - 17.7) 58.6 (43.8 - 78.2) 217 (155 - 363) 549 (329 - 983) 396 6 - - 28.6 (21.4 - 38.1) 22.7 (17.8 - 30.3) 62.1 (43.5 14 100) 260 (150 - 408) 542 (290 - 878) 409 13 - 19 years 11 - 12 26.3 (19.0 - 36.5) 17.0 (9.80 - 31.2) 121 (62.4 - 219) 538 (376 - 667) 772 (609 - 996) 388 12 13 14 40.5 (32.7 - 50.1) 32.0 (25.2 - 41.7) 147 (89.6 - 193) 452 (309 - 725) 942 (612 - 1220) 462 - 11 12 46.8 (41.3 - 53.1) 48.9 (37.8 - 61.0) 188 (158 - 231) 477 (409 - 611) 870 (676 - 1070) 1705 20 years and older - - - 52.2 (46.0 - 59.3) 46.8 (37.8 - 57.3) 179 (163 14 201) 457 (417 - 525) 823 (663 - 918) 1815 13 Gender - - 12 23.2 (19.2 - 28.1) 17.3 (12.5 Males 23.4) 81.9 (65.7 - 119) 312 (224 - 396) 575 (401 - 822) 1259 11 13 (67.2 14 31.1 (26.8 - 36.2) 24.4 (20.1 - 29.8) 77.2 - 94.6) 273 (230 - 328) 561 (408 - 740) 1285 - (201 Females - 12 68.6 (59.0 - 79.9) 76.9 (67.5 - 89.2) 248 11 - 309) 637 (493 - 819) 972 (772 - 1190) 1230 13 - 14 72.8 (63.6 - 83.4) 73.9 (61.0 - 94.1) 248 (217 - 276) 583 (490 - 680) 904 (801 - 1070) 1401 Race/ethnicity 11 12 43.9 (31.5 - 61.2) 44.9 (26.2 - 68.1) 192 (111 - 302) 529 (328 - 912) 1080 (471 - 1740) 316 Mexican Americans - - - 62.1 (49.2 - 78.4) 57.4 (45.1 - 84.0) 230 (154 14 341) 518 (361 - 725) 915 (535 - 1530) 438 13 - Hispanic blacks 11 - 12 123 (100 - 152) 155 (115 - 199) 450 Non - 579) 934 (819 - 1110) 1390 (1020 - 1990) 665 (341 - 14 111 (96.1 - 129) 110 (86.4 - 143) 375 (313 - 482) 927 (709 - 1180) 1430 (1020 - 2040) 609 13 - 11 - 12 31.0 (26.9 - 35.8) 30.0 (23.4 - 36.4) 130 Non (96.8 - 160) 372 (269 - 453) 603 (453 - 772) 813 Hispanic whites 13 - 14 37.9 (32.8 - 43.7) 32.5 (28.3 - 39.0) 123 (94.3 - 153) 328 (267 - 391) 573 (422 - 711) 988 All Hispanics - 12 50.1 (40.5 - 62.1) 46.0 (39.5 - 59.4) 203 (130 - 301) 666 (406 - 1080) 1170 (766 - 2100) 571 11 (161 13 14 61.9 (52.2 - 73.3) 60.0 (49.0 - 73.5) 221 - - 291) 539 (417 - 702) 842 (639 - 1070) 690 Asians 11 - 12 36.1 (29.2 - 44.5) 37.1 (24.6 - 57.4) 140 (97.9 - 175) 395 (259 - 509) 692 (461 - 1030) 352 (118 14 45.0 (37.9 - 53.5) 38.9 (30.5 - 53.0) 168 - - 197) 384 (271 - 475) 663 (393 - 914) 289 13 Limit of detection (LOD, see Data Analysis section) for Survey years 11 - 12 and 13 - 14 are 1.0 and 1.0, respectively. Biomonitoring Summary http://www.cdc.gov/biomonitor ing/Parabens_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Parabens_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 66

86 Urinary Methyl paraben (creatinine corrected) (2005 – 2010) onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 06 55.0 (46.8 - 64.6) 58.8 (47.0 - 73.4) 221 (170 - 264) 527 (426 - 685) 902 (753 Total 995) 2548 05 - - 60.6 (49.8 - 73.8) 61.0 (45.3 - 83.2) 228 (188 - 08 538 (439 - 645) 820 (694 - 1000) 2604 07 288) - 10 59.6 (53.5 - 66.3) 57.7 (52.3 - 68.5) 232 (195 - 262) 544 (468 - 632) (734 - 1020) 2749 09 887 Age group - 11 years - 06 36.8 (27.9 - 48.7) 26.9 (21.0 - 36.6) 108 (55.9 05 164) 259 (195 - 753) 1540 (313 - 2510) 356 - 6 - 08 43.4 (31.3 - 60.2) 33.1 (21.8 - 55.0) 118 - 197) 424 (218 - 668) 817 (558 - 1020) 389 07 (62.3 09 10 44.2 (35.7 - 54.6) 32.3 (26.5 - 42.9) 110 (67.6 - 158) 483 (258 - 722) 849 (535 - 1080) 415 - - 19 years 05 - 06 40.1 (33.7 - 47.8) 41.7 (31.5 - 56.3) 160 (129 - 178) 362 (280 - 428) 549 (434 - 656) 702 12 07 08 50.5 (40.1 - 63.7) 52.8 (36.6 - 78.1) 167 (111 - 245) 336 (292 - 395) 475 (376 - 623) 401 - 09 - 43.3 (33.5 - 55.9) 43.5 (27.5 - 68.6) 168 (123 - 221) 399 (292 - 558) 632 (425 - 890) 420 10 05 - 06 60.5 (50.5 - 72.5) 69.6 (51.5 - 90.9) 251 (189 320) 602 (462 - 729) 930 (788 - 1010) 1490 20 years and older - - - 64.7 (52.9 - 79.2) 69.7 (51.1 - 92.5) 256 (209 08 316) 576 (450 - 710) 865 (697 - 1130) 1814 07 09 - 10 64.6 (57.0 - 73.3) 71.2 (56.6 - 84.7) 251 (217 - 287) 566 (495 - 673) 924 (753 - 1060) 1914 Gender - 06 23.9 (20.6 - 27.8) 21.1 (17.4 - 25.3) 72.1 (58.0 - 89.5) 209 (160 - 260) 368 (262 - 498) 1270 Males 05 07 - 08 28.3 (22.8 - 35.0) 23.5 (17.2 - 33.2) 80.7 - 111) 257 (181 - 318) 444 (386 - 558) 1294 (56.9 - 10 28.4 (25.1 - 32.2) 23.3 (19.3 - 26.9) 77.7 09 - 105) 260 (212 - 370) 516 (412 - 633) 1399 (59.6 Females 05 - 06 123 (99.3 - 152) 147 (111 - 196) 377 (319 - 445) 788 (676 - 910) 1050 (937 - 1290) 1278 07 08 126 (109 - 145) 160 (134 - 182) 374 (325 - 422) 734 (576 - 879) 1040 (835 - 1260) 1310 - (606 09 121 (107 - 137) 146 (125 - 162) 359 (307 - 426) 745 10 - 890) 1080 (924 - 1390) 1350 - Race/ethnicity 05 - 06 70.3 (57.1 - 86.7) 85.8 (67.2 - 106) 249 (191 - 303) 515 (431 - 656) 870 (656 - Mexican Americans 637 1080) - 08 78.5 (63.6 - 97.0) 96.2 (59.4 - 127) 293 (245 - 370) 627 (541 - 728) 831 (729 - 963) 531 07 (237 09 10 82.3 (71.1 - 95.2) 95.2 (76.0 - 113) 284 - - 337) 623 (459 - 899) 1130 (657 - 2120) 566 Non - Hispanic blacks 05 - 06 122 (93.0 - 161) 161 (98.2 - 225) 377 (334 - 462) 792 (581 - 1100) 1220 (916 - 1590) 678 07 08 118 (105 - 133) 134 (111 - 155) 356 (311 - 403) 757 (573 - 882) 1030 (847 - 1290) 597 - (356 10 138 (118 - 163) 165 (127 - 203) 403 - - 498) 928 (729 - 1120) 1350 (1080 - 1680) 516 09 Non - Hispanic whites 05 - 06 46.1 (39.0 - 54.4) 45.6 (34.5 - 59.7) 170 (142 - 234) 447 (339 - 706) 814 (640 - 995) 1038 (154 08 51.0 (40.5 - 64.2) 46.7 (35.8 - 66.3) 191 - - 230) 481 (383 - 614) 747 (574 - 966) 1077 07 09 - 10 48.9 (44.5 - 53.7) 45.9 (39.5 - 51.9) 184 (154 - 215) 468 (388 - 560) 734 (631 - 924) 1206 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Parabens_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Parabens_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 67

87 Urinary Methyl paraben (creatinine corrected) (2011 – 2014) onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 12 46.0 (41.3 - 51.3) 47.9 (36.9 Total 61.7) 203 (179 - 228) 494 (399 - 571) 797 (632 - 993) 2487 11 - - 14 48.2 (43.1 - 53.9) 41.8 (35.5 - 49.1) 180 (145 - 205) 410 (379 - 460) 653 (585 - 697) 2684 13 Age group 11 years - 11 - 12 26.4 (22.8 - 30.7) 19.4 (14.6 - 23.8) 69.9 (53.0 - 113) 282 (182 - 458) 644 (354 - 1220) 395 6 - - 36.1 (28.0 - 46.5) 28.2 (20.9 - 36.5) 72.7 (50.9 14 122) 263 (160 - 564) 588 (341 - 881) 409 13 - 19 years 11 - 12 25.7 (19.3 - 34.2) 17.1 (11.8 - 33.4) 100 12 (53.2 - 175) 335 (213 - 545) 609 (450 - 773) 388 - 14 32.9 (27.7 - 39.0) 24.3 (18.1 - 33.8) 99.5 (75.3 - 145) 339 (234 - 412) 495 (377 - 655) 462 13 - 12 53.4 (47.7 - 59.8) 64.9 (53.2 - 75.2) 228 (199 - 250) 523 (429 - 623) 815 (669 - 1110) 1704 20 years and older 11 13 - 14 52.6 (46.6 - 59.4) 47.5 (38.7 - 58.5) 199 (170 - 229) 429 (390 - 476) 666 (591 - 781) 1813 Gender 560) - 12 21.8 (18.3 - 26.0) 16.2 (12.5 - 21.1) 74.1 (57.1 - 93.3) 250 (181 - 321) 450 (327 - Males 1258 11 (52.1 13 14 26.1 (22.9 - 29.8) 18.4 (16.6 - 22.2) 61.3 - - 74.0) 215 (172 - 284) 411 (323 - 479) 1284 Females 11 - 12 94.5 (83.1 - 108) 119 (101 - 136) 309 (259 - 356) 682 (571 - 805) 1090 (797 - 1300) 1229 13 14 86.5 (74.1 - 101) 90.5 (72.2 - 125) 266 (237 - 307) 564 (506 - 614) 828 (665 - 998) 1400 - Race/ethnicity - 11 12 49.5 (37.0 - 66.2) 50.5 (32.5 - 200 (133 - 298) 496 (316 - 982) 1090 (484 - 2160) 316 Mexican Americans 79.7) 13 - 14 63.3 (46.8 - 85.5) 67.9 (45.6 - 96.0) 229 (146 - 317) 570 (360 - 764) 883 (578 - 1130) 438 Non Hispanic blacks 11 - 12 96.1 (79.4 - 116) 117 (88.0 - 157) 341 (274 - 382) 696 (626 - 842) 1090 (879 - 1190) 665 - - 14 82.0 (75.2 - 89.5) 84.6 (65.8 - 100) 251 13 - 289) 584 (521 - 672) 924 (655 - 1120) 609 (211 Non - Hispanic whites 11 - 12 37.8 (33.1 - 43.2) 33.4 (25.7 - 47.6) 177 (141 - 208) 425 (321 - 556) 719 (544 - 833) 811 13 14 39.9 (34.5 - 46.2) 31.8 (26.4 - 38.7) 139 (104 - 182) 357 (294 - 404) 560 (444 - 640) 987 - (160 All Hispanics - 12 56.1 (46.3 - 68.0) 57.1 (47.2 - 75.2) 217 11 - 332) 577 (456 - 813) 1090 (662 - 1490) 571 13 - 14 61.4 (49.8 - 75.7) 60.8 (51.7 - 74.6) 227 (179 - 270) 542 (390 - 637) 774 (570 - 1070) 690 (167 Asians - 12 48.3 (39.5 - 59.2) 54.9 (31.6 - 79.8) 198 11 - 238) 473 (344 - 600) 840 (528 - 1170) 352 13 - 14 56.9 (45.2 - 71.6) 59.1 (35.7 - 82.0) 202 (160 - 275) 469 (365 - 608) 761 (475 - 911) 288 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Parabens_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Parabens_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 68

88 Urinary n - – 2010) Propyl paraben (2005 d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 06 7.91 (6.41 - 9.77) 8.70 (5.90 - 12.4) 48.9 (36.6 - 64.8) 160 (129 - 200) 299 (237 Total 354) 2548 05 - - 7.59 (6.22 - 9.26) 7.60 (5.70 - 10.6) 44.1 (34.1 - 08 144 (115 - 196) 268 (231 - 290) 2604 07 55.6) - 10 6.97 (5.96 - 8.16) 6.40 (5.10 - 8.00) 44.3 (38.6 - 50.3) 153 (133 - 183) (233 - 334) 2749 09 297 Age group - 11 years - 06 3.41 (2.43 - 4.77) 2.50 (1.60 - 4.30) 11.1 (7.10 05 21.0) 47.5 (30.0 - 91.9) 125 (55.8 - 383) 356 - 6 - 08 3.61 (2.39 - 5.44) 3.50 (1.90 - 6.00) 13.7 - 22.8) 49.1 (21.7 - 99.6) 99.6 (80.4 - 120) 389 07 (7.60 09 10 3.28 (2.58 - 4.17) 2.70 (2.00 - 4.00) 10.2 (7.00 - 14.0) 42.9 (28.2 - 61.6) 114 (56.8 - 239) 415 - - 19 years 05 - 06 8.16 (5.70 - 11.7) 8.40 (5.00 - 13.9) 46.4 (24.1 - 68.5) 165 (96.7 - 222) 310 (201 - 361) 702 12 07 08 8.85 (6.73 - 11.6) 7.90 (5.30 - 12.0) 49.2 (31.1 - 62.2) 193 (100 - 234) 271 (195 - 314) 401 - 09 - 7.01 (5.13 - 9.58) 7.90 (4.40 - 11.0) 39.7 (24.8 - 57.8) 153 (78.1 - 299) 367 (136 - 694) 420 10 05 - 06 8.67 (6.83 - 11.0) 11.2 (7.70 - 14.4) 55.6 (41.2 75.6) 172 (130 - 233) 302 (237 - 367) 1490 20 years and older - - - 8.04 (6.56 - 9.84) 8.40 (6.10 - 11.9) 48.8 (38.3 08 61.1) 152 (118 - 202) 272 (232 - 312) 1814 07 09 - 10 7.58 (6.28 - 9.15) 7.50 (5.30 - 9.90) 48.9 (42.6 - 58.0) 166 (139 - 199) 298 (251 - 334) 1914 Gender - 06 2.96 (2.33 - 3.77) 2.30 (1.60 - 3.10) 13.8 (9.00 - 18.0) 51.7 (39.7 - 70.9) 125 (77.2 - 185) 1270 Males 05 07 - 08 3.02 (2.47 - 3.71) 2.30 (1.70 - 3.30) 12.6 - 17.4) 56.4 (38.9 - 89.5) 140 (98.1 - 209) 1294 (8.40 - 10 2.77 (2.26 - 3.40) 2.00 (1.40 - 2.60) 11.4 09 - 15.4) 57.3 (44.6 - 67.8) 134 (86.1 - 184) 1399 (7.70 Females 05 - 06 20.4 (16.0 - 25.9) 29.1 (21.6 - 37.5) 93.0 (75.7 - 129) 254 (193 - 318) 357 (318 - 395) 1278 07 08 18.4 (15.7 - 21.5) 23.3 (20.5 - 26.1) 76.3 (62.9 - 100) 210 (164 - 269) 312 (271 - 363) 1310 - (171 09 16.9 (14.6 - 19.4) 20.2 (17.0 - 25.9) 83.3 (70.0 - 92.4) 227 10 - 295) 361 (297 - 502) 1350 - Race/ethnicity 05 - 06 10.6 (8.08 - 13.8) 12.1 (7.00 - 17.5) 65.9 (43.5 - 93.3) 247 (174 - 293) 389 (293 - 453) 637 Mexican Americans 07 08 7.82 (5.98 - 10.2) 7.00 (4.20 - 12.9) 52.1 (36.9 - 64.1) 146 (105 - 201) 217 (161 - 401) 531 - 09 68.5) 10 8.94 (7.25 - 11.0) 8.70 (5.70 - 13.3) 58.9 (45.7 - 182 (117 - 299) 451 (269 - 911) 566 - - 05 - 06 26.8 (21.5 - 33.3) 34.7 (28.3 - 44.2) 125 Non (89.5 - 165) 331 (236 - 411) 531 (367 - 730) 678 Hispanic blacks 07 - 08 21.3 (18.4 - 24.7) 28.6 (21.8 - 34.8) 85.4 (70.8 - 96.9) 222 (176 - 282) 410 (277 - 506) 597 09 10 26.1 (21.8 - 31.3) 29.9 (23.4 - 39.5) 129 (87.4 - 167) 322 (229 - 503) 572 (369 - 654) 516 - - 05 - 06 6.21 (5.02 - 7.68) 6.00 (4.60 - 9.10) 35.7 Non (28.4 - 49.6) 130 (92.1 - 157) 229 (156 - 318) 1038 Hispanic whites 07 - 08 6.49 (5.05 - 8.33) 6.10 (4.50 - 9.20) 36.8 (26.9 - 47.5) 129 (91.3 - 196) 251 (190 - 290) 1077 (26.1 10 5.34 (4.55 - 6.27) 4.40 (3.60 - 5.70) 35.6 - - 44.3) 128 (92.4 - 141) 235 (170 - 300) 1206 09 Limit of detection (LOD, see Data Analysis section) for Survey years 05 - 06, 07 - 08, and 09 - 10 are 0.2, 0.2, and 0.2 respectively. Biomonitoring Summary http: //www.cdc.gov/biomonitoring/Parabens_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Parabens_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 69

89 Urinary n - – 2014) Propyl paraben (2011 of urine concentrations (in μg/L) for the U.S. population from the National Health and Geometric mean and selected percentiles Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 5.39 (4.69 - 6.19) 4.70 (3.80 Total 5.90) 28.5 (24.5 - 34.1) 126 (94.0 - 142) 200 (163 - 278) 2489 11 - - 14 5.74 (5.06 - 6.50) 4.80 (3.90 - 5.70) 33.7 (27.1 - 41.1) 120 (106 - 130) (193 - 284) 2686 13 224 Age group 11 years - 11 - 12 2.20 (1.81 - 2.68) 1.40 (1.20 - 1.80) 6.40 (4.80 - 11.8) 28.1 (17.9 - 53.4) 77.7 (41.3 - 185) 396 6 - - 2.96 (2.20 - 3.99) 2.40 (1.80 - 2.80) 7.60 (5.90 14 15.4) 44.7 (28.5 - 75.6) 113 (45.3 - 213) 409 13 - 19 years 11 - 12 3.69 (2.77 - 4.92) 2.80 (1.80 - 4.20) 14.7 (9.50 - 23.4) 81.8 (51.5 - 151) 208 (122 - 357) 388 12 13 14 5.15 (3.89 - 6.83) 3.10 (2.40 - 4.90) 24.5 (12.5 - 54.0) 119 (90.5 - 147) 217 (139 - 299) 462 - 11 12 6.29 (5.45 - 7.25) 6.20 (4.80 - 8.50) 35.4 (29.2 - 43.2) 135 (98.1 - 151) 213 (163 - 323) 1705 20 years and older - - - 6.27 (5.51 - 7.12) 5.70 (4.40 - 7.20) 39.2 (31.3 14 43.2) 126 (112 - 161) 235 (202 - 304) 1815 13 Gender - - 12 2.44 (1.99 - 2.98) 1.70 (1.40 Males 2.10) 8.90 (6.70 - 12.0) 46.5 (28.0 - 80.6) 137 (65.8 - 258) 1259 11 13 (6.20 14 2.61 (2.20 - 3.09) 1.70 (1.30 - 2.20) 9.20 - 13.3) 49.8 (37.1 - 65.8) 128 (94.0 - 175) 1285 - (48.6 Females - 12 11.6 (10.0 - 13.4) 13.8 (12.4 - 16.3) 54.7 11 - 67.2) 151 (141 - 175) 252 (183 - 323) 1230 13 - 14 12.2 (10.6 - 14.1) 13.5 (10.3 - 18.2) 57.0 (50.1 - 67.6) 179 (143 - 203) 329 (230 - 376) 1401 Race/ethnicity 11 12 6.15 (3.98 - 9.52) 6.50 (2.60 - 11.1) 30.0 (22.7 - 57.5) 181 (70.4 - 312) 312 (146 - 1060) 316 Mexican Americans - - - 7.76 (5.55 - 10.8) 6.00 (3.60 - 14.0) 45.0 (29.7 14 57.4) 124 (80.7 - 184) 195 (137 - 342) 438 13 - Hispanic blacks 11 - 12 16.4 (14.1 - 19.1) 18.0 (13.4 - 23.1) 61.1 Non - 82.9) 183 (147 - 225) 340 (221 - 477) 665 (49.9 - 14 15.4 (13.1 - 18.0) 15.7 (10.8 - 20.3) 71.8 (58.2 - 86.4) 249 (187 - 305) 396 (344 - 430) 609 13 - 11 - 12 4.14 (3.57 - 4.79) 3.30 (2.50 - 4.20) 21.0 Non (15.3 - 30.8) 94.6 (70.3 - 135) 163 (137 - 202) 813 Hispanic whites 13 - 14 4.46 (3.78 - 5.27) 3.40 (2.70 - 4.20) 23.8 (17.4 - 32.2) 98.3 (78.6 - 120) 202 (130 - 241) 988 All Hispanics - 12 6.87 (5.42 - 8.71) 6.70 (3.80 - 9.30) 33.6 (26.1 - 50.4) 181 (95.3 - 273) 333 (236 - 556) 571 11 (35.7 13 14 7.73 (6.26 - 9.56) 6.20 (4.40 - 10.4) 45.0 - - 54.1) 127 (112 - 157) 207 (165 - 324) 690 Asians 11 - 12 5.07 (4.06 - 6.34) 5.50 (3.40 - 7.70) 27.0 (22.3 - 37.2) 95.8 (63.6 - 143) 169 (123 - 292) 352 (19.3 14 4.42 (3.71 - 5.27) 3.90 (2.20 - 8.10) 28.8 - - 41.1) 77.8 (60.6 - 120) 158 (95.5 - 209) 289 13 Limit of detection (LOD, see Data Analysis section) for Survey years 11 - 12 and 13 - 14 are 0.2 and 0.1, respectively. Biomonitoring Summary http://www.cdc.gov/biomonitor ing/Parabens_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Parabens_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 70

90 Urinary n - – 2010) Propyl paraben (creatinine corrected) (2005 onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 06 7.71 (6.40 - 9.30) 8.27 (5.87 - 11.3) 52.9 (41.6 - 66.1) 161 (140 - 178) 263 (226 Total 288) 2548 05 - - 7.65 (6.22 - 9.40) 8.00 (5.34 - 11.6) 50.0 (39.5 - 08 138 (115 - 168) 235 (199 - 293) 2604 07 59.8) - 10 7.28 (6.30 - 8.41) 6.67 (5.35 - 8.50) 45.1 (37.3 - 53.5) 155 (128 - 187) (223 - 300) 2749 09 253 Age group - 11 years - 06 3.75 (2.67 - 5.26) 2.70 (1.89 - 4.43) 11.5 (8.07 05 16.0) 52.1 (22.9 - 100) 121 (55.5 - 352) 356 - 6 - 08 4.45 (3.03 - 6.53) 3.50 (1.79 - 6.85) 16.5 - 28.8) 59.1 (28.6 - 94.4) 98.4 (65.0 - 139) 389 07 (8.82 09 10 4.27 (3.34 - 5.47) 3.33 (2.41 - 4.62) 12.0 (8.52 - 16.6) 46.1 (27.5 - 108) 143 (72.5 - 243) 415 - - 19 years 05 - 06 6.08 (4.36 - 8.49) 5.44 (3.03 - 10.5) 33.0 (20.7 - 48.7) 116 (81.9 - 161) 175 (140 - 239) 702 12 07 08 6.88 (5.30 - 8.94) 5.68 (3.51 - 9.90) 33.2 (26.7 - 46.5) 103 (87.2 - 112) 132 (105 - 235) 401 - 09 - 5.64 (4.17 - 7.62) 5.19 (3.53 - 9.03) 32.9 (20.4 - 42.4) 107 (57.6 - 217) 218 (101 - 397) 420 10 05 - 06 8.70 (7.08 - 10.7) 10.8 (7.39 - 15.2) 63.2 (49.7 80.5) 178 (152 - 198) 270 (236 - 293) 1490 20 years and older - - - 8.26 (6.70 - 10.2) 9.91 (6.15 - 12.6) 57.9 (47.3 08 69.1) 161 (127 - 199) 273 (212 - 312) 1814 07 09 - 10 8.03 (6.74 - 9.56) 8.27 (6.10 - 10.8) 55.5 (43.5 - 66.0) 164 (136 - 200) 270 (232 - 314) 1914 Gender - 06 2.38 (1.92 - 2.95) 1.84 (1.42 - 2.46) 9.52 (6.79 - 12.8) 40.5 (31.1 - 51.5) 90.8 (56.8 - 125) 1270 Males 05 07 - 08 2.55 (2.06 - 3.15) 1.74 (1.40 - 2.53) 10.7 - 15.4) 44.7 (29.0 - 66.1) 112 (77.4 - 144) 1294 (5.99 - 10 2.48 (2.05 - 3.00) 1.71 (1.35 - 2.25) 8.85 09 - 14.2) 40.3 (33.8 - 57.6) 105 (74.5 - 143) 1399 (6.12 Females 05 - 06 23.9 (19.9 - 28.8) 34.9 (26.9 - 46.6) 114 (101 - 132) 235 (193 - 263) 306 (277 - 342) 1278 07 08 22.0 (18.7 - 25.8) 30.4 (25.2 - 36.3) 93.3 (80.8 - 110) 199 (161 - 245) 302 (271 - 370) 1310 - (191 09 20.4 (17.8 - 23.3) 25.7 (21.8 - 30.7) 97.1 (81.8 - 115) 223 10 - 248) 334 (295 - 389) 1350 - Race/ethnicity 05 - 06 9.49 (7.29 - 12.4) 11.0 (6.69 - 16.4) 55.2 (44.9 - 79.6) 186 (147 - 271) 329 (194 - Mexican Americans 637 441) - 08 7.63 (5.72 - 10.2) 6.60 (4.10 - 13.4) 47.9 (39.5 - 66.7) 162 (123 - 187) 273 (187 - 304) 531 07 (42.3 09 10 8.87 (7.42 - 10.6) 7.97 (5.87 - 12.8) 54.7 - - 73.8) 184 (140 - 269) 325 (221 - 575) 566 Non - Hispanic blacks 05 - 06 18.8 (15.2 - 23.3) 23.6 (19.0 - 30.8) 83.7 (61.8 - 105) 217 (169 - 255) 318 (242 - 377) 678 07 08 16.6 (14.1 - 19.5) 22.9 (18.0 - 27.2) 64.2 (51.4 - 73.3) 141 (117 - 172) 254 (169 - 311) 597 - (59.5 10 18.9 (15.2 - 23.5) 21.1 (18.2 - 27.7) 80.9 - - 109) 200 (151 - 249) 301 (223 - 376) 516 09 Non - Hispanic whites 05 - 06 6.53 (5.32 - 8.02) 6.45 (3.96 - 9.11) 47.4 (32.6 - 65.3) 146 (119 - 184) 241 (184 - 278) 1038 - 08 6.77 (5.14 - 8.93) 5.81 (3.94 - 10.5) 45.4 (32.2 - 61.4) 132 (105 - 172) 215 (169 - 295) 1 077 07 09 - 10 6.00 (5.19 - 6.94) 5.12 (4.05 - 6.25) 37.8 (32.1 - 49.2) 148 (115 - 183) 242 (215 - 272) 1206 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Parabens_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Parabens_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 71

91 Urinary n - – 2014) Propyl paraben (creatinine corrected) (2011 ona l Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 12 6.16 (5.42 - 6.99) 5.35 (3.97 Total 7.07) 36.7 (31.1 - 42.2) 129 (105 - 162) 215 (183 - 321) 2487 11 - - 14 5.74 (5.10 - 6.46) 4.75 (3.81 - 5.91) 36.7 (30.3 - 41.9) 124 (99.0 - 148) 222 (186 - 253) 2684 13 Age group 11 years - 11 - 12 3.18 (2.62 - 3.87) 2.09 (1.58 - 3.16) 9.11 (5.71 - 12.2) 37.0 (19.8 - 53.1) 116 (43.6 - 202) 395 6 - - 3.74 (2.84 - 4.94) 2.73 (1.75 - 4.00) 10.9 (7.00 14 18.3) 40.5 (24.4 - 98.6) 153 (52.1 - 271) 409 13 - 19 years 11 - 12 3.60 (2.75 - 4.70) 2.46 (1.93 - 3.52) 14.9 12 (9.36 - 24.9) 69.8 (32.3 - 130) 133 (75.6 - 202) 388 - 14 4.18 (3.24 - 5.39) 2.82 (2.03 - 4.46) 20.7 (9.86 - 39.0) 76.0 (56.4 - 102) 118 (94.2 - 197) 462 13 - 12 7.17 (6.22 - 8.27) 7.28 (5.23 - 9.77) 45.7 (38.1 - 51.6) 152 (117 - 183) 258 (190 - 365) 1704 20 years and older 11 13 - 14 6.30 (5.61 - 7.08) 5.71 (4.40 - 7.22) 41.8 (35.9 - 47.8) 138 (112 - 166) 231 (199 - 259) 1813 Gender 190) - 12 2.29 (1.90 - 2.75) 1.38 (1.21 - 1.67) 7.39 (6.02 - 9.39) 46.2 (28.5 - 72.7) 94.5 (57.3 - Males 1258 11 (5.24 13 14 2.19 (1.87 - 2.56) 1.35 (1.17 - 1.59) 7.42 - - 8.93) 42.2 (32.3 - 52.2) 110 (78.9 - 141) 1284 Females 11 - 12 16.0 (13.9 - 18.4) 20.9 (16.7 - 25.7) 74.7 (62.3 - 88.7) 185 (164 - 213) 345 (239 - 426) 1229 13 14 14.4 (12.1 - 17.2) 17.5 (13.2 - 22.3) 65.9 (56.9 - 82.9) 198 (152 - 226) 281 (237 - 338) 1400 - Race/ethnicity - 11 12 6.93 (4.57 - 10.5) 7.19 (3.71 - 40.5 (24.4 - 75.9) 159 (90.0 - 236) 315 (159 - 536) 316 Mexican Americans 10.9) 13 - 14 7.90 (5.27 - 11.9) 6.75 (3.60 - 16.0) 52.7 (30.9 - 67.2) 134 (89.0 - 205) 231 (158 - 284) 438 Non Hispanic blacks 11 - 12 12.8 (11.3 - 14.4) 13.9 (11.3 - 18.0) 54.5 (43.4 - 65.7) 140 (105 - 185) 207 (166 - 333) 665 - - 14 11.4 (10.0 - 12.9) 10.8 (7.87 - 13.9) 56.0 13 - 67.6) 137 (108 - 186) 233 (191 - 274) 609 (44.6 Non - Hispanic whites 11 - 12 5.06 (4.35 - 5.88) 3.20 (2.50 - 5.06) 31.1 (27.3 - 37.1) 120 (88.2 - 164) 213 (164 - 345) 811 13 14 4.69 (4.01 - 5.48) 3.58 (2.66 - 4.63) 29.2 (22.9 - 36.2) 112 (81.6 - 158) 212 (165 - 259) 987 - (35.2 All Hispanics - 12 7.70 (5.99 - 9.90) 7.47 (5.00 - 10.1) 51.5 11 - 72.9) 162 (119 - 196) 318 (185 - 473) 571 13 - 14 7.67 (5.91 - 9.97) 6.40 (4.71 - 10.3) 46.5 (35.4 - 61.9) 139 (109 - 205) 240 (173 - 285) 690 (35.6 Asians - 12 6.80 (5.47 - 8.45) 6.90 (3.41 - 13.7) 46.5 11 - 59.5) 136 (94.4 - 188) 222 (168 - 304) 352 13 - 14 5.54 (4.23 - 7.26) 5.22 (2.70 - 8.39) 43.9 (31.4 - 57.0) 104 (87.0 - 137) 153 (113 - 250) 288 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Parabens_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Parabens_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 72

92 Urinary 2,4 - – 2010) Dichlorophenol (2003 Metabolite of other chlorophenols Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size 04 1.04 (.895 - 1.21) .900 (.800 - - 2.70 (2.30 - 3.10) 8.80 (6.60 - 11.9) 21.3 (14.1 - 29.5) 2525 03 Total 1.10) 06 .945 (.791 - 1.13) .800 (.700 - 1.00) 2.00 (1.60 - 2.40) 4.90 (3.90 - 6.30) 11.9 (7.00 - 20.4) 2548 05 - 08 .970 (.852 - 1.11) .800 (.700 - .900) 1.80 (1.50 - 2.30) 5.10 (3.80 - 7.60) 12.6 (9.00 - 18.1) 2604 07 - - 10 .803 - - .885) .700 (.700 - .800) 1.50 (1.40 - 1.70) 4.00 (3.30 5.00) 8.80 (6.40 - 15.7) 2749 09 (.729 Age group 6 03 - 04 1.01 (.796 - 1.28) .800 (.600 - 1.20) 2.30 (1.70 - 3.20) 7.70 (3.80 - 20.1) 23.5 (9.40 - 31.0) 314 - 11 years 05 06 1.01 (.879 - 1.15) .800 (.800 - 1.10) 2.00 (1.60 - 2.30) 4.90 (3.30 - 6.60) 9.80 (6.30 - 17.6) 356 - 2.80) - 1.04 (.778 - 1.39) .900 (.700 - 1.20) 1.80 (1.20 - 5.90 (2.90 - 10.1) 11.4 (6.60 - 20.7) 389 07 08 - 10 .975 (.768 - 1.24) .700 (.600 - .900) 1.80 (1.40 - 2.30) 5.00 (3.20 - 8.40) 14.2 (4.40 - 90.9) 415 09 - 03 - 04 1.27 (.971 - 1.67) 1.10 (.800 - 1.50) 3.40 19 years (2.50 - 5.00) 13.6 (6.10 - 25.5) 31.5 (14.5 - 85.0) 722 12 05 - 06 1.18 (.997 - 1.39) 1.00 (.900 - 1.20) (2.00 - 3.10) 5.50 (4.00 - 8.30) 13.9 (7.10 - 33.6) 702 2.50 - 08 1.19 (.989 - 1.44) 1.10 (.800 - 1.40) 2.60 (2.00 - 3.00) 5.60 (3.10 - 10.8) 11.6 (5.70 - 36.5) 401 07 09 - .967 (.794 - 1.18) .800 (.700 - .900) 1.60 (1.40 - 2.70) 5.80 (3.70 - 10.1) 14.4 (7.10 - 24.8) 420 10 3.00) 03 1.01 (.874 - 1.17) .900 (.700 - 1.10) 2.60 (2.20 - 04 8.50 (6.60 - 10.4) 19.4 (12.2 - 27.0) 1489 - 20 years and older - 06 .907 (.737 - 1.12) .800 (.600 - 1.00) 2.00 (1.50 2.40) 4.90 (3.70 - 6.40) 11.1 (6.50 - 20.9) 1490 05 - 07 08 .932 (.820 - 1.06) .800 (.700 - .900) 1.70 (1.40 - 2.20) 5.00 (3.80 - 7.60) 13.2 (9.20 - 18.1) 1814 - 09 - 10 .764 (.699 - .836) .700 (.600 - .700) 1.40 (1.30 - 1.60) 3.60 (3.10 - 4.50) 8.00 (5.60 - 13.9) 1914 Gender - 04 1.22 (1.02 - 1.45) 1.10 (.800 - 1.50) 3.00 (2.50 - 3.50) 9.40 (6.80 - 13.9) 22.7 (13.6 - 40.9) 1231 Males 03 05 - 06 1.16 (.973 - 1.37) 1.00 (.900 - 1.20) 2.40 (2.00 - 2.80) 5.50 (4.40 - 7.90) 12.9 (7.30 - 25.3) 1270 07 08 1.06 (.943 - 1.19) .900 (.800 - 1.00) 1.90 (1.60 - 2.20) 5.40 (3.90 - 8.20) 13.6 (10.1 - 18.1) 1294 - (1.40 10 .879 (.789 - .979) .800 (.700 - .800) 1.60 - - 1.80) 4.00 (3.20 - 5.70) 10.4 (5.20 - 18.4) 1399 09 Females 03 - 04 .896 (.754 - 1.07) .800 (.600 - .900) 2.30 (2.00 - 2.70) 8.10 (5.70 - 11.1) 19.8 (12.0 - 27.5) 1294 05 06 .779 (.637 - .954) .700 (.500 - .800) 1.50 (1.30 - 2.10) 4.30 (2.80 - 6.20) 9.40 (5.40 - 19.6) 1278 - 07 - .893 (.750 - 1.06) .700 (.600 - .800) 1.80 (1.20 - 2.50) 4.70 (3.10 - 8.00) 11.9 (7.60 - 18.6) 1310 08 (3.00 - .737 09 (.659 - .824) .600 (.600 - .700) 1.40 (1.30 - 1.70) 4.00 10 - 5.50) 7.80 (5.80 - 15.8) 1350 Race/ethnicity 03 - 04 1.94 (1.46 - 2.56) 1.70 (1.20 - 2.10) 4.50 (2.80 - 9.30) 26.9 (12.7 - 52.1) 66.0 (47.5 - 84.2) 617 Mexican Americans 05 06 1.97 (1.49 - 2.59) 1.60 (1.20 - 2.10) 5.00 (3.30 - 6.60) 20.9 (8.80 - 39.7) 46.5 (21.9 - 79.5) 637 - - 07 1.59 (.969 - 2.60) 1.20 (.600 - 2.60) 4.20 (2.10 08 9.50) 13.4 (7.90 - 29.6) 38.0 (16.4 - 74.0) 531 - 09 - 10 1.25 (.860 - 1.81) .900 (.700 - 1.30) 2.70 (1.60 - 11.3 (4.30 - 26.3) 29.1 (7.60 - 76.3) 566 4.30) Non Hispanic blacks 03 - 04 2.42 (1.92 - 3.06) 2.20 (1.70 - 2.70) - (4.00 - 9.60) 20.8 (11.2 - 38.3) 49.2 (24.0 - 69.7) 636 7.40 05 - 06 2.45 (1.93 - 3.12) 2.10 (1.70 - 2.40) 5.20 (3.90 - 7.40) 20.3 (10.6 - 36.9) 42.6 (21.3 - 129) 678 07 08 1.73 (1.49 - 2.01) 1.40 (1.10 - 1.60) 3.70 (2.90 - 4.90) 17.8 (9.70 - 25.8) 37.7 (24.6 - 56.8) 597 - 09 4.80) 10 1.54 (1.06 - 2.23) 1.20 (.800 - 2.00) 3.10 (2.10 - 12.4 (4.30 - 46.4) 35.2 (7.80 - 107) 516 - - 03 - 04 .837 (.698 - 1.00) .700 (.600 - .900) 2.10 Non (1.70 - 2.60) 6.20 (4.00 - 8.80) 13.4 (8.60 - 22.0) 1077 Hispanic whites 05 - 06 .734 (.610 - .883) .700 (.500 - .900) 1.40 (1.20 - 1.80) 3.10 (2.70 - 3.90) 5.30 (4.30 - 7.90) 1038 (1.20 08 .817 (.732 - .911) .700 (.600 - .800) 1.50 - - 1.80) 3.10 (2.60 - 4.40) 6.40 (4.60 - 8.80) 1077 07 09 - 10 .651 (.594 - .712) .600 (.500 - .700) 1.30 (1.10 - 1.40) 2.80 (2.20 - 3.50) 5.60 (3.80 - 7.40) 1206 08 Limit of detection (LOD, see Data Analysis section) for Survey years 03 - 04, 05 - 06, 07 - and 09 - 10 are 0.17, 0.2, 0.2, and 0.2 respectively. Biomonitoring S ummary http://www.cdc.gov/biomonitoring/24D_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 73

93 Urinary 2,4 - – 2014) Dichlorophenol (2011 of urine concentrations (in μg/L) for the U.S. population from the National Health and Geometric mean and selected percentiles Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 12 .695 (.619 - .781) .600 (.600 Total .700) 1.30 (1.10 - 1.60) 3.50 (2.80 - 4.40) 9.00 (5.60 - 13.0) 2489 11 - - 14 .669 (.603 - .743) .600 (.500 - .700) 1.30 (1.20 - 1.40) 3.00 (2.70 - 3.50) 6.40 (4.80 - 11.5) 2686 13 Age group 11 years - 11 - 12 .672 (.558 - .810) .600 (.400 - .700) 1.10 (1.00 - 1.40) 3.60 (1.90 - 5.50) 11.3 (4.10 - 23.2) 396 6 - - .773 (.646 - .925) .700 (.600 - .900) 1.20 (1.10 14 1.60) 2.90 (2.10 - 4.80) 8.90 (3.30 - 21.8) 409 13 - 19 years 11 - 12 .711 (.591 - .857) .600 (.500 - .800) 1.30 (1.00 - 1.50) 3.30 (2.10 - 5.80) 9.00 (4.10 - 13.0) 388 12 13 14 .668 (.576 - .775) .600 (.500 - .700) 1.10 (.900 - 1.40) 2.40 (1.70 - 4.40) 7.30 (3.10 - 13.8) 462 - 11 12 .695 (.613 - .789) .600 (.500 - .700) 1.30 (1.10 - 1.60) 3.50 (2.80 - 4.60) 9.00 (5.20 - 13.1) 1705 20 years and older - - - .659 (.593 - .732) .600 (.500 - .700) 1.30 (1.20 14 1.40) 3.10 (2.70 - 3.50) 6.20 (4.90 - 10.8) 1815 13 Gender - - 12 .717 (.641 - .802) .600 (.600 Males .700) 1.30 (1.10 - 1.60) 3.20 (2.20 - 4.40) 7.10 (4.60 - 10.6) 1259 11 13 (1.10 14 .708 (.637 - .786) .600 (.600 - .700) 1.30 - 1.60) 2.90 (2.60 - 3.30) 6.20 (4.10 - 11.3) 1285 - (1.00 Females - 12 .675 (.581 - .784) .600 (.500 - .700) 1.20 11 - 1.60) 3.80 (2.80 - 6.00) 11.1 (4.90 - 24.3) 1230 13 - 14 .635 (.553 - .729) .600 (.500 - .700) 1.20 (1.10 - 1.40) 3.10 (2.50 - 4.10) 7.60 (4.40 - 12.3) 1401 Race/ethnicity 11 12 .895 (.720 - 1.11) .800 (.600 - 1.00) 1.80 (1.30 - 2.60) 6.60 (3.50 - 10.5) 14.5 (7.40 - 27.0) 316 Mexican Americans - - - .807 (.609 - 1.07) .600 (.400 - 1.00) 1.70 (1.10 14 2.90) 4.00 (3.00 - 12.2) 14.6 (3.90 - 49.9) 438 13 - Hispanic blacks 11 - 12 1.23 (.965 - 1.57) .900 (.800 - 1.20) 2.20 Non - 3.30) 6.90 (4.20 - 14.8) 25.0 (8.40 - 53.6) 665 (1.60 - 14 1.11 (.791 - 1.54) .800 (.700 - 1.10) 2.00 (1.40 - 3.30) 8.20 (3.00 - 28.2) 23.5 (6.50 - 81.9) 609 13 - 11 - 12 .577 (.514 - .647) .500 (.500 - .600) 1.00 Non (.900 - 1.20) 2.50 (1.70 - 3.70) 4.90 (3.30 - 9.40) 813 Hispanic whites 13 - 14 .588 (.525 - .659) .500 (.500 - .600) 1.10 (1.00 - 1.30) 2.60 (2.30 - 2.90) 4.60 (3.10 - 5.50) 988 All Hispanics - 12 .981 (.760 - 1.27) .800 (.600 - 1.00) 2.10 (1.30 - 3.10) 6.10 (3.90 - 13.0) 15.9 (7.00 - 42.0) 571 11 (1.20 13 14 .786 (.641 - .965) .600 (.500 - .800) 1.60 - - 2.10) 3.50 (3.10 - 7.80) 12.4 (4.20 - 26.1) 690 Asians 11 - 12 .621 (.478 - .807) .500 (.400 - .700) 1.10 (.800 - 1.60) 3.60 (1.70 - 7.10) 11.1 (3.50 - 17.7) 352 (.800 14 .567 (.435 - .738) .500 (.300 - .700) 1.20 - - 1.60) 2.70 (1.70 - 5.80) 7.30 (2.50 - 58.9) 289 13 Limit of detection (LOD, see Data Analysis section) for Survey years 11 - 12 and 13 - 14 are 0.2 and 0.1, respectively. Biomonitoring Summary http://www.cdc.gov/biomonitoring/24D_Biomonit oringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 74

94 Urinary 2,4 - – 2010) Dichlorophenol (creatinine corrected) (2003 Metabolite of other chlorophenols Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati onal Health and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 04 1.02 (.873 - 1.18) .880 (.770 - 1.00) 2.19 (1.84 - 2.73) 7.39 (5.00 - 9.83) 15.4 (11.1 Total 20.9) 2522 03 - - .922 (.798 - 1.06) .750 (.660 - .880) 1.58 (1.33 - 06 4.00 (3.00 - 5.71) 8.90 (5.98 - 16.6) 2548 05 1.86) - 08 .978 (.867 - 1.10) .790 (.700 - .880) 1.63 (1.36 - 1.89) 4.00 (3.14 - 5.63) 11.7 (6.82 - 18.9) 2604 07 09 10 .838 (.757 - .929) .680 (.630 - .740) 1.33 (1.18 - 1.58) 3.48 (2.77 - 4.55) 8.17 (5.44 - 14.3) 2749 - Age group 11 years 03 - 04 1.23 (.965 - 1.56) 1.03 (.750 - 1.45) 2.39 (1.82 - 3.36) 9.29 (3.98 - 16.5) 20.9 (12.9 - 6 314 - 38.1) 05 06 1.11 (.950 - 1.29) .970 (.800 - 1.08) 1.74 (1.38 - 2.19) 4.38 (3.33 - 7.80) 10.9 (5.12 - 23.3) 356 - 07 - 08 1.28 (1.00 - 1.63) 1.06 (.750 - 1.40) 2.06 (1.44 - 3.21) 4.49 (3.13 - 9.27) 11.2 (5.70 - 24.4) 389 - 10 1.27 (.986 - 1.64) .930 (.820 - 1.20) 2.03 (1.54 - 2.94) 5.89 (3.50 - 11.0) 15.9 (5.71 - 121) 415 09 - 19 years 03 - 04 .954 (.725 - 1.26) .790 (.660 - 1.00) 2.08 (1.44 - 3.75) 8.02 (4.72 - 12.5) 14.8 (8.02 - 40.0) 720 12 - - .878 (.765 - 1.01) .700 (.600 - .800) 1.65 (1.22 06 1.93) 3.92 (2.90 - 4.82) 8.28 (4.82 - 15.9) 702 05 07 - 08 .927 (.776 - 1.11) .790 (.640 - 1.00) 1.51 (1.14 - 2.22) 3.81 (2.38 - 5.92) 10.3 (4.28 - 21.8) 401 09 10 .778 (.656 - .921) .580 (.510 - .690) 1.18 (.970 - 1.40) 3.38 (2.11 - 6.27) 7.38 (3.39 - 19.4) 420 - - 04 1.00 (.863 - 1.16) .870 (.770 - 1.00) 2.17 (1.80 - 2.69) 7.16 (4.88 - 9.01) 15.0 (10.6 - 20.8) 1488 20 years and older 03 05 - 06 .909 (.774 - 1.07) .740 (.650 - .870) 1.55 - 1.89) 4.00 (2.84 - 6.19) 8.80 (5.71 - 16.8) 1490 (1.25 - 08 .958 (.847 - 1.08) .770 (.670 - .880) 1.60 07 - 1.85) 3.98 (3.14 - 5.59) 12.1 (8.15 - 18.9) 1814 (1.32 09 - 10 .810 (.735 - .892) .670 (.620 - .730) 1.27 (1.11 - 1.56) 3.33 (2.65 - 4.23) 7.64 (5.16 - 12.3) 1914 Gender 03 04 .995 (.850 - 1.17) .900 (.730 - 1.06) 2.23 (1.82 - 2.82) 6.84 (4.54 - 9.01) 13.7 (9.29 - 21.8) 1230 Males - 1.86) - .927 (.814 - 1.06) .770 (.670 - .880) 1.60 (1.36 - 4.12 (3.08 - 5.45) 8.90 (5.19 - 16.6) 1270 05 06 - 08 .891 (.808 - .984) .720 (.660 - .790) 1.44 (1.29 1.67) 4.00 (2.97 - 5.30) 9.96 (6.82 - 13.4) 1294 07 - 09 10 .788 (.706 - .879) .620 (.580 - .660) 1.25 (1.06 - 1.48) 3.66 (2.52 - 5.47) 7.69 (4.84 - 16.9) 1399 - 03 - 04 1.03 (.845 - 1.27) .870 (.770 - 1.00) 2.17 (1.73 - 2.73) Females (4.57 - 12.1) 17.2 (11.1 - 23.7) 1292 8.00 - 06 .916 (.770 - 1.09) .740 (.640 - .880) 1.56 (1.19 - 1.96) 3.91 (2.66 - 6.50) 8.93 (5.53 - 23.7) 1278 05 - 07 1.07 (.910 - 1.26) .850 (.720 - 1.00) 1.75 (1.43 08 2.29) 4.07 (3.13 - 7.65) 14.4 (6.50 - 26.8) 1310 - 09 - 10 .890 (.789 - 1.00) .740 (.660 - .850) 1.41 (1.24 - 1.67) 3.39 (2.76 - 4.52) 8.79 (5.16 - 14.8) 1350 Race/ethnicity (2.29 - 04 1.76 (1.30 - 2.38) 1.33 (1.04 Mexican Americans 1.74) 3.85 03 - 8.81) 23.8 (10.6 - 51.6) 71.4 (30.8 - 88.8) 616 - 05 - 06 1.77 (1.38 - 2.27) 1.25 (.990 - 1.73) 3.79 (2.70 - 5.35) 16.6 (6.75 - 31.8) 38.1 (23.8 - 55.3) 637 07 08 1.55 (.925 - 2.60) 1.18 (.630 - 2.28) 3.33 (1.93 - 6.50) 14.2 (5.65 - 30.6) 33.1 (16.6 - 60.0) 531 - - 09 1.24 (.860 - 1.78) .910 (.630 - 1.28) 2.03 (1.43 10 3.90) 11.0 (3.54 - 26.4) 26.4 (10.2 - 93.5) 566 - - Hispanic blacks 03 - 04 1.66 (1.28 - 2.16) 1.47 (1.06 - 1.96) 4.14 (2.46 - 7.31) 14.9 (7.93 - 20.1) 22.9 (16.7 - 45.0) 635 Non - 06 1.72 (1.39 - 2.14) 1.32 (1.11 - 1.56) 3.28 (2.33 - 5.35) 14.9 (7.40 - 28.1) 37.0 (15.0 - 83.4) 678 05 (1.85 07 08 1.34 (1.14 - 1.59) .990 (.800 - 1.17) 2.36 - - 3.12) 13.1 (5.70 - 23.3) 33.8 (22.7 - 41.1) 597 09 - 10 1.11 (.739 - 1.67) .890 (.630 - 1.19) 2.07 (1.25 - 3.87) 8.37 (2.99 - 22.0) 22.0 (7.05 - 83.1) 516 Non 03 - 04 .864 (.721 - 1.03) .780 (.690 - .890) 1.86 (1.54 - 2.23) 5.08 (3.58 - 8.00) 10.8 (6.84 - 18.2) 1076 Hispanic whites - - 06 .772 (.660 - .904) .670 (.580 - .790) 1.25 05 - 1.56) 2.78 (2.11 - 3.52) 4.82 (3.33 - 8.62) 1038 (1.07 07 - 08 .853 (.765 - .950) .730 (.660 - .810) 1.36 (1.14 - 1.67) 2.97 (2.53 - 3.33) 5.16 (3.84 - 9.38) 1077 2.76 - 10 .731 (.674 - .793) .630 (.580 - .690) 1.13 (1.01 - 1.25) 09 (2.29 - 3.30) 5.16 (3.79 - 6.46) 1206 Biomonitoring Summary http://www.cdc.gov/biomonitoring/24D_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 75

95 Urinary 2,4 - – 2014) Dichlorophenol (creatinine corrected) (2011 on al Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 12 .791 (.706 - .886) .614 (.560 Total .690) 1.29 (1.08 - 1.48) 3.33 (2.67 - 4.57) 8.10 (5.65 - 11.2) 2487 11 - - 14 .668 (.611 - .730) .556 (.510 - .595) 1.13 (1.03 - 1.29) 2.73 (2.26 - 3.33) 5.96 (4.41 - 8.38) 2684 13 Age group 11 years - 11 - 12 .964 (.807 - 1.15) .741 (.620 - .851) 1.38 (1.07 - 1.61) 3.51 (2.22 - 7.36) 12.4 (5.13 - 34.9) 395 6 - - .977 (.833 - 1.14) .800 (.698 - .909) 1.52 (1.20 14 1.94) 3.41 (2.22 - 6.60) 9.68 (4.48 - 23.7) 409 13 - 19 years 11 - 12 .693 (.582 - .825) .545 (.465 - .678) 1.15 12 (.875 - 1.50) 2.73 (1.96 - 4.00) 4.82 (3.06 - 9.75) 388 - 14 .542 (.472 - .623) .439 (.385 - .519) .833 (.678 - 1.13) 1.72 (1.31 - 3.08) 4.10 (2.45 - 5.27) 462 13 - 12 .790 (.694 - .898) .610 (.556 - .675) 1.30 (1.07 - 1.54) 3.33 (2.55 - 4.77) 8.33 (5.75 - 11.3) 1704 20 years and older 11 13 - 14 .661 (.600 - .728) .538 (.495 - .588) 1.14 (.991 - 1.31) 2.77 (2.22 - 3.47) 5.96 (4.39 - 8.53) 1813 Gender 7.63) - 12 .670 (.594 - .756) .538 (.462 - .609) 1.08 (.903 - 1.27) 2.89 (2.10 - 3.46) 5.65 (4.26 - Males 1258 11 (.906 13 14 .595 (.550 - .642) .496 (.455 - .538) 1.03 - - 1.12) 2.41 (2.11 - 2.77) 4.39 (3.06 - 7.65) 1284 Females 11 - 12 .928 (.816 - 1.06) .714 (.634 - .833) 1.45 (1.27 - 1.76) 4.02 (3.06 - 6.37) 11.2 (6.37 - 18.1) 1229 13 14 .747 (.667 - .836) .616 (.560 - .676) 1.29 (1.11 - 1.43) 3.29 (2.37 - 4.15) 7.69 (4.69 - 12.6) 1400 - Race/ethnicity - 11 12 1.01 (.856 - 1.19) .788 (.620 - 1.67 (1.50 - 2.14) 5.94 (3.50 - 9.36) 14.7 (6.16 - 33.3) 316 Mexican Americans 1.04) 13 - 14 .823 (.614 - 1.10) .632 (.452 - .864) 1.43 (.938 - 2.29) 6.25 (2.45 - 12.0) 13.5 (6.32 - 37.3) 438 Non Hispanic blacks 11 - 12 .959 (.766 - 1.20) .737 (.588 - .851) 1.56 (1.18 - 2.34) 5.26 (3.00 - 15.0) 19.9 (6.61 - 40.7) 665 - - 14 .815 (.617 - 1.08) .576 (.500 - .704) 1.40 13 - 2.30) 5.32 (2.37 - 14.7) 15.4 (4.69 - 51.3) 609 (.952 Non - Hispanic whites 11 - 12 .700 (.609 - .805) .563 (.519 - .619) 1.08 (.885 - 1.33) 2.89 (1.79 - 3.78) 5.75 (3.27 - 9.67) 811 13 14 .615 (.557 - .679) .521 (.476 - .570) 1.05 (.906 - 1.24) 2.22 (1.88 - 2.78) 3.64 (3.01 - 5.71) 987 - (1.54 All Hispanics - 12 1.10 (.919 - 1.31) .870 (.700 - 1.12) 2.00 11 - 2.72) 5.70 (3.96 - 9.26) 14.7 (6.37 - 43.5) 571 13 - 14 .780 (.628 - .970) .629 (.508 - .774) 1.30 (.980 - 1.98) 4.48 (3.03 - 6.81) 11.1 (6.16 - 23.8) 690 (1.01 Asians - 12 .832 (.629 - 1.10) .667 (.513 - .952) 1.42 11 - 2.12) 3.50 (2.31 - 7.82) 8.00 (3.50 - 17.0) 352 13 - 14 .720 (.540 - .961) .588 (.469 - .813) 1.38 (1.06 - 1.71) 3.51 (1.95 - 6.78) 7.65 (2.54 - 54.1) 288 Biomonitoring Summary http://www.cdc.gov/biomonitoring/24D_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 76

96 Urinary 2,5 - ophenol (2003 – 2010) Dichlor - Dichlorobenzene (Paradichlorobenzene) and other chlorophenols Metabolite of 1,4 Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample 75th Percentile 90th Percentile 50th Percentile 95th Percentile Geometric mean Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 04 12.9 (10.1 - 16.3) 10.5 (8.00 - 14.2) 40.9 (29.8 - 54.7) 190 Total (133 - 282) 705 (342 - 1330) 2525 03 - 9.55 (6.67 - 13.7) 8.10 (5.60 - 11.5) 26.4 (19.0 - 06 111 (69.9 - 166) 332 (175 - 794) 2548 05 36.6) - 08 9.04 (7.22 - 11.3) 6.60 (5.50 - 8.30) 25.7 (19.2 - 34.7) 131 (90.2 - 473 (296 - 753) 2604 07 222) 09 10 6.10 (4.94 - 7.53) 4.70 (3.70 - 5.90) 18.4 (13.3 - 26.0) 101 (68.0 - 146) 301 (168 - 618) 2749 - Age group 11 years 03 - 04 12.5 (8.22 - 18.9) 9.10 (5.60 - 17.4) 42.1 (21.7 - 83.9) 161 (111 - 626) 928 (249 - 6 314 - 1640) 05 06 10.5 (8.29 - 13.4) 7.80 (5.90 - 10.6) 28.1 (17.8 - 40.2) 104 (55.4 - 226) 336 (189 - 785) 356 - 07 - 08 9.31 (6.20 - 14.0) 6.50 (4.60 - 10.9) 23.3 (12.2 - 45.6) 151 (61.1 - 306) 464 (222 - 389 934) - 10 7.19 (4.36 - 11.8) 4.80 (2.70 - 9.90) 30.4 (12.4 - 50.7) 146 (63.7 - 368) 503 (103 - 4940) 415 09 - 19 years 03 - 04 16.9 (11.1 - 26.0) 11.5 (8.20 - 20.6) 49.9 (26.8 - 94.0) 233 (94.5 - 1060) 1080 (287 - 3970) 722 12 - - 11.9 (8.47 - 16.8) 9.60 (6.40 - 16.7) 36.0 (22.3 06 54.4) 127 (89.9 - 160) 459 (160 - 894) 702 05 07 - 08 11.3 (8.78 - 14.5) 7.40 (6.20 - 9.10) 30.1 (18.5 - 52.6) 193 (66.7 - 448) 611 (254 - 1560) 401 09 10 8.01 (5.53 - 11.6) 4.80 (3.50 - 8.80) 24.9 (19.1 - 42.7) 191 (61.2 - 368) 526 (243 - 1140) 420 - - 04 12.3 (9.97 - 15.3) 10.4 (8.00 - 14.0) 40.5 (30.1 - 49.2) 181 (141 - 250) 583 (316 - 924) 1489 20 years and older 03 05 - 06 9.12 (6.15 - 13.5) 7.80 (5.20 - 11.5) 24.9 - 35.3) 110 (62.9 - 183) 327 (159 - 852) 1490 (17.3 - 08 8.71 (6.83 - 11.1) 6.60 (5.10 - 8.70) 24.6 07 - 34.5) 124 (95.9 - 186) 452 (286 - 672) 1814 (18.8 09 - 10 5.75 (4.77 - 6.92) 4.60 (3.70 - 5.70) 16.9 (12.7 - 23.1) 88.4 (66.4 - 117) 266 (156 - 450) 1914 Gender 03 04 14.9 (11.8 - 18.8) 12.5 (9.00 - 16.5) 40.5 (30.7 - 54.5) 152 (120 - 259) 631 (259 - 1950) 1231 Males - 40.5) - 12.0 (8.55 - 16.7) 9.90 (7.80 - 13.8) 29.0 (21.8 - 114 (71.7 - 200) 396 (175 - 916) 1270 05 06 - 08 10.9 (8.86 - 13.4) 8.30 (6.30 - 9.90) 29.4 (23.2 - 39.6) 139 (100 - 248) 546 (311 - 727) 1294 07 09 - 7.09 (5.68 - 8.85) 5.30 (4.40 - 6.70) 21.9 (15.2 - 33.5) 103 (63.3 - 191) 311 (133 - 736) 1399 10 - 04 11.2 (8.51 - 14.7) 8.50 (6.30 - 12.0) 42.8 (26.0 - 64.2) 212 (141 - 364) 732 (371 - 1100) 1294 Females 03 05 - 06 (5.17 - 11.4) 5.90 (3.90 - 9.40) 21.1 (14.3 - 35.7) 110 (60.5 - 183) 317 (141 - 794) 1278 7.69 - 08 7.57 (5.70 - 10.1) 5.50 (4.40 - 7.30) 20.6 (13.9 - 31.8) 118 (57.4 - 268) 442 (213 - 838) 1310 07 - 09 5.28 (4.17 - 6.69) 3.90 (3.00 - 5.10) 16.7 (12.1 10 22.1) 99.5 (58.2 - 156) 287 (158 - 591) 1350 - Race/ethnicity - - 04 30.1 (19.2 - 47.2) 23.7 (14.7 Mexican Americans 39.8) 103 (57.4 - 156) 841 (282 - 2040) 2370 (2040 - 3710) 617 03 (69.6 05 06 32.2 (22.2 - 46.7) 23.0 (14.9 - 37.1) 120 - - 228) 867 (298 - 1320) 1630 (916 - 3650) 637 07 - 08 22.2 (9.88 - 49.8) 16.4 (5.40 - 60.7) 104 (35.2 - 364) 566 (313 - 1710) 1920 (672 - 3460) 531 09 10 13.0 (5.80 - 29.1) 10.3 (3.30 - 26.2) 53.6 (19.4 - 199) 361 (124 - 900) 998 (247 - 3700) 566 - (97.0 - 03 - 04 54.0 (35.9 - 81.2) 43.9 (26.2 - 65.6) 159 - 338) 817 (342 - 2330) 2330 (887 - 3730) 636 Non Hispanic blacks 05 - 06 43.9 (33.2 - 58.1) 33.2 (25.3 - 47.6) 161 (79.9 - 255) 722 (360 - 1370) 1700 (886 - 6440) 678 - 08 27.4 (21.3 - 35.2) 18.5 (13.2 - 26.7) 102 (61.9 - 147) 682 (364 - 943) 1490 (933 - 1870) 597 07 (38.6 09 10 23.0 (13.0 - 40.8) 17.3 (8.00 - 42.7) 82.7 - - 168) 443 (119 - 2180) 1240 (273 - 4940) 516 Non - Hispanic whites 03 - 04 8.94 (7.15 - 11.2) 7.80 (6.30 - 9.40) 25.9 (19.3 - 36.6) 115 (61.8 - 171) 255 (148 - 522) 1077 05 06 6.19 (4.18 - 9.17) 5.90 (3.80 - 9.20) 15.7 (11.4 - 21.9) 43.7 (31.2 - 73.1) 105 (62.2 - 166) 1038 - (12.2 08 6.24 (5.04 - 7.74) 5.10 (4.20 - 6.20) 15.4 - - 19.9) 49.8 (37.0 - 90.2) 142 (103 - 294) 1077 07 09 - 10 4.10 (3.22 - 5.21) 3.30 (2.60 - 4.40) 10.9 (8.10 - 15.5) 45.5 (29.0 - 82.7) 124 (79.3 - 215) 1206 08 Limit of detection (LOD, see Data Analysis section) for Survey years 03 - 04, 05 - 06, 07 - and 09 - 10 are 0.12, 0.2, 0.2, and 0.2 respectively. Biomonitoring S ummary http://www.cdc.gov/biomonitoring/25D_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 77

97 Urinary 2,5 - – 2014) Dichlorophenol (2011 of urine concentrations (in μg/L) for the U.S. population from the National Health and Geometric mean and selected percentiles Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 12 4.21 (3.15 - 5.62) 3.10 (2.30 Total 3.90) 13.4 (9.40 - 18.9) 69.9 (40.9 - 117) 213 (121 - 404) 2489 11 - - 14 2.78 (2.15 - 3.59) 1.80 (1.40 - 2.50) 7.50 (5.30 - 11.4) 37.7 (23.8 - 58.0) 148 (78.4 - 266) 2686 13 Age group 11 years - 11 - 12 3.45 (2.11 - 5.64) 2.30 (1.60 - 3.30) 9.20 (4.40 - 21.2) 69.1 (27.8 - 168) 369 (99.9 - 986) 396 6 - - 2.90 (1.98 - 4.24) 2.00 (1.30 - 3.00) 8.20 (4.30 14 14.9) 29.6 (19.7 - 73.8) 123 (38.0 - 438) 409 13 - 19 years 11 - 12 4.15 (2.43 - 7.10) 3.20 (1.60 - 8.00) 14.0 (7.30 - 28.8) 55.7 (28.6 - 209) 236 (71.2 - 468) 388 12 13 14 2.72 (1.75 - 4.24) 2.10 (1.30 - 3.30) 6.00 (3.80 - 14.0) 21.7 (10.6 - 77.7) 77.7 (21.7 - 315) 462 - 11 12 4.31 (3.21 - 5.78) 3.20 (2.30 - 4.10) 14.2 (9.40 - 19.2) 71.4 (39.5 - 118) 198 (118 - 408) 1705 20 years and older - - - 2.78 (2.20 - 3.51) 1.80 (1.40 - 2.40) 7.80 (5.50 14 11.5) 42.7 (25.2 - 61.2) 169 (87.2 - 308) 1815 13 Gender - - 12 4.42 (3.38 - 5.78) 3.30 (2.40 Males 4.50) 13.2 (9.40 - 20.8) 55.5 (37.1 - 106) 194 (99.8 - 341) 1259 11 13 (5.20 14 2.96 (2.31 - 3.80) 2.00 (1.50 - 2.60) 7.20 - 11.5) 36.1 (23.1 - 52.6) 175 (77.6 - 250) 1285 - (9.20 Females - 12 4.01 (2.86 - 5.61) 2.80 (2.00 - 3.70) 13.9 11 - 17.7) 83.3 (42.4 - 124) 352 (117 - 614) 1230 13 - 14 2.61 (1.96 - 3.48) 1.70 (1.30 - 2.50) 7.80 (5.20 - 11.9) 38.3 (21.6 - 63.8) 136 (63.2 - 376) 1401 Race/ethnicity 11 12 5.92 (3.36 - 10.4) 4.00 (2.20 - 8.40) 21.2 (14.2 - 42.7) 178 (58.4 - 341) 362 (119 - 1130) 316 Mexican Americans - - - 4.60 (2.78 - 7.61) 2.70 (1.40 - 6.30) 14.5 (6.70 14 29.2) 90.5 (32.9 - 486) 584 (85.3 - 1840) 438 13 - Hispanic blacks 11 - 12 16.6 (10.4 - 26.2) 13.4 (8.80 - 19.4) 47.9 Non - 100) 227 (108 - 569) 759 (341 - 2480) 665 (24.9 - 14 9.58 (5.03 - 18.2) 7.20 (3.90 - 14.2) 27.6 (15.6 - 70.7) 175 (51.4 - 874) 843 (150 - 3710) 609 13 - 11 - 12 2.78 (2.13 - 3.63) 2.00 (1.60 - 2.50) 7.40 Non (5.40 - 9.70) 34.4 (18.1 - 67.6) 112 (52.1 - 178) 813 Hispanic whites 13 - 14 1.95 (1.54 - 2.46) 1.40 (1.10 - 1.90) 4.70 (3.30 - 6.50) 19.0 (12.8 - 25.9) 53.7 (25.2 - 131) 988 All Hispanics - 12 7.96 (4.50 - 14.1) 6.30 (3.20 - 14.9) 29.1 (16.0 - 66.7) 196 (84.1 - 399) 536 (194 - 1630) 571 11 (7.20 13 14 4.26 (2.84 - 6.40) 2.80 (1.50 - 5.00) 11.8 - - 22.4) 77.7 (42.7 - 236) 420 (112 - 807) 690 Asians 11 - 12 3.77 (2.17 - 6.53) 2.40 (1.40 - 5.40) 13.0 (5.40 - 43.4) 86.8 (38.6 - 160) 378 (86.8 - 810) 352 (3.30 14 2.66 (1.64 - 4.32) 1.70 (1.20 - 2.90) 6.20 - - 18.5) 50.3 (13.0 - 154) 154 (38.7 - 2450) 289 13 Limit of detection (LOD, see Data Analysis section) for Survey years 11 - 12 and 13 - 14 are 0.2 and 0.1, respectively. Biomonitoring Summary http://www.cdc.gov/biomonitoring/25D_Biomonit oringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 78

98 Urinary 2,5 - – 2010) Dichlorophenol (creatinine corrected) (2003 - Dichlorobenzene (Paradichlorobenzene) and other chlorophenols Metabolite of 1,4 Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati onal Health and Nutrition Examination Survey. Survey Sample 75th Percentile 90th Percentile 50th Percentile 95th Percentile Geometric mean Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 04 12.5 (10.1 - 15.6) 9.29 (7.25 - 12.5) 34.4 (26.8 - 45.4) 141 Total (100 - 251) 578 (313 - 851) 2522 03 - 9.31 (6.70 - 12.9) 7.32 (5.33 - 10.2) 20.4 (14.8 - 06 89.3 (54.9 - 176) 292 (176 - 640) 2548 05 30.5) - 08 9.12 (7.35 - 11.3) 6.24 (5.00 - 7.77) 24.2 (17.2 - 30.3) 109 (70.8 - 409 (234 - 745) 2604 07 175) 09 10 6.36 (5.07 - 7.99) 4.12 (3.31 - 5.16) 16.2 (11.7 - 22.8) 80.2 (59.5 - 127) 269 (144 - 505) 2749 - Age group 11 years 03 - 04 15.2 (9.93 - 23.1) 10.6 (5.87 - 26.7) 44.7 (28.9 - 80.0) 183 (95.3 - 617) 830 (330 - 6 314 - 2150) 05 06 11.6 (8.90 - 15.1) 8.00 (5.95 - 12.6) 24.7 (16.8 - 37.8) 129 (55.8 - 242) 419 (151 - 709) 356 - 07 - 08 11.5 (7.95 - 16.5) 7.70 (5.41 - 11.7) 29.5 (19.6 - 50.9) 131 (59.9 - 239) 420 (170 - 389 1110) - 10 9.36 (5.65 - 15.5) 6.25 (4.09 - 9.60) 33.9 (12.6 - 65.0) 177 (66.1 - 496) 536 (111 - 5950) 415 09 - 19 years 03 - 04 12.7 (8.50 - 18.9) 9.05 (6.17 - 13.3) 34.8 (18.6 - 67.0) 177 (67.0 - 516) 549 (187 - 2120) 720 12 - - 8.88 (6.34 - 12.4) 6.91 (4.15 - 11.1) 23.4 (17.7 06 30.0) 78.0 (58.5 - 112) 279 (112 - 659) 702 05 07 - 08 8.79 (6.81 - 11.4) 5.56 (4.42 - 7.50) 20.9 (13.8 - 34.9) 130 (41.8 - 251) 353 (158 - 799) 401 09 10 6.44 (4.40 - 9.42) 4.05 (2.34 - 8.69) 19.4 (11.6 - 37.7) 121 (49.3 - 218) 257 (119 - 1180) 420 - - 04 12.2 (10.1 - 14.8) 9.13 (7.25 - 12.4) 32.7 (26.7 - 42.9) 140 (103 - 203) 552 (283 - 838) 1488 20 years and older 03 05 - 06 9.15 (6.43 - 13.0) 7.29 (5.29 - 10.0) 19.6 - 30.4) 90.7 (48.5 - 197) 274 (163 - 701) 1490 (14.2 - 08 8.94 (7.07 - 11.3) 6.15 (4.93 - 8.00) 24.3 07 - 30.6) 101 (70.0 - 162) 422 (234 - 729) 1814 (16.6 09 - 10 6.09 (4.97 - 7.45) 3.97 (3.27 - 4.78) 14.7 (11.0 - 20.5) 72.5 (56.6 - 97.2) 261 (141 - 446) 1914 Gender 03 04 12.2 (9.73 - 15.3) 9.65 (7.23 - 12.7) 32.7 (25.3 - 39.1) 108 (79.0 - 183) 358 (161 - 1080) 1230 Males - 28.2) - 9.60 (7.17 - 12.9) 8.11 (5.95 - 10.5) 20.5 (15.9 - 74.9 (50.5 - 141) 249 (137 - 534) 1270 05 06 - 08 9.17 (7.63 - 11.0) 6.24 (5.22 - 7.81) 25.5 (19.7 32.4) 110 (70.7 - 167) 353 (234 - 572) 1294 07 - 09 10 6.36 (5.04 - 8.02) 4.21 (3.36 - 4.97) 16.7 (11.7 - 24.0) 83.2 (53.7 - 141) 280 (111 - 727) 1399 - 03 - 04 12.9 (9.91 - 16.8) 8.95 (6.98 - 13.2) 37.1 (26.7 - 56.9) Females (124 - 362) 660 (408 - 940) 1292 209 - 06 9.04 (6.18 - 13.2) 6.60 (4.56 - 10.4) 20.4 (14.1 - 33.8) 104 (55.8 - 199) 309 (149 - 933) 1278 05 - 07 9.07 (6.91 - 11.9) 6.08 (4.71 - 8.04) 22.4 (14.7 08 30.6) 107 (59.2 - 216) 509 (185 - 908) 1310 - 09 - 10 6.37 (4.92 - 8.25) 4.10 (3.09 - 5.69) 15.6 (11.3 - 22.1) 77.1 (53.3 - 148) 267 (151 - 481) 1350 Race/ethnicity (45.8 - 04 27.3 (17.4 - 42.9) 17.8 (9.86 Mexican Americans 36.3) 79.8 03 - 138) 809 (196 - 2110) 2200 (1250 - 2480) 616 - 05 - 06 29.0 (20.5 - 41.0) 18.6 (12.9 - 27.3) 99.4 (61.6 - 165) 675 (296 - 1400) 1680 (718 - 2720) 637 07 08 21.6 (9.44 - 49.6) 16.4 (5.09 - 58.9) 83.9 (30.8 - 281) 572 (182 - 1490) 1490 (700 - 2220) 531 - - 09 12.9 (5.78 - 28.8) 9.12 (3.38 - 26.7) 45.0 (17.3 10 236) 460 (105 - 1000) 1000 (380 - 2800) 566 - - Hispanic blacks 03 - 04 37.1 (24.3 - 56.7) 27.4 (17.5 - 47.7) 103 (63.8 - 216) 609 (248 - 1210) 1240 (627 - 2430) 635 Non - 06 30.9 (23.6 - 40.3) 20.5 (17.3 - 29.1) 104 (57.7 - 180) 480 (294 - 1080) 1480 (515 - 3100) 678 05 (48.0 07 08 21.3 (16.2 - 27.9) 14.6 (10.2 - 19.7) 64.6 - - 101) 529 (217 - 884) 1130 (793 - 1560) 597 09 - 10 16.7 (9.19 - 30.2) 12.5 (6.74 - 22.0) 58.9 (22.3 - 106) 349 (92.6 - 878) 878 (277 - 3890) 516 Non 03 - 04 9.24 (7.48 - 11.4) 7.14 (5.67 - 8.76) 24.8 (18.7 - 31.7) 79.7 (50.2 - 141) 216 (124 - 516) 1076 Hispanic whites - - 06 6.52 (4.51 - 9.43) 5.60 (3.86 - 8.51) 14.1 05 - 19.7) 40.2 (28.4 - 61.6) 110 (47.3 - 224) 1038 (10.7 07 - 08 6.52 (5.26 - 8.07) 4.89 (3.95 - 6.20) 14.4 (11.4 - 19.2) 53.2 (40.1 - 75.9) 131 (82.5 - 249) 1077 41.3 - 10 4.60 (3.59 - 5.90) 3.27 (2.77 - 4.10) 10.4 (7.22 - 15.2) 09 (25.0 - 69.1) 130 (73.4 - 180) 1206 Biomonitoring Summary http://www.cdc.gov/biomonitoring/25D_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 79

99 Urinary 2,5 - – 2014) Dichlorophenol (creatinine corrected) (2011 on al Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 12 4.80 (3.65 - 6.32) 3.19 (2.38 Total 4.43) 11.4 (7.97 - 17.9) 66.4 (39.9 - 125) 215 (145 - 342) 2487 11 - - 14 2.77 (2.12 - 3.62) 1.82 (1.43 - 2.40) 6.80 (4.62 - 9.72) 32.2 (21.9 - 45.5) 108 (58.4 - 270) 2684 13 Age group 11 years - 11 - 12 5.01 (3.10 - 8.09) 3.02 (2.00 - 5.00) 10.6 (5.53 - 21.7) 98.1 (32.9 - 166) 377 (125 - 1180) 395 6 - - 3.66 (2.50 - 5.36) 2.41 (1.62 - 3.54) 9.73 (5.25 14 15.6) 37.6 (16.9 - 110) 172 (70.4 - 615) 409 13 - 19 years 11 - 12 4.04 (2.51 - 6.52) 2.41 (1.54 - 5.34) 12.1 12 (5.67 - 27.6) 47.9 (26.3 - 99.5) 157 (55.1 - 324) 388 - 14 2.21 (1.44 - 3.40) 1.53 (.915 - 2.52) 5.16 (2.63 - 12.0) 22.7 (12.2 - 38.9) 54.2 (21.7 - 236) 462 13 - 12 4.90 (3.67 - 6.56) 3.33 (2.50 - 4.51) 11.5 (8.04 - 18.0) 70.3 (38.8 - 136) 226 (145 - 342) 1704 20 years and older 11 13 - 14 2.78 (2.15 - 3.59) 1.81 (1.44 - 2.29) 6.67 (4.62 - 9.47) 32.6 (21.1 - 51.0) 126 (58.4 - 325) 1813 Gender 233) - 12 4.15 (3.14 - 5.49) 2.87 (2.14 - 4.13) 9.73 (6.88 - 16.1) 52.8 (31.4 - 106) 157 (125 - Males 1258 11 (4.18 13 14 2.49 (1.93 - 3.22) 1.69 (1.23 - 2.22) 5.49 - - 8.11) 27.4 (19.6 - 45.8) 88.7 (58.4 - 160) 1284 Females 11 - 12 5.53 (4.14 - 7.37) 3.39 (2.57 - 5.00) 13.1 (8.84 - 19.5) 90.1 (45.2 - 147) 331 (145 - 557) 1229 13 14 3.07 (2.30 - 4.09) 1.96 (1.52 - 2.54) 8.22 (5.07 - 11.9) 33.8 (21.7 - 56.2) 140 (50.4 - 374) 1400 - Race/ethnicity - 11 12 6.67 (4.04 - 11.0) 4.85 (2.25 - 22.4 (12.6 - 37.6) 189 (49.2 - 249) 383 (213 - 981) 316 Mexican Americans 8.69) 13 - 14 4.68 (2.72 - 8.06) 2.47 (1.36 - 5.71) 14.5 (7.24 - 25.0) 91.8 (26.9 - 559) 559 (89.0 - 1330) 438 Non Hispanic blacks 11 - 12 12.9 (8.32 - 19.9) 9.41 (6.35 - 15.1) 34.5 (18.1 - 75.0) 174 (83.7 - 567) 744 (236 - 1790) 665 - - 14 7.07 (3.87 - 12.9) 5.62 (2.55 - 10.4) 21.2 13 - 54.1) 128 (32.7 - 527) 415 (103 - 2580) 609 (10.0 Non - Hispanic whites 11 - 12 3.40 (2.57 - 4.49) 2.36 (1.76 - 3.19) 6.96 (4.70 - 9.67) 34.5 (16.4 - 80.1) 126 (55.3 - 232) 811 13 14 2.03 (1.53 - 2.69) 1.48 (1.13 - 1.91) 4.15 (2.96 - 6.34) 18.2 (10.6 - 32.5) 45.8 (26.0 - 86.3) 987 - (16.6 All Hispanics - 12 8.92 (5.45 - 14.6) 6.55 (3.50 - 13.8) 28.8 11 - 53.6) 184 (97.2 - 266) 383 (213 - 1240) 571 13 - 14 4.23 (2.77 - 6.47) 2.50 (1.41 - 5.07) 11.5 (6.84 - 18.7) 84.6 (32.2 - 226) 401 (135 - 993) 690 (6.51 Asians - 12 5.05 (2.93 - 8.69) 2.99 (1.74 - 7.04) 15.3 11 - 45.6) 106 (58.7 - 177) 236 (97.5 - 632) 352 13 - 14 3.40 (2.10 - 5.52) 2.06 (1.33 - 3.26) 8.99 (3.21 - 20.8) 45.2 (17.3 - 158) 207 (32.6 - 3020) 288 Biomonitoring Summary http://www.cdc.gov/biomonitoring/25D_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 80

100 Urinary Bis(1 - - 2 - propyl) phosphate (BCPP) (2013 – 2014) chloro - chloro 2 - propyl) phosphate (TCPP) Metabolite of Tris(1 - Geometric mean and selected percentiles of concentrations (in μg/L) for the U.S. population from the National Health and Nutr ition Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 .188 (.174 - .202) .160 (.140 - .180) .380 (.330 - .410) .790 (.690 - Total 1.25 (1.07 - 1.48) 2665 .880) Age group (.400 11 years 13 - 14 .267 (.227 - .314) .250 (.200 - .300) .490 - .590) 1.08 (.630 - 1.98) 2.12 (1.28 - 4.21) 421 6 - - 19 years 13 - 14 .190 (.164 - .220) 12 (.130 - .220) .410 (.290 - .520) .670 (.600 - .790) 1.04 (.700 - 1.31) 427 .160 20 years and older 13 - 14 * .150 (.130 - .170) .350 (.310 - .390) .760 (.690 - .860) 1.25 (1.05 - 1.55) 1817 Gender 13 - 14 .199 (.183 - .217) .170 (.140 - .200) .420 (.360 - .480) .880 (.760 - .980) 1.34 Males - 1.67) 1344 (1.17 Females 13 - 14 * .150 (.130 - .180) .340 (.280 .390) .700 (.560 - .830) 1.11 (.870 - 1.52) 1321 - Race/ethnicity Mexican Americans - 14 * .130 (

101 Urinary Bis(1 - - 2 - propyl) phosphate (BCPP) (creatinine corrected) (2013 – 2014) chloro - chloro 2 - propyl) phosphate (TCPP) Metabolite of Tris(1 - Geometric mean and selected percentiles of concentrations (in μg/g of creatinine) for the U.S. population from the Natio nal Health and Nutrition Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 .200 Total - .218) .187 (.173 - .201) .347 (.313 - .375) .701 (.619 - .787) 1.21 (1.03 - 1.49) 2663 (.184 Age group - 11 years 13 - 14 .344 (.296 - .399) .349 (.292 - .381) .568 (.500 - .701) 1.37 (.953 - 2.13) 2.41 (1.26 - 3.30) 6 421 12 19 years 13 - 14 .162 (.135 - .194) .159 (.130 - .191) .314 (.226 - .384) .500 (.416 - .667) .753 (.500 - 1.26) 427 - - 14 * .184 (.168 - .196) .320 (.284 - .365) .665 20 years and older (.571 - .769) 1.17 (.936 - 1.50) 1815 13 Gender (.284 - 14 .182 (.165 - .201) .167 (.152 Males .179) .333 13 - .382) .722 (.610 - .842) 1.21 (1.00 - 1.56) 1343 - Females 13 - 14 * .210 (.187 - .233) .352 (.316 - .390) .688 (.560 - .847) 1.26 (.921 - 1.53) 1320 Race/ethnicity 14 * .153 (

102 Urinary Bis(2 - – 2014) chloroethyl) phosphate (BCEtP) (2013 - chloroethyl) phosphate (TCEtP) Metabolite of Tris(2 Geometric mean and selected percentiles of concentrations (in μg/L) for the U.S. population from the National Health and Nutr ition Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 .419 Total - .466) .390 (.350 - .420) .950 (.840 - 1.12) 2.31 (1.90 - 2.82) 3.94 (3.08 - 5.17) 2651 (.376 Age group - 11 years 13 - 14 .662 (.545 - .804) .660 (.500 - .850) 1.50 (1.05 - 1.77) 2.91 (1.77 - 5.63) 5.63 (2.99 - 7.34) 418 6 12 - 13 - 14 .602 (.508 - .713) .570 (.450 - .730) 1.47 (.950 - 2.21) 3.18 (2.57 - 3.80) 4.24 (3.76 - 6.40) 423 19 years - 14 .378 (.339 - .421) .350 (.310 - .390) .850 (.740 - .960) 20 years and older 2.06 (1.69 - 2.64) 3.55 (2.76 - 5.17) 1810 13 Gender (.890 - 14 .458 (.401 - .523) .420 (.390 Males .470) 1.03 13 - 1.28) 2.46 (1.85 - 3.07) 4.00 (3.00 - 6.92) 1337 - Females 13 - 14 .384 (.335 - .439) .350 (.310 - .390) .850 (.740 - 1.03) 2.28 (1.90 - 2.75) 3.90 (2.98 - 4.64) 1314 Race/ethnicity - 14 .502 (.397 - .636) .500 (.370 - .660) 1.14 (.710 - 1.88) 2.70 (1.69 - 4.00) 4.47 (3.30 - 7.73) Mexican Americans 428 13 - 13 - 14 .483 (.431 - .541) .400 (.380 - .480) 1.03 Non (.820 - 1.26) 2.41 (1.95 - 2.88) 4.26 (2.84 - 5.60) 578 Hispanic blacks Non - Hispanic whites 13 - 14 .394 (.352 - .441) .360 (.310 - .400) .910 (.820 - 1.09) 2.28 (1.85 - 2.75) 3.73 (2.82 - 5.41) 1012 (.770 All Hispanics - 14 .478 (.398 - .575) .470 (.390 - .570) 1.06 13 - 1.52) 2.38 (1.71 - 3.50) 4.00 (3.01 - 5.35) 668 Asians 13 - 14 .375 (.316 - .445) .340 (.270 - .400) .770 (.620 - 1.14) 2.26 (1.32 - 3.55) 4.68 (2.79 - 6.93) 291 Survey Limit of detection (LOD, see Data Analysis section) for year 13 - 14 is 0.08. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 83

103 Urinary Bis(2 - – 2014) chloroethyl) phosphate (BCEtP) (creatinine corrected) (2013 - chloroethyl) phosphate (TCEtP) Metabolite of Tris(2 h and Geometric mean and selected percentiles of concentrations (in μg/g of creatinine) for the U.S. population from the National Healt Nutrition Examination Survey. Sample Survey 50th Percentile 95th Percentile 75th Percentile Geometric mean 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 .447 Total - .505) .388 (.337 - .444) .856 (.743 - .981) 2.03 (1.72 - 2.38) 3.94 (2.74 - 5.13) 2649 (.396 Age group - 11 years 13 - 14 .855 (.720 - 1.02) .833 (.676 - .981) 1.60 6 (1.18 - 2.12) 4.25 (3.39 - 5.43) 6.83 (4.97 - 8.99) 418 12 19 years 13 - 14 .516 (.429 - .620) .442 (.350 - .568) 1.06 (.768 - 1.38) 2.33 (1.70 - 3.03) 4.48 (2.42 - 6.77) 423 - 1.87 - 20 years and older .408 (.362 - .460) .349 (.313 - .393) .742 (.632 - .875) 13 (1.42 - 2.31) 3.12 (2.38 - 4.69) 1808 14 Gender Males 13 - 14 .420 (.370 - .476) .373 (.322 - .406) .826 (.725 - .954) 2.01 (1.50 - 2.43) 3.70 (2.44 - 5.50) 1336 Females - 14 .476 (.417 - .543) .407 (.350 - .467) .909 (.742 - 1.04) 2.06 (1.75 - 2.41) 3.99 (2.61 - 5.26) 1313 13 Race/ethnicity (.665 - 14 .515 (.394 - .672) .477 (.343 Mexican Americans .637) 1.01 13 - 1.47) 2.35 (1.57 - 3.03) 3.19 (2.43 - 6.34) 426 - Non - Hispanic blacks 13 - 14 .374 (.321 - .435) .328 (.267 - .450) .732 (.630 - .867) 1.56 (1.18 - 1.80) 2.41 (1.86 - 3.17) 578 Non 13 - 14 .446 (.393 - .506) .379 (.333 - .437) .857 Hispanic whites (.731 - 1.00) 2.03 (1.64 - 2.44) 4.68 (2.51 - 5.58) 1012 - All Hispanics 13 - 14 .495 (.406 - .604) .472 (.371 - .585) .980 (.736 - 1.36) 2.27 (1.69 - 2.75) 3.14 (2.53 - 3.94) 666 1.28) Asians 13 - 14 .477 (.412 - .553) .442 (.371 - .500) .792 (.606 - 2.33 (1.51 - 3.46) 4.18 (2.76 - 9.34) 291 _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 84

104 Urinary Bis(1,3 - - 2 - propyl) phosphate (BDCPP) (2013 – 2014) dichloro - dichloro 2 - propyl) phosphate (TDCPP) Metabolite of Tris(1,3 - Geometric mean and selected percentiles of concentrations (in μg/L) for the U.S. population from the National Health and Nut rition Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 .856 Total - .976) .880 (.790 - .970) 2.21 (1.90 - 2.57) 4.77 (3.88 - 5.77) 7.23 (6.07 - 8.60) 2646 (.750 Age group - 11 years 13 - 14 2.25 (1.82 - 2.77) 2.31 (1.62 - 2.86) 5.40 (3.69 - 7.33) 11.3 (7.39 - 14.9) 14.9 (10.8 - 25.4) 421 6 12 19 years 13 - 14 1.34 (1.13 - 1.59) 1.43 (1.23 - 1.74) 3.08 (2.39 - 3.99) 5.58 (4.02 - 8.18) 8.61 (5.58 - 9.87) 427 - - 14 .720 (.633 - .818) .710 (.630 - .830) 1.84 (1.62 - 2.09) 20 years and older 3.96 (3.14 - 4.75) 6.29 (4.93 - 7.16) 1798 13 Gender (1.87 - 14 .914 (.802 - 1.04) .940 (.830 Males 1.06) 2.20 13 - 2.59) 4.49 (3.47 - 5.75) 7.15 (5.18 - 9.41) 1331 - Females 13 - 14 .803 (.679 - .949) .820 (.690 - .960) 2.25 (1.81 - 2.60) 5.09 (3.98 - 6.30) 7.48 (6.17 - 8.83) 1315 Race/ethnicity - 14 1.08 (.904 - 1.28) 1.16 (.900 - 1.54) 2.51 (1.87 - 3.11) 5.09 (3.63 - 7.48) 8.19 (5.50 - 11.3) Mexican Americans 423 13 - 13 - 14 .975 (.873 - 1.09) .960 (.860 - 1.12) 2.16 Non (1.86 - 2.54) 4.23 (3.43 - 4.94) 6.18 (5.08 - 7.02) 585 Hispanic blacks Non - Hispanic whites 13 - 14 .833 (.708 - .980) .850 (.710 - .990) 2.26 (1.93 - 2.66) 4.93 (3.98 - 6.44) 7.42 (6.76 - 8.83) 1005 (1.76 All Hispanics - 14 .977 (.840 - 1.14) 1.02 (.850 - 1.22) 2.20 13 - 2.61) 4.39 (3.30 - 5.43) 7.39 (4.83 - 9.07) 665 Asians 13 - 14 .508 (.438 - .589) .480 (.390 - .610) 1.19 (.900 - 1.49) 3.19 (1.93 - 4.33) 4.62 (3.61 - 9.06) 289 Survey Limit of detection (LOD, see Data Analysis section) for year 13 - 14 is 0.11. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 85

105 Urinary Bis(1,3 - - 2 - propyl) phosphate (BDCPP) (creatinine corrected) (2013 – 2014) dichloro - dichloro 2 - propyl) phosphate (TDCPP) Metabolite of Tris(1,3 - Geometric mean and selected percentiles of concentrations (in μg/g of creatinine) for the U.S. populatio n from the National Health and Nutrition Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 .913 Total - 1.05) .874 (.746 - 1.03) 1.90 (1.58 - 2.22) 3.72 (2.88 - 4.97) 6.30 (4.77 - 7.93) 2644 (.795 Age group - 11 years 13 - 14 2.89 (2.38 - 3.51) 2.81 (2.28 - 3.66) 6 (4.42 - 7.98) 11.0 (8.41 - 14.3) 14.8 (11.2 - 21.1) 421 6.10 12 19 years 13 - 14 1.14 (.931 - 1.40) 1.10 (.887 - 1.45) 2.20 (1.75 - 2.57) 4.26 (2.75 - 6.46) 6.82 (3.43 - 10.5) 427 - 2.85 - 20 years and older .777 (.682 - .886) .734 (.627 - .875) 1.55 (1.37 - 1.77) 13 (2.38 - 3.57) 4.29 (3.29 - 5.29) 1796 14 Gender Males 13 - 14 .837 (.723 - .968) .825 (.696 - .964) 1.69 (1.41 - 2.05) 3.07 (2.53 - 4.30) 4.97 (3.71 - 6.96) 1330 Females - 14 .993 (.853 - 1.16) .917 (.750 - 1.15) 2.07 (1.74 - 2.48) 4.26 (3.18 - 5.63) 7.02 (5.23 - 8.90) 1314 13 Race/ethnicity (1.62 - 14 1.11 (.905 - 1.36) 1.08 (.865 Mexican Americans 1.32) 2.15 13 - 2.86) 4.16 (3.13 - 5.91) 6.38 (4.69 - 8.48) 421 - Non - Hispanic blacks 13 - 14 .750 (.674 - .834) .731 (.630 - .842) 1.44 (1.29 - 1.60) 2.81 (2.21 - 3.54) 4.27 (3.38 - 5.80) 585 Non 13 - 14 .943 (.806 - 1.10) .896 (.708 - 1.09) 2.00 Hispanic whites (1.68 - 2.43) 3.94 (3.00 - 5.11) 6.77 (5.00 - 9.20) 1005 - All Hispanics 13 - 14 1.01 (.862 - 1.19) .977 (.833 - 1.19) 1.92 (1.62 - 2.23) 3.97 (2.87 - 4.69) 5.80 (4.19 - 7.84) 663 1.62) Asians 13 - 14 .648 (.554 - .758) .582 (.515 - .727) 1.30 (1.01 - 2.59 (1.88 - 4.70) 4.99 (2.78 - 6.91) 289 _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 86

106 Urinary Di benzyl phosphate (DBzP) (2013 2014) – Metabolite of Tribenzyl phosphate (TBzP) Geometric mean and selected percentiles of concentrations (in μg/L) for the U.S. population from the National Health and Nutr ition Examination Survey. Sample Survey Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 * < LOD Total < LOD < LOD < LOD 2665 Age group < LOD 11 years 13 - 14 - * < LOD < LOD < LOD 421 6 - 19 years 13 12 14 * < LOD < LOD < LOD < LOD 427 - 20 years and older 13 - 14 * < LOD < LOD < LOD < LOD 1817 Gender 13 - 14 * < LOD < LOD < LOD < LOD 1344 Males < LOD Females - 14 * < LOD < LOD < LOD 13 1321 Race/ethnicity Mexican Americans 13 - 14 * < LOD < LOD < LOD < LOD 428 Non - 13 - 14 * < LOD < LOD < LOD < LOD 587 Hispanic blacks - 13 - 14 * < LOD < LOD < LOD < LOD 1014 Non Hispanic whites - 14 * < LOD All Hispanics < LOD < LOD < LOD 671 13 < LOD Asians - 14 * < LOD 13 < LOD < LOD 291 Limit of detection (LOD, see Data Analysis section) for Survey year 13 - 14 is 0.05. vary < means less than the limit of detection, which may LOD for some chemicals by year and by individual sample. * Not calculated: proportion of re sults below limit of detection was too high to provide a valid result. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 87

107 Urinary Dibenzyl phosphate (DBzP) (creatinine corrected) (2013 – 2014) Metabolite of Tribenzyl phosphate (TBzP) Geometric mean and selected percentiles of concentrations (in μg/g of creatinine) for the U.S. population from the National Health and Nutrition Examination Survey. Sample Survey 90th Percentile Geometric mean 95th Percentile 75th Percentile 50th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 14 * < LOD < LOD < LOD - 2663 Total < LOD Age group - 11 years 13 - 14 * < LOD < LOD < LOD < LOD 421 6 12 - 13 - 14 * < LOD < LOD < LOD < LOD 427 19 years 14 * < LOD < LOD - < LOD < LOD 1815 20 years and older 13 Gender - 14 Males * < LOD < LOD < LOD < LOD 1343 13 < LOD Females - 14 * < LOD 13 < LOD < LOD 1320 Race/ethnicity Mexican Americans - 14 * < LOD < LOD < LOD < LOD 426 13 < LOD - 13 - 14 * < LOD < LOD < LOD 587 Non Hispanic blacks - Hispanic whites 13 - 14 * Non < LOD < LOD < LOD 1014 < LOD All Hispanics 13 - 14 * < LOD < LOD < LOD < LOD 669 Asians 13 - 14 * < LOD < LOD < LOD < LOD 291 for < means less than the limit of detection LOD the urine levels not corrected for creatinine. * Not calculated: proportion of results below limit of detection was too high to provide a valid result. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 88

108 Urinary Dibutyl phosphate (DBuP) (2013 – 2014) - n butyl phosphate (TBuP) Metabolite of Tri - Geometric mean and selected percentiles of concentrations (in μg/L) for the U.S. population from the National Health and Nutr ition Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 .188 Total - .217) .250 (.220 - .280) .370 (.350 - .400) .520 (.490 - .570) .670 (.610 - .750) 2663 (.162 Age group - 11 years 13 - 14 .272 (.203 - .365) .340 (.270 - .390) .490 (.450 - .590) .790 (.660 - .980) 1.10 (.740 - 5.23) 421 6 - 12 13 - 14 .207 (.175 - .244) .270 (.240 - .320) .390 (.340 - .440) .570 (.450 - .750) .790 (.600 - 1.19) 427 19 years - 14 .177 (.153 - .206) .230 (.200 - .270) .350 (.330 - .380) 20 years and older .500 (.460 - .530) .600 (.570 - .650) 1815 13 Gender (.350 - 14 .191 (.166 - .221) .260 (.220 Males .290) .380 13 - .410) .530 (.500 - .570) .670 (.590 - .850) 1342 - Females 13 - 14 .184 (.157 - .216) .240 (.210 - .270) .360 (.330 - .400) .510 (.460 - .580) .670 (.590 - .790) 1321 Race/ethnicity - 14 .187 (.145 - .239) .240 (.160 - .310) .370 (.330 - .410) .520 (.470 - .590) .700 (.570 - .870) Mexican Americans 428 13 - 13 - 14 .235 (.206 - .268) .300 (.280 - .320) .420 Non (.370 - .460) .610 (.520 - .740) .810 (.690 - .980) 587 Hispanic blacks Non - Hispanic whites 13 - 14 .189 (.161 - .222) .250 (.210 - .280) .370 (.340 - .400) .510 (.480 - .570) .640 (.590 - .740) 1012 (.330 All Hispanics - 14 .185 (.151 - .228) .230 (.190 - .280) .360 13 - .420) .510 (.450 - .590) .700 (.570 - .870) 671 Asians 13 - 14 .106 (.091 - .124) .080 (.060 - .130) .260 (.200 - .310) .380 (.340 - .470) .510 (.400 - .680) 291 Survey Limit of detection (LOD, see Data Analysis section) for year 13 - 14 is 0.05. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 89

109 Urinary Dibutyl phosphate (DBuP) (creatinine corrected) (2013 – 2014) - n butyl phosphate (TBuP) Metabolite of Tri - Geometric mean and selected percentiles of concentrations (in μg/g of creatinine) for the U.S. population from the National Health and y. Nutrition Examination Surve Sample Survey 50th Percentile 95th Percentile 75th Percentile Geometric mean 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 .200 Total - .234) .215 (.186 - .246) .357 (.321 - .393) .545 (.500 - .583) .719 (.612 - .813) 2661 (.171 Age group - 11 years 13 - 14 .350 (.266 - .461) .373 (.304 - .435) 6 (.484 - .660) .909 (.682 - 1.47) 1.47 (.875 - 4.17) 421 .543 12 19 years 13 - 14 .177 (.152 - .205) .191 (.157 - .223) .286 (.256 - .326) .440 (.373 - .548) .566 (.481 - .619) 427 - .526 - 20 years and older .192 (.163 - .225) .209 (.180 - .239) .342 (.311 - .376) 13 (.473 - .565) .651 (.570 - .762) 1813 14 Gender Males 13 - 14 .175 (.151 - .204) .192 (.159 - .227) .308 (.278 - .342) .479 (.415 - .515) .582 (.543 - .619) 1341 Females - 14 .227 (.191 - .271) .238 (.205 - .286) .407 (.361 - .444) .585 (.542 - .704) .763 (.696 - .892) 1320 13 Race/ethnicity (.279 - 14 .191 (.152 - .239) .203 (.161 Mexican Americans .256) .324 13 - .383) .526 (.436 - .581) .651 (.533 - .865) 426 - Non - Hispanic blacks 13 - 14 .181 (.157 - .208) .194 (.167 - .217) .323 (.269 - .375) .473 (.424 - .519) .609 (.519 - .734) 587 Non 13 - 14 .214 (.179 - .257) .234 (.196 - .265) .378 Hispanic whites (.333 - .417) .561 (.521 - .617) .762 (.617 - .893) 1012 - All Hispanics 13 - 14 .191 (.158 - .231) .200 (.174 - .246) .323 (.281 - .370) .518 (.441 - .571) .651 (.554 - .864) 669 .333) Asians 13 - 14 .135 (.113 - .161) .138 (.116 - .162) .265 (.212 - .487 (.337 - .583) .588 (.508 - .674) 291 _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 90

110 Urinary Di o - cresylphosphate (DoCP) (2013 – 2014) - - o cresylphosphate (ToCP) Metabolite of Tri - Geometric mean and selected percentiles of concentrations (in μg/L) for the U.S. population from the National Health and Nutr ition Examination Survey. Sample Survey Geometric mean 75th Percentile 90th Percentile 50th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 14 * < LOD < LOD < LOD < LOD - 2665 Total Age group - 11 years 13 - 14 * < LOD < LOD < LOD < LOD 421 6 - 12 13 - 14 * < LOD < LOD < LOD < LOD 427 19 years 14 * < LOD < LOD < LOD < LOD - 1817 20 years and older 13 Gender 13 - 14 * < LOD Males < LOD < LOD 1344 < LOD Females 13 - 14 * < LOD < LOD < LOD 1321 < LOD Race/ethnicity Mexican Americans 13 - 14 * < LOD < LOD < LOD < LOD 428 Non - 13 - 14 * < LOD < LOD < LOD < LOD 587 Hispanic blacks - 13 - 14 * < LOD < LOD < LOD < LOD 1014 Non Hispanic whites - 14 * < LOD All Hispanics < LOD < LOD < LOD 671 13 < LOD Asians - 14 * < LOD 13 < LOD < LOD 291 Limit of detection (LOD, see Data Analysis section) for Survey year 13 - 14 is 0.05. vary < means less than the limit of detection, which may LOD for some chemicals by year and by individual sample. * Not calculated: proportion of re sults below limit of detection was too high to provide a valid result. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 91

111 Urinary Di - - cresylphosphate (DoCP) (creatinine corrected) (2013 – 2014) o - o cresylphosphate (ToCP) Metabolite of Tri - Geometric mean and selected percentiles of concentrations (in μg/g of creatinine) for the U.S. population from the National Health and Nutrition Examination Survey. Sample Survey Geometric mean 75th Percentile 90th Percentile 50th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 14 * < LOD < LOD < LOD < LOD - 2663 Total Age group - 11 years 13 - 14 * 6 < LOD < LOD < LOD 421 < LOD 12 19 years 13 - 14 * < LOD < LOD < LOD < LOD 427 - - 14 * < LOD < LOD < LOD 20 years and older < LOD 1815 13 Gender < LOD - 14 Males * < LOD 13 < LOD < LOD 1343 Females 13 - 14 * < LOD < LOD < LOD < LOD 1320 Race/ethnicity 14 * < LOD < LOD - < LOD < LOD 426 Mexican Americans 13 - Hispanic blacks 13 - 14 * < LOD < LOD < LOD < LOD 587 Non Non - 13 - 14 * < LOD < LOD < LOD < LOD 1014 Hispanic whites < LOD - 14 * < LOD 13 < LOD < LOD 669 All Hispanics Asians 13 - 14 * < LOD < LOD < LOD < LOD 291 for < means less than the limit of detection LOD the urine levels not corrected for creatinine. * Not calculated: proportion of results below limit of detection was too high to provide a valid result. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 92

112 Urinary Di - - cresylphosphate (DpCP) (2013 – 2014) p - p cresylphosphate (TpCP) Metabolite of Tri - Geometric mean and selected percentiles of concentrations (in μg/L) for the U.S. population from the National Health and Nutr ition Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 * < LOD < LOD .070 (.060 - .080) Total (.090 - .160) 2664 .110 Age group .150 11 years 13 - 14 * < LOD .060 - (

113 Urinary Di - - cresylphosphate (DpCP) (creatinine corrected) (2013 – 2014) p - p cresylphosphate (TpCP) Metabolite of Tri - Geometric mean and selected percentiles of concentrat ions (in μg/g of creatinine) for the U.S. population from the National Health and Nutrition Examination Survey. Survey Sample 50th Percentile 90th Percentile 75th Percentile 95th Percentile Geometric mean Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 14 * < LOD < LOD .133 (.125 - .152) .200 - (.182 - .219) 2662 Total 13 Age group - 11 years 13 - 14 * < LOD .125 (

114 Urinary Diphenyl phosphate (DPhP) (2013 – 2014) Metabolite of Triphenyl phosphate (TPhP) Geometric mean and selected percentiles of concentrations (in μg/L) for the U.S. population from the National Health and Nutr ition Examination Survey. Sample Survey Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 .845 (.772 Total .925) .820 (.750 - .920) 1.77 (1.58 - 1.91) 3.71 (3.14 - 4.63) 6.23 (5.16 - 7.90) 2660 - Age group - 11 years 13 - 14 1.69 (1.37 - 2.10) 1.70 (1.24 - 2.02) 3.47 (2.71 - 4.35) 8.17 (5.70 - 10.0) 13.0 (8.17 - 17.8) 420 6 - 19 years 13 - 14 1.41 (1.19 - 1.67) 1.44 (1.24 - 1.79) 2.99 (2.20 - 3.57) 5.31 (4.42 - 6.99) 7.96 (6.28 - 13.0) 426 12 - 14 .727 (.668 - .791) .720 (.630 - .790) 1.44 (1.36 - 1.57) 20 years and older 3.00 (2.66 - 3.43) 5.43 (3.98 - 6.23) 1814 13 Gender (1.38 - 14 .778 (.695 - .871) .800 (.690 Males .910) 1.56 13 - 1.73) 3.00 (2.44 - 3.71) 4.91 (3.68 - 6.23) 1341 - Females 13 - 14 .915 (.826 - 1.01) .890 (.760 - 1.00) 2.02 (1.81 - 2.25) 4.81 (3.56 - 5.81) 8.17 (5.69 - 11.3) 1319 Race/ethnicity - 14 .898 (.798 - 1.01) .850 (.730 - 1.07) 1.85 (1.50 - 2.38) 3.98 (2.90 - 5.32) 5.89 (4.64 - 8.32) Mexican Americans 427 13 - 13 - 14 1.09 (.944 - 1.27) 1.05 (.920 - 1.16) 2.16 Non (1.81 - 2.65) 5.06 (3.33 - 8.22) 8.69 (5.85 - 13.5) 586 Hispanic blacks Non - Hispanic whites 13 - 14 .819 (.726 - .923) .800 (.680 - .930) 1.71 (1.49 - 1.87) 3.54 (2.98 - 4.91) 6.23 (5.11 - 8.17) 1011 (1.48 All Hispanics - 14 .880 (.775 - 1.00) .830 (.740 - 1.02) 1.79 13 - 2.29) 3.71 (2.97 - 4.51) 5.51 (4.43 - 6.40) 670 Asians 13 - 14 .564 (.483 - .659) .570 (.410 - .760) 1.28 (1.05 - 1.50) 2.65 (1.72 - 3.62) 4.11 (3.21 - 5.69) 291 Survey Limit of detection (LOD, see Data Analysis section) for year 13 - 14 is 0.16. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 95

115 Urinary Diphenyl phosphate (DPhP) (creatinine corrected) (2013 – 2014) Metabolite of Triphenyl phosphate (TPhP) Geometric mean and selected percentiles of concentrations (in μg/g of creatinine) for the U.S. population from the National Health and Nutrition Examination Surve y. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 .904 (.846 Total .966) .794 (.762 - .850) 1.60 (1.40 - 1.81) 3.34 (2.84 - 4.10) 5.51 (4.72 - 6.36) 2658 - Age group - 11 years 13 - 14 2.18 (1.89 - 2.51) 1.95 (1.66 - 2.26) 3.70 6 - 4.56) 7.17 (5.72 - 8.69) 9.66 (7.06 - 17.8) 420 (3.05 12 19 years 13 - 14 1.21 (1.07 - 1.37) 1.12 (.940 - 1.32) 2.21 (1.62 - 2.79) 3.77 (3.00 - 5.46) 6.59 (4.02 - 8.47) 426 - 2.70 - 20 years and older .786 (.742 - .834) .695 (.643 - .762) 1.30 (1.15 - 1.44) 13 (2.31 - 3.19) 4.82 (3.91 - 5.51) 1812 14 Gender Males 13 - 14 .715 (.671 - .761) .653 (.605 - .715) 1.14 (1.08 - 1.28) 2.26 (1.96 - 2.67) 3.91 (2.69 - 4.90) 1340 Females - 14 1.13 (1.05 - 1.23) 1.00 (.910 - 1.11) 2.02 (1.80 - 2.36) 4.65 (3.60 - 5.46) 6.84 (5.77 - 8.47) 1318 13 Race/ethnicity (1.33 - 14 .928 (.820 - 1.05) .800 (.654 Mexican Americans 1.02) 1.57 13 - 1.92) 3.27 (2.70 - 4.08) 4.99 (3.77 - 6.44) 425 - Non - Hispanic blacks 13 - 14 .842 (.701 - 1.01) .701 (.627 - .789) 1.57 (1.19 - 2.06) 3.53 (2.37 - 5.46) 6.26 (4.01 - 9.66) 586 Non 13 - 14 .930 (.855 - 1.01) .824 (.757 - .931) 1.64 Hispanic whites (1.43 - 1.85) 3.55 (2.79 - 4.54) 5.52 (4.56 - 6.84) 1011 - All Hispanics 13 - 14 .913 (.807 - 1.03) .800 (.669 - .944) 1.56 (1.32 - 1.95) 3.24 (2.69 - 4.04) 5.18 (3.89 - 6.50) 668 1.44) Asians 13 - 14 .718 (.646 - .799) .681 (.574 - .788) 1.19 (1.00 - 2.19 (1.72 - 3.62) 4.21 (2.62 - 5.04) 291 _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 96

116 Urinary 2,3,4,5 - – 2014) Tetrabromobenzoic acid (TBBA) (2013 - Ethylhexyl 2,3,4,5 - tetrabromobenzoate (EH - TBB) Metabolite of 2 - Geometric mean and selected percentiles of concentrations (in μg/L) for the U.S. population from the National Health and Nutr ition Examination Survey. Sample Survey Geometric mean 75th Percentile 90th Percentile 50th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 * < LOD < LOD < LOD .050 Total (

117 Urinary 2,3,4,5 - – 2014) Tetrabromobenzoic acid (TBBA) (creatinine corrected) (2013 - Ethylhexyl 2,3,4,5 - tetrabromobenzoate (EH - TBB) Metabolite of 2 - Geometric mean and selected percentiles of concentrations (in μg/g of creatinine) for the U.S. population from the Na tional Health and Nutrition Examination Survey. Sample Survey Geometric mean 75th Percentile 90th Percentile 50th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 13 - 14 * < LOD < LOD < LOD .174 Total (

118 Urinary ortho - – 2010)‡ Phenylphenol (2003 d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * .100 (

119 Urinary ortho - – 2010)‡ Phenylphenol (creatinine corrected) (2003 or the U.S. population from the National Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) f and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * .150 (

120 Urinary Ethylene thiourea (2003 – 2008) Metabolite of Several Dithiocarbamate Fungicides Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 04 * < LOD < LOD < LOD .310 (

121 Urinary Ethylene thiourea (creatinine corrected) (2003 – 2008) Metabolite of Several Dithiocarbamate Fungicides Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati onal and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 04 * < LOD < LOD < LOD .434 (

122 Urinary Pentachlorophenol (2003 – 2004) Also a Metabolite of Several Organochlorine Insecticides concentrations (in μg/L) for the U.S. population from the National Health and Geometric mean and selected percentiles of urine Nutrition Examination Survey. Sample Survey Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 03 - 04 * < LOD 1.12 (.570 - 1.58) 2.57 (2.08 - 2.99) Total 3.63 (2.98 - 4.61) 2354 Age group 3.23 11 years 03 - 04 * < LOD 1.57 - (.970 - 2.25) (2.12 - 5.67) 5.67 (2.94 - 6.38) 290 6 - 19 years 03 - 04 * < LOD 1.36 12 (.760 - 1.99) 2.88 (2.08 - 3.53) 3.80 (3.06 - 6.38) 674 20 59 years 03 - 04 * < LOD .980 (

123 Urinary Pentachlorophenol (creatinine corrected) (2003 – 2004) Also a Metabolite of Several Organochlorine Insecticides National Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the and Nutrition Examination Survey. Sample Survey Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 03 - 04 Total * < LOD 1.22 (1.01 - 1.52) 2.30 (1.84 - 2.77) 3.44 (2.69 - 3.96) 2352 Age group - 11 years 03 - 04 * < LOD 1.75 (1.38 - 2.69) 3.72 (2.50 - 4.96) 4.96 (3.59 - 10.6) 6 290 12 19 years 03 - 04 * < LOD 1.11 (.800 - 1.28) 1.67 (1.31 - 2.65) 2.76 (1.64 - 3.89) 673 - - (1.66 03 - 04 * < LOD 1.10 (

124 Urinary Propylene thiourea (2003 – 2008) Metabolite of Propineb Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample 50th Percentile Geometric mean 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 04 * < LOD < LOD < LOD Total < LOD 2456 03 - * < LOD < LOD 06 < LOD 2628 05 < LOD - 08 * < LOD < LOD < LOD < LOD 2573 07 Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 305 - 6 - 06 * < LOD < LOD < LOD < LOD 349 05 07 - * < LOD < LOD < LOD < LOD 382 08 < LOD 19 years 03 - 04 * < LOD - < LOD < LOD 702 12 05 - 06 * < LOD < LOD < LOD 718 < LOD - 08 * < LOD < LOD < LOD < LOD 387 07 - 59 years 03 - 04 * < LOD < LOD < LOD < LOD 926 20 - < LOD * < LOD 05 < LOD < LOD 1086 06 07 * < LOD < LOD 08 < LOD < LOD 1170 - 03 - 04 * < LOD < LOD < LOD < LOD 523 60 years and older 05 06 * < LOD < LOD < LOD < LOD 475 - 07 * < LOD < LOD 08 < LOD < LOD 634 - Gender - 04 Males * < LOD < LOD < LOD < LOD 1209 03 < LOD 05 06 * < LOD - < LOD < LOD 1246 07 - 08 * < LOD < LOD < LOD < LOD 1289 Females - 04 * < LOD < LOD < LOD < LOD 1247 03 05 - * < LOD < LOD < LOD < LOD 1382 06 - 1284 * < LOD < LOD < LOD < LOD 07 08 Race/ethnicity 03 04 < LOD < LOD - < LOD < LOD 598 Mexican Americans * 05 - 06 * < LOD < LOD < LOD < LOD 693 - 08 * < LOD < LOD < LOD < LOD 493 07 - 03 - 04 * < LOD < LOD < LOD < LOD 637 Non Hispanic blacks 05 06 * < LOD < LOD < LOD < LOD 720 - < LOD 08 * < LOD - < LOD < LOD 570 07 Non - Hispanic whites 03 - 04 * < LOD < LOD < LOD < LOD 1062 05 06 * < LOD < LOD < LOD < LOD 1006 - 07 * < LOD < LOD 08 < LOD < LOD 1084 - of detection (LOD, see Data Analysis section) Limit Survey years 03 - 04, 05 - 06, and 07 - 08 are 0.1, 0.37, and 0.36 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by individual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/ETUPTU_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 105

125 Urinary Propylene thiourea (creatinine corrected) (2003 – 2008) Metabolite of Propineb Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati onal Health and Nutrition Exami nation Survey. Survey Sample 75th Percentile 90th Percentile 50th Percentile 95th Percentile Geometric mean Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 04 Total * < LOD < LOD < LOD < LOD 2454 03 - * < LOD < LOD 06 < LOD 2628 05 < LOD - 08 * < LOD < LOD < LOD < LOD 2571 07 Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 305 - 6 - 06 * < LOD < LOD < LOD 349 05 < LOD 07 08 * < LOD < LOD - < LOD < LOD 382 - 19 years 03 - 04 * 12 < LOD < LOD < LOD < LOD 701 - 06 * < LOD < LOD < LOD < LOD 718 05 07 - * < LOD < LOD < LOD < LOD 385 08 59 years < LOD 03 - 04 * < LOD - < LOD < LOD 925 20 - * < LOD < LOD 06 < LOD < LOD 1086 05 07 - 08 * < LOD < LOD < LOD 1170 < LOD 60 years and older 03 - 04 * < LOD < LOD < LOD < LOD 523 05 < LOD 06 * < LOD < LOD < LOD 475 - 07 08 < LOD < LOD < LOD < LOD - 634 * Gender Males 03 - 04 * < LOD < LOD < LOD < LOD 1208 05 06 * < LOD < LOD < LOD < LOD 1246 - 07 - * < LOD < LOD < LOD < LOD 1288 08 03 04 * < LOD < LOD < LOD < LOD 1246 Females - - * < LOD < LOD 06 < LOD < LOD 1382 05 07 - 08 * < LOD < LOD < LOD < LOD 1283 Race/ethnicity 04 * < LOD < LOD - < LOD < LOD 597 Mexican Americans 03 05 - 06 * < LOD < LOD < LOD < LOD 693 07 - 08 * < LOD < LOD < LOD < LOD 492 - 03 - 04 * < LOD Non < LOD < LOD < LOD 637 Hispanic blacks 05 - 06 * < LOD < LOD < LOD < LOD 720 07 08 * < LOD < LOD < LOD < LOD 569 - - 03 - 04 * < LOD < LOD < LOD < LOD 1061 Non Hispanic whites 05 06 * < LOD < LOD < LOD < LOD 1006 - < LOD 08 * < LOD - < LOD < LOD 1084 07 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/ETUPTU_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 106

126 Urinary Atrazine (2007 – 2008)‡ d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 07 - 08 * < LOD Total < LOD < LOD 2588 < LOD Age group < LOD 11 years 07 - 08 - * < LOD < LOD < LOD 384 6 - 19 years 12 07 - 08 * < LOD < LOD < LOD < LOD 390 20 59 years 07 - 08 * < LOD < LOD < LOD < LOD 1179 - - 08 * < LOD < LOD < LOD 60 years and older < LOD 635 07 Gender < LOD - 08 Males * < LOD 07 < LOD < LOD 1294 Females 07 - 08 * < LOD < LOD < LOD < LOD 1294 Race/ethnicity 08 * < LOD < LOD - < LOD < LOD 501 Mexican Americans 07 - Hispanic blacks 07 - 08 * < LOD Non < LOD < LOD 573 < LOD Non Hispanic whites 07 - 08 * - < LOD < LOD < LOD 1085 < LOD Limit of detection (LOD, see Data Analysis section) for Survey year 07 - 08 is 0.5. vary < means less than the limit of detection, which may LOD for some chemicals by year and by individual sample. * Not calculated: proportion of res ults below limit of detection was too high to provide a valid result. ‡Only - 2008. measured in Survey years 2007 _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 107

127 Urinary Atrazine (creatinine corrected) (2007 – 2008)‡ onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examinati on Survey. Survey Sample 50th Percentile 90th Percentile 75th Percentile 95th Percentile Geometric mean Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size 07 08 * < LOD < LOD < LOD < LOD - 2586 Total Age group - 11 years 07 - 08 * < LOD < LOD 6 < LOD < LOD 384 12 19 years 07 - 08 * < LOD < LOD < LOD < LOD 388 - - < LOD 07 - 08 * < LOD < LOD 20 < LOD 1179 59 years < LOD - 60 years and older * < LOD < LOD < LOD 07 635 08 Gender Males 07 - 08 * < LOD < LOD < LOD < LOD 1293 Females - 08 * < LOD < LOD < LOD < LOD 1293 07 Race/ethnicity 07 - 08 * < LOD < LOD < LOD < LOD Mexican Americans 500 Non Hispanic blacks 07 - 08 * - < LOD < LOD < LOD 572 < LOD Non - Hispanic whites 07 - 08 * < LOD < LOD < LOD < LOD 1085 for < means less than the limit of detection LOD the urine levels not corrected for creatinine. * Not calculated: proportion of results below limit of detection was too high to provide a valid result. ‡ 2007 - 2008. Only measured in Survey years _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 108

128 Urinary Atrazine mercapturate (2007 – 2008)‡ Metabolite of Atrazine Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examina tion Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 08 * < LOD < LOD < LOD < LOD - 2588 Total 07 Age group - 11 years 07 - 08 * < LOD < LOD < LOD < LOD 384 6 12 - 07 - 08 * < LOD < LOD < LOD < LOD 390 19 years < LOD - 07 - 08 * < LOD < LOD < LOD 1179 20 59 years 07 - 08 * < LOD < LOD < LOD 60 years and older < LOD 635 Gender < LOD - 08 Males * < LOD 07 < LOD < LOD 1294 Females 07 - 08 * < LOD < LOD < LOD < LOD 1294 Race/ethnicity 08 * < LOD < LOD - < LOD < LOD 501 Mexican Americans 07 - Hispanic blacks 07 - 08 * < LOD Non < LOD < LOD 573 < LOD Non Hispanic whites 07 - 08 * - < LOD < LOD < LOD 1085 < LOD Limit of detection (LOD, see Data Analysis section) for Survey year 07 - 08 is 0.5. vary < means less than the limit of detection, which may LOD for some chemicals by year and by individual sample. * Not calculated: proportion of res ults below limit of detection was too high to provide a valid result. ‡ - 2008. Only measured in Survey years 2007 _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 109

129 Urinary Atrazine mercapturate (creatinine corrected) (2007 – 2008)‡ Metabolite of Atrazine Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the National Health and Nutrition Examination Survey. Sample Survey 90th Percentile Geometric mean 95th Percentile 75th Percentile 50th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 07 08 * < LOD < LOD < LOD - 2586 Total < LOD Age group - 11 years 07 - 08 * < LOD < LOD 6 < LOD < LOD 384 12 19 years 07 - 08 * < LOD < LOD < LOD < LOD 388 - - < LOD 07 - 08 * < LOD < LOD 20 < LOD 1179 59 years < LOD - 60 years and older * < LOD < LOD < LOD 07 635 08 Gender Males 07 - 08 * < LOD < LOD < LOD < LOD 1293 Females - 08 * < LOD < LOD < LOD < LOD 1293 07 Race/ethnicity 07 - 08 * < LOD < LOD < LOD < LOD Mexican Americans 500 Non Hispanic blacks 07 - 08 * - < LOD < LOD < LOD 572 < LOD Non - Hispanic whites 07 - 08 * < LOD < LOD < LOD < LOD 1085 for < means less than the limit of detection LOD the urine levels not corrected for creatinine. * Not calculated: proportion of results below limit of detection was too high to provide a valid result. ‡ 2007 - 2008. Only measured in Survey years _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 110

130 Urinary Desethyl atrazine (2007 – 2008)‡ Metabolite of Atrazine Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Survey. Nutrition Examination Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 08 * < LOD < LOD < LOD < LOD - 2482 Total 07 Age group - 11 years 07 - 08 * < LOD < LOD < LOD < LOD 360 6 12 - 07 - 08 * < LOD < LOD < LOD < LOD 382 19 years < LOD - 07 - 08 * < LOD < LOD < LOD 1129 20 59 years 07 - 08 * < LOD < LOD < LOD 60 years and older < LOD 611 Gender < LOD - 08 Males * < LOD 07 < LOD < LOD 1234 Females 07 - 08 * < LOD < LOD < LOD < LOD 1248 Race/ethnicity 08 * < LOD < LOD - < LOD < LOD 462 Mexican Americans 07 - Hispanic blacks 07 - 08 * < LOD Non < LOD < LOD 563 < LOD Non Hispanic whites 07 - 08 * - < LOD < LOD < LOD 1048 < LOD Limit of detection (LOD, see Data Analysis section) for Survey year 07 - 08 is 0.25. vary < means less than the limit of detection, which may LOD for some chemicals by year and by individual sample. * Not calculated: proportion of re sults below limit of detection was too high to provide a valid result. ‡Only - 2008. measured in Survey years 2007 _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 111

131 Urinary Desethyl atrazine (creatinine corrected) (2007 – 2008)‡ Metabolite of Atrazine Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinin e) for the U.S. population from the National Health and Nutrition Examination Survey. Sample Survey 90th Percentile Geometric mean 95th Percentile 75th Percentile 50th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 07 08 * < LOD < LOD < LOD - 2480 Total < LOD Age group - 11 years 07 - 08 * < LOD < LOD 6 < LOD < LOD 360 12 19 years 07 - 08 * < LOD < LOD < LOD < LOD 380 - - < LOD 07 - 08 * < LOD < LOD 20 < LOD 1129 59 years < LOD - 60 years and older * < LOD < LOD < LOD 07 611 08 Gender Males 07 - 08 * < LOD < LOD < LOD < LOD 1233 Females - 08 * < LOD < LOD < LOD < LOD 1247 07 Race/ethnicity 07 - 08 * < LOD < LOD < LOD < LOD Mexican Americans 461 Non Hispanic blacks 07 - 08 * - < LOD < LOD < LOD 562 < LOD Non - Hispanic whites 07 - 08 * < LOD < LOD < LOD < LOD 1048 for < means less than the limit of detection LOD the urine levels not corrected for creatinine. * Not calculated: proportion of results below limit of detection was too high to provide a valid result. ‡Only 2007 - 2008. measured in Survey years _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 112

132 Urinary Desisopropyl atrazine (2007 – 2008)‡ Metabolite of Atrazine Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examina tion Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 08 * < LOD < LOD < LOD < LOD - 2445 Total 07 Age group - 11 years 07 - 08 * < LOD < LOD < LOD < LOD 367 6 12 - 07 - 08 * < LOD < LOD < LOD < LOD 361 19 years < LOD - 07 - 08 * < LOD < LOD < LOD 1113 20 59 years 07 - 08 * < LOD < LOD < LOD 60 years and older < LOD 604 Gender < LOD - 08 Males * < LOD 07 < LOD < LOD 1224 Females 07 - 08 * < LOD < LOD < LOD < LOD 1221 Race/ethnicity 08 * < LOD < LOD - < LOD < LOD 493 Mexican Americans 07 - Hispanic blacks 07 - 08 * < LOD Non < LOD < LOD 537 < LOD Non Hispanic whites 07 - 08 * - < LOD < LOD < LOD 1010 < LOD Limit of detection (LOD, see Data Analysis section) for Survey year 07 - 08 is 0.25. vary < means less than the limit of detection, which may LOD for some chemicals by year and by individual sample. * Not calculated: proportion of re sults below limit of detection was too high to provide a valid result. ‡Only - 2008. measured in Survey years 2007 _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 113

133 Urinary Desisopropyl atrazine (creatinine corrected) (2007 – 2008)‡ Metabolite of Atrazine Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the National Health and Nutrition Examination Survey. Sample Survey 90th Percentile Geometric mean 95th Percentile 75th Percentile 50th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 07 08 * < LOD < LOD < LOD - 2444 Total < LOD Age group - 11 years 07 - 08 * < LOD < LOD 6 < LOD < LOD 367 12 19 years 07 - 08 * < LOD < LOD < LOD < LOD 360 - - < LOD 07 - 08 * < LOD < LOD 20 < LOD 1113 59 years < LOD - 60 years and older * < LOD < LOD < LOD 07 604 08 Gender Males 07 - 08 * < LOD < LOD < LOD < LOD 1223 Females - 08 * < LOD < LOD < LOD < LOD 1221 07 Race/ethnicity 07 - 08 * < LOD < LOD < LOD < LOD Mexican Americans 492 Non Hispanic blacks 07 - 08 * - < LOD < LOD < LOD 537 < LOD Non - Hispanic whites 07 - 08 * < LOD < LOD < LOD < LOD 1010 for < means less than the limit of detection LOD the urine levels not corrected for creatinine. * Not calculated: proportion of results below limit of detection was too high to provide a valid result. 2008. ‡Only measured in Survey years 2007 - _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 114

134 Urinary Desisopropyl atrazine mercapturate (2007 – 2008)‡ Metabolite of Atrazine Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutri tion Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 08 * < LOD < LOD < LOD < LOD - 2480 Total 07 Age group - 11 years 07 - 08 * < LOD < LOD < LOD < LOD 366 6 12 - 07 - 08 * < LOD < LOD < LOD < LOD 372 19 years < LOD - 07 - 08 * < LOD < LOD < LOD 1135 20 59 years 07 - 08 * < LOD < LOD < LOD 60 years and older < LOD 607 Gender < LOD - 08 Males * < LOD 07 < LOD < LOD 1233 Females 07 - 08 * < LOD < LOD < LOD < LOD 1247 Race/ethnicity 08 * < LOD < LOD - < LOD < LOD 486 Mexican Americans 07 - Hispanic blacks 07 - 08 * < LOD Non < LOD < LOD 531 < LOD Non Hispanic whites 07 - 08 * - < LOD < LOD < LOD 1039 < LOD Limit of detection (LOD, see Data Analysis section) for Survey year 07 - 08 is 0.1. vary < means less than the limit of detection, which may LOD for some chemicals by year and by individual sample. * Not calculated: proportion of res ults below limit of detection was too high to provide a valid result . ‡Only - 2008. measured in Survey years 2007 _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 115

135 Urinary Desisopropyl atrazine mercapturate (creatinine corrected) (2007 – 2008)‡ Metabolite of Atrazine Geometric mean and selected percenti les of urine concentrations (in μg/g of creatinine) for the U.S. population from the National Health and Nutrition Examination Survey. Sample Survey 90th Percentile Geometric mean 95th Percentile 75th Percentile 50th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 07 08 * < LOD < LOD < LOD - 2478 Total < LOD Age group - 11 years 07 - 08 * < LOD < LOD 6 < LOD < LOD 366 12 19 years 07 - 08 * < LOD < LOD < LOD < LOD 370 - - < LOD 07 - 08 * < LOD < LOD 20 < LOD 1135 59 years < LOD - 60 years and older * < LOD < LOD < LOD 07 607 08 Gender Males 07 - 08 * < LOD < LOD < LOD < LOD 1232 Females - 08 * < LOD < LOD < LOD < LOD 1246 07 Race/ethnicity 07 - 08 * < LOD < LOD < LOD < LOD Mexican Americans 485 Non Hispanic blacks 07 - 08 * - < LOD < LOD < LOD 530 < LOD Non - Hispanic whites 07 - 08 * < LOD < LOD < LOD < LOD 1039 for < means less than the limit of detection LOD the urine levels not corrected for creatinine. * Not calculated: proportion of results below limit of detection was too high to provide a valid result. ‡Only 2007 - 2008. measured in Survey years _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 116

136 Urinary Diaminochloroatrazine (2007 – 2008)‡ Metabolite of Atrazine Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examinat ion Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 08 * < LOD < LOD < LOD < LOD - 2588 Total 07 Age group - 11 years 07 - 08 * < LOD < LOD < LOD < LOD 384 6 12 - 07 - 08 * < LOD < LOD < LOD < LOD 390 19 years < LOD - 07 - 08 * < LOD < LOD < LOD 1179 20 59 years 07 - 08 * < LOD < LOD < LOD 60 years and older < LOD 635 Gender < LOD - 08 Males * < LOD 07 < LOD < LOD 1294 Females 07 - 08 * < LOD < LOD < LOD < LOD 1294 Race/ethnicity 08 * < LOD < LOD - < LOD < LOD 501 Mexican Americans 07 - Hispanic blacks 07 - 08 * < LOD Non < LOD < LOD 573 < LOD Non Hispanic whites 07 - 08 * - < LOD < LOD < LOD 1085 < LOD Limit of detection (LOD, see Data Analysis section) for Survey year 07 - 08 is 0.5. vary < means less than the limit of detection, which may LOD for some chemicals by year and by individual sample. * Not calculated: proportion of res ults below limit of detection was too high to provide a valid result. ‡Only - 2008. measured in Survey years 2007 _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 117

137 Urinary Diaminochloroatrazine (creatinine corrected) (2007 – 2008)‡ Metabolite of Atrazine creatinine) for the U.S. population from the National Health Geometric mean and selected percentiles of urine concentrations (in μg/g of and Nutrition Examination Survey. Sample Survey 90th Percentile Geometric mean 95th Percentile 75th Percentile 50th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 07 08 * < LOD < LOD < LOD - 2586 Total < LOD Age group - 11 years 07 - 08 * < LOD 6 < LOD < LOD 384 < LOD 12 19 years 07 - 08 * < LOD < LOD < LOD < LOD 388 - - < LOD 07 - 08 * < LOD < LOD 20 < LOD 1179 59 years < LOD - 60 years and older * < LOD < LOD < LOD 07 635 08 Gender Males 07 - 08 * < LOD < LOD < LOD < LOD 1293 Females - 08 * < LOD < LOD < LOD < LOD 1293 07 Race/ethnicity 07 - 08 * < LOD < LOD < LOD < LOD Mexican Americans 500 Non Hispanic blacks 07 - 08 * - < LOD < LOD < LOD 572 < LOD Non - Hispanic whites 07 - 08 * < LOD < LOD < LOD < LOD 1085 for < means less than the limit of detection LOD the urine levels not corrected for creatinine. * Not calculated: proportion of results below limit of detection was too high to provide a valid result. ‡Only 2007 - 2008. measured in Survey years _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 118

138 Urinary 2,4 - – 2010)‡ Dichlorophenoxyacetic acid (1999 d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size Total < LOD < LOD < LOD < LOD 1977 99 - 00 * 02 * < LOD .220 (

139 Urinary 2,4 - – 2010)‡ Dichlorophenoxyacetic acid (1999 d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size Race/ethnicity < LOD - * < LOD < LOD 00 < LOD 695 99 Mexican Americans - 02 * < LOD .250 (

140 Urinary 2,4 - – 2010)‡ Dichlorophenoxyacetic acid (creatinine corrected) (1999 onal He alth Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size 00 - < LOD < LOD < LOD < LOD 1977 99 Total * 02 * < LOD .378 (

141 Urinary 2,4 - – 2010)‡ Dichlorophenoxyacetic acid (creatinine corrected) (1999 onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size Race/ethnicity < LOD - * < LOD < LOD 00 < LOD 695 99 Mexican Americans - 02 * < LOD .350 (

142 Urinary 2,4,5 - (1999 – 2010)‡ Trichlorophenoxyacetic acid d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 00 * < LOD < LOD < LOD < LOD 1814 Total 99 02 * - < LOD < LOD < LOD < LOD 3047 01 .140 04 - < LOD < LOD < LOD (

143 Urinary 2,4,5 - – 2010)‡ Trichlorophenoxyacetic acid (1999 d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Sur vey. Survey Sample 95th Percentile Geometric mean 50th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 * < LOD < LOD Mexican Americans < LOD 652 < LOD 01 02 * < LOD < LOD < LOD < LOD 766 - - - 03 < LOD < LOD .120 (

144 Urinary 2,4,5 - – 2010)‡ Trichlorophenoxyacetic acid (creatinine corrected) (1999 onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 00 * < LOD < LOD < LOD Total < LOD 1814 99 - * < LOD < LOD 02 < LOD 3045 01 < LOD - 04 * < LOD < LOD < LOD .333 (

145 Urinary 2,4,5 - – 2010)‡ Trichlorophenoxyacetic acid (creatinine corrected) (1999 onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutr ition Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 Mexican Americans 00 * < LOD < LOD < LOD < LOD 652 - - * < LOD < LOD 02 < LOD < LOD 766 01 03 - 04 * < LOD < LOD .200 (

146 Urinary Bensulfuron - – 2008) methyl (2003 d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD Total < LOD 2355 03 - * < LOD < LOD 06 < LOD 2634 05 < LOD - 08 * < LOD < LOD < LOD 2494 07 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 286 - 6 - 06 * < LOD < LOD < LOD 350 05 < LOD 07 08 * < LOD < LOD - < LOD < LOD 374 - 19 years 03 - 04 * 12 < LOD < LOD < LOD 671 < LOD - 06 * < LOD < LOD < LOD < LOD 718 05 07 - * < LOD < LOD < LOD < LOD 381 08 03 04 * < LOD < LOD < LOD < LOD 1398 20 years and older - - * < LOD < LOD 06 < LOD < LOD 1566 05 07 - 08 * < LOD < LOD < LOD < LOD 1739 Gender 04 * < LOD < LOD - < LOD < LOD 1150 Males 03 05 - 06 * < LOD < LOD < LOD 1247 < LOD - 08 * < LOD 07 < LOD < LOD 1240 < LOD Females 03 - 04 * < LOD < LOD < LOD < LOD 1205 05 06 * < LOD < LOD < LOD < LOD 1387 - 07 - * < LOD < LOD < LOD < LOD 1254 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD Mexican Americans 567 05 06 * < LOD < LOD - < LOD < LOD 697 07 - 08 * < LOD < LOD < LOD < LOD 477 Non Hispanic blacks 03 - 04 * < LOD < LOD < LOD < LOD 617 - 05 * < LOD < LOD 06 < LOD < LOD 720 - 07 - 08 * < LOD < LOD < LOD 558 < LOD Non Hispanic whites 03 - 04 * - < LOD < LOD < LOD 1018 < LOD 05 - 06 * < LOD < LOD < LOD < LOD 1007 07 08 * < LOD < LOD < LOD < LOD 1053 - detection (LOD, see Data Analysis section) Limit Survey years 03 - 04, of 05 - 06, and 07 - 08 are 0.05, 0.05, and 0.05 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by i ndividual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 127

147 Urinary Bensul furon methyl (creatinine corrected) (2003 – 2008) - onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size < LOD - * < LOD < LOD 03 < LOD 2353 Total 04 - 06 * < LOD < LOD < LOD < LOD 2634 05 - 07 * < LOD < LOD < LOD < LOD 2492 08 Age group 11 years 03 - 04 * < LOD < LOD < LOD 6 286 - < LOD 05 06 * < LOD < LOD - < LOD < LOD 350 07 - 08 * < LOD < LOD < LOD < LOD 374 12 - 03 - 04 * < LOD < LOD < LOD < LOD 670 19 years 05 - * < LOD < LOD < LOD < LOD 718 06 - < LOD * < LOD < LOD 07 < LOD 379 08 04 * < LOD < LOD - < LOD < LOD 1397 20 years and older 03 05 - 06 * < LOD < LOD < LOD < LOD 1566 - 08 * < LOD < LOD < LOD < LOD 1739 07 Gender 03 - 04 * < LOD < LOD < LOD Males 1149 < LOD - 06 * < LOD 05 < LOD < LOD 1247 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 1239 Females - 04 * < LOD < LOD < LOD < LOD 1204 03 05 - * < LOD < LOD < LOD < LOD 1387 06 1253 - * 07 < LOD < LOD < LOD < LOD 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD 566 Mexican Americans 05 06 * < LOD < LOD < LOD < LOD 697 - 07 * < LOD < LOD 08 < LOD < LOD 476 - - Hispanic blacks 03 - 04 * < LOD Non < LOD < LOD < LOD 617 - 06 * < LOD 05 < LOD < LOD 720 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 557 Non - 03 - 04 * < LOD < LOD < LOD < LOD 1017 Hispanic whites 05 06 * < LOD < LOD < LOD < LOD 1007 - < LOD 08 * < LOD - < LOD < LOD 1053 07 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 128

148 Urinary Chlorsulfuron (2003 – 2008) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD Total < LOD 2100 03 - * < LOD < LOD 06 < LOD 2419 05 < LOD - 08 * < LOD < LOD < LOD 2566 07 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 259 - 6 - 06 * < LOD < LOD < LOD 314 05 < LOD 07 08 * < LOD < LOD - < LOD < LOD 380 - 19 years 03 - 04 * < LOD < LOD < LOD < LOD 601 12 - 06 * < LOD < LOD < LOD < LOD 653 05 07 - * < LOD < LOD < LOD < LOD 386 08 03 04 * < LOD < LOD < LOD < LOD 1240 20 years and older - - * < LOD < LOD 06 < LOD < LOD 1452 05 07 - 08 * < LOD < LOD < LOD < LOD 1800 Gender 04 * < LOD < LOD - < LOD < LOD 1031 Males 03 05 - 06 * < LOD < LOD < LOD < LOD 1151 07 08 * < LOD < LOD < LOD < LOD 1285 - < LOD Females - 04 * < LOD 03 < LOD < LOD 1069 05 - 06 * < LOD < LOD < LOD < LOD 1268 07 08 * < LOD < LOD < LOD < LOD 1281 - Race/ethnicity 03 04 * < LOD < LOD < LOD < LOD 506 Mexican Americans - - * < LOD < LOD 06 < LOD < LOD 633 05 07 - 08 * < LOD < LOD < LOD < LOD 491 - 03 - 04 Non * < LOD < LOD < LOD < LOD 568 Hispanic blacks 05 * < LOD < LOD 06 < LOD < LOD 658 - 07 - 08 * < LOD < LOD < LOD 570 < LOD Non Hispanic whites 03 - 04 * - < LOD < LOD < LOD 894 < LOD 05 - 06 * < LOD < LOD < LOD < LOD 940 07 08 * < LOD < LOD < LOD < LOD 1081 - detection (LOD, see Data Analysis section) Limit Survey years 03 - 04, of 05 - 06, and 07 - 08 are 0.06, 0.06, and 0.06 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by i ndividual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 129

149 Urinary Chlorsulfur on (creatinine corrected) (2003 2008) – onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size < LOD - * < LOD < LOD 03 < LOD 2098 Total 04 - 06 * < LOD < LOD < LOD < LOD 2419 05 - 07 * < LOD < LOD < LOD < LOD 2564 08 Age group 11 years 03 - 04 * < LOD < LOD < LOD 6 259 - < LOD 05 06 * < LOD < LOD - < LOD < LOD 314 07 - 08 * < LOD < LOD < LOD < LOD 380 12 - 03 - 04 * < LOD < LOD < LOD < LOD 600 19 years 05 - * < LOD < LOD < LOD < LOD 653 06 - < LOD * < LOD < LOD 07 < LOD 384 08 04 * < LOD < LOD - < LOD < LOD 1239 20 years and older 03 05 - 06 * < LOD < LOD < LOD < LOD 1452 - 08 * < LOD < LOD < LOD < LOD 1800 07 Gender 03 - 04 * < LOD < LOD < LOD Males 1030 < LOD - 06 * < LOD 05 < LOD < LOD 1151 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 1284 Females - 04 * < LOD < LOD < LOD < LOD 1068 03 05 - * < LOD < LOD < LOD < LOD 1268 06 1280 - * 07 < LOD < LOD < LOD < LOD 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD 505 Mexican Americans 05 06 * < LOD < LOD < LOD < LOD 633 - 07 * < LOD < LOD 08 < LOD < LOD 490 - - Hispanic blacks 03 - 04 * < LOD Non < LOD < LOD < LOD 568 - 06 * < LOD 05 < LOD < LOD 658 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 569 Non - 03 - 04 * < LOD < LOD < LOD < LOD 893 Hispanic whites 05 06 * < LOD < LOD < LOD < LOD 940 - < LOD 08 * < LOD - < LOD < LOD 1081 07 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 130

150 Urinary Ethametsulfuron - – 2008) methyl (2003 d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD Total < LOD 2321 03 - * < LOD < LOD 06 < LOD 2634 05 < LOD - 08 * < LOD < LOD < LOD 2458 07 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 294 - 6 - 06 * < LOD < LOD < LOD 350 05 < LOD 07 08 * < LOD < LOD - < LOD < LOD 366 - 19 years 03 - 04 * 12 < LOD < LOD < LOD 671 < LOD - 06 * < LOD < LOD < LOD < LOD 718 05 07 - * < LOD < LOD < LOD < LOD 381 08 03 04 * < LOD < LOD < LOD < LOD 1356 20 years and older - - * < LOD < LOD 06 < LOD < LOD 1566 05 07 - 08 * < LOD < LOD < LOD < LOD 1711 Gender 04 * < LOD < LOD - < LOD < LOD 1132 Males 03 05 - 06 * < LOD < LOD < LOD 1247 < LOD - 08 * < LOD 07 < LOD < LOD 1218 < LOD Females 03 - 04 * < LOD < LOD < LOD < LOD 1189 05 06 * < LOD < LOD < LOD < LOD 1387 - 07 - * < LOD < LOD < LOD < LOD 1240 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD Mexican Americans 590 05 06 * < LOD < LOD - < LOD < LOD 697 07 - 08 * < LOD < LOD < LOD < LOD 468 Non Hispanic blacks 03 - 04 * < LOD < LOD < LOD < LOD 608 - 05 * < LOD < LOD 06 < LOD < LOD 720 - 07 - 08 * < LOD < LOD < LOD 534 < LOD Non Hispanic whites 03 - 04 * - < LOD < LOD < LOD 974 < LOD 05 - 06 * < LOD < LOD < LOD < LOD 1007 07 08 * < LOD < LOD < LOD < LOD 1052 - detection (LOD, see Data Analysis section) Limit Survey year 03 - 04, of 05 - 06, and 07 - 08 are 0.1, 0.1, and 0.1 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by indiv idual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 131

151 Urinary Et hametsulfuron methyl (creatinine corrected) (2003 – 2008) - onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size < LOD - * < LOD < LOD 03 < LOD 2319 Total 04 - 06 * < LOD < LOD < LOD < LOD 2634 05 - 07 * < LOD < LOD < LOD < LOD 2456 08 Age group 11 years 03 - 04 * < LOD < LOD < LOD 6 294 - < LOD 05 06 * < LOD < LOD - < LOD < LOD 350 07 - 08 * < LOD < LOD < LOD < LOD 366 12 - 03 - 04 * < LOD < LOD < LOD < LOD 670 19 years 05 - * < LOD < LOD < LOD < LOD 718 06 - < LOD * < LOD < LOD 07 < LOD 379 08 04 * < LOD < LOD - < LOD < LOD 1355 20 years and older 03 05 - 06 * < LOD < LOD < LOD < LOD 1566 - 08 * < LOD < LOD < LOD < LOD 1711 07 Gender 03 - 04 * < LOD < LOD < LOD Males 1131 < LOD - 06 * < LOD 05 < LOD < LOD 1247 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 1217 Females - 04 * < LOD < LOD < LOD < LOD 1188 03 05 - * < LOD < LOD < LOD < LOD 1387 06 1239 - * 07 < LOD < LOD < LOD < LOD 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD 589 Mexican Americans 05 06 * < LOD < LOD < LOD < LOD 697 - 07 * < LOD < LOD 08 < LOD < LOD 467 - - Hispanic blacks 03 - 04 * < LOD Non < LOD < LOD < LOD 608 - 06 * < LOD 05 < LOD < LOD 720 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 533 Non - 03 - 04 * < LOD < LOD < LOD < LOD 973 Hispanic whites 05 06 * < LOD < LOD < LOD < LOD 1007 - < LOD 08 * < LOD - < LOD < LOD 1052 07 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 132

152 Urinary Foramsulfuron (2003 – 2008) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD Total < LOD 2255 03 - * < LOD < LOD 06 < LOD 2534 05 < LOD - 08 * < LOD < LOD < LOD 2423 07 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 283 - 6 - 06 * < LOD < LOD < LOD 334 05 < LOD 07 08 * < LOD < LOD - < LOD < LOD 364 - 19 years 03 - 04 * < LOD < LOD < LOD < LOD 653 12 - 06 * < LOD < LOD < LOD < LOD 688 05 07 - * < LOD < LOD < LOD < LOD 364 08 03 04 * < LOD < LOD < LOD < LOD 1319 20 years and older - - * < LOD < LOD 06 < LOD < LOD 1512 05 07 - 08 * < LOD < LOD < LOD < LOD 1695 Gender 04 * < LOD < LOD - < LOD < LOD 1097 Males 03 05 - 06 * < LOD < LOD < LOD < LOD 1203 07 08 * < LOD < LOD < LOD < LOD 1205 - < LOD Females - 04 * < LOD 03 < LOD < LOD 1158 05 - 06 * < LOD < LOD < LOD < LOD 1331 07 08 * < LOD < LOD < LOD < LOD 1218 - Race/ethnicity 03 04 * < LOD < LOD < LOD < LOD 587 Mexican Americans - - * < LOD < LOD 06 < LOD < LOD 632 05 07 - 08 * < LOD < LOD < LOD < LOD 487 - 03 - 04 Non * < LOD < LOD < LOD < LOD 584 Hispanic blacks 05 * < LOD < LOD 06 < LOD < LOD 711 - 07 - 08 * < LOD < LOD < LOD 523 < LOD Non Hispanic whites 03 - 04 * - < LOD < LOD < LOD 935 < LOD 05 - 06 * < LOD < LOD < LOD < LOD 990 07 08 * < LOD < LOD < LOD < LOD 1004 - detection (LOD, see Data Analysis section) Limit Survey years 03 - 04, of 05 - 06, and 07 - 08 are 0.05, 0.05, and 0.05 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by i ndividual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 133

153 Urinary Foramsulfur on (creatinine corrected) (2003 2008) – onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size < LOD - * < LOD < LOD 03 < LOD 2253 Total 04 - 06 * < LOD < LOD < LOD < LOD 2534 05 - 07 * < LOD < LOD < LOD < LOD 2421 08 Age group 11 years 03 - 04 * < LOD < LOD < LOD 6 283 - < LOD 05 06 * < LOD < LOD - < LOD < LOD 334 07 - 08 * < LOD < LOD < LOD < LOD 364 12 - 03 - 04 * < LOD < LOD < LOD < LOD 652 19 years 05 - * < LOD < LOD < LOD < LOD 688 06 - < LOD * < LOD < LOD 07 < LOD 362 08 04 * < LOD < LOD - < LOD < LOD 1318 20 years and older 03 05 - 06 * < LOD < LOD < LOD < LOD 1512 - 08 * < LOD < LOD < LOD < LOD 1695 07 Gender 03 - 04 * < LOD < LOD < LOD Males 1096 < LOD - 06 * < LOD 05 < LOD < LOD 1203 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 1204 Females - 04 * < LOD < LOD < LOD < LOD 1157 03 05 - * < LOD < LOD < LOD < LOD 1331 06 1217 - * 07 < LOD < LOD < LOD < LOD 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD 586 Mexican Americans 05 06 * < LOD < LOD < LOD < LOD 632 - 07 * < LOD < LOD 08 < LOD < LOD 486 - - Hispanic blacks 03 - 04 * < LOD Non < LOD < LOD < LOD 584 - 06 * < LOD 05 < LOD < LOD 711 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 522 Non - 03 - 04 * < LOD < LOD < LOD < LOD 934 Hispanic whites 05 06 * < LOD < LOD < LOD < LOD 990 - < LOD 08 * < LOD - < LOD < LOD 1004 07 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 134

154 Urinary Halosulfuron (2003 – 2008) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD Total < LOD 2356 03 - * < LOD < LOD 06 < LOD 2485 05 < LOD - 08 * < LOD < LOD < LOD 2530 07 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 291 - 6 - 06 * < LOD < LOD < LOD 331 05 < LOD 07 08 * < LOD < LOD - < LOD < LOD 377 - 19 years 03 - 04 * < LOD < LOD < LOD < LOD 672 12 - 06 * < LOD < LOD < LOD < LOD 679 05 07 - * < LOD < LOD < LOD < LOD 385 08 03 04 * < LOD < LOD < LOD < LOD 1393 20 years and older - - * < LOD < LOD 06 < LOD < LOD 1475 05 07 - 08 * < LOD < LOD < LOD < LOD 1768 Gender 04 * < LOD < LOD - < LOD < LOD 1148 Males 03 05 - 06 * < LOD < LOD < LOD < LOD 1184 07 08 * < LOD < LOD < LOD < LOD 1261 - < LOD Females - 04 * < LOD 03 < LOD < LOD 1208 05 - 06 * < LOD < LOD < LOD < LOD 1301 07 08 * < LOD < LOD < LOD < LOD 1269 - Race/ethnicity 03 04 * < LOD < LOD < LOD < LOD 592 Mexican Americans - - * < LOD < LOD 06 < LOD < LOD 650 05 07 - 08 * < LOD < LOD < LOD < LOD 485 - 03 - 04 Non * < LOD < LOD < LOD < LOD 609 Hispanic blacks 05 * < LOD < LOD 06 < LOD < LOD 694 - 07 - 08 * < LOD < LOD < LOD 565 < LOD Non Hispanic whites 03 - 04 * - < LOD < LOD < LOD 1005 < LOD 05 - 06 * < LOD < LOD < LOD < LOD 950 07 08 * < LOD < LOD < LOD < LOD 1068 - detection (LOD, see Data Analysis section) Limit Survey years 03 - 04, of 05 - 06, and 07 - 08 are 0.1, 0.1, and 0.1 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by indi vidual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 135

155 Urinary Halosulfuron – 2008) (creatinine corrected) (2003 onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size < LOD - * < LOD < LOD 03 < LOD 2354 Total 04 - 06 * < LOD < LOD < LOD < LOD 2485 05 - 07 * < LOD < LOD < LOD < LOD 2528 08 Age group 11 years 03 - 04 * < LOD < LOD < LOD 6 291 - < LOD 05 06 * < LOD < LOD - < LOD < LOD 331 07 - 08 * < LOD < LOD < LOD < LOD 377 12 - 03 - 04 * < LOD < LOD < LOD < LOD 671 19 years 05 - * < LOD < LOD < LOD < LOD 679 06 - < LOD * < LOD < LOD 07 < LOD 383 08 04 * < LOD < LOD - < LOD < LOD 1392 20 years and older 03 05 - 06 * < LOD < LOD < LOD < LOD 1475 - 08 * < LOD < LOD < LOD < LOD 1768 07 Gender 03 - 04 * < LOD < LOD < LOD Males 1147 < LOD - 06 * < LOD 05 < LOD < LOD 1184 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 1260 Females - 04 * < LOD < LOD < LOD < LOD 1207 03 05 - * < LOD < LOD < LOD < LOD 1301 06 1268 - * 07 < LOD < LOD < LOD < LOD 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD 591 Mexican Americans 05 06 * < LOD < LOD < LOD < LOD 650 - 07 * < LOD < LOD 08 < LOD < LOD 484 - - Hispanic blacks 03 - 04 * < LOD Non < LOD < LOD < LOD 609 - 06 * < LOD 05 < LOD < LOD 694 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 564 Non - 03 - 04 * < LOD < LOD < LOD < LOD 1004 Hispanic whites 05 06 * < LOD < LOD < LOD < LOD 950 - < LOD 08 * < LOD - < LOD < LOD 1068 07 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 136

156 Urinary Mesosulfuron - – 2008) methyl (2003 d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD Total < LOD 2427 03 - * < LOD < LOD 06 < LOD 2634 05 < LOD - 08 * < LOD < LOD < LOD 2494 07 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 302 - 6 - 06 * < LOD < LOD < LOD 350 05 < LOD 07 08 * < LOD < LOD - < LOD < LOD 372 - 19 years 03 - 04 * 12 < LOD < LOD < LOD 694 < LOD - 06 * < LOD < LOD < LOD < LOD 718 05 07 - * < LOD < LOD < LOD < LOD 371 08 03 04 * < LOD < LOD < LOD < LOD 1431 20 years and older - - * < LOD < LOD 06 < LOD < LOD 1566 05 07 - 08 * < LOD < LOD < LOD < LOD 1751 Gender 04 * < LOD < LOD - < LOD < LOD 1189 Males 03 05 - 06 * < LOD < LOD < LOD 1247 < LOD - 08 * < LOD 07 < LOD < LOD 1245 < LOD Females 03 - 04 * < LOD < LOD < LOD < LOD 1238 05 06 * < LOD < LOD < LOD < LOD 1387 - 07 - * < LOD < LOD < LOD < LOD 1249 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD Mexican Americans 596 05 06 * < LOD < LOD - < LOD < LOD 697 07 - 08 * < LOD < LOD < LOD < LOD 465 Non Hispanic blacks 03 - 04 * < LOD < LOD < LOD < LOD 634 - 05 * < LOD < LOD 06 < LOD < LOD 720 - 07 - 08 * < LOD < LOD < LOD 554 < LOD Non Hispanic whites 03 - 04 * - < LOD < LOD < LOD 1039 < LOD 05 - 06 * < LOD < LOD < LOD < LOD 1007 07 08 * < LOD < LOD < LOD < LOD 1059 - detection (LOD, see Data Analysis section) Limit Survey years 03 - 04, of 05 - 06, and 07 - 08 are 0.06, 0.06, and 0.06 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by i ndividual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 137

157 Urinary Mesos ulfuron methyl (creatinine corrected) (2003 – 2008) - onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size < LOD - * < LOD < LOD 03 < LOD 2425 Total 04 - 06 * < LOD < LOD < LOD < LOD 2634 05 - 07 * < LOD < LOD < LOD < LOD 2492 08 Age group 11 years 03 - 04 * < LOD < LOD < LOD 6 302 - < LOD 05 06 * < LOD < LOD - < LOD < LOD 350 07 - 08 * < LOD < LOD < LOD < LOD 372 12 - 03 - 04 * < LOD < LOD < LOD < LOD 693 19 years 05 - * < LOD < LOD < LOD < LOD 718 06 - < LOD * < LOD < LOD 07 < LOD 369 08 04 * < LOD < LOD - < LOD < LOD 1430 20 years and older 03 05 - 06 * < LOD < LOD < LOD < LOD 1566 - 08 * < LOD < LOD < LOD < LOD 1751 07 Gender 03 - 04 * < LOD < LOD < LOD Males 1188 < LOD - 06 * < LOD 05 < LOD < LOD 1247 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 1244 Females - 04 * < LOD < LOD < LOD < LOD 1237 03 05 - * < LOD < LOD < LOD < LOD 1387 06 1248 - * 07 < LOD < LOD < LOD < LOD 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD 595 Mexican Americans 05 06 * < LOD < LOD < LOD < LOD 697 - 07 * < LOD < LOD 08 < LOD < LOD 464 - - Hispanic blacks 03 - 04 * < LOD Non < LOD < LOD < LOD 634 - 06 * < LOD 05 < LOD < LOD 720 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 553 Non - 03 - 04 * < LOD < LOD < LOD < LOD 1038 Hispanic whites 05 06 * < LOD < LOD < LOD < LOD 1007 - < LOD 08 * < LOD - < LOD < LOD 1059 07 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 138

158 Urinary Metsulfuron - – 2008) methyl (2003 d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD Total < LOD 2360 03 - * < LOD < LOD 06 < LOD 2634 05 < LOD - 08 * < LOD < LOD < LOD 2494 07 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 297 - 6 - 06 * < LOD < LOD < LOD 350 05 < LOD 07 08 * < LOD < LOD - < LOD < LOD 373 - 19 years 03 - 04 * 12 < LOD < LOD < LOD 675 < LOD - 06 * < LOD < LOD < LOD < LOD 718 05 07 - * < LOD < LOD < LOD < LOD 374 08 03 04 * < LOD < LOD < LOD < LOD 1388 20 years and older - - * < LOD < LOD 06 < LOD < LOD 1566 05 07 - 08 * < LOD < LOD < LOD < LOD 1747 Gender 04 * < LOD < LOD - < LOD < LOD 1152 Males 03 05 - 06 * < LOD < LOD < LOD 1247 < LOD - 08 * < LOD 07 < LOD < LOD 1246 < LOD Females 03 - 04 * < LOD < LOD < LOD < LOD 1208 05 06 * < LOD < LOD < LOD < LOD 1387 - 07 - * < LOD < LOD < LOD < LOD 1248 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD Mexican Americans 595 05 06 * < LOD < LOD - < LOD < LOD 697 07 - 08 * < LOD < LOD < LOD < LOD 470 Non Hispanic blacks 03 - 04 * < LOD < LOD < LOD < LOD 596 - 05 * < LOD < LOD 06 < LOD < LOD 720 - 07 - 08 * < LOD < LOD < LOD 538 < LOD Non Hispanic whites 03 - 04 * - < LOD < LOD < LOD 1013 < LOD 05 - 06 * < LOD < LOD < LOD < LOD 1007 07 08 * < LOD < LOD < LOD < LOD 1066 - detection (LOD, see Data Analysis section) Limit Survey years 03 - 04, of 05 - 06, and 07 - 08 are 0.05, 0.05, and 0.05 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by i ndividual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 139

159 Urinary Metsul furon methyl (creatinine corrected) (2003 – 2008) - onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size < LOD - * < LOD < LOD 03 < LOD 2358 Total 04 - 06 * < LOD < LOD < LOD < LOD 2634 05 - 07 * < LOD < LOD < LOD < LOD 2492 08 Age group 11 years 03 - 04 * < LOD < LOD < LOD 6 297 - < LOD 05 06 * < LOD < LOD - < LOD < LOD 350 07 - 08 * < LOD < LOD < LOD < LOD 373 12 - 03 - 04 * < LOD < LOD < LOD < LOD 674 19 years 05 - * < LOD < LOD < LOD < LOD 718 06 - < LOD * < LOD < LOD 07 < LOD 372 08 04 * < LOD < LOD - < LOD < LOD 1387 20 years and older 03 05 - 06 * < LOD < LOD < LOD < LOD 1566 - 08 * < LOD < LOD < LOD < LOD 1747 07 Gender 03 - 04 * < LOD < LOD < LOD Males 1151 < LOD - 06 * < LOD 05 < LOD < LOD 1247 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 1245 Females - 04 * < LOD < LOD < LOD < LOD 1207 03 05 - * < LOD < LOD < LOD < LOD 1387 06 1247 - * 07 < LOD < LOD < LOD < LOD 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD 594 Mexican Americans 05 06 * < LOD < LOD < LOD < LOD 697 - 07 * < LOD < LOD 08 < LOD < LOD 469 - - Hispanic blacks 03 - 04 * < LOD Non < LOD < LOD < LOD 596 - 06 * < LOD 05 < LOD < LOD 720 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 537 Non - 03 - 04 * < LOD < LOD < LOD < LOD 1012 Hispanic whites 05 06 * < LOD < LOD < LOD < LOD 1007 - < LOD 08 * < LOD - < LOD < LOD 1066 07 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 140

160 Urinary Nicosulfuron (2003 – 2008) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD Total < LOD 2322 03 - * < LOD < LOD 06 < LOD 2570 05 < LOD - 08 * < LOD < LOD < LOD 2422 07 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 296 - 6 - 06 * < LOD < LOD < LOD 341 05 < LOD 07 08 * < LOD < LOD - < LOD < LOD 363 - 19 years 03 - 04 * < LOD < LOD < LOD < LOD 666 12 - 06 * < LOD < LOD < LOD < LOD 699 05 07 - * < LOD < LOD < LOD < LOD 364 08 03 04 * < LOD < LOD < LOD < LOD 1360 20 years and older - - * < LOD < LOD 06 < LOD < LOD 1530 05 07 - 08 * < LOD < LOD < LOD < LOD 1695 Gender 04 * < LOD < LOD - < LOD < LOD 1131 Males 03 05 - 06 * < LOD < LOD < LOD < LOD 1222 07 08 * < LOD < LOD < LOD < LOD 1210 - < LOD Females - 04 * < LOD 03 < LOD < LOD 1191 05 - 06 * < LOD < LOD < LOD < LOD 1348 07 08 * < LOD < LOD < LOD < LOD 1212 - Race/ethnicity 03 04 * < LOD < LOD < LOD < LOD 589 Mexican Americans - - * < LOD < LOD 06 < LOD < LOD 656 05 07 - 08 * < LOD < LOD < LOD < LOD 486 - 03 - 04 Non * < LOD < LOD < LOD < LOD 601 Hispanic blacks 05 * < LOD < LOD 06 < LOD < LOD 719 - 07 - 08 * < LOD < LOD < LOD 524 < LOD Non Hispanic whites 03 - 04 * - < LOD < LOD < LOD 980 < LOD 05 - 06 * < LOD < LOD < LOD < LOD 993 07 08 * < LOD < LOD < LOD < LOD 1007 - detection (LOD, see Data Analysis section) Limit Survey years 03 - 04, of 05 - 06, and 07 - 08 are 0.1, 0.1, and 0.1 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by indi vidual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 141

161 Urinary Nicosulfuron – 2008) (creatinine corrected) (2003 onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size < LOD - * < LOD < LOD 03 < LOD 2320 Total 04 - 06 * < LOD < LOD < LOD < LOD 2570 05 - 07 * < LOD < LOD < LOD < LOD 2420 08 Age group 11 years 03 - 04 * < LOD < LOD < LOD 6 296 - < LOD 05 06 * < LOD < LOD - < LOD < LOD 341 07 - 08 * < LOD < LOD < LOD < LOD 363 12 - 03 - 04 * < LOD < LOD < LOD < LOD 665 19 years 05 - * < LOD < LOD < LOD < LOD 699 06 - < LOD * < LOD < LOD 07 < LOD 362 08 04 * < LOD < LOD - < LOD < LOD 1359 20 years and older 03 05 - 06 * < LOD < LOD < LOD < LOD 1530 - 08 * < LOD < LOD < LOD < LOD 1695 07 Gender 03 - 04 * < LOD < LOD < LOD Males 1130 < LOD - 06 * < LOD 05 < LOD < LOD 1222 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 1209 Females - 04 * < LOD < LOD < LOD < LOD 1190 03 05 - * < LOD < LOD < LOD < LOD 1348 06 1211 - * 07 < LOD < LOD < LOD < LOD 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD 588 Mexican Americans 05 06 * < LOD < LOD < LOD < LOD 656 - 07 * < LOD < LOD 08 < LOD < LOD 485 - - Hispanic blacks 03 - 04 * < LOD Non < LOD < LOD < LOD 601 - 06 * < LOD 05 < LOD < LOD 719 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 523 Non - 03 - 04 * < LOD < LOD < LOD < LOD 979 Hispanic whites 05 06 * < LOD < LOD < LOD < LOD 993 - < LOD 08 * < LOD - < LOD < LOD 1007 07 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 142

162 Urinary Oxasulfuron (2003 – 2008) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD Total < LOD 2355 03 - * < LOD < LOD 06 < LOD 2634 05 < LOD - 08 * < LOD < LOD < LOD 2540 07 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 290 - 6 - 06 * < LOD < LOD < LOD 350 05 < LOD 07 08 * < LOD < LOD - < LOD < LOD 379 - 19 years 03 - 04 * < LOD < LOD < LOD < LOD 672 12 - 06 * < LOD < LOD < LOD < LOD 718 05 07 - * < LOD < LOD < LOD < LOD 381 08 03 04 * < LOD < LOD < LOD < LOD 1393 20 years and older - - * < LOD < LOD 06 < LOD < LOD 1566 05 07 - 08 * < LOD < LOD < LOD < LOD 1780 Gender 04 * < LOD < LOD - < LOD < LOD 1150 Males 03 05 - 06 * < LOD < LOD < LOD < LOD 1247 07 08 * < LOD < LOD < LOD < LOD 1269 - < LOD Females - 04 * < LOD 03 < LOD < LOD 1205 05 - 06 * < LOD < LOD < LOD < LOD 1387 07 08 * < LOD < LOD < LOD < LOD 1271 - Race/ethnicity 03 04 * < LOD < LOD < LOD < LOD 579 Mexican Americans - - * < LOD < LOD 06 < LOD < LOD 697 05 07 - 08 * < LOD < LOD < LOD < LOD 487 - 03 - 04 Non * < LOD < LOD < LOD < LOD 616 Hispanic blacks 05 * < LOD < LOD 06 < LOD < LOD 720 - 07 - 08 * < LOD < LOD < LOD 567 < LOD Non Hispanic whites 03 - 04 * - < LOD < LOD < LOD 1018 < LOD 05 - 06 * < LOD < LOD < LOD < LOD 1007 07 08 * < LOD < LOD < LOD < LOD 1076 - detection (LOD, see Data Analysis section) Limit Survey years 03 - 04, of 05 - 06, and 07 - 08 are 0.06, 0.06, and 0.06 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by i ndividual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 143

163 Urinary Oxasulfuron ( creatinine corrected) (2003 2008) – onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size < LOD - * < LOD < LOD 03 < LOD 2353 Total 04 - 06 * < LOD < LOD < LOD < LOD 2634 05 - 07 * < LOD < LOD < LOD < LOD 2538 08 Age group 11 years 03 - 04 * < LOD < LOD < LOD 6 290 - < LOD 05 06 * < LOD < LOD - < LOD < LOD 350 07 - 08 * < LOD < LOD < LOD < LOD 379 12 - 03 - 04 * < LOD < LOD < LOD < LOD 671 19 years 05 - * < LOD < LOD < LOD < LOD 718 06 - < LOD * < LOD < LOD 07 < LOD 379 08 04 * < LOD < LOD - < LOD < LOD 1392 20 years and older 03 05 - 06 * < LOD < LOD < LOD < LOD 1566 - 08 * < LOD < LOD < LOD < LOD 1780 07 Gender 03 - 04 * < LOD < LOD < LOD Males 1149 < LOD - 06 * < LOD 05 < LOD < LOD 1247 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 1268 Females - 04 * < LOD < LOD < LOD < LOD 1204 03 05 - * < LOD < LOD < LOD < LOD 1387 06 1270 - * 07 < LOD < LOD < LOD < LOD 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD 578 Mexican Americans 05 06 * < LOD < LOD < LOD < LOD 697 - 07 * < LOD < LOD 08 < LOD < LOD 486 - - Hispanic blacks 03 - 04 * < LOD Non < LOD < LOD < LOD 616 - 06 * < LOD 05 < LOD < LOD 720 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 566 Non - 03 - 04 * < LOD < LOD < LOD < LOD 1017 Hispanic whites 05 06 * < LOD < LOD < LOD < LOD 1007 - < LOD 08 * < LOD - < LOD < LOD 1076 07 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 144

164 Urinary Primisulfuron - – 2008) methyl (2003 d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD Total < LOD 2250 03 - * < LOD < LOD 06 < LOD 2455 05 < LOD - 08 * < LOD < LOD < LOD 2422 07 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 285 - 6 - 06 * < LOD < LOD < LOD 327 05 < LOD 07 08 * < LOD < LOD - < LOD < LOD 356 - 19 years 03 - 04 * 12 < LOD < LOD < LOD 627 < LOD - 06 * < LOD < LOD < LOD < LOD 665 05 07 - * < LOD < LOD < LOD < LOD 376 08 03 04 * < LOD < LOD < LOD < LOD 1338 20 years and older - - * < LOD < LOD 06 < LOD < LOD 1463 05 07 - 08 * < LOD < LOD < LOD < LOD 1690 Gender 04 * < LOD < LOD - < LOD < LOD 1107 Males 03 05 - 06 * < LOD < LOD < LOD 1160 < LOD - 08 * < LOD 07 < LOD < LOD 1207 < LOD Females 03 - 04 * < LOD < LOD < LOD < LOD 1143 05 06 * < LOD < LOD < LOD < LOD 1295 - 07 - * < LOD < LOD < LOD < LOD 1215 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD Mexican Americans 574 05 06 * < LOD < LOD - < LOD < LOD 667 07 - 08 * < LOD < LOD < LOD < LOD 456 Non Hispanic blacks 03 - 04 * < LOD < LOD < LOD < LOD 556 - 05 * < LOD < LOD 06 < LOD < LOD 661 - 07 - 08 * < LOD < LOD < LOD 549 < LOD Non Hispanic whites 03 - 04 * - < LOD < LOD < LOD 975 < LOD 05 - 06 * < LOD < LOD < LOD < LOD 938 07 08 * < LOD < LOD < LOD < LOD 1030 - detection (LOD, see Data Analysis section) Limit Survey years 03 - 04, of 05 - 06, and 07 - 08 are 0.07, 0.07, and 0.07 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by i ndividual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 145

165 Urinary Prim isulfuron methyl (creatinine corrected) (2003 – 2008) - onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size < LOD - * < LOD < LOD 03 < LOD 2249 Total 04 - 06 * < LOD < LOD < LOD < LOD 2455 05 - 07 * < LOD < LOD < LOD < LOD 2420 08 Age group 11 years 03 - 04 * < LOD < LOD < LOD 6 285 - < LOD 05 06 * < LOD < LOD - < LOD < LOD 327 07 - 08 * < LOD < LOD < LOD < LOD 356 12 - 03 - 04 * < LOD < LOD < LOD < LOD 626 19 years 05 - * < LOD < LOD < LOD < LOD 665 06 - < LOD * < LOD < LOD 07 < LOD 374 08 04 * < LOD < LOD - < LOD < LOD 1338 20 years and older 03 05 - 06 * < LOD < LOD < LOD < LOD 1463 - 08 * < LOD < LOD < LOD < LOD 1690 07 Gender 03 - 04 * < LOD < LOD < LOD Males 1107 < LOD - 06 * < LOD 05 < LOD < LOD 1160 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 1206 Females - 04 * < LOD < LOD < LOD < LOD 1142 03 05 - * < LOD < LOD < LOD < LOD 1295 06 1214 - * 07 < LOD < LOD < LOD < LOD 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD 573 Mexican Americans 05 06 * < LOD < LOD < LOD < LOD 667 - 07 * < LOD < LOD 08 < LOD < LOD 455 - - Hispanic blacks 03 - 04 * < LOD Non < LOD < LOD < LOD 556 - 06 * < LOD 05 < LOD < LOD 661 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 548 Non - 03 - 04 * < LOD < LOD < LOD < LOD 975 Hispanic whites 05 06 * < LOD < LOD < LOD < LOD 938 - < LOD 08 * < LOD - < LOD < LOD 1030 07 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 146

166 Urinary Prosulfuron (2003 – 2008) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD Total < LOD 2247 03 - * < LOD < LOD 06 < LOD 2461 05 < LOD - 08 * < LOD < LOD < LOD 2566 07 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 284 - 6 - 06 * < LOD < LOD < LOD 326 05 < LOD 07 08 * < LOD < LOD - < LOD < LOD 380 - 19 years 03 - 04 * < LOD < LOD < LOD < LOD 640 12 - 06 * < LOD < LOD < LOD < LOD 676 05 07 - * < LOD < LOD < LOD < LOD 386 08 03 04 * < LOD < LOD < LOD < LOD 1323 20 years and older - - * < LOD < LOD 06 < LOD < LOD 1459 05 07 - 08 * < LOD < LOD < LOD < LOD 1800 Gender 04 * < LOD < LOD - < LOD < LOD 1100 Males 03 05 - 06 * < LOD < LOD < LOD < LOD 1165 07 08 * < LOD < LOD < LOD < LOD 1285 - < LOD Females - 04 * < LOD 03 < LOD < LOD 1147 05 - 06 * < LOD < LOD < LOD < LOD 1296 07 08 * < LOD < LOD < LOD < LOD 1281 - Race/ethnicity 03 04 * < LOD < LOD < LOD < LOD 589 Mexican Americans - - * < LOD < LOD 06 < LOD < LOD 673 05 07 - 08 * < LOD < LOD < LOD < LOD 491 - 03 - 04 Non * < LOD < LOD < LOD < LOD 565 Hispanic blacks 05 * < LOD < LOD 06 < LOD < LOD 677 - 07 - 08 * < LOD < LOD < LOD 570 < LOD Non Hispanic whites 03 - 04 * - < LOD < LOD < LOD 940 < LOD 05 - 06 * < LOD < LOD < LOD < LOD 924 07 08 * < LOD < LOD < LOD < LOD 1081 - detection (LOD, see Data Analysis section) Limit Survey years 03 - 04, of 05 - 06, and 07 - 08 are 0.05, 0.05, and 0.05 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by i ndividual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 147

167 Urinary Prosulfuron ( creatinine corrected) (2003 2008) – onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size < LOD - * < LOD < LOD 03 < LOD 2245 Total 04 - 06 * < LOD < LOD < LOD < LOD 2461 05 - 07 * < LOD < LOD < LOD < LOD 2564 08 Age group 11 years 03 - 04 * < LOD < LOD < LOD 6 284 - < LOD 05 06 * < LOD < LOD - < LOD < LOD 326 07 - 08 * < LOD < LOD < LOD < LOD 380 12 - 03 - 04 * < LOD < LOD < LOD < LOD 639 19 years 05 - * < LOD < LOD < LOD < LOD 676 06 - < LOD * < LOD < LOD 07 < LOD 384 08 04 * < LOD < LOD - < LOD < LOD 1322 20 years and older 03 05 - 06 * < LOD < LOD < LOD < LOD 1459 - 08 * < LOD < LOD < LOD < LOD 1800 07 Gender 03 - 04 * < LOD < LOD < LOD Males 1099 < LOD - 06 * < LOD 05 < LOD < LOD 1165 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 1284 Females - 04 * < LOD < LOD < LOD < LOD 1146 03 05 - * < LOD < LOD < LOD < LOD 1296 06 1280 - * 07 < LOD < LOD < LOD < LOD 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD 588 Mexican Americans 05 06 * < LOD < LOD < LOD < LOD 673 - 07 * < LOD < LOD 08 < LOD < LOD 490 - - Hispanic blacks 03 - 04 * < LOD Non < LOD < LOD < LOD 565 - 06 * < LOD 05 < LOD < LOD 677 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 569 Non - 03 - 04 * < LOD < LOD < LOD < LOD 939 Hispanic whites 05 06 * < LOD < LOD < LOD < LOD 924 - < LOD 08 * < LOD - < LOD < LOD 1081 07 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 148

168 Urinary Rimsulfuron (2003 – 2008) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD Total < LOD 2284 03 - * < LOD < LOD 06 < LOD 2593 05 < LOD - 08 * < LOD < LOD < LOD 2530 07 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 279 - 6 - 06 * < LOD < LOD < LOD 346 05 < LOD 07 08 * < LOD < LOD - < LOD < LOD 376 - 19 years 03 - 04 * < LOD < LOD < LOD < LOD 654 12 - 06 * < LOD < LOD < LOD < LOD 706 05 07 - * < LOD < LOD < LOD < LOD 383 08 03 04 * < LOD < LOD < LOD < LOD 1351 20 years and older - - * < LOD < LOD 06 < LOD < LOD 1541 05 07 - 08 * < LOD < LOD < LOD < LOD 1771 Gender 04 * < LOD < LOD - < LOD < LOD 1110 Males 03 05 - 06 * < LOD < LOD < LOD < LOD 1224 07 08 * < LOD < LOD < LOD < LOD 1271 - < LOD Females - 04 * < LOD 03 < LOD < LOD 1174 05 - 06 * < LOD < LOD < LOD < LOD 1369 07 08 * < LOD < LOD < LOD < LOD 1259 - Race/ethnicity 03 04 * < LOD < LOD < LOD < LOD 561 Mexican Americans - - * < LOD < LOD 06 < LOD < LOD 675 05 07 - 08 * < LOD < LOD < LOD < LOD 463 - 03 - 04 Non * < LOD < LOD < LOD < LOD 592 Hispanic blacks 05 * < LOD < LOD 06 < LOD < LOD 715 - 07 - 08 * < LOD < LOD < LOD 568 < LOD Non Hispanic whites 03 - 04 * - < LOD < LOD < LOD 985 < LOD 05 - 06 * < LOD < LOD < LOD < LOD 998 07 08 * < LOD < LOD < LOD < LOD 1080 - detection (LOD, see Data Analysis section) Limit Survey years 03 - 04, of 05 - 06, and 07 - 08 are 0.05, 0.05, and 0.05 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by i ndividual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 149

169 Urinary Rimsulfuron ( creatinine corrected) (2003 2008) – onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size < LOD - * < LOD < LOD 03 < LOD 2282 Total 04 - 06 * < LOD < LOD < LOD < LOD 2593 05 - 07 * < LOD < LOD < LOD < LOD 2528 08 Age group 11 years 03 - 04 * < LOD < LOD < LOD 6 279 - < LOD 05 06 * < LOD < LOD - < LOD < LOD 346 07 - 08 * < LOD < LOD < LOD < LOD 376 12 - 03 - 04 * < LOD < LOD < LOD < LOD 653 19 years 05 - * < LOD < LOD < LOD < LOD 706 06 - < LOD * < LOD < LOD 07 < LOD 381 08 04 * < LOD < LOD - < LOD < LOD 1350 20 years and older 03 05 - 06 * < LOD < LOD < LOD < LOD 1541 - 08 * < LOD < LOD < LOD < LOD 1771 07 Gender 03 - 04 * < LOD < LOD < LOD Males 1109 < LOD - 06 * < LOD 05 < LOD < LOD 1224 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 1270 Females - 04 * < LOD < LOD < LOD < LOD 1173 03 05 - * < LOD < LOD < LOD < LOD 1369 06 1258 - * 07 < LOD < LOD < LOD < LOD 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD 560 Mexican Americans 05 06 * < LOD < LOD < LOD < LOD 675 - 07 * < LOD < LOD 08 < LOD < LOD 462 - - Hispanic blacks 03 - 04 * < LOD Non < LOD < LOD < LOD 592 - 06 * < LOD 05 < LOD < LOD 715 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 567 Non - 03 - 04 * < LOD < LOD < LOD < LOD 984 Hispanic whites 05 06 * < LOD < LOD < LOD < LOD 998 - < LOD 08 * < LOD - < LOD < LOD 1080 07 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 150

170 Urinary Sulfometuron - – 2008) methyl (2003 d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD Total < LOD 2067 03 - * < LOD < LOD 06 < LOD 2598 05 < LOD - 08 * < LOD < LOD < LOD 2458 07 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 252 - 6 - 06 * < LOD < LOD < LOD 345 05 < LOD 07 08 * < LOD < LOD - < LOD < LOD 352 - 19 years 03 - 04 * 12 < LOD < LOD < LOD 587 < LOD - 06 * < LOD < LOD < LOD < LOD 710 05 07 - * < LOD < LOD < LOD < LOD 373 08 03 04 * < LOD < LOD < LOD < LOD 1228 20 years and older - - * < LOD < LOD 06 < LOD < LOD 1543 05 07 - 08 * < LOD < LOD < LOD < LOD 1733 Gender 04 * < LOD < LOD - < LOD < LOD 1007 Males 03 05 - 06 * < LOD < LOD < LOD 1233 < LOD - 08 * < LOD 07 < LOD < LOD 1226 < LOD Females 03 - 04 * < LOD < LOD < LOD < LOD 1060 05 06 * < LOD < LOD < LOD < LOD 1365 - 07 - * < LOD < LOD < LOD < LOD 1232 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD Mexican Americans 441 05 06 * < LOD < LOD - < LOD < LOD 697 07 - 08 * < LOD < LOD < LOD < LOD 454 Non Hispanic blacks 03 - 04 * < LOD < LOD < LOD < LOD 569 - 05 * < LOD < LOD 06 < LOD < LOD 698 - 07 - 08 * < LOD < LOD < LOD 557 < LOD Non Hispanic whites 03 - 04 * - < LOD < LOD < LOD 916 < LOD 05 - 06 * < LOD < LOD < LOD < LOD 996 07 08 * < LOD < LOD < LOD < LOD 1045 - detection (LOD, see Data Analysis section) Limit Survey years 03 - 04, of 05 - 06, and 07 - 08 are 0.05, 0.05, and 0.05 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by i ndividual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 151

171 Urinary Sulfo meturon methyl (creatinine corrected) (2003 – 2008) - onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size < LOD - * < LOD < LOD 03 < LOD 2065 Total 04 - 06 * < LOD < LOD < LOD < LOD 2598 05 - 07 * < LOD < LOD < LOD < LOD 2456 08 Age group 11 years 03 - 04 * < LOD < LOD < LOD 6 252 - < LOD 05 06 * < LOD < LOD - < LOD < LOD 345 07 - 08 * < LOD < LOD < LOD < LOD 352 12 - 03 - 04 * < LOD < LOD < LOD < LOD 586 19 years 05 - * < LOD < LOD < LOD < LOD 710 06 - < LOD * < LOD < LOD 07 < LOD 371 08 04 * < LOD < LOD - < LOD < LOD 1227 20 years and older 03 05 - 06 * < LOD < LOD < LOD < LOD 1543 - 08 * < LOD < LOD < LOD < LOD 1733 07 Gender 03 - 04 * < LOD < LOD < LOD Males 1006 < LOD - 06 * < LOD 05 < LOD < LOD 1233 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 1225 Females - 04 * < LOD < LOD < LOD < LOD 1059 03 05 - * < LOD < LOD < LOD < LOD 1365 06 1231 - * 07 < LOD < LOD < LOD < LOD 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD 440 Mexican Americans 05 06 * < LOD < LOD < LOD < LOD 697 - 07 * < LOD < LOD 08 < LOD < LOD 453 - - Hispanic blacks 03 - 04 * < LOD Non < LOD < LOD < LOD 569 - 06 * < LOD 05 < LOD < LOD 698 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 556 Non - 03 - 04 * < LOD < LOD < LOD < LOD 915 Hispanic whites 05 06 * < LOD < LOD < LOD < LOD 996 - < LOD 08 * < LOD - < LOD < LOD 1045 07 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 152

172 Urinary Sulfosulfuron (2003 – 2008) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD Total < LOD 2391 03 - * < LOD < LOD 06 < LOD 2593 05 < LOD - 08 * < LOD < LOD < LOD 2530 07 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 294 - 6 - 06 * < LOD < LOD < LOD 344 05 < LOD 07 08 * < LOD < LOD - < LOD < LOD 377 - 19 years 03 - 04 * < LOD < LOD < LOD < LOD 681 12 - 06 * < LOD < LOD < LOD < LOD 708 05 07 - * < LOD < LOD < LOD < LOD 385 08 03 04 * < LOD < LOD < LOD < LOD 1416 20 years and older - - * < LOD < LOD 06 < LOD < LOD 1541 05 07 - 08 * < LOD < LOD < LOD < LOD 1768 Gender 04 * < LOD < LOD - < LOD < LOD 1170 Males 03 05 - 06 * < LOD < LOD < LOD < LOD 1230 07 08 * < LOD < LOD < LOD < LOD 1261 - < LOD Females - 04 * < LOD 03 < LOD < LOD 1221 05 - 06 * < LOD < LOD < LOD < LOD 1363 07 08 * < LOD < LOD < LOD < LOD 1269 - Race/ethnicity 03 04 * < LOD < LOD < LOD < LOD 594 Mexican Americans - - * < LOD < LOD 06 < LOD < LOD 673 05 07 - 08 * < LOD < LOD < LOD < LOD 485 - 03 - 04 Non * < LOD < LOD < LOD < LOD 617 Hispanic blacks 05 * < LOD < LOD 06 < LOD < LOD 719 - 07 - 08 * < LOD < LOD < LOD 565 < LOD Non Hispanic whites 03 - 04 * - < LOD < LOD < LOD 1026 < LOD 05 - 06 * < LOD < LOD < LOD < LOD 997 07 08 * < LOD < LOD < LOD < LOD 1068 - detection (LOD, see Data Analysis section) Limit Survey years 03 - 04, of 05 - 06, and 07 - 08 are 0.1, 0.1, and 0.1 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by indi vidual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 153

173 Urinary Sulfosulfur on (creatinine corrected) (2003 2008) – onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size < LOD - * < LOD < LOD 03 < LOD 2389 Total 04 - 06 * < LOD < LOD < LOD < LOD 2593 05 - 07 * < LOD < LOD < LOD < LOD 2528 08 Age group 11 years 03 - 04 * < LOD < LOD < LOD 6 294 - < LOD 05 06 * < LOD < LOD - < LOD < LOD 344 07 - 08 * < LOD < LOD < LOD < LOD 377 12 - 03 - 04 * < LOD < LOD < LOD < LOD 680 19 years 05 - * < LOD < LOD < LOD < LOD 708 06 - < LOD * < LOD < LOD 07 < LOD 383 08 04 * < LOD < LOD - < LOD < LOD 1415 20 years and older 03 05 - 06 * < LOD < LOD < LOD < LOD 1541 - 08 * < LOD < LOD < LOD < LOD 1768 07 Gender 03 - 04 * < LOD < LOD < LOD Males 1169 < LOD - 06 * < LOD 05 < LOD < LOD 1230 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 1260 Females - 04 * < LOD < LOD < LOD < LOD 1220 03 05 - * < LOD < LOD < LOD < LOD 1363 06 1268 - * 07 < LOD < LOD < LOD < LOD 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD 593 Mexican Americans 05 06 * < LOD < LOD < LOD < LOD 673 - 07 * < LOD < LOD 08 < LOD < LOD 484 - - Hispanic blacks 03 - 04 * < LOD Non < LOD < LOD < LOD 617 - 06 * < LOD 05 < LOD < LOD 719 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 564 Non - 03 - 04 * < LOD < LOD < LOD < LOD 1025 Hispanic whites 05 06 * < LOD < LOD < LOD < LOD 997 - < LOD 08 * < LOD - < LOD < LOD 1068 07 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 154

174 Urinary Thifensulfuron - – 2008) methyl (2003 d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD Total < LOD 2355 03 - * < LOD < LOD 06 < LOD 2634 05 < LOD - 08 * < LOD < LOD < LOD 2495 07 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 291 - 6 - 06 * < LOD < LOD < LOD 350 05 < LOD 07 08 * < LOD < LOD - < LOD < LOD 370 - 19 years 03 - 04 * 12 < LOD < LOD < LOD 677 < LOD - 06 * < LOD < LOD < LOD < LOD 718 05 07 - * < LOD < LOD < LOD < LOD 375 08 03 04 * < LOD < LOD < LOD < LOD 1387 20 years and older - - * < LOD < LOD 06 < LOD < LOD 1566 05 07 - 08 * < LOD < LOD < LOD < LOD 1750 Gender 04 * < LOD < LOD - < LOD < LOD 1145 Males 03 05 - 06 * < LOD < LOD < LOD 1247 < LOD - 08 * < LOD 07 < LOD < LOD 1252 < LOD Females 03 - 04 * < LOD < LOD < LOD < LOD 1210 05 06 * < LOD < LOD < LOD < LOD 1387 - 07 - * < LOD < LOD < LOD < LOD 1243 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD Mexican Americans 566 05 06 * < LOD < LOD - < LOD < LOD 697 07 - 08 * < LOD < LOD < LOD < LOD 479 Non Hispanic blacks 03 - 04 * < LOD < LOD < LOD < LOD 616 - 05 * < LOD < LOD 06 < LOD < LOD 720 - 07 - 08 * < LOD < LOD < LOD 542 < LOD Non Hispanic whites 03 - 04 * - < LOD < LOD < LOD 1022 < LOD 05 - 06 * < LOD < LOD < LOD < LOD 1007 07 08 * < LOD < LOD < LOD < LOD 1056 - detection (LOD, see Data Analysis section) Limit Survey years 03 - 04, of 05 - 06, and 07 - 08 are 0.08, 0.08, and 0.08 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by i ndividual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 155

175 Urinary Thi fensulfuron methyl (creatinine corrected) (2003 – 2008) - onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size < LOD - * < LOD < LOD 03 < LOD 2353 Total 04 - 06 * < LOD < LOD < LOD < LOD 2634 05 - 07 * < LOD < LOD < LOD < LOD 2493 08 Age group 11 years 03 - 04 * < LOD < LOD < LOD 6 291 - < LOD 05 06 * < LOD < LOD - < LOD < LOD 350 07 - 08 * < LOD < LOD < LOD < LOD 370 12 - 03 - 04 * < LOD < LOD < LOD < LOD 676 19 years 05 - * < LOD < LOD < LOD < LOD 718 06 - < LOD * < LOD < LOD 07 < LOD 373 08 04 * < LOD < LOD - < LOD < LOD 1386 20 years and older 03 05 - 06 * < LOD < LOD < LOD < LOD 1566 - 08 * < LOD < LOD < LOD < LOD 1750 07 Gender 03 - 04 * < LOD < LOD < LOD Males 1144 < LOD - 06 * < LOD 05 < LOD < LOD 1247 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 1251 Females - 04 * < LOD < LOD < LOD < LOD 1209 03 05 - * < LOD < LOD < LOD < LOD 1387 06 1242 - * 07 < LOD < LOD < LOD < LOD 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD 565 Mexican Americans 05 06 * < LOD < LOD < LOD < LOD 697 - 07 * < LOD < LOD 08 < LOD < LOD 478 - - Hispanic blacks 03 - 04 * < LOD Non < LOD < LOD < LOD 616 - 06 * < LOD 05 < LOD < LOD 720 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 541 Non - 03 - 04 * < LOD < LOD < LOD < LOD 1021 Hispanic whites 05 06 * < LOD < LOD < LOD < LOD 1007 - < LOD 08 * < LOD - < LOD < LOD 1056 07 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 156

176 Urinary Triasulfuron (2003 – 2008) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD Total < LOD 2250 03 - * < LOD < LOD 06 < LOD 2557 05 < LOD - 08 * < LOD < LOD < LOD 2530 07 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 278 - 6 - 06 * < LOD < LOD < LOD 341 05 < LOD 07 08 * < LOD < LOD - < LOD < LOD 378 - 19 years 03 - 04 * < LOD < LOD < LOD < LOD 643 12 - 06 * < LOD < LOD < LOD < LOD 695 05 07 - * < LOD < LOD < LOD < LOD 385 08 03 04 * < LOD < LOD < LOD < LOD 1329 20 years and older - - * < LOD < LOD 06 < LOD < LOD 1521 05 07 - 08 * < LOD < LOD < LOD < LOD 1767 Gender 04 * < LOD < LOD - < LOD < LOD 1101 Males 03 05 - 06 * < LOD < LOD < LOD < LOD 1210 07 08 * < LOD < LOD < LOD < LOD 1265 - < LOD Females - 04 * < LOD 03 < LOD < LOD 1149 05 - 06 * < LOD < LOD < LOD < LOD 1347 07 08 * < LOD < LOD < LOD < LOD 1265 - Race/ethnicity 03 04 * < LOD < LOD < LOD < LOD 549 Mexican Americans - - * < LOD < LOD 06 < LOD < LOD 677 05 07 - 08 * < LOD < LOD < LOD < LOD 488 - 03 - 04 Non * < LOD < LOD < LOD < LOD 580 Hispanic blacks 05 * < LOD < LOD 06 < LOD < LOD 713 - 07 - 08 * < LOD < LOD < LOD 547 < LOD Non Hispanic whites 03 - 04 * - < LOD < LOD < LOD 973 < LOD 05 - 06 * < LOD < LOD < LOD < LOD 968 07 08 * < LOD < LOD < LOD < LOD 1073 - detection (LOD, see Data Analysis section) Limit Survey years 03 - 04, of 05 - 06, and 07 - 08 are 0.07, 0.07, and 0.07 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by i ndividual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 157

177 Urinary Triasulfuron – 2008) (creatinine corrected) (2003 onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size < LOD - * < LOD < LOD 03 < LOD 2248 Total 04 - 06 * < LOD < LOD < LOD < LOD 2557 05 - 07 * < LOD < LOD < LOD < LOD 2528 08 Age group 11 years 03 - 04 * < LOD < LOD < LOD 6 278 - < LOD 05 06 * < LOD < LOD - < LOD < LOD 341 07 - 08 * < LOD < LOD < LOD < LOD 378 12 - 03 - 04 * < LOD < LOD < LOD < LOD 642 19 years 05 - * < LOD < LOD < LOD < LOD 695 06 - < LOD * < LOD < LOD 07 < LOD 383 08 04 * < LOD < LOD - < LOD < LOD 1328 20 years and older 03 05 - 06 * < LOD < LOD < LOD < LOD 1521 - 08 * < LOD < LOD < LOD < LOD 1767 07 Gender 03 - 04 * < LOD < LOD < LOD Males 1100 < LOD - 06 * < LOD 05 < LOD < LOD 1210 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 1264 Females - 04 * < LOD < LOD < LOD < LOD 1148 03 05 - * < LOD < LOD < LOD < LOD 1347 06 1264 - * 07 < LOD < LOD < LOD < LOD 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD 548 Mexican Americans 05 06 * < LOD < LOD < LOD < LOD 677 - 07 * < LOD < LOD 08 < LOD < LOD 487 - - Hispanic blacks 03 - 04 * < LOD Non < LOD < LOD < LOD 580 - 06 * < LOD 05 < LOD < LOD 713 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 546 Non - 03 - 04 * < LOD < LOD < LOD < LOD 972 Hispanic whites 05 06 * < LOD < LOD < LOD < LOD 968 - < LOD 08 * < LOD - < LOD < LOD 1073 07 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 158

178 Urinary Triflusulfuron - – 2008) methyl (2003 d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD Total < LOD 2427 03 - * < LOD < LOD 06 < LOD 2562 05 < LOD - 08 * < LOD < LOD < LOD 2494 07 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 302 - 6 - 06 * < LOD < LOD < LOD 340 05 < LOD 07 08 * < LOD < LOD - < LOD < LOD 374 - 19 years 03 - 04 * 12 < LOD < LOD < LOD 694 < LOD - 06 * < LOD < LOD < LOD < LOD 702 05 07 - * < LOD < LOD < LOD < LOD 381 08 03 04 * < LOD < LOD < LOD < LOD 1431 20 years and older - - * < LOD < LOD 06 < LOD < LOD 1520 05 07 - 08 * < LOD < LOD < LOD < LOD 1739 Gender 04 * < LOD < LOD - < LOD < LOD 1189 Males 03 05 - 06 * < LOD < LOD < LOD 1216 < LOD - 08 * < LOD 07 < LOD < LOD 1240 < LOD Females 03 - 04 * < LOD < LOD < LOD < LOD 1238 05 06 * < LOD < LOD < LOD < LOD 1346 - 07 - * < LOD < LOD < LOD < LOD 1254 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD Mexican Americans 596 05 06 * < LOD < LOD - < LOD < LOD 693 07 - 08 * < LOD < LOD < LOD < LOD 477 Non Hispanic blacks 03 - 04 * < LOD < LOD < LOD < LOD 634 - 05 * < LOD < LOD 06 < LOD < LOD 699 - 07 - 08 * < LOD < LOD < LOD 558 < LOD Non Hispanic whites 03 - 04 * - < LOD < LOD < LOD 1039 < LOD 05 - 06 * < LOD < LOD < LOD < LOD 972 07 08 * < LOD < LOD < LOD < LOD 1053 - detection (LOD, see Data Analysis section) Limit Survey years 03 - 04, of 05 - 06, and 07 - 08 are 0.05, 0.05, and 0.05 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by i ndividual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 159

179 Urinary Tri flusulfuron methyl (creatinine corrected) (2003 – 2008) - onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size < LOD - * < LOD < LOD 03 < LOD 2425 Total 04 - 06 * < LOD < LOD < LOD < LOD 2562 05 - 07 * < LOD < LOD < LOD < LOD 2492 08 Age group 11 years 03 - 04 * < LOD < LOD < LOD 6 302 - < LOD 05 06 * < LOD < LOD - < LOD < LOD 340 07 - 08 * < LOD < LOD < LOD < LOD 374 12 - 03 - 04 * < LOD < LOD < LOD < LOD 693 19 years 05 - * < LOD < LOD < LOD < LOD 702 06 - < LOD * < LOD < LOD 07 < LOD 379 08 04 * < LOD < LOD - < LOD < LOD 1430 20 years and older 03 05 - 06 * < LOD < LOD < LOD < LOD 1520 - 08 * < LOD < LOD < LOD < LOD 1739 07 Gender 03 - 04 * < LOD < LOD < LOD Males 1188 < LOD - 06 * < LOD 05 < LOD < LOD 1216 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 1239 Females - 04 * < LOD < LOD < LOD < LOD 1237 03 05 - * < LOD < LOD < LOD < LOD 1346 06 1253 - * 07 < LOD < LOD < LOD < LOD 08 Race/ethnicity 03 - 04 * < LOD < LOD < LOD < LOD 595 Mexican Americans 05 06 * < LOD < LOD < LOD < LOD 693 - 07 * < LOD < LOD 08 < LOD < LOD 476 - - Hispanic blacks 03 - 04 * < LOD Non < LOD < LOD < LOD 634 - 06 * < LOD 05 < LOD < LOD 699 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 557 Non - 03 - 04 * < LOD < LOD < LOD < LOD 1038 Hispanic whites 05 06 * < LOD < LOD < LOD < LOD 972 - < LOD 08 * < LOD - < LOD < LOD 1053 07 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/SulfonylureaHerbicides_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 160

180 Urinary N,N - - meta - toluamide (DEET) (2007 – 2010) diethyl r the U.S. population from the National Health and Geometric mean and selected percentiles of urine concentrations (in μg/L) fo Nutrition Examination Survey. Survey Sample 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size < LOD - 07 * < LOD < LOD 08 < LOD 2565 Total - 10 * < LOD < LOD < LOD 2744 09 < LOD Age group 11 years 07 - 08 * < LOD < LOD < LOD - < LOD 380 6 - * < LOD < LOD 10 < LOD < LOD 386 09 - 19 years 07 - 08 * < LOD 12 < LOD < LOD < LOD 386 - 10 * < LOD < LOD < LOD < LOD 400 09 - 59 years 07 - 08 * < LOD < LOD < LOD < LOD 1169 20 - * < LOD < LOD 10 < LOD < LOD 1307 09 07 - 08 * < LOD < LOD < LOD 60 years and older < LOD 630 - 10 * < LOD < LOD < LOD < LOD 651 09 Gender < LOD - 08 Males * < LOD 07 < LOD < LOD 1286 09 - 10 * < LOD < LOD < LOD < LOD 1343 Females - 08 * < LOD < LOD < LOD < LOD 1279 07 09 - * < LOD < LOD < LOD < LOD 1401 10 Race/ethnicity 07 08 < LOD < LOD - < LOD < LOD 499 Mexican Americans * 09 - 10 * < LOD < LOD < LOD < LOD 600 Non Hispanic blacks 07 - 08 * < LOD < LOD < LOD < LOD 570 - 09 < LOD 10 * < LOD < LOD < LOD 504 - - 07 - 08 * < LOD Non < LOD < LOD < LOD 1071 Hispanic whites 09 - 10 * < LOD < LOD < LOD < LOD 1199 Limit detection (LOD, see Data Analysis section) for Survey year of 07 - 08 and 09 - 10 are 0.083 and 0.083. < LOD means less than the limit of detection, which may vary for some chemicals by year and by individual sample. was * Not calcu lated: proportion of results below limit of detection too high to provide a valid result. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 161

181 Urinary N,N - - meta - toluamide (DEET) (2011 – 2014) diethyl d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 * < LOD < LOD < LOD < LOD Total 2430 11 - * < LOD < LOD < LOD 14 (

182 Urinary N,N - - meta - toluamide (DEET) (creatinine corrected) (2007 – 2010) diethyl onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 07 - 08 * < LOD < LOD < LOD < LOD 2563 Total - 09 * < LOD < LOD < LOD < LOD 2744 10 Age group < LOD 11 years 07 - 08 - * < LOD < LOD < LOD 380 6 09 - 10 * < LOD < LOD < LOD < LOD 386 - 19 years 07 - 08 * < LOD < LOD < LOD < LOD 384 12 09 - * < LOD < LOD < LOD < LOD 400 10 < LOD 59 years 07 - 08 * < LOD - < LOD < LOD 1169 20 09 - 10 * < LOD < LOD < LOD 1307 < LOD 60 years and older 07 - 08 * < LOD < LOD < LOD < LOD 630 09 10 * < LOD < LOD < LOD < LOD - 651 Gender Males 07 - 08 * < LOD < LOD < LOD < LOD 1285 09 10 * < LOD < LOD < LOD < LOD 1343 - 07 08 * < LOD < LOD < LOD < LOD 1278 Females - - * < LOD < LOD 10 < LOD < LOD 1401 09 Race/ethnicity * - 08 Mexican Americans < LOD < LOD < LOD < LOD 498 07 09 10 * < LOD < LOD < LOD < LOD 600 - - 07 - 08 * < LOD Non < LOD < LOD < LOD 569 Hispanic blacks 09 - 10 * < LOD < LOD < LOD < LOD 504 Non 07 - 08 * < LOD < LOD < LOD < LOD 1071 Hispanic whites - - 10 * < LOD 09 < LOD < LOD 1199 < LOD < LOD means less than the limit of detection for the urine levels not corrected for creatinine. was * Not calculated: proportion of results below limit of detection too high to provide a valid result. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 163

183 Uri nary N,N diethyl - meta - toluamide (DEET) (creatinine corrected) (2011 – 2014) - Health and Geometric mean and selected percentiles of concentrations (in μg/g of creatinine) for the U.S. population from the National Nutrition Examination Survey. Survey Sample 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size < LOD - 11 * < LOD < LOD 12 < LOD 2430 Total - 14 * < LOD < LOD < LOD (

184 Urinary 3 - – 2010) (Diethylcarbamoyl) benzoic acid (DCBA) (2007 Metabolite of DEET Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 08 3.50 (2.64 - 4.64) 2.37 (1.88 Total 3.10) 9.14 (5.61 - 14.5) 33.9 (20.5 - 53.1) 79.2 (37.9 - 145) 2538 07 - - 10 4.54 (3.35 - 6.15) 3.40 (2.31 - 4.95) 13.8 (8.63 - 20.6) 51.9 (31.1 - 108) 165 (57.8 - 464) 2735 09 Age group 11 years - 07 - 08 4.44 (3.73 - 5.29) 3.44 (2.70 - 5.87) 12.7 (9.54 - 15.9) 42.0 (24.2 - 70.4) 79.7 (44.9 - 114) 378 6 - - 6.44 (3.72 - 11.1) 5.35 (2.58 - 8.86) 18.5 (8.15 10 37.9) 83.8 (28.4 - 439) 316 (41.2 - 3970) 385 09 - 19 years 07 - 08 5.26 (3.47 - 7.98) 4.37 (2.68 12 5.98) 13.1 (6.81 - 25.8) 35.4 (20.4 - 71.2) 71.2 (30.7 - 700) 380 - - 10 6.58 (4.49 - 9.66) 4.63 (2.82 - 8.64) 18.9 (10.7 - 33.6) 87.8 (32.9 - 186) 186 (31.1 - 1130) 398 09 (5.05 - 07 - 08 3.33 (2.56 - 4.35) 2.23 (1.83 - 2.90) 7.95 - 14.5) 30.8 (17.4 - 53.1) 75.6 (39.3 - 131) 1157 20 59 years 09 - 10 4.39 (3.29 - 5.86) 3.33 (2.23 - 4.95) 14.0 (8.36 - 20.9) 51.4 (32.6 - 95.8) 138 (52.9 - 280) 1300 60 years and older - 08 2.78 (1.75 - 4.42) 1.64 (.936 - 3.06) 6.15 (3.08 - 16.9) 34.7 (16.3 - 75.4) 103 (32.4 - 200) 623 07 (5.33 09 10 3.42 (2.39 - 4.91) 2.13 (1.45 - 4.00) 9.63 - - 17.1) 35.4 (19.7 - 63.8) 103 (43.2 - 346) 652 Gender Males - 08 4.15 (2.88 - 6.00) 2.90 (2.13 - 4.34) 11.3 (6.63 - 19.7) 37.7 (20.7 - 82.0) 112 (34.7 - 556) 1269 07 - 09 5.58 (3.94 - 7.90) 4.39 (2.67 - 6.24) 18.7 (10.8 10 30.6) 78.3 (37.3 - 174) 199 (96.2 - 525) 1340 - 07 - 08 2.97 (2.32 - 3.80) 2.06 (1.64 - 2.59) 6.84 (4.41 - 10.8) 30.8 (15.0 - 40.8) 52.6 (36.4 - 103) 1269 Females 09 3.73 10 (2.79 - 4.98) 2.76 (1.87 - 4.24) 9.91 (6.35 - 15.9) 36.2 (22.4 - 70.4) 94.9 (40.2 - 278) 1395 - Race/ethnicity (5.93 - 08 3.70 (2.57 - 5.33) 3.26 (1.87 Mexican Americans 5.17) 9.63 07 - 17.6) 28.0 (14.7 - 69.1) 69.1 (27.5 - 133) 490 - 09 - 10 2.63 (1.61 - 4.28) 2.03 (.932 - 4.71) 7.35 (4.22 - 14.5) 23.1 (12.5 - 48.2) 48.9 (26.0 - 94.3) 599 Non 07 - 08 4.36 (3.18 - 5.96) 3.54 (2.24 - 6.04) 10.3 (6.78 - 17.4) 31.9 (19.3 - 51.6) 62.4 (40.4 - 103) 562 Hispanic blacks - - 10 3.91 (2.85 - 5.35) 3.22 (2.24 - 4.75) 9.53 09 - 14.4) 23.4 (18.0 - 33.4) 38.4 (29.1 - 60.5) 497 (5.88 Non - Hispanic whites 07 - 08 3.47 (2.35 - 5.14) 2.22 (1.65 - 3.19) 9.12 (4.82 - 17.0) 36.5 (17.7 - 82.0) 86.9 (32.9 - 356) 1064 (10.5 10 5.48 (3.83 - 7.84) 4.31 (2.64 - 6.25) 17.7 - - 28.4) 67.9 (32.6 - 195) 200 (63.8 - 832) 1199 09 Limit of detection (LOD, see Data Analysis section) for Survey year 07 - 08 and 09 - 10 are 0.93 and 0.475. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 165

185 Urinary 3 - – 2014) (Diethylcarbamoyl) benzoic acid (DCBA) (2011 of DEET Metabolite Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 12 2.49 Total (1.88 - 3.29) 1.95 (1.45 - 2.59) 6.47 (4.52 - 8.28) 20.8 (12.6 - 42.0) 61.1 (25.2 - 181) 2426 11 - 14 2.46 (1.84 - 3.30) 1.77 (1.34 - 2.30) 6.26 (4.10 - 9.15) 25.0 (13.2 - 75.9 (31.7 - 218) 2663 13 46.1) Age group 11 years - 11 - 12 4.24 (2.76 - 6.53) 3.84 (2.32 - 6.11) 11.8 (7.06 - 17.2) 27.5 (17.7 - 84.9) 100 (24.6 - 448) 400 6 - - 4.82 (3.20 - 7.25) 3.64 (2.50 - 5.02) 11.4 (6.46 14 19.3) 41.6 (17.1 - 223) 202 (37.9 - 649) 420 13 - 19 years 11 - 12 3.91 (3.03 - 5.04) 3.46 (2.42 - 4.00) 12 9.64 (6.42 - 14.7) 25.0 (16.9 - 43.0) 60.1 (26.4 - 161) 390 - 14 4.41 (2.95 - 6.59) 3.71 (2.58 - 7.24) 12.2 (7.70 - 19.1) 37.4 (19.1 - 79.7) 96.0 (37.7 - 172) 427 13 - 12 2.19 (1.66 - 2.90) 1.63 (1.22 - 2.21) 5.43 (3.64 - 7.44) 18.8 (10.4 - 38.4) 55.4 (23.9 - 159) 1636 20 years and older 11 13 - 14 2.10 (1.55 - 2.86) 1.40 (1.10 - 1.84) 4.91 (3.21 - 7.99) 20.4 (10.7 - 40.1) 60.9 (26.0 - 221) 1816 Gender 198) - 12 2.87 (2.12 - 3.90) 2.42 (1.74 - 3.45) 7.31 (5.05 - 10.4) 25.2 (12.6 - 51.1) 57.3 (25.7 - Males 1230 11 (4.62 13 14 2.94 (2.08 - 4.17) 2.10 (1.57 - 2.72) 7.41 - - 12.3) 31.5 (15.4 - 81.2) 103 (39.9 - 325) 1343 Females 11 - 12 2.17 (1.63 - 2.90) 1.60 (1.20 - 2.12) 5.32 (3.54 - 7.44) 17.7 (9.64 - 42.7) 63.7 (17.7 - 242) 1196 13 14 2.07 (1.59 - 2.71) 1.52 (1.11 - 1.91) 5.13 (3.67 - 7.99) 18.9 (9.44 - 38.6) 43.8 (23.9 - 138) 1320 - Race/ethnicity - 11 12 2.62 (1.15 - 5.96) 2.11 (.605 - 8.37 (3.43 - 22.0) 32.9 (12.9 - 100) 75.6 (15.9 - 481) 289 Mexican Americans 7.86) 13 - 14 2.27 (1.58 - 3.26) 1.89 (1.03 - 2.91) 7.62 (3.80 - 10.3) 17.2 (11.0 - 26.0) 35.8 (18.8 - 106) 427 Non Hispanic blacks 11 - 12 3.32 (2.41 - 4.57) 2.71 (2.08 - 3.55) 8.08 (4.73 - 12.2) 22.5 (11.4 - 55.1) 53.5 (22.5 - 157) 667 - - 14 2.56 (1.94 - 3.38) 2.18 (1.69 - 2.89) 5.54 13 - 7.95) 16.0 (8.88 - 34.7) 35.7 (17.4 - 83.5) 585 (3.93 Non - Hispanic whites 11 - 12 2.36 (1.71 - 3.28) 1.83 (1.39 - 2.50) 5.80 (3.89 - 8.10) 18.0 (9.01 - 53.0) 62.3 (16.9 - 252) 783 13 14 2.62 (1.77 - 3.87) 1.72 (1.15 - 2.54) 6.96 (3.80 - 12.8) 31.5 (13.5 - 93.4) 103 (37.7 - 373) 1016 - (3.77 - 12 2.85 (1.59 - 5.12) 2.11 (.964 - 4.45) 7.94 All Hispanics - 15.9) 35.9 (14.8 - 100) 152 (24.6 - 481) 558 11 (3.51 13 14 2.12 (1.57 - 2.86) 1.73 (1.12 - 2.54) 5.68 - - 8.32) 15.7 (11.0 - 22.8) 26.6 (18.8 - 68.7) 670 Asians 11 - 12 1.40 (.933 - 2.09) .959 (.544 - 1.88) 3.27 (1.80 - 7.62) 12.7 (6.77 - 28.8) 28.8 (13.3 - 50.2) 330 (2.14 14 1.68 (1.23 - 2.31) 1.02 (.656 - 1.54) 3.94 - - 6.41) 18.7 (10.8 - 44.6) 82.7 (26.5 - 251) 290 13 Limit of detection (LOD, see Data Analysis section) for Survey year 11 - 12 and 13 - 14 are 0.475 and 0.475, respectively. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 166

186 Urinary 3 - – 2010) (Diethylcarbamoyl) benzoic acid (DCBA) (creatinine corrected) (2007 Metabolite of DEET Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati onal Health and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 08 3.60 (2.79 - 4.65) 2.79 (2.14 Total 3.55) 8.55 (5.49 - 13.2) 27.3 (17.8 - 47.9) 70.8 (34.1 - 170) 2537 07 - - 10 4.74 (3.48 - 6.46) 3.35 (2.30 - 5.26) 12.9 (8.53 - 20.6) 44.6 (28.3 - 86.3) 131 (47.0 - 405) 2735 09 Age group (10.7 11 years 07 - 08 5.64 (4.72 - 6.75) 4.84 (3.65 - 5.78) 14.2 - 19.8) 47.7 (34.2 - 55.1) 88.6 (47.9 - 182) 378 6 - 09 - 10 8.72 (5.03 - 15.1) 6.42 (4.02 - 11.6) 23.5 (13.2 - 36.7) 75.4 (28.6 - 673) 365 (46.2 - 4980) 385 12 19 years 07 - 08 4.08 (2.81 - 5.93) 2.96 (2.14 - 5.36) 11.0 (6.38 - 16.0) 24.3 (14.8 - 53.4) 53.4 (19.3 - 345) 379 - - 09 5.65 (3.76 - 8.50) 3.76 (2.56 - 6.22) 16.5 (7.29 10 31.7) 68.6 (25.3 - 182) 154 (25.3 - 1270) 398 - - 59 years 07 - 08 3.34 (2.61 - 4.27) 2.73 (1.99 - 3.46) 7.57 (4.92 - 12.1) 24.8 (14.9 - 44.7) 57.8 (30.9 - 117) 1157 20 09 10 4.41 (3.25 - 5.97) 2.98 (2.11 - 5.32) 11.7 (7.71 - 19.6) 39.1 (24.7 - 82.6) 112 (51.3 - 228) 1300 - (4.25 60 years and older - 08 3.42 (2.33 - 5.02) 2.47 (1.45 - 3.64) 7.33 07 - 16.8) 33.8 (15.9 - 86.0) 93.3 (34.2 - 244) 623 09 - 10 4.06 (2.95 - 5.59) 2.68 (2.10 - 3.96) 10.8 (6.79 - 15.9) 37.7 (22.2 - 51.1) 108 (42.7 - 393) 652 Gender 07 08 3.46 (2.46 - 4.87) 2.72 (1.76 - 3.73) 8.68 (5.34 - 14.4) 27.8 (16.9 - 69.4) 87.0 (27.8 - 403) 1269 Males - - - 4.97 (3.49 - 7.08) 3.29 (2.14 - 5.94) 14.7 (9.13 10 24.0) 60.0 (28.5 - 134) 185 (74.8 - 433) 1340 09 07 - 08 Females 3.74 (2.99 - 4.68) 2.88 (2.27 - 3.63) 8.55 (5.36 - 13.2) 27.2 (16.2 - 46.3) 54.8 (34.2 - 117) 1268 - 10 4.54 (3.40 - 6.05) 3.35 (2.39 - 4.67) 11.8 (7.55 - 18.4) 09 (24.2 - 53.4) 77.6 (36.7 - 252) 1395 35.3 Race/ethnicity Mexican Americans 07 - 08 3.79 (2.57 - 5.58) 3.60 (1.99 - 5.96) 9.91 (6.55 - 16.9) 27.8 (15.0 - 60.6) 60.6 (24.4 - 107) 490 09 10 2.74 (1.75 - 4.28) 2.03 (1.12 - 5.18) 7.57 (3.92 - 14.0) 23.3 (13.6 - 31.8) 37.4 (23.6 - 90.5) 599 - - 07 - 08 3.33 (2.46 - 4.49) 2.74 (1.91 - 3.76) 7.07 Non (4.88 - 11.9) 22.5 (12.6 - 45.1) 53.9 (28.7 - 103) 561 Hispanic blacks 09 - 10 2.98 (2.26 - 3.94) 2.41 (1.70 - 3.37) 6.73 (4.34 - 9.46) 16.5 (13.0 - 20.4) 30.6 (19.4 - 51.1) 497 Non 07 - 08 3.78 (2.69 - 5.32) 2.82 (2.05 - 4.02) 8.70 Hispanic whites (5.23 - 14.9) 30.7 (16.7 - 57.2) 76.9 (26.7 - 432) 1064 - 09 - 10 5.97 (4.13 - 8.64) 4.41 (2.61 - 7.43) 17.4 (10.7 - 26.7) 61.1 (29.0 - 189) 189 (56.4 - 849) 1199 _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 167

187 Urinary 3 - – 2014) (Diethylcarbamoyl) benzoic acid (DCBA) (creatinine corrected) (2011 Metabolite of DEET for the U.S. population from the National Health and Geometric mean and selected percentiles of concentrations (in μg/g of creatinine) Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 12 2.61 (1.96 - 3.46) 2.07 (1.59 Total 2.63) 5.40 (3.90 - 7.83) 19.0 (12.7 - 36.4) 60.1 (22.5 - 150) 2426 11 - - 14 2.63 (1.94 - 3.56) 1.85 (1.47 - 2.26) 5.24 (3.92 - 7.72) 23.8 (10.3 - 55.1) 68.9 (26.9 - 223) 2661 13 Age group 11 years - 11 - 12 5.96 (3.63 - 9.80) 5.22 (3.17 - 7.29) 15.9 (7.97 - 21.5) 43.3 (18.5 - 208) 105 (38.0 - 1120) 400 6 - - 6.21 (4.04 - 9.55) 4.14 (2.92 - 5.43) 13.5 (7.13 14 28.5) 62.2 (23.4 - 251) 251 (62.2 - 1060) 420 13 - 19 years 11 - 12 3.49 (2.71 - 4.49) 3.07 (2.40 - 3.69) 12 (5.21 - 10.5) 21.3 (13.2 - 40.3) 44.2 (17.4 - 203) 390 6.86 - 14 3.77 (2.49 - 5.72) 3.36 (2.02 - 4.98) 7.08 (5.05 - 17.1) 34.0 (12.6 - 86.6) 86.6 (31.1 - 198) 427 13 - 12 2.27 (1.72 - 3.01) 1.79 (1.34 - 2.42) 4.36 (3.29 - 6.53) 15.6 (10.5 - 28.5) 59.3 (21.1 - 112) 1636 20 years and older 11 13 - 14 2.27 (1.67 - 3.08) 1.53 (1.30 - 1.85) 4.43 (3.23 - 6.48) 18.1 (8.08 - 46.6) 53.0 (20.3 - 212) 1814 Gender 176) - 12 2.62 (1.89 - 3.63) 2.07 (1.51 - 2.80) 6.06 (3.88 - 9.34) 19.3 (13.0 - 31.0) 55.8 (19.4 - Males 1230 11 (3.85 13 14 2.69 (1.84 - 3.93) 1.87 (1.35 - 2.39) 6.08 - - 9.76) 30.8 (12.5 - 64.2) 86.6 (38.8 - 347) 1342 Females 11 - 12 2.59 (1.97 - 3.42) 2.07 (1.60 - 2.66) 5.18 (3.77 - 7.04) 17.8 (10.4 - 45.1) 61.4 (19.3 - 112) 1196 13 14 2.57 (1.98 - 3.33) 1.82 (1.53 - 2.17) 4.96 (3.92 - 6.40) 19.9 (7.90 - 45.7) 47.7 (23.2 - 205) 1319 - Race/ethnicity - 11 12 2.61 (1.12 - 6.06) 2.23 (.632 - 8.29 (3.05 - 20.9) 27.9 (8.78 - 126) 66.3 (11.2 - 360) 289 Mexican Americans 8.29) 13 - 14 2.32 (1.63 - 3.30) 2.01 (1.32 - 2.94) 5.87 (3.92 - 8.12) 16.6 (8.35 - 34.9) 38.2 (16.6 - 88.2) 425 Non Hispanic blacks 11 - 12 2.45 (1.80 - 3.33) 2.04 (1.52 - 2.56) 4.78 (3.20 - 8.50) 14.2 (8.73 - 27.3) 28.8 (14.8 - 94.6) 667 - - 14 1.97 (1.46 - 2.66) 1.50 (1.05 - 2.57) 4.61 13 - 5.75) 10.3 (6.48 - 23.4) 25.4 (10.8 - 78.8) 585 (2.97 Non - Hispanic whites 11 - 12 2.64 (1.89 - 3.67) 2.08 (1.54 - 3.01) 5.17 (3.72 - 7.29) 19.3 (11.5 - 46.0) 62.3 (17.4 - 167) 783 13 14 2.96 (1.99 - 4.41) 1.89 (1.42 - 2.58) 5.87 (3.83 - 12.2) 33.0 (12.1 - 103) 118 (36.0 - 598) 1016 - (3.71 All Hispanics - 12 2.87 (1.59 - 5.16) 2.18 (1.10 - 4.73) 8.13 11 - 14.4) 27.1 (11.2 - 104) 104 (19.0 - 830) 558 13 - 14 2.18 (1.63 - 2.92) 1.78 (1.44 - 2.32) 4.88 (3.47 - 6.48) 13.3 (7.83 - 23.4) 30.2 (16.6 - 54.6) 668 (2.25 Asians - 12 1.85 (1.26 - 2.73) 1.40 (.933 - 2.24) 3.95 11 - 8.68) 13.7 (7.88 - 33.3) 33.3 (14.8 - 55.8) 330 13 - 14 2.13 (1.52 - 2.99) 1.29 (1.02 - 1.81) 4.19 (2.75 - 7.36) 21.1 (9.36 - 46.6) 89.2 (35.3 - 426) 290 _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 168

188 Urinary N,N - - 3 - (hydroxymethyl) benzamide (DHMB) (2007 – 2010) Diethyl Metabolite of DEET Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 08 * < LOD Total < LOD .229 (

189 Urinary N,N - - 3 - (hydroxymethyl) benzamide (DHMB) (2011 – 2014) Diethyl Metabolite of DEET Geometric mean and select ed percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 12 * < LOD < LOD < LOD .536 (

190 Urinary N,N - - 3 - (hydroxymethyl) benzamide (DHMB) (creatinine corrected) (2007 – 2010) Diethyl Metabolite of DEET Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati onal Health and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 08 * < LOD Total < LOD .331 (

191 Urinary N,N - - 3 - (hydroxymethyl) benzamide (DHMB) (creatinine corrected) (2011 – 2014) Diethyl Metabolite of DEET d Geometric mean and selected percentiles of concentrations (in μg/g of creatinine) for the U.S. population from the National Health an Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size .661 - * 11 < LOD < LOD < LOD 12 (

192 Urinary Carbofuranphenol (1999 – 2004) Metabolite of Benfuracarb, Carbofuran, Carbosulfan, and Furathiocar Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 00 * < LOD < LOD < LOD .770 Total (

193 Urinary Carbofuranphenol (creatinine corrected) (1999 – 2004) Metabolite of Benfuracarb, Carbofuran, Carbosulfan, and Furathiocar Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. populatio n from the National Health and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 00 * < LOD < LOD < LOD .778 Total (

194 Urinary 2 - – 2004) Isopropoxyphenol (1999 Metabolite of Propoxur Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 00 * < LOD < LOD < LOD Total < LOD 1917 99 - * < LOD < LOD 02 < LOD 2994 01 < LOD - 04 * < LOD < LOD < LOD < LOD 2387 03 Age group 11 years - 00 * < LOD < LOD 99 < LOD < LOD 456 - 6 - 02 * < LOD < LOD < LOD 574 01 < LOD 03 04 * < LOD < LOD - < LOD < LOD 295 - 19 years 99 - 00 * < LOD < LOD < LOD < LOD 655 12 - 02 * < LOD < LOD < LOD < LOD 820 01 03 - * < LOD < LOD < LOD < LOD 686 04 59 years < LOD 99 - 00 * < LOD - < LOD < LOD 806 20 - * < LOD < LOD 02 < LOD < LOD 1109 01 03 - 04 * < LOD < LOD < LOD < LOD 900 - 02 60 years and older * < LOD < LOD < LOD < LOD 491 01 03 * < LOD < LOD 04 < LOD < LOD 506 - Gender - 00 Males * < LOD < LOD < LOD < LOD 936 99 < LOD 01 02 * < LOD - < LOD < LOD 1406 03 - 04 * < LOD < LOD < LOD < LOD 1161 Females - 00 * < LOD < LOD < LOD < LOD 981 99 01 - * < LOD < LOD < LOD < LOD 1588 02 - 1226 * < LOD < LOD < LOD < LOD 03 04 Race/ethnicity 99 00 < LOD < LOD - < LOD < LOD 664 Mexican Americans * 01 - 02 * < LOD < LOD < LOD < LOD 762 - 04 * < LOD < LOD < LOD < LOD 594 03 - 99 - 00 * < LOD < LOD < LOD < LOD 500 Non Hispanic blacks 01 02 * < LOD < LOD < LOD < LOD 770 - < LOD 04 * < LOD - < LOD < LOD 601 03 Non - Hispanic whites 99 - 00 * < LOD < LOD < LOD < LOD 585 01 02 * < LOD < LOD < LOD < LOD 1241 - 03 * < LOD < LOD 04 < LOD < LOD 1041 - of detection (LOD, see Data Analysis section) Limit Survey years 99 - 00, 01 - 02, and 03 - 04 are 1.1, 0.4, and 0.4 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by indi vidual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Propoxur_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 175

195 Urinary 2 - – 2004) Isopropoxyphenol (creatinine corrected) (1999 Metabolite of Propoxur Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati onal Health and Nutrition Examin ation Survey. Survey Sample 75th Percentile 90th Percentile 50th Percentile 95th Percentile Geometric mean Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 00 Total * < LOD < LOD < LOD < LOD 1917 99 - * < LOD < LOD 02 < LOD 2993 01 < LOD - 04 * < LOD < LOD < LOD < LOD 2385 03 Age group 11 years - 00 * < LOD < LOD 99 < LOD < LOD 456 - 6 - 02 * < LOD < LOD < LOD 574 01 < LOD 03 04 * < LOD < LOD - < LOD < LOD 295 - 19 years 99 - 00 * 12 < LOD < LOD < LOD 655 < LOD - 02 * < LOD < LOD < LOD < LOD 819 01 03 - * < LOD < LOD < LOD < LOD 685 04 59 years < LOD 99 - 00 * < LOD - < LOD < LOD 806 20 - * < LOD < LOD 02 < LOD < LOD 1109 01 03 - 04 * < LOD < LOD < LOD 899 < LOD 60 years and older 01 - 02 * < LOD < LOD < LOD < LOD 491 03 < LOD 04 * < LOD < LOD < LOD 506 - Gender < LOD - 00 Males * < LOD 99 < LOD < LOD 936 01 - 02 * < LOD < LOD < LOD < LOD 1406 03 04 * < LOD < LOD < LOD < LOD 1160 - 99 00 * < LOD < LOD < LOD < LOD 981 Females - - * < LOD < LOD 01 < LOD < LOD 1587 02 03 * < LOD < LOD 04 < LOD < LOD 1225 - Race/ethnicity * - 00 Mexican Americans < LOD < LOD < LOD < LOD 664 99 01 * < LOD < LOD 02 < LOD < LOD 762 - 03 - 04 * < LOD < LOD < LOD 593 < LOD Non Hispanic blacks 99 - 00 * - < LOD < LOD < LOD 500 < LOD 01 - 02 * < LOD < LOD < LOD < LOD 769 03 04 * < LOD < LOD < LOD < LOD 601 - - 99 - 00 * < LOD < LOD < LOD < LOD 585 Non Hispanic whites 01 02 * < LOD < LOD < LOD < LOD 1241 - < LOD 04 * < LOD - < LOD < LOD 1040 03 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Propoxur_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 176

196 Urinary 2,4,5 - – 2010)‡ Trichlorophenol (2003 Metabolite of Several Organochlorine Insecticides Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD .100 - - .100) .200 (.200 .300) .400 (.300 - .400) 2525 03 Total (.100 06 * < LOD .100 (.100 - .200) .300 (.200 - .300) .400 (.300 - .500) 2548 05 - - * < LOD .100 (

197 Urinary 2,4,5 - – 2010)‡ Trichlorophenol (creatinine corrected) (2003 Metabolite of Several Organochlorine Insecticides Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati onal Health and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD .170 - - .180) .280 (.260 .310) .370 (.330 - .420) 2522 03 Total (.160 06 * < LOD .160 (.150 - .180) .290 (.260 - .320) .410 (.360 - .450) 2548 05 - - * < LOD .150 (

198 Urinary 2,4,6 - – 2010)‡ Trichlorophenol (2003 Metabolite of Several Organochlorine Insecticides Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 04 * < LOD .500 (

199 Urinary 2,4,6 - – 2010)‡ Trichlorophenol (creatinine corrected) (2003 Metabolite of Several Organochlorine Insecticides Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati onal Health and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD .710 - - .780) 1.25 (1.17 1.35) 1.75 (1.59 - 2.06) 2522 03 Total (

200 Urinary Acephate (2003 – 2008) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD < LOD 2491 Total 03 06 * < LOD < LOD < LOD < LOD 2546 05 - < LOD - * < LOD < LOD < LOD 2505 07 08 Age group - 03 - 04 * < LOD < LOD < LOD < LOD 309 6 11 years < LOD - * < LOD < LOD < LOD 343 05 06 - 08 * < LOD < LOD < LOD < LOD 374 07 - 03 - 04 * < LOD 19 years < LOD < LOD < LOD 715 12 05 - 06 * < LOD < LOD < LOD < LOD 696 - 08 * < LOD < LOD < LOD < LOD 375 07 - 59 years 03 - 04 * < LOD < LOD < LOD < LOD 939 20 - < LOD * < LOD 05 < LOD < LOD 1050 06 07 * < LOD < LOD 08 < LOD < LOD 1134 - 03 - 04 * < LOD < LOD < LOD < LOD 528 60 years and older 05 06 * < LOD < LOD < LOD < LOD 457 - 07 * < LOD < LOD 08 < LOD < LOD 622 - Gender - 04 Males * < LOD < LOD < LOD < LOD 1221 03 < LOD 05 06 * < LOD - < LOD < LOD 1205 07 - 08 * < LOD < LOD < LOD < LOD 1250 Females - 04 * < LOD < LOD < LOD < LOD 1270 03 05 - * < LOD < LOD < LOD < LOD 1341 06 - 1255 * < LOD < LOD < LOD < LOD 07 08 Race/ethnicity 03 04 < LOD < LOD - < LOD < LOD 608 Mexican Americans * 05 - 06 * < LOD < LOD < LOD < LOD 666 - 08 * < LOD < LOD < LOD < LOD 476 07 - 03 - 04 * < LOD < LOD < LOD < LOD 647 Non Hispanic blacks 05 06 * < LOD < LOD < LOD < LOD 698 - < LOD 08 * < LOD - < LOD < LOD 551 07 Non - Hispanic whites 03 - 04 * < LOD < LOD < LOD < LOD 1077 05 06 * < LOD < LOD < LOD < LOD 979 - 07 * < LOD < LOD 08 < LOD < LOD 1062 - of detection (LOD, see Data Analysis section) Limit Survey years 03 - 04, 05 - 06, and 07 - 08 are 0.1, 0.25, and 0.27 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by individual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Acephate_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 181

201 Urinary Acephate (cre atinine corrected) (2003 2008) – onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD Total < LOD 2489 03 - * < LOD < LOD 06 < LOD 2546 05 < LOD - 08 * < LOD < LOD < LOD 2503 07 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 309 - 6 - 06 * < LOD < LOD < LOD 343 05 < LOD 07 08 * < LOD < LOD - < LOD < LOD 374 - 19 years 03 - 04 * < LOD 12 < LOD < LOD < LOD 714 - 06 * < LOD < LOD < LOD < LOD 696 05 07 - * < LOD < LOD < LOD < LOD 373 08 59 years < LOD 03 - 04 * < LOD - < LOD < LOD 938 20 - * < LOD < LOD 06 < LOD < LOD 1050 05 07 - 08 * < LOD < LOD < LOD 1134 < LOD 60 years and older 03 - 04 * < LOD < LOD < LOD < LOD 528 05 < LOD 06 * < LOD < LOD < LOD 457 - 07 08 < LOD < LOD < LOD < LOD - 622 * Gender Males 03 - 04 * < LOD < LOD < LOD < LOD 1220 05 06 * < LOD < LOD < LOD < LOD 1205 - 07 - * < LOD < LOD < LOD < LOD 1249 08 03 04 * < LOD < LOD < LOD < LOD 1269 Females - - * < LOD < LOD 06 < LOD < LOD 1341 05 07 - 08 * < LOD < LOD < LOD < LOD 1254 Race/ethnicity 04 * < LOD < LOD - < LOD < LOD 607 Mexican Americans 03 05 - 06 * < LOD < LOD < LOD < LOD 666 07 - 08 * < LOD < LOD < LOD < LOD 475 - 03 - 04 * < LOD Non < LOD < LOD < LOD 647 Hispanic blacks 05 - 06 * < LOD < LOD < LOD < LOD 698 07 08 * < LOD < LOD < LOD < LOD 550 - - 03 - 04 * < LOD < LOD < LOD < LOD 1076 Non Hispanic whites 05 06 * < LOD < LOD < LOD < LOD 979 - < LOD 08 * < LOD - < LOD < LOD 1062 07 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Acephate_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 182

202 Urinary Dimethoate (2003 – 2008) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD < LOD 2455 Total 03 06 * < LOD < LOD < LOD < LOD 2628 05 - < LOD - * < LOD < LOD < LOD 2573 07 08 Age group - 03 - 04 * < LOD < LOD < LOD < LOD 306 6 11 years < LOD - * < LOD < LOD < LOD 349 05 06 - 08 * < LOD < LOD < LOD < LOD 382 07 - 03 - 04 * < LOD 19 years < LOD < LOD < LOD 708 12 05 - 06 * < LOD < LOD < LOD < LOD 718 - 08 * < LOD < LOD < LOD < LOD 388 07 - 59 years 03 - 04 * < LOD < LOD < LOD < LOD 922 20 - < LOD * < LOD 05 < LOD < LOD 1087 06 07 * < LOD < LOD 08 < LOD < LOD 1170 - 03 - 04 * < LOD < LOD < LOD < LOD 519 60 years and older 05 06 * < LOD < LOD < LOD < LOD 474 - 07 * < LOD < LOD 08 < LOD < LOD 633 - Gender - 04 Males * < LOD < LOD < LOD < LOD 1197 03 < LOD 05 06 * < LOD - < LOD < LOD 1245 07 - 08 * < LOD < LOD < LOD < LOD 1290 Females - 04 * < LOD < LOD < LOD < LOD 1258 03 05 - * < LOD < LOD < LOD < LOD 1383 06 - 1283 * < LOD < LOD < LOD < LOD 07 08 Race/ethnicity 03 04 < LOD < LOD - < LOD < LOD 605 Mexican Americans * 05 - 06 * < LOD < LOD < LOD < LOD 693 - 08 * < LOD < LOD < LOD < LOD 493 07 - 03 - 04 * < LOD < LOD < LOD < LOD 629 Non Hispanic blacks 05 06 * < LOD < LOD < LOD < LOD 719 - < LOD 08 * < LOD - < LOD < LOD 570 07 Non - Hispanic whites 03 - 04 * < LOD < LOD < LOD < LOD 1068 05 06 * < LOD < LOD < LOD < LOD 1007 - 07 * < LOD < LOD 08 < LOD < LOD 1084 - of detection (LOD, see Data Analysis section) Limit Survey years 03 - 04, 05 - 06, and 07 - 08 are 0.1, 0.25, and 0.1 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by individual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/DimethoateOmethoate_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 183

203 Urinary Dimethoate (creatinine corrected) (2003 2008) – onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD Total < LOD 2453 03 - * < LOD < LOD 06 < LOD 2628 05 < LOD - 08 * < LOD < LOD < LOD 2571 07 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 306 - 6 - 06 * < LOD < LOD < LOD 349 05 < LOD 07 08 * < LOD < LOD - < LOD < LOD 382 - 19 years 03 - 04 * < LOD 12 < LOD < LOD < LOD 707 - 06 * < LOD < LOD < LOD < LOD 718 05 07 - * < LOD < LOD < LOD < LOD 386 08 59 years < LOD 03 - 04 * < LOD - < LOD < LOD 921 20 - * < LOD < LOD 06 < LOD < LOD 1087 05 07 - 08 * < LOD < LOD < LOD 1170 < LOD 60 years and older 03 - 04 * < LOD < LOD < LOD < LOD 519 05 < LOD 06 * < LOD < LOD < LOD 474 - 07 08 < LOD < LOD < LOD < LOD - 633 * Gender Males 03 - 04 * < LOD < LOD < LOD < LOD 1196 05 06 * < LOD < LOD < LOD < LOD 1245 - 07 - * < LOD < LOD < LOD < LOD 1289 08 03 04 * < LOD < LOD < LOD < LOD 1257 Females - - * < LOD < LOD 06 < LOD < LOD 1383 05 07 - 08 * < LOD < LOD < LOD < LOD 1282 Race/ethnicity 04 * < LOD < LOD - < LOD < LOD 604 Mexican Americans 03 05 - 06 * < LOD < LOD < LOD < LOD 693 07 - 08 * < LOD < LOD < LOD < LOD 492 - 03 - 04 * < LOD Non < LOD < LOD < LOD 629 Hispanic blacks 05 - 06 * < LOD < LOD < LOD < LOD 719 07 08 * < LOD < LOD < LOD < LOD 569 - - 03 - 04 * < LOD < LOD < LOD < LOD 1067 Non Hispanic whites 05 06 * < LOD < LOD < LOD < LOD 1007 - < LOD 08 * < LOD - < LOD < LOD 1084 07 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/DimethoateOmethoate_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 184

204 Urinary Methamidophos (2003 – 200 8) Also a metabolite of Acephate d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD < LOD 2379 Total 03 06 * < LOD < LOD < LOD < LOD 2591 05 - < LOD - * < LOD < LOD < LOD 2573 07 08 Age group - 03 - 04 * < LOD < LOD < LOD < LOD 295 6 11 years < LOD - * < LOD < LOD < LOD 346 05 06 - 08 * < LOD < LOD < LOD < LOD 382 07 - 03 - 04 * < LOD 19 years < LOD < LOD < LOD 683 12 05 - 06 * < LOD < LOD < LOD < LOD 710 - 08 * < LOD < LOD < LOD < LOD 388 07 - 59 years 03 - 04 * < LOD < LOD < LOD < LOD 893 20 - < LOD * < LOD 05 < LOD < LOD 1070 06 07 * < LOD < LOD 08 < LOD < LOD 1169 - 03 - 04 * < LOD < LOD < LOD < LOD 508 60 years and older 05 06 * < LOD < LOD < LOD < LOD 465 - 07 * < LOD < LOD 08 < LOD < LOD 634 - Gender - 04 Males * < LOD < LOD < LOD < LOD 1171 03 < LOD 05 06 * < LOD - < LOD < LOD 1232 07 - 08 * < LOD < LOD < LOD < LOD 1290 Females - 04 * < LOD < LOD < LOD < LOD 1208 03 05 - * < LOD < LOD < LOD < LOD 1359 06 - 1283 * < LOD < LOD < LOD < LOD 07 08 Race/ethnicity 03 04 < LOD < LOD - < LOD < LOD 564 Mexican Americans * 05 - 06 * < LOD < LOD < LOD < LOD 688 - 08 * < LOD < LOD < LOD < LOD 492 07 - 03 - 04 * < LOD < LOD < LOD < LOD 631 Non Hispanic blacks 05 06 * < LOD < LOD < LOD < LOD 717 - < LOD 08 * < LOD - < LOD < LOD 571 07 Non - Hispanic whites 03 - 04 * < LOD < LOD < LOD < LOD 1034 05 06 * < LOD < LOD < LOD < LOD 979 - 07 * < LOD < LOD 08 < LOD < LOD 1084 - of detection (LOD, see Data Analysis section) Limit Survey years 03 - 04, 05 - 06, and 07 - 08 are 0.1, 0.37, and 0.41 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by individual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Methamidophos_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 185

205 Urinary Methamidophos (creatinine corrected) (2003 – 2008) Also a metabolite of Acephate onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Ex amination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD Total < LOD 2377 03 - * < LOD < LOD 06 < LOD 2591 05 < LOD - 08 * < LOD < LOD < LOD 2571 07 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 295 - 6 - 06 * < LOD < LOD < LOD 346 05 < LOD 07 08 * < LOD < LOD - < LOD < LOD 382 - 19 years 03 - 04 * 12 < LOD < LOD < LOD 682 < LOD - 06 * < LOD < LOD < LOD < LOD 710 05 07 - * < LOD < LOD < LOD < LOD 386 08 59 years < LOD 03 - 04 * < LOD - < LOD < LOD 892 20 - * < LOD < LOD 06 < LOD < LOD 1070 05 07 - 08 * < LOD < LOD < LOD 1169 < LOD 60 years and older 03 - 04 * < LOD < LOD < LOD < LOD 508 05 < LOD 06 * < LOD < LOD < LOD 465 - 07 08 < LOD < LOD < LOD < LOD - 634 * Gender Males 03 - 04 * < LOD < LOD < LOD < LOD 1170 05 06 * < LOD < LOD < LOD < LOD 1232 - 07 - * < LOD < LOD < LOD < LOD 1289 08 03 04 * < LOD < LOD < LOD < LOD 1207 Females - - * < LOD < LOD 06 < LOD < LOD 1359 05 07 - 08 * < LOD < LOD < LOD < LOD 1282 Race/ethnicity 04 * < LOD < LOD - < LOD < LOD 563 Mexican Americans 03 05 - 06 * < LOD < LOD < LOD < LOD 688 07 - 08 * < LOD < LOD < LOD < LOD 491 - 03 - 04 * < LOD Non < LOD < LOD < LOD 631 Hispanic blacks 05 - 06 * < LOD < LOD < LOD < LOD 717 07 08 * < LOD < LOD < LOD < LOD 570 - - 03 - 04 * < LOD < LOD < LOD < LOD 1033 Non Hispanic whites 05 06 * < LOD < LOD < LOD < LOD 979 - < LOD 08 * < LOD - < LOD < LOD 1084 07 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Methamidophos_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 186

206 Urinary Omethoate (2003 – 2008) Metabolite of Dimethoate Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample 50th Percentile Geometric mean 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 04 * < LOD < LOD < LOD Total < LOD 2455 03 - * < LOD < LOD 06 < LOD 2628 05 < LOD - 08 * < LOD < LOD < LOD < LOD 2574 07 Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 303 - 6 - 06 * < LOD < LOD < LOD < LOD 349 05 07 - * < LOD < LOD < LOD < LOD 382 08 < LOD 19 years 03 - 04 * < LOD - < LOD < LOD 707 12 05 - 06 * < LOD < LOD < LOD 718 < LOD - 08 * < LOD < LOD < LOD < LOD 388 07 - 59 years 03 - 04 * < LOD < LOD < LOD < LOD 923 20 - < LOD * < LOD 05 < LOD < LOD 1086 06 07 * < LOD < LOD 08 < LOD < LOD 1170 - 03 - 04 * < LOD < LOD < LOD < LOD 522 60 years and older 05 06 * < LOD < LOD < LOD < LOD 475 - 07 * < LOD < LOD 08 < LOD < LOD 634 - Gender - 04 Males * < LOD < LOD < LOD < LOD 1207 03 < LOD 05 06 * < LOD - < LOD < LOD 1245 07 - 08 * < LOD < LOD < LOD < LOD 1290 Females - 04 * < LOD < LOD < LOD < LOD 1248 03 05 - * < LOD < LOD < LOD < LOD 1383 06 - 1284 * < LOD < LOD < LOD < LOD 07 08 Race/ethnicity 03 04 < LOD < LOD - < LOD < LOD 606 Mexican Americans * 05 - 06 * < LOD < LOD < LOD < LOD 693 - 08 * < LOD < LOD < LOD < LOD 493 07 - 03 - 04 * < LOD < LOD < LOD < LOD 637 Non Hispanic blacks 05 06 * < LOD < LOD < LOD < LOD 719 - < LOD 08 * < LOD - < LOD < LOD 571 07 Non - Hispanic whites 03 - 04 * < LOD < LOD < LOD < LOD 1055 05 06 * < LOD < LOD < LOD < LOD 1007 - 07 * < LOD < LOD 08 < LOD < LOD 1084 - of detection (LOD, see Data Analysis section) Limit Survey years 03 - 04, 05 - 06, and 07 - 08 are 0.1, 0.14, and 0.1 respectively. for < LOD means less than the limit of detection, which may vary for some chemicals by year and by individual sample. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/DimethoateOmethoate_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 187

207 Urinary Omethoate (creatinine corrected) (2003 – 2008) Metabolite of Dimethoate Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati onal Health and Nutrition Examination S urvey. Survey Sample 75th Percentile 90th Percentile 50th Percentile 95th Percentile Geometric mean Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 04 Total * < LOD < LOD < LOD < LOD 2453 03 - * < LOD < LOD 06 < LOD 2628 05 < LOD - 08 * < LOD < LOD < LOD < LOD 2572 07 Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 303 - 6 - 06 * < LOD < LOD < LOD 349 05 < LOD 07 08 * < LOD < LOD - < LOD < LOD 382 - 19 years 03 - 04 * 12 < LOD < LOD < LOD < LOD 706 - 06 * < LOD < LOD < LOD < LOD 718 05 07 - * < LOD < LOD < LOD < LOD 386 08 59 years < LOD 03 - 04 * < LOD - < LOD < LOD 922 20 - * < LOD < LOD 06 < LOD < LOD 1086 05 07 - 08 * < LOD < LOD < LOD 1170 < LOD 60 years and older 03 - 04 * < LOD < LOD < LOD < LOD 522 05 < LOD 06 * < LOD < LOD < LOD 475 - 07 08 < LOD < LOD < LOD < LOD - 634 * Gender Males 03 - 04 * < LOD < LOD < LOD < LOD 1206 05 06 * < LOD < LOD < LOD < LOD 1245 - 07 - * < LOD < LOD < LOD < LOD 1289 08 03 04 * < LOD < LOD < LOD < LOD 1247 Females - - * < LOD < LOD 06 < LOD < LOD 1383 05 07 - 08 * < LOD < LOD < LOD < LOD 1283 Race/ethnicity 04 * < LOD < LOD - < LOD < LOD 605 Mexican Americans 03 05 - 06 * < LOD < LOD < LOD < LOD 693 07 - 08 * < LOD < LOD < LOD < LOD 492 - 03 - 04 * < LOD Non < LOD < LOD < LOD 637 Hispanic blacks 05 - 06 * < LOD < LOD < LOD < LOD 719 07 08 * < LOD < LOD < LOD < LOD 570 - - 03 - 04 * < LOD < LOD < LOD < LOD 1054 Non Hispanic whites 05 06 * < LOD < LOD < LOD < LOD 1007 - < LOD 08 * < LOD - < LOD < LOD 1084 07 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/DimethoateOmethoate_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 188

208 Urinary Malathion dicarboxylic acid (1999 – 2010) Metabolite of Malathion Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size 00 - < LOD < LOD < LOD < LOD 1920 99 Total * 08 * < LOD < LOD .980 (.900 - 1.08) 1.65 (1.44 - 1.94) 2581 07 - - * < LOD < LOD .990 (.830 - 10 2.05 (1.64 - 2.33) 2742 09 1.09) Age group - 99 - 00 * < LOD < LOD < LOD 2.80 (

209 Urinary Malathion dicarboxylic acid (creatinine corrected) (1999 – 2010) Metabolite of Malathion Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati onal Health and Nutr ition Examination Survey. Survey Sample 75th Percentile 90th Percentile 50th Percentile 95th Percentile Geometric mean Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 00 * < LOD Total < LOD < LOD < LOD 1920 99 - * < LOD < LOD 1.46 (1.30 - 08 2.19 (1.85 - 2.72) 2579 07 1.71) - 10 * < LOD < LOD 1.52 (1.40 - 1.65) 2.50 (2.13 2.94) 2742 09 - Age group 11 years - 00 * < LOD < LOD < LOD 99 3.74 (

210 Urinary 2 - - 4 - methyl - 6 - hydroxypyrimidine (IMPY) (1999 – 2010) Isopropyl Metabolite of Diazinon Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Total < LOD < LOD < LOD < LOD 1842 99 - 00 * 02 * < LOD < LOD < LOD < LOD 3044 01 - 08 * < LOD - < LOD .350 (.260 - .470) .720 (.530 - .890) 2588 07 - 10 * - < LOD .180 (.100 - .280) .440 (.310 .660) 2747 09 < LOD Age group 11 years 99 - 00 * < LOD < LOD < LOD 6 < LOD 454 - 01 02 * < LOD < LOD < LOD 1.45 (

211 Urinary 2 - - 4 - methyl - 6 - hydroxypyrimidine (IMPY) (creatinine corrected) (1999 – 2010) Isopropyl Metabolite of Diazinon Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati onal and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 00 * < LOD < LOD < LOD Total < LOD 1842 99 - * < LOD < LOD 02 < LOD 3042 01 < LOD - 08 * < LOD < LOD .412 (.333 - .508) .731 (.538 - 1.00) 2586 07 09 10 * < LOD < LOD .313 (.269 - .350) .526 (.429 - .636) 2747 - Age group 11 years 99 - 00 * < LOD < LOD < LOD < LOD 6 - 454 01 02 * < LOD < LOD < LOD - 2.72 (

212 Urinary para - – 2010) Nitrophenol (1999 Metabolite of Ethyl Parathion, Methyl Parathion, and Nitrobenzene Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size 00 1989 * < LOD < LOD 2.50 (1.40 - 4.50) 5.00 (2.90 - 11.0) - Total 99 - < LOD 1.33 (1.20 - 1.46) 2.69 (2.39 02 3.01) 3.72 (3.46 - 4.15) 2975 - 01 * 08 .673 (.595 - .761) .740 (.660 - .830) 1.49 (1.32 - 1.66) 2.77 (2.19 - 3.45) 4.50 (3.50 - 5.42) 2564 07 - - .454 (.407 - .506) .510 (.440 - .580) 1.09 (1.00 - 1.19) 2.18 10 - 2.34) 3.14 (2.85 - 3.55) 2744 09 (1.99 Age group 11 years 99 - 00 * < LOD .940 (

213 Urinary para - – 2010) Nitrophenol (creatinine corrected) (1999 Metabolite of Ethyl Parathion, Methyl Parathion, and Nitrobenzene Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati onal Health and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size 00 1989 * < LOD < LOD 2.08 (1.33 - 3.91) 4.25 (2.15 - 10.2) - Total 99 - < LOD .987 (.868 - 1.10) 1.97 (1.86 02 2.13) 2.98 (2.60 - 3.33) 2973 - 01 * 08 .692 (.632 - .757) .673 (.624 - .737) 1.28 (1.15 - 1.40) 2.38 (2.11 - 2.66) 3.57 (2.94 - 4.39) 2562 07 - - .473 (.430 - .521) .490 (.438 - .531) .923 (.851 - 1.01) 1.87 10 - 2.06) 2.62 (2.32 - 2.91) 2744 09 (1.60 Age group 11 years 99 - 00 * < LOD .938 (

214 Urinary 3,5,6 - - 2 - pyridinol (1999 – 2010) Trichloro - methyl Metabolite of Chlorpyrifos and Chlorpyrifos Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample 95th Percentile Geometric mean 75th Percentile 90th Percentile 50th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size 00 1.77 (1.46 - Total 1.70 (1.40 - 2.20) 3.50 (2.50 - 5.20) 7.30 (4.80 - 10.0) 10.0 (7.70 - 15.0) 1994 99 - 2.14) 02 1.72 (1.50 - 1.97) 2.17 (1.81 - 2.51) 4.87 (4.45 - 5.24) 8.80 (7.80 - 9.77) 12.4 (10.7 - 15.2) 3011 01 - - 1.29 (1.20 - 1.39) 1.48 (1.31 - 1.65) 2.63 (2.39 - 08 4.55 (4.03 - 5.14) 6.11 (5.60 - 6.93) 2588 07 2.94) - 10 .779 (.706 - .859) 1.03 (.920 - 1.16) 1.96 (1.80 - 2.20) 3.34 (2.96 - 4.47 (4.04 - 5.15) 2747 09 3.68) Age group - 11 years - 00 2.88 (1.99 - 4.16) 2.80 (1.60 - 4.90) 7.09 (3.40 99 10.0) 12.0 (7.70 - 17.0) 16.0 (10.0 - 28.0) 481 - 6 - 02 2.67 (2.13 - 3.35) 3.09 (2.50 - 4.22) 6.36 (4.97 - 7.97) 10.9 (7.98 - 15.3) 15.3 (11.5 - 24.0) 573 01 - 1.72 (1.48 - 2.01) 1.85 (1.49 - 2.22) 3.18 (2.58 - 3.68) 4.69 (3.90 - 5.74) 6.04 (5.12 - 7.63) 385 07 08 - 09 1.12 (.899 - 1.39) 1.46 (1.27 - 1.64) 2.38 (1.96 10 2.75) 4.29 (2.67 - 6.07) 5.81 (4.14 - 7.16) 386 - - 19 years 99 - 00 2.37 (1.89 - 2.97) 2.10 (1.60 - 3.00) 4.50 (2.90 - 7.10) 8.10 (5.50 - 14.0) 12.5 (8.00 - 24.0) 681 12 - 02 2.71 (2.19 - 3.35) 3.57 (2.66 - 4.34) 6.60 (5.61 - 7.59) 11.3 (8.66 - 15.1) 18.0 (13.7 - 23.7) 823 01 07 - 1.54 (1.27 - 1.86) 1.81 (1.39 - 2.20) 2.75 (2.34 - 3.29) 4.70 (3.66 - 5.72) 6.33 (4.98 - 7.96) 390 08 2.28) - .884 (.793 - .985) 1.08 (.960 - 1.30) 1.89 (1.64 - 3.04 (2.28 - 4.21) 4.30 (3.14 - 5.60) 401 09 10 59 years 99 - 00 1.53 (1.29 - 1.83) 1.50 (1.30 - 1.80) 2.90 20 - 4.30) 5.90 (3.90 - 8.90) 8.90 (6.70 - 11.0) 832 - (2.20 01 02 1.51 (1.32 - 1.72) 1.91 (1.44 - 2.26) 4.44 (3.90 - 4.80) 7.78 (7.00 - 8.91) 10.9 (9.52 - 12.4) 1113 - 07 - 08 1.19 (1.07 - 1.33) 1.36 (1.22 - 1.53) 2.55 (2.21 - 2.98) (3.82 - 5.30) 5.85 (5.40 - 6.93) 1180 4.46 - 10 .710 (.634 - .795) .970 (.860 - 1.12) 1.89 (1.70 - 2.07) 3.14 (2.81 - 3.49) 4.18 (3.66 - 4.73) 1309 09 - 02 1.51 (1.21 - 1.89) 1.76 (1.22 - 2.33) 4.36 (3.54 - 5.08) 9.11 (6.67 - 13.0) 13.5 (11.2 - 15.5) 502 60 years and older 01 07 - 08 1.31 (1.17 - 1.47) 1.51 (1.27 - 1.70) 2.51 (2.34 - 2.78) (3.97 - 5.81) 6.69 (5.14 - 8.14) 633 4.64 - 10 .812 (.710 - .929) .990 (.870 - 1.15) 2.30 (1.73 - 2.58) 09 (3.16 - 4.67) 5.32 (4.23 - 6.85) 651 3.90 Gender Males 99 - 00 1.92 (1.60 - 2.32) 1.90 (1.50 - 2.40) 3.60 (2.70 - 5.60) 7.40 (5.04 - 10.0) 10.0 (7.70 - 16.0) 972 01 02 2.13 (1.82 - 2.49) 2.67 (2.24 - 3.16) 5.33 (4.81 - 6.05) 9.69 (8.45 - 11.5) 15.0 (11.7 - 17.7) 1416 - 07 - 1.49 (1.36 - 1.64) 1.70 (1.49 - 1.92) 2.85 (2.50 - 3.17) 4.87 (4.17 - 5.52) 6.01 (5.56 - 6.67) 1293 08 2.35) - .865 (.775 - .965) 1.16 (1.03 - 1.27) 2.10 (1.87 - 3.50 (2.97 - 3.93) 4.66 (3.96 - 5.84) 1343 09 10 99 - 00 1.63 (1.31 - 2.02) 1.50 (1.20 - 2.00) 3.30 (2.30 Females 5.30) 7.20 (4.30 - 12.0) 11.0 (7.20 - 16.0) 1022 - 01 02 1.40 (1.21 - 1.62) 1.63 (1.32 - 2.01) 4.31 (3.57 - 4.84) 7.78 (6.52 - 9.20) 10.9 (8.62 - 13.2) 1595 - 07 - 08 1.13 (1.04 - 1.22) 1.26 (1.13 - 1.40) 2.41 (2.15 - 2.79) 4.32 (3.76 - 4.98) 6.30 (5.27 - 7.59) 1295 - 10 .704 (.631 - .786) .940 (.830 - 1.04) 1.88 (1.63 - 2.11) 3.22 (2.78 - 3.72) 4.40 (4.09 - 4.73) 1404 09 Race/ethnicity 99 - 00 1.61 (1.31 - 2.00) 1.67 (1.30 - 2.20) 3.20 (2.60 - 3.80) 5.10 (3.80 - 8.40) 7.40 (5.10 - 17.0) 697 Mexican Americans 01 - 02 1.98 (1.77 - 2.21) 2.54 (2.21 2.89) 4.55 (4.09 - 5.22) 8.94 (7.06 - 10.4) 11.9 (10.0 - 15.7) 744 - (1.89 08 1.13 (.926 - 1.38) 1.26 (1.06 - 1.53) 2.34 - - 2.94) 4.04 (3.13 - 4.92) 5.36 (4.37 - 7.16) 500 07 09 - 10 .761 (.650 - .892) .950 (.850 - 1.18) 1.90 (1.66 - 2.11) 3.31 (2.76 - 4.19) 4.64 (4.19 - 5.46) 602 Non - 99 - 00 2.17 (1.59 - 2.97) 1.90 (1.43 - 2.80) 4.30 (2.50 - 8.30) 9.40 (6.40 - 13.7) 13.0 (9.40 - 26.0) 521 Hispanic blacks 01 02 2.14 (1.61 - 2.84) 2.85 (2.16 - 3.38) 5.45 (4.57 - 6.96) 9.27 (7.21 - 11.7) 12.9 (9.57 - 17.5) 776 - 07 (2.65 08 1.64 (1.36 - 1.97) 1.86 (1.47 - 2.24) 3.22 - 4.17) 5.79 (4.85 - 7.17) 7.97 (6.49 - 9.58) 574 - (2.00 10 .918 (.823 - 1.02) 1.22 (1.06 - 1.38) 2.24 - - 2.52) 3.49 (2.99 - 4.14) 4.99 (3.93 - 6.17) 504 09 Non - Hispanic whites 99 - 00 1.76 (1.51 - 2.05) 1.70 (1.50 - 2.10) 3.50 (2.50 - 4.86) 7.10 (4.30 - 11.0) 10.0 (7.20 - 14.0) 602 01 02 1.67 (1.44 - 1.94) 2.11 (1.64 - 2.47) 4.85 (4.38 - 5.29) 8.91 (7.63 - 9.97) 12.9 (10.4 - 15.7) 1267 - (2.35 08 1.23 (1.16 - 1.30) 1.44 (1.27 - 1.58) 2.57 - - 2.83) 4.41 (3.89 - 4.87) 5.69 (5.40 - 6.14) 1084 07 09 - 10 .768 (.667 - .885) 1.03 (.890 - 1.18) 1.96 (1.71 - 2.31) 3.42 (2.93 - 3.86) 4.46 (3.93 - 5.32) 1200 - Limit of detection (LOD, see Data Analysis section) for Survey years 99 - 00, 01 - 02, 07 08, and 09 - 10 are 0.4, 0.4, 0.1, and 0.1 respectively. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Chlorpyrifos_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 195

215 Urinary 3,5,6 - - 2 - pyridinol (creatinine corrected) (1999 – 2010) Trichloro - methyl Metabolite of Chlorpyrifos and Chlorpyrifos Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati onal Health and Nutrition Examination Survey. Survey Sample 95th Percentile Geometric mean 75th Percentile 90th Percentile 50th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size 00 1.58 (1.35 - Total 1.47 (1.24 - 1.74) 2.85 (2.12 - 3.59) 5.43 (4.22 - 6.68) 8.42 (6.25 - 11.6) 1994 99 - 1.85) 02 1.75 (1.53 - 2.00) 1.94 (1.66 - 2.25) 3.80 (3.13 - 4.48) 6.53 (5.24 - 8.23) 9.27 (7.46 - 12.1) 3009 01 - - 1.33 (1.22 - 1.44) 1.34 (1.25 - 1.48) 2.29 (2.06 - 2.48) 3.80 (3.44 - 4.15) 4.91 (4.47 - 5.83) 2586 07 08 1.80) 10 .812 (.748 - .881) .979 (.917 - 1.05) 1.66 (1.52 - 2.67 (2.40 - 2.94) 3.53 (3.15 - 4.02) 2747 09 - Age group 11 years - 99 - 00 3.11 (2.31 - 4.19) 3.20 (2.05 - 4.80) 6.39 (4.14 - 8.19) 10.1 (7.26 - 14.0) 14.1 (10.1 - 21.0) 481 6 8.57) - 3.48 (2.80 - 4.32) 3.76 (3.17 - 4.36) 6.22 (4.88 - 12.2 (7.24 - 24.4) 16.9 (12.1 - 38.0) 573 01 02 - 08 2.18 (1.89 - 2.53) 2.21 (1.86 - 2.66) 3.23 (2.86 - 3.89) 4.67 (4.23 - 5.00) 5.94 (4.76 - 6.58) 385 07 - 10 1.51 (1.28 - 1.78) 1.77 (1.49 - 1.95) 2.62 (2.26 - 2.90) 3.67 (2.93 - 4.42) 4.42 (3.76 - 5.95) 386 09 (1.98 19 years 99 - 00 1.60 (1.34 - 1.91) 1.45 (1.21 - 1.81) 2.58 - - 3.92) 4.83 (3.44 - 6.16) 6.16 (4.43 - 10.6) 681 12 01 - 02 2.09 (1.72 - 2.55) 2.24 (1.92 - 2.66) 3.97 (3.30 - 4.72) 6.33 (5.62 - 7.89) 10.3 (7.65 - 15.2) 822 - 08 1.19 (1.05 - 1.34) 1.20 (1.05 - 1.33) 1.85 (1.61 - 2.22) 2.66 (2.32 - 3.62) 4.00 (2.70 - 5.77) 388 07 09 - .757 (.675 - .850) .861 (.766 - .935) 1.34 (1.15 - 1.55) 2.27 (1.55 - 2.68) 2.67 (2.13 - 4.21) 401 10 - 59 years - 00 1.41 (1.23 - 1.62) 1.33 (1.12 - 1.58) 2.37 (1.87 99 3.01) 4.29 (3.53 - 5.56) 6.42 (5.11 - 9.02) 832 - 20 - 02 1.49 (1.30 - 1.71) 1.64 (1.39 - 1.88) 3.11 - 3.91) 5.51 (4.33 - 7.23) 7.44 (5.80 - 11.0) 1113 01 (2.60 07 08 1.19 (1.09 - 1.30) 1.22 (1.10 - 1.33) 2.04 (1.78 - 2.32) 3.42 (2.93 - 3.96) 4.84 (3.96 - 6.31) 1180 - 09 - 10 .710 (.644 - .784) .875 (.813 - .943) 1.47 (1.35 - 1.62) (1.99 - 2.66) 3.20 (2.75 - 3.64) 1309 2.27 60 years and older 01 - 02 1.84 (1.55 - 2.18) 2.15 (1.71 - 2.60) 4.08 (3.61 - 4.84) 7.43 (6.50 - 8.50) 11.2 (7.95 - 13.5) 501 - 07 1.61 (1.43 - 1.81) 1.68 (1.48 - 1.92) 2.88 (2.38 08 3.46) 4.46 (3.87 - 4.91) 5.59 (4.64 - 7.03) 633 - 09 - 10 .963 (.838 - 1.11) 1.18 (1.01 - 1.34) 2.03 (1.87 - 2.19) 3.14 (2.73 - 4.02) 4.36 (3.47 - 5.36) 651 Gender (2.05 - 00 1.48 (1.27 - 1.72) 1.44 (1.19 Males 1.68) 2.54 99 - 3.38) 4.95 (3.84 - 6.54) 7.63 (5.65 - 11.0) 972 - 01 - 02 1.75 (1.51 - 2.02) 1.93 (1.66 - 2.24) 3.61 (3.01 - 4.22) 6.33 (5.08 - 8.88) 11.3 (7.54 - 13.5) 1416 07 08 1.24 (1.13 - 1.35) 1.29 (1.15 - 1.46) 2.12 (1.87 - 2.34) 3.44 (3.03 - 3.78) 4.41 (3.82 - 4.97) 1292 - 09 - .769 (.712 - .831) .930 (.863 - .988) 1.55 (1.39 - 1.70) 2.54 (2.18 - 2.80) 3.41 (3.01 - 3.93) 1343 10 99 - 00 1.69 (1.42 - 2.01) 1.51 (1.25 - 1.85) 2.97 (2.25 4.02) 5.63 (4.27 - 7.39) 8.44 (5.79 - 13.3) 1022 Females - - - 1.75 (1.52 - 2.02) 1.96 (1.61 - 2.30) 3.96 (3.16 02 4.78) 6.58 (5.37 - 7.95) 8.98 (7.07 - 11.8) 1593 01 07 - 08 1.42 (1.30 - 1.55) 1.40 (1.29 - 1.53) 2.43 (2.22 - 2.70) 4.18 (3.73 - 4.74) 5.77 (4.76 - 7.03) 1294 09 .855 10 (.765 - .954) 1.04 (.951 - 1.14) 1.76 (1.60 - 1.96) 2.79 (2.40 - 3.18) 3.68 (3.18 - 4.10) 1404 - Race/ethnicity 99 - 00 1.46 (1.20 - 1.77) 1.44 (1.05 - 1.93) 2.39 (2.09 - 2.96) 3.86 (3.24 - 5.09) 5.85 (3.88 - 9.57) 697 Mexican Americans 01 - 02 1.86 (1.64 - 2.10) 2.06 (1.85 2.30) 3.79 (3.23 - 4.46) 6.52 (5.73 - 7.58) 8.71 (7.68 - 11.0) 744 - (1.55 08 1.15 (.895 - 1.46) 1.18 (.941 - 1.50) 1.97 - - 2.38) 3.04 (2.31 - 4.41) 4.41 (2.92 - 7.11) 499 07 09 - 10 .796 (.680 - .930) .959 (.821 - 1.07) 1.58 (1.39 - 1.76) 2.61 (2.25 - 2.99) 3.46 (3.16 - 4.01) 602 Non - 99 - 00 1.47 (1.09 - 1.99) 1.33 (.936 - 1.94) 2.86 (1.58 - 5.05) 5.91 (4.05 - 8.93) 9.02 (5.91 - 13.7) 521 Hispanic blacks 01 02 1.58 (1.19 - 2.08) 1.95 (1.56 - 2.48) 3.53 (2.84 - 4.28) 5.60 (4.68 - 6.40) 7.21 (5.83 - 9.11) 775 - 07 (1.86 08 1.25 (1.05 - 1.49) 1.24 (1.03 - 1.47) 2.25 - 2.86) 3.91 (3.13 - 4.68) 5.39 (4.12 - 8.30) 573 - (1.28 10 .694 (.613 - .786) .813 (.698 - .981) 1.41 - - 1.62) 2.28 (2.00 - 2.55) 2.93 (2.55 - 3.50) 504 09 Non - Hispanic whites 99 - 00 1.66 (1.45 - 1.91) 1.55 (1.31 - 1.83) 2.93 (2.09 - 3.97) 5.56 (4.21 - 6.75) 8.44 (6.25 - 12.3) 602 (3.03 02 1.81 (1.55 - 2.11) 2.00 (1.65 - 2.35) 3.91 - - 4.91) 6.94 (5.24 - 9.22) 10.6 (7.76 - 12.6) 1266 01 07 - 08 1.33 (1.22 - 1.45) 1.37 (1.26 - 1.53) 2.31 (2.02 - 2.54) 3.76 (3.40 - 4.03) 4.73 (4.35 - 5.68) 1084 2.75 - 10 .837 (.750 - .934) 1.01 (.919 - 1.12) 1.73 (1.55 - 1.93) 09 (2.40 - 3.14) 3.64 (3.10 - 4.36) 1200 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Chlorpyrifos_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 196

216 Urinary Diethylphosphate (DEP) (1999 – 2008) Metabolite of Several Organophosphorus Insecticides Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 00 1.03 (.670 - 1.58) 1.20 (.750 - 1.70) 3.20 (2.30 - 4.80) 7.60 (5.00 - 12.0) 13.0 (7.70 - 23.0) 1949 Total 99 02 * - < LOD 2.90 (2.50 - 3.26) 6.68 (5.78 - 7.52) 10.6 (9.14 - 12.0) 3018 01 (9.00 - * < LOD 4.56 (3.57 - 5.83) 10.2 - 11.5) 15.5 (13.5 - 16.8) 2453 03 04 - 06 * < LOD 1.46 (.780 - 2.17) 7.01 (5.67 - 8.94) 13.3 (10.2 - 16.0) 2635 05 07 08 * < LOD 2.48 (1.44 - 3.33) 8.74 (7.51 - 10.3) 15.3 (13.1 - 17.8) 2591 - Age group 11 years 99 - 00 1.32 (.757 - 2.29) 1.50 (.860 - 2.60) 4.50 (2.10 - 7.90) 11.0 (4.80 - 24.0) 16.0 6 - 36.0) 471 - (8.50 01 02 * .290 (

217 Urinary Diethylphosphate – 2008) (DEP) (1999 Metabolite of Several Organophosphorus Insecticides Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Sample Survey Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 1.22 (.740 - 2.01) 1.20 (.840 - 1.80) 4.10 (2.20 - 7.00) 11.0 (6.40 - 19.0) 18.0 (12.0 Mexican Americans 27.0) 672 - 01 02 * .600 (

218 Urinary Diethylphosphate (DEP) (creatinine corrected) (1999 – 2008) Metabolite of Several Organophosphorus Insecticides Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati onal Health and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 00 .924 (.608 - 1.41) .920 (.570 - 1.40) 2.73 (1.68 - 4.60) 7.94 (4.40 - 12.2) 12.2 (8.00 - 19.6) 1949 Total 99 02 * - < LOD 2.56 (2.17 - 2.85) 5.36 (4.75 - 6.06) 8.72 (7.19 - 10.3) 3017 01 (7.85 - * < LOD 4.64 (3.82 - 5.79) 9.18 - 10.8) 13.1 (10.5 - 16.1) 2450 03 04 - 06 * < LOD 2.23 (1.49 - 3.09) 7.72 (6.26 - 9.36) 13.5 (11.0 - 19.0) 2634 05 07 08 * < LOD 3.20 (2.37 - 4.12) 8.86 (7.52 - 10.7) 15.7 (11.9 - 19.8) 2589 - Age group 11 years 99 - 00 1.43 (.870 - 2.34) 1.47 (1.02 - 2.41) 3.94 (2.20 - 8.57) 10.5 (4.55 - 20.8) 16.6 (10.5 - 32.7) 471 6 - - * .886 01 (

219 Urinary Diethylphosphate (DEP) (creatinine corrected) (1999 – 2008) es Metabolite of Several Organophosphorus Insecticid onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample 95th Percentile Geometric mean 50th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 1.09 (.633 - 1.89) 1.05 (.650 - Mexican Americans 3.78 (2.11 - 6.46) 9.84 (5.66 - 15.7) 15.7 (8.61 - 29.0) 672 1.98) 01 02 * .891 (

220 U rinary Dimethylphosphate (DMP) (1999 2008) – Metabolite of Several Organophosphorus Insecticides Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 00 * .740 (

221 Urinary Dimethylphosphate (DMP) (1999 – 2008) Metabolite of Several Organophosphorus Insecticides U.S. population from the National Health and Geometric mean and selected percentiles of urine concentrations (in μg/L) for the Nutrition Examination Survey. Sample Survey Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 * 1.10 (

222 Urinary Dimethylphosphate (DMP) (creatinine corrected) (1999 – 2008) Metabolite of Several Organophosphorus Insecticides h Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati onal Healt and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 00 * .810 (

223 Urinary Dimethylphosphate (DMP) (creatinine corrected) (1999 – 2008) cides Metabolite of Several Organophosphorus Insecti onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample 95th Percentile Geometric mean 50th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 * 1.06 (

224 Urinary Diethylthiophosphate (DETP) (1999 – 2008) Metabolite of Several Organophosphorus Insecticides Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size 00 * .500 (

225 Urinary Diethy lthiophosphate (DETP) (1999 2008) – Metabolite of Several Organophosphorus Insecticides Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Sample Survey Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 * .570 (

226 Urinary Diethylthiophosphate (DETP) (creatinine corrected) (1999 – 2008) Metabolite of Several Organophosphorus Insecticides Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati onal Health and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size 00 * .250 (

227 Urinary Diethylthiophosphate (DETP) (creatinine corrected) (1999 – 2008) Metabolite of Several Organophosphorus Insecticides Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. popula tion from the National Health and Nutrition Examination Survey. Sample Survey Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 * .330 (

228 Urinary Dimethylthiophosphate (DMTP) (1999 – 2008) Metabolite of Several Organophosphorus Insecticides Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Geometric mean 50th Percentile 95th Percentile 90th Percentile 75th Percentile Survey Sample (95% conf. (95% conf. interval) (95% conf. interval) Categories (95% conf. interval) (95% conf. interval) size years interval) - 00 1.82 (1.36 - 2.44) 2.70 (1.40 - 4.10) 11.0 (8.40 - 16.0) 38.0 (25.0 - 41.0) 48.0 (38.0 - 62.0) Total 1948 99 - * .580 (

229 Urinary Dimethylthiophosphate (DMTP) (1999 – 2008) Metabolite of Several Organophosphorus Insecticides Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nu trition Examination Survey. Survey Sample 95th Percentile Geometric mean 50th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 1.79 (1.05 - 3.05) 2.00 (.530 - 4.40) 11.0 (6.70 - 17.0) 39.0 (32.0 - 62.0) 140 (46.0 Mexican Americans 230) 671 - 01 02 * < LOD 3.93 (3.05 - 5.06) 15.1 (11.1 - 19.1) 35.6 (22.7 - 46.0) 763 - - - 03 (1.88 - 3.09) 2.54 (1.41 - 3.98) 6.43 (4.90 04 8.02) 17.2 (12.0 - 22.3) 28.9 (19.2 - 39.8) 610 2.41 05 - 06 2.37 (2.07 - 2.71) 2.26 (1.95 - 2.68) 5.65 (4.86 6.44) 16.4 (12.9 - 21.4) 28.3 (23.3 - 41.4) 693 - - 08 2.10 (1.83 - 2.42) 1.98 (1.63 - 2.31) 5.18 (4.17 - 6.61) 13.6 (11.5 - 20.0) 31.0 (20.0 - 43.5) 501 07 - 99 - 00 2.13 (1.57 - 2.88) 3.60 (2.10 - 4.70) 12.0 (8.80 - 18.0) 38.0 (20.0 - 41.0) 41.0 (37.0 - 110) 509 Non Hispanic blacks 01 02 1.54 (1.15 - 2.07) 1.18 (.580 - 1.97) 5.21 (3.11 - 8.25) 20.0 (13.4 - 27.2) 39.1 (25.9 - 62.8) 755 - (3.87 04 2.13 (1.83 - 2.48) 1.85 (1.65 - 2.20) 5.44 - - 8.28) 20.4 (15.8 - 24.9) 31.1 (24.9 - 51.9) 631 03 05 - 06 1.94 (1.63 - 2.31) 1.63 (1.23 - 2.02) 5.21 (3.93 - 7.18) 16.8 (13.3 - 21.6) 28.4 (21.5 - 40.6) 723 07 08 2.12 (1.89 - 2.38) 1.97 (1.64 - 2.26) 5.63 (4.15 - 6.94) 20.8 (12.9 - 23.9) 33.5 (26.3 - 47.6) 573 - (7.50 - 99 - 00 1.77 (1.23 - 2.53) 2.70 (.830 - 4.40) 11.0 - 17.0) 38.0 (17.0 - 53.0) 48.0 (38.0 - 69.0) 595 Non Hispanic whites 01 - 02 * .540 (

230 Urinary Dimethylthiophosphate (DMTP) (creatinine corrected) (1999 – 2008) Metabolite of Several Organophosphorus Insecticides Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati onal and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 00 1.64 (1.22 - 2.20) 2.12 (1.22 - 3.35) 9.57 (6.59 - 15.8) 32.0 (23.9 - 41.1) 51.0 Total (39.0 - 70.1) 1948 99 - * .933 (

231 Urinary Dimethylthiophosphate (DMTP) (creatinine corrected) (199 9 2008) – sphorus Insecticides Metabolite of Several Organopho onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample 95th Percentile Geometric mean 50th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 1.60 (.899 - 2.86) 1.83 Mexican Americans - 4.23) 10.4 (5.95 - 16.9) 37.0 (23.1 - 63.1) 112 (40.5 - 190) 671 (.680 01 02 * < LOD 3.55 (2.65 - 4.68) 13.8 - (9.88 - 22.9) 30.4 (22.9 - 47.2) 763 03 - 04 2.20 (1.65 - 2.94) 2.24 (1.70 - 3.00) 5.95 (4.14 - 8.68) 15.7 (10.7 - 20.1) 24.5 (18.9 - 36.9) 609 05 06 2.24 (1.96 - 2.55) 2.14 (1.89 - 2.40) 5.19 (4.33 - 6.18) 14.7 (10.9 - 20.0) 28.4 (21.5 - 36.3) 693 - - 07 2.14 (1.92 - 2.38) 1.88 (1.61 - 2.22) 4.84 (4.08 08 6.48) 13.2 (10.0 - 18.6) 26.2 (18.6 - 34.1) 500 - - Hispanic blacks 99 - 00 1.45 (1.03 - 2.06) 1.75 (1.17 - 3.06) 8.48 Non (4.36 - 13.4) 25.5 (15.4 - 39.3) 54.4 (25.5 - 97.6) 509 - 02 1.13 (.889 - 1.44) 1.00 (.693 - 1.23) 3.62 01 - 5.41) 12.4 (9.17 - 17.5) 23.3 (17.4 - 43.1) 754 (2.29 03 - 04 1.46 (1.28 - 1.67) 1.22 (1.06 - 1.37) 3.90 (2.77 - 5.34) 12.7 (8.09 - 18.7) 26.0 (14.6 - 38.7) 630 05 06 1.40 (1.14 - 1.71) 1.12 (.938 - 1.37) 3.58 (2.63 - 5.06) 12.0 (8.44 - 19.3) 25.6 (17.4 - 31.2) 722 - - 07 1.61 (1.45 - 1.80) 1.38 (1.22 - 1.61) 4.26 (3.41 08 5.20) 14.7 (10.7 - 18.8) 27.5 (20.9 - 37.4) 572 - - Hispanic whites 99 - 00 1.68 (1.16 - 2.43) 2.22 (.870 - 3.51) Non 9.40 (5.58 - 17.0) 33.3 (20.6 - 49.4) 52.9 (39.0 - 71.1) 595 - 02 * .966 (

232 Urinary Diethyldithiophosphate (DEDTP) (1999 – 2008) Metabolite of Several Organophosphorus Insecticides Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 00 * .090 (

233 Urinary Diethyldithiophosphate (DEDTP) (1999 – 2008) Metabolite of Several Organophosphorus Insecticides Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the Nation al Health and Nutrition Examination Survey. Sample Survey Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 .130 (.099 - .171) .100 (.050 Mexican Americans .200) .310 (.230 - .390) .650 (.530 - .860) 1.10 (.860 - 1.60) 672 - 01 02 * < LOD .200 (

234 Urinary Diethyldithiophosphate (DEDTP) (creatinine corrected) (1999 – 2008) Metabolite of Several Organophosphorus Insecticides l Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati ona and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 00 * .070 (

235 Urinary Diethyldithiophosphate (DEDTP) (creatinine correct ed) (1999 2008) – anophosphorus Insecticides Metabolite of Several Org onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample 95th Percentile Geometric mean 50th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 .116 (.084 - .161) .090 Mexican Americans - .170) .300 (.190 - .410) .810 (.570 - .990) 1.19 (.860 - 2.66) 672 (.060 01 02 * < LOD .292 (

236 Urinary Dimethyldithiophosphate (DMDTP) (1999 – 2008) Metabolite of Several Organophosphorus Insecticides Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 00 * < LOD 2.30 - - 3.90) 13.0 (5.00 17.0) 19.0 (17.0 - 38.0) 1949 99 Total (1.30 02 * < LOD .920 (.330 - 1.30) 2.61 (2.04 - 3.45) 5.96 (4.41 - 7.90) 3015 01 - - * < LOD .700 (.570 - .920) 2.54 04 - 3.87) 5.74 (3.63 - 9.85) 2458 03 (1.64 - 06 * < LOD < LOD 1.96 (1.41 - 2.59) 3.87 (2.77 6.09) 2635 05 - 07 08 * < LOD < LOD 2.37 (1.93 - 2.93) 5.60 (4.62 - 6.79) 2571 - Age group 11 years 99 - 00 .691 (.425 - 1.12) .740 (.080 - 1.80) 4.30 (2.40 - 8.60) 17.0 (6.90 - 37.0) 32.0 (17.0 - 44.0) 471 6 - - * 01 < LOD 1.30 (.750 - 2.11) 3.53 (2.20 - 4.50) 7.33 (4.32 - 9.74) 575 02 03 * < LOD .900 (.620 - 1.14) 2.94 04 (1.14 - 5.48) 5.48 (2.94 - 8.53) 306 - 05 - 06 * < LOD < LOD 1.84 (.540 - 3.69 (2.67 - 9.95) 350 3.35) - 08 * < LOD .950 (

237 Urinary Dimethyldithiophosphate (DMDTP) (1999 – 2008) Metabolite of Several Organophosphorus Insecticides Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the Nati onal Health and Nutrition Examination Survey. Sample Survey Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 * .250 (

238 Urinary Dimethyldithiophosphate (DMDTP) (creatinine corrected) (1999 – 2008) Metabolite of Several Organophosphorus Insecticides Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati onal Health and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 00 * < LOD 1.88 - - 3.86) 10.1 (5.31 18.3) 21.7 (12.8 - 33.7) 1949 99 Total (.970 02 * < LOD .717 (.389 - 1.12) 2.80 (2.21 - 3.96) 6.84 (4.96 - 8.09) 3014 01 - - * < LOD .572 (.411 - .772) 2.62 04 - 4.12) 6.40 (3.85 - 9.75) 2455 03 (1.72 - 06 * < LOD < LOD 2.18 (1.64 - 3.00) 4.62 (3.23 7.12) 2634 05 - 07 08 * < LOD < LOD 2.63 (2.17 - 3.08) 6.12 (4.15 - 8.24) 2569 - Age group 11 years 99 - 00 .748 (.474 - 1.18) .790 (.190 - 1.60) 4.07 (2.31 - 7.18) 16.2 (8.22 - 27.0) 30.8 (20.2 - 38.9) 471 6 - - * 01 < LOD 1.36 (.805 - 2.31) 4.10 (2.67 - 6.24) 6.98 (4.40 - 12.8) 575 02 03 * < LOD .962 (.584 - 1.57) 3.39 04 (2.29 - 6.15) 7.12 (4.48 - 7.55) 306 - 05 - 06 * < LOD < LOD 2.57 (1.39 - 4.50 (3.17 - 9.35) 350 4.14) - 08 * < LOD 1.50 (

239 Urinary Dimethyldithiophosphate (DMDTP) (creatinine corrected) (1999 – 2008) Metabolite of Several Organophosphorus Insecticides Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S . population from the National Health and Nutrition Examination Survey. Sample Survey Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 * .270 (

240 Urinary trans - - (2,2 - Dichlorovin yl) - 2,2 - dimethylcyclopropane carboxylic acid (trans - DCCA) (1999 – 3 2010) Cypermethrin, and trans - Permethrin Metabolite of Cyfluthrin, trans - Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Total 00 * < LOD .560 (.480 - .700) 1.40 (1.17 - 1.77) 3.42 (2.39 - 5.56) 1976 99 - - 02 * < LOD .430 (

241 Urinary trans - - (2,2 - Dichlorovinyl) - 2,2 - dimethylcyclopropane carboxylic acid (trans - DCCA) (1999 – 3 2010) Cypermethrin , and trans - Permethrin Metabolite of Cyfluthrin, trans - Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample 95th Percentile Geometric mean 50th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 * < LOD Mexican Americans (.410 - .530) 1.23 (.830 - 1.60) 1.87 (1.49 - 3.35) 691 .470 01 02 * < LOD .410 (

242 Urinary trans - - (2,2 - Dichlorovinyl) - 2,2 - dimethylcyclopropane carboxylic acid (trans - DCCA) (creatinine 3 – corrected) (1999 2010) Cypermethrin, and trans Metabolite of Cyfluthrin, trans - - Permethrin trations (in μg/g of creatinine) for the U.S. population from the National Health Geometric mean and selected percentiles of urine concen and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years (1.33 - * < LOD .700 (.609 - .778) 1.56 00 - 1.87) 2.65 (2.15 - 3.89) 1976 99 Total - 02 * < LOD .737 (

243 Urinary trans - - (2,2 - Dichlorovinyl) - 2,2 - dimethylcyclopropane carboxylic acid (trans - D CCA) (creatinine 3 – corrected) (1999 2010) Cypermethrin, and trans - Metabolite of Cyfluthrin, trans - Permethrin Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati onal Health and Nutrition Examination Survey. Survey Sample 90th Percentile 75th Percentile 50th Percentile 95th Percentile Geometric mean Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 00 * < LOD .583 - .745) 1.35 - (1.02 - 1.65) 2.00 (1.56 - 2.80) 691 Mexican Americans (.500 01 - 02 * < LOD .573 (

244 Urinary cis - - (2,2 - Dibromovinyl) - 2,2 - dimethylcyclopropane carbox ylic acid (cis - DBCA) (1999 – 2010) 3 Metabolite of Deltamethrin Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 00 * < LOD < LOD < LOD < LOD 1698 Total 99 02 * < LOD < LOD < LOD < LOD 3048 01 - < LOD - * < LOD < LOD < LOD 2583 07 08 - 10 * < LOD < LOD < LOD < LOD 2746 09 Age group 11 years - 00 * < LOD < LOD 99 < LOD < LOD 415 - 6 - 02 * < LOD < LOD < LOD < LOD 580 01 - * < LOD < LOD < LOD < LOD 384 07 08 09 * < LOD < LOD 10 < LOD < LOD 386 - - 19 years 99 - 00 * < LOD < LOD < LOD < LOD 570 12 01 < LOD 02 * < LOD < LOD < LOD 831 - 07 - * < LOD < LOD < LOD < LOD 389 08 < LOD - * < LOD < LOD < LOD 401 09 10 59 years 99 - 00 * < LOD < LOD < LOD < LOD 713 20 - - * < LOD < LOD < LOD < LOD 1128 01 02 07 * < LOD < LOD 08 < LOD < LOD 1177 - 09 - 10 * < LOD < LOD < LOD 1308 < LOD 60 years and older 01 - 02 * < LOD < LOD < LOD < LOD 509 07 * < LOD < LOD 08 < LOD < LOD 633 - 09 - 10 * < LOD < LOD < LOD < LOD 651 Gender < LOD - 00 * < LOD < LOD < LOD Males 818 99 < LOD 01 02 * < LOD - < LOD < LOD 1429 07 - 08 * < LOD < LOD < LOD < LOD 1290 09 10 * < LOD < LOD < LOD < LOD 1343 - 99 00 * < LOD < LOD < LOD < LOD 880 Females - < LOD - * < LOD < LOD < LOD 1619 01 02 - 08 * < LOD < LOD < LOD < LOD 07 1293 09 10 * < LOD < LOD < LOD < LOD - 1403 Race/ethnicity 99 - 00 * < LOD < LOD < LOD < LOD 578 Mexican Americans 01 * 02 < LOD < LOD < LOD < LOD 767 - 07 - * < LOD < LOD < LOD < LOD 500 08 09 * < LOD < LOD 10 < LOD < LOD 602 - - Hispanic blacks 99 - 00 * < LOD Non < LOD < LOD < LOD 445 - 02 * < LOD < LOD < LOD < LOD 776 01 < LOD 07 08 * < LOD - < LOD < LOD 572 09 - 10 * < LOD < LOD < LOD < LOD 503 Non - 99 - 00 * < LOD < LOD < LOD < LOD 527 Hispanic whites 01 02 * < LOD < LOD < LOD < LOD 1281 - 07 < LOD 08 * < LOD < LOD < LOD 1082 - < LOD 10 * < LOD - < LOD < LOD 1200 09 Limit of detection (LOD, see Data Analysis section) for Survey years 99 - 00, 01 - 02, 07 - 08, and 09 - 10 are 0.1, 0.1, 0.5, and 0.5 respectively. vary < means less than the limit of detection, which may LOD for some chemicals by year a nd by individual sample. * Not calculated: proportion of results below limit of detection was too high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Deltamethrin_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 225

245 Urinary cis - - (2,2 - Dibromovinyl) - 2,2 - dimethylcyclopropane carboxylic acid (cis - DBCA) (creatinine 3 – corrected) (1999 2010) Metabolite of Deltamethrin population from the National Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 00 * < LOD < LOD < LOD Total < LOD 1698 99 - * < LOD < LOD < LOD < LOD 3046 01 02 < LOD 08 * < LOD < LOD < LOD 2581 07 - - 10 * < LOD < LOD < LOD < LOD 2746 09 Age group 11 years - 00 * < LOD < LOD 99 < LOD < LOD 415 - 6 - 02 * < LOD < LOD < LOD < LOD 580 01 - * < LOD < LOD < LOD < LOD 384 07 08 09 * < LOD < LOD 10 < LOD < LOD 386 - - 19 years 99 - 00 12 * < LOD < LOD < LOD < LOD 570 - 02 * < LOD < LOD < LOD < LOD 830 01 07 - * < LOD < LOD < LOD < LOD 387 08 < LOD - * < LOD < LOD < LOD 401 09 10 59 years 99 - 00 * < LOD 20 < LOD < LOD 713 - < LOD 01 02 * < LOD < LOD - < LOD < LOD 1128 07 - 08 * < LOD < LOD < LOD 1177 < LOD - 10 * < LOD < LOD < LOD < LOD 1308 09 02 * < LOD < LOD - < LOD < LOD 508 60 years and older 01 07 - 08 * < LOD < LOD < LOD 633 < LOD - 10 * < LOD < LOD < LOD 09 651 < LOD Gender Males 99 - 00 * < LOD < LOD < LOD < LOD 818 01 02 * < LOD < LOD < LOD < LOD 1429 - 07 - * < LOD < LOD < LOD < LOD 1289 08 < LOD - * < LOD < LOD < LOD 1343 09 10 99 - 00 * < LOD < LOD Females < LOD < LOD 880 01 02 * < LOD < LOD - < LOD < LOD 1617 07 - 08 * < LOD < LOD < LOD < LOD 1292 09 * 10 < LOD < LOD < LOD < LOD 1403 - Race/ethnicity 99 00 < LOD < LOD - < LOD < LOD 578 Mexican Americans * 01 - 02 * < LOD < LOD < LOD 767 < LOD - 08 * < LOD < LOD < LOD < LOD 499 07 < LOD 09 10 * < LOD - < LOD < LOD 602 Non - Hispanic blacks 99 - 00 * < LOD < LOD < LOD < LOD 445 01 02 * < LOD < LOD < LOD < LOD 775 - 07 * < LOD < LOD 08 < LOD < LOD 571 - 09 - 10 * < LOD < LOD < LOD < LOD 503 - 99 - 00 * < LOD < LOD < LOD < LOD 527 Non Hispanic whites - 02 * < LOD 01 < LOD < LOD 1280 < LOD 07 - 08 * < LOD < LOD < LOD < LOD 1082 < LOD 10 * < LOD - < LOD < LOD 1200 09 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. too * Not calculated: proportion of results below limit of detection was high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Deltamethrin_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 226

246 Urinary 4 - - 3 - phenoxybenzoic acid (1999 – 2010) Fluoro Metabolite of Cyfluthrin Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample 50th Percentile Geometric mean 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 00 * < LOD < LOD < LOD < LOD 1949 Total 99 02 * - < LOD < LOD < LOD < LOD 3048 01 .140 08 - < LOD < LOD < LOD (

247 Urinary 4 - - 3 - phenoxybenzoic acid (creatinine corrected) (1999 – 2010) Fluoro Metabolite of Cyfluthrin Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati onal Health and N utrition Examination Survey. Survey Sample 75th Percentile 90th Percentile 50th Percentile 95th Percentile Geometric mean Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 00 * < LOD < LOD < LOD < LOD Total 99 1949 - * < LOD < LOD < LOD < LOD 3046 01 02 .350 08 * < LOD < LOD < LOD - (

248 Urinary 3 - – 2010 ) Phenoxybenzoic acid (1999 Metabolite of Cypermethrin, Deltamethrin, and Permethrin Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an d Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size 00 .292 (.247 - .345) .250 (.190 - - .730 (.590 - .850) 1.75 (1.49 - 2.16) 4.33 (2.62 - 6.30) 1998 99 Total .320) 02 .318 (.275 - .368) .270 (.220 - .340) .700 (.570 - .810) 1.73 (1.49 - 2.16) 3.54 (2.69 - 5.25) 3048 01 - 08 .401 (.350 - .460) .390 (.340 - .450) 1.10 (.870 - 1.39) 3.22 (2.55 - 4.19) 6.63 (4.99 - 8.24) 2454 07 - - 10 .418 - - .449) .400 (.350 - .460) 1.06 (.970 - 1.19) 3.12 (2.69 3.77) 6.50 (5.57 - 8.04) 2723 09 (.389 Age group 6 99 - 00 .417 (.292 - .595) .320 (.210 - .490) 1.12 (.700 - 1.60) 4.18 (2.02 - 6.54) 8.63 (3.89 - 71.1) 483 - 11 years 01 02 .325 (.260 - .406) .300 (.200 - .420) .760 (.570 - 1.05) 1.81 (1.42 - 2.78) 3.38 (2.25 - 4.12) 580 - 1.55) - .397 (.339 - .464) .360 (.280 - .410) 1.13 (.780 - 3.40 (2.19 - 5.87) 9.88 (3.40 - 17.3) 371 07 08 - 10 .549 (.389 - .774) .480 (.350 - .700) 1.43 (1.00 - 2.15) 4.43 (2.80 - 8.04) 8.51 (4.12 - 39.4) 383 09 - 99 - 00 .336 (.265 - .427) .290 (.200 - .440) .870 19 years (.620 - 1.04) 1.93 (1.49 - 2.90) 4.33 (1.83 - 11.1) 682 12 01 - 02 .353 (.288 - .434) .300 (.250 - .390) .800 (.560 - 1.13) 1.86 (1.48 - 2.35) 3.45 (2.14 - 6.69) 831 07 08 .393 (.273 - .565) .360 (.200 - .640) 1.15 (.720 - 1.83) 2.96 (2.11 - 6.73) 7.42 (2.96 - 12.1) 361 - 09 - .403 (.346 - .470) .410 (.310 - .510) .970 (.810 - 1.29) 2.25 (1.80 - 3.19) 3.92 (2.55 - 5.85) 398 10 - 59 years - 00 .267 (.227 - .314) .230 (.160 - .300) .640 (.510 99 .820) 1.49 (1.25 - 1.78) 3.21 (2.04 - 5.41) 833 - 20 - 02 .314 (.271 - .364) .270 (.220 - .340) .670 - .780) 1.65 (1.27 - 2.34) 3.25 (2.51 - 6.16) 1128 01 (.530 07 08 .427 (.376 - .485) .420 (.370 - .470) 1.11 (.900 - 1.39) 3.38 (2.42 - 4.99) 6.65 (4.86 - 9.69) 1110 - 09 - 10 .416 (.382 - .454) .390 (.330 - .470) 1.07 (.930 - 1.23) 3.50 (2.67 - 4.45) 6.95 (5.57 - 9.31) 1296 - 02 60 years and older .303 (.233 - .394) .250 (.180 - .350) .690 (.490 - 1.10) 2.03 (1.45 - 3.68) 5.16 (2.77 - 6.61) 509 01 - 07 .335 (.270 - .416) .300 (.210 - .470) 1.05 (.690 08 1.54) 2.68 (1.84 - 3.97) 4.70 (2.83 - 6.43) 612 - 09 - 10 .382 (.343 - .427) .360 (.290 - .450) .980 (.860 - 1.17) 2.56 (2.07 - 2.88) 5.93 (3.21 - 8.95) 646 Gender 3.79) - 00 .273 (.226 - .330) .250 (.180 - .330) .710 (.570 - .820) 1.49 (1.29 - 1.73) 2.41 (1.92 - Males 974 99 (.570 01 02 .326 (.281 - .379) .300 (.230 - .360) .690 - - .750) 1.60 (1.37 - 2.15) 3.23 (2.56 - 5.25) 1429 07 - 08 .419 (.361 - .487) .430 (.370 - .500) 1.11 (.830 - 1.48) 3.12 (2.15 - 4.58) 5.91 (4.19 - 7.56) 1215 09 10 .421 (.391 - .454) .400 (.340 - .450) 1.07 (.900 - 1.29) 3.21 (2.51 - 4.45) 6.50 (5.51 - 9.07) 1331 - 99 00 .311 (.253 - .384) .250 (.190 - .340) .740 (.510 - .990) 2.30 (1.63 - 3.36) 6.03 (3.27 - 11.8) 1024 Females - - - .311 (.260 - .371) .250 (.200 - .320) .730 (.550 01 .920) 1.81 (1.53 - 2.47) 3.76 (2.51 - 6.55) 1619 02 - 07 .385 (.322 - .462) .360 (.290 - .450) 1.07 (.820 08 1.42) 3.30 (2.32 - 5.30) 6.79 (5.15 - 9.69) 1239 - 09 - 10 .415 (.366 - .471) .400 (.350 - .480) 1.06 (.910 - 1.26) 2.92 (2.51 - 3.84) 6.50 (4.89 - 8.50) 1392 Race/ethnicity - 00 .260 (.230 - .295) .230 (.190 - .270) .600 (.430 - .750) 1.35 (1.16 - 1.53) 2.18 (1.53 - 3.26) 697 Mexican Americans 99 01 - 02 .290 (.233 - .361) .260 (.190 - .350) .650 (.490 - .810) 1.26 (.860 - 2.17) 2.65 (1.50 - 3.44) 767 07 08 .369 (.302 - .451) .400 (.280 - .460) .940 (.740 - 1.15) 2.27 (1.58 - 3.39) 3.62 (2.70 - 12.7) 476 - (.750 10 .371 (.316 - .436) .380 (.300 - .480) .830 - - 1.02) 1.93 (1.55 - 2.53) 3.70 (2.53 - 4.81) 596 09 Non - Hispanic blacks 99 - 00 .454 (.352 - .586) .450 (.350 - .610) 1.13 (.750 - 1.46) 2.32 (1.45 - 5.35) 5.35 (2.32 - 21.1) 524 01 02 .507 (.430 - .599) .520 (.440 - .630) .980 (.840 - 1.20) 2.03 (1.72 - 2.52) 3.86 (3.05 - 5.84) 776 - - 07 .420 (.353 - .501) .430 (.320 - .540) 1.12 (.770 08 1.66) 3.11 (2.44 - 4.26) 6.13 (4.12 - 8.39) 533 - 09 - 10 .464 (.349 - .616) .500 (.360 - .650) 1.29 (.790 - 2.86 (2.07 - 4.59) 5.86 (3.42 - 8.50) 499 1.94) Non Hispanic whites 99 - 00 .288 (.233 - .355) .240 (.160 - .320) - (.530 - .850) 1.78 (1.41 - 3.05) 5.34 (2.62 - 8.43) 603 .710 01 - 02 .297 (.248 - .355) .240 (.190 - .320) .600 (.490 - .780) 1.75 (1.46 - 2.34) 3.70 (2.52 - 6.16) 1281 (.780 08 .394 (.329 - .470) .380 (.310 - .450) 1.09 - - 1.42) 3.38 (2.42 - 4.92) 6.53 (5.15 - 8.24) 1040 07 09 - 10 .412 (.384 - .441) .370 (.330 - .420) 1.06 (.920 - 1.19) 3.83 (2.82 - 4.46) 8.08 (5.93 - 11.1) 1192 08, Limit of detection (LOD, see Data Analysis section) for Survey years 99 - 00, 01 - 02, 07 - and 09 - 10 are 0.1, 0.1, 0.1, and 0.1 respectively. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Cyhalothrin_Cypermethrin_Deltamethrin_Fenpropathrin_Permethrin_Tralomethrin_BiomonitoringSum mary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 229

249 Urinary 3 - – 2010) Phenoxybenzoic acid (creatinine corrected) (1999 Metabolite of Cypermethrin, Deltamethrin, and Permethrin Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati onal Health and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size 00 .261 (.224 - .304) .246 (.203 - - .550 (.459 - .629) 1.40 (1.13 - 1.73) 3.19 (2.16 - 4.55) 1998 99 Total .280) 02 .324 (.284 - .371) .290 (.247 - .336) .600 (.512 - .743) 1.54 (1.26 - 1.91) 3.35 (2.50 - 4.92) 3046 01 - 08 .426 (.374 - .485) .384 (.333 - .450) 1.02 (.886 - 1.19) 3.08 (2.31 - 4.04) 5.83 (4.52 - 7.51) 2452 07 - - 10 .438 - - .469) .384 (.342 - .432) 1.01 (.898 - 1.13) 2.88 (2.50 3.19) 5.44 (4.52 - 6.38) 2723 09 (.409 Age group 6 99 - 00 .450 (.299 - .677) .371 (.241 - .592) 1.13 (.733 - 1.62) 3.97 (1.75 - 8.07) 9.91 (2.43 - 64.0) 483 - 11 years 01 02 .423 (.335 - .534) .383 (.296 - .500) .864 (.594 - 1.35) 2.21 (1.61 - 2.95) 3.32 (2.64 - 5.40) 580 - 1.83) - .511 (.431 - .605) .448 (.363 - .545) 1.20 (.886 - 3.81 (2.13 - 7.27) 9.86 (3.81 - 15.7) 371 07 08 - 10 .744 (.537 - 1.03) .667 (.503 - .838) 1.87 (1.30 - 2.60) 4.73 (2.88 - 9.57) 10.2 (4.48 - 51.9) 383 09 - 99 - 00 .227 (.178 - .290) .205 (.156 - .269) .486 19 years (.379 - .732) 1.37 (1.03 - 1.62) 2.52 (1.41 - 4.44) 682 12 01 - 02 .274 (.229 - .328) .236 (.189 - .313) .539 - .730) 1.11 (.864 - 1.63) 2.35 (1.36 - 6.19) 830 (.424 - 08 .316 (.230 - .434) .281 (.191 - .425) .869 (.523 - 1.29) 3.13 (1.47 - 4.37) 5.41 (3.36 - 9.20) 359 07 09 - .347 (.302 - .399) .301 (.256 - .397) .733 (.575 - .903) 1.53 (1.33 - 2.46) 2.64 (1.76 - 3.75) 398 10 - 59 years - 00 .246 (.216 - .278) .239 (.200 - .272) .505 (.405 99 .590) 1.11 (.861 - 1.49) 2.53 (1.73 - 4.09) 833 - 20 - 02 .311 (.271 - .357) .282 (.245 - .328) .552 - .673) 1.44 (1.02 - 1.91) 3.22 (1.91 - 4.92) 1128 01 (.444 07 08 .443 (.384 - .510) .401 (.353 - .472) 1.01 (.867 - 1.16) 2.95 (2.22 - 4.04) 6.29 (4.18 - 8.05) 1110 - 09 - 10 .419 (.389 - .451) .365 (.326 - .421) .993 (.826 - 1.10) (2.35 - 3.62) 4.72 (4.17 - 6.15) 1296 2.93 60 years and older 01 - 02 .372 (.301 - .462) .319 (.241 - .406) .785 (.541 - 1.05) 2.16 (1.30 - 3.50) 4.65 (2.63 - 6.15) 508 - 07 .418 (.351 - .498) .363 (.288 - .473) 1.06 (.832 08 1.59) 3.11 (2.22 - 4.43) 4.93 (3.37 - 7.62) 612 - 09 - 10 .455 (.417 - .496) .397 (.342 - .455) 1.06 (.875 - 1.30) 2.88 (2.37 - 3.61) 5.44 (3.77 - 8.53) 646 Gender (.388 - 00 .210 (.173 - .253) .195 (.152 Males .254) .513 99 - .582) 1.09 (.841 - 1.41) 1.72 (1.49 - 2.52) 974 - 01 - 02 .269 (.233 - .310) .239 (.203 - .280) .500 (.429 - .571) 1.27 (1.05 - 1.59) 2.95 (1.74 - 4.00) 1429 07 08 .359 (.314 - .411) .333 (.291 - .392) .840 (.722 - 1.00) 2.58 (1.58 - 3.57) 4.42 (3.40 - 6.46) 1214 - 09 - .377 (.348 - .409) .323 (.295 - .368) .865 (.744 - 1.01) 2.48 (1.98 - 2.97) 4.72 (3.53 - 6.45) 1331 10 99 - 00 .323 (.270 - .387) .273 (.235 - .333) .608 (.477 .743) 1.94 (1.35 - 3.00) 5.04 (3.19 - 6.90) 1024 Females - - - .388 (.331 - .455) .344 (.284 - .408) .737 (.563 02 .938) 1.84 (1.46 - 2.35) 4.43 (2.62 - 5.59) 1617 01 07 - 08 .500 (.416 - .601) .433 (.355 - .540) 1.28 (.995 - 1.60) 3.56 (2.40 - 4.93) 7.20 (5.15 - 9.57) 1238 09 .505 10 (.453 - .564) .446 (.394 - .500) 1.15 (1.00 - 1.33) 3.19 (2.54 - 3.73) 5.86 (4.58 - 8.90) 1392 - Race/ethnicity 99 - 00 .234 (.202 - .272) .219 (.187 - .234) .475 (.368 - .594) 1.04 (.700 - 1.39) 1.67 (1.06 - 3.00) 697 Mexican Americans 01 - 02 .274 (.230 - .328) .242 (.206 .316) .512 (.404 - .654) 1.03 (.750 - 1.67) 1.83 (1.15 - 2.75) 767 - (.692 08 .386 (.320 - .466) .379 (.287 - .488) .911 - - 1.24) 1.94 (1.47 - 2.38) 3.16 (2.08 - 9.55) 475 07 09 - 10 .390 (.341 - .446) .355 (.305 - .438) .696 (.631 - .774) 1.62 (1.40 - 2.15) 3.22 (2.19 - 3.89) 596 Non - 99 - 00 .309 (.238 - .401) .268 (.224 - .353) .636 (.456 - .935) 1.49 (1.05 - 3.43) 3.86 (1.51 - 7.25) 524 Hispanic blacks 01 02 .374 (.308 - .455) .357 (.290 - .430) .675 (.561 - .817) 1.44 (1.20 - 2.31) 2.91 ( 2.03 - 3.76) 775 - 07 (.621 08 .335 (.287 - .391) .320 (.269 - .375) .748 - 1.03) 2.30 (1.68 - 3.35) 4.62 (3.21 - 6.54) 532 - (.587 10 .352 (.281 - .442) .360 (.289 - .436) .865 - - 1.21) 1.93 (1.48 - 2.59) 4.03 (2.43 - 4.91) 499 09 Non - Hispanic whites 99 - 00 .272 (.225 - .329) .250 (.200 - .292) .552 (.443 - .667) 1.55 (1.09 - 2.27) 4.02 (2.07 - 5.49) 603 (.468 02 .321 (.274 - .377) .281 (.238 - .333) .586 - - .811) 1.59 (1.26 - 2.19) 3.57 (2.25 - 5.59) 1280 01 07 - 08 .438 (.369 - .519) .368 (.304 - .488) 1.00 (.849 - 1.23) 3.41 (2.41 - 4.37) 6.29 (4.52 - 8.37) 1040 - 10 .451 (.417 - .488) .388 (.328 - .438) 1.07 (.889 - 1.25) 3.16 09 (2.63 - 3.71) 6.09 (4.69 - 9.08) 1192 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Cyhalothrin_Cypermethrin_Deltamethrin_Fenpropathrin_Permethrin_Tralomethrin_BiomonitoringSum mary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 230

250 Urinary Antimony (1999 – 2010) ntiles of urine concentrations (in μg/L) for the U.S. population from the National Health and Geometric mean and selected perce Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - .132 (.120 - .145) .130 (.120 - Total .220 (.200 .230) .330 (.300 - .350) .430 (.390 - .470) 2276 99 - 00 .150) 02 .134 (.126 - .142) .130 (.130 - .140) .190 (.180 - .200) .270 (.250 - .310) .350 (.320 - .400) 2690 01 - - * .080 (

251 Urinary Antimony (1999 – 2010) urine concentrations (in μg/L) for the U.S. population from the National Health and Geometric mean and selected percentiles of Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity - 00 .132 (.108 - Mexican Americans .140 (.120 - .170) .210 (.180 - .240) .300 (.260 - .390) .430 (.330 - .560) 787 99 .161) - 02 .142 (.130 - .154) .130 (.130 - .150) .200 - .230) .260 (.240 - .320) .360 (.300 - .400) 683 01 (.170 03 04 .093 (.079 - .110) .090 (

252 Urinary Antimony (2011 – 2014) rom the National Health and Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population f Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 * .047 (.042 - .052) Total .083 (.075 - .091) .144 (.125 - .158) .188 (.169 - .222) 2504 11 - 14 .043 (.039 - .048) .041 (.036 - .046) .076 (.069 - .086) .130 (.120 - .144) .189 - .214) 2664 13 (.170 Age group 11 years - 11 - 12 .064 (.059 - .069) .059 (.049 - .072) .108 (.094 - .124) .169 (.152 - .188) .206 (.182 - .257) 399 6 - - .052 (.045 - .060) .053 (.046 - .065) .096 (.089 14 .105) .151 (.128 - .172) .228 (.168 - .254) 402 13 - 19 years 11 - 12 .065 (.057 - .073) .065 (.048 - .081) .106 (.098 - .126) .173 (.137 - .202) .218 (.166 - .283) 12 390 - 14 .051 (.043 - .061) .051 (.041 - .062) .088 (.070 - .112) .138 (.121 - .166) .203 (.152 - .235) 451 13 11 12 * .044 (

253 Urinary Antimony (creati nine corrected) (1999 2010) – onal Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati Health and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 00 .124 (.108 - .143) .119 (.102 - .143) .185 (.164 - .214) .276 (.233 - .333) .385 (.333 Total .430) 2276 99 - - .126 (.119 - .134) .120 (.115 - .126) .173 (.162 - 02 .267 (.242 - .300) .364 (.320 - .414) 2689 01 .188) - 04 * .080 (

254 Urinary Antimony (creatinine corrected) (1999 – 2010) onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Survey Sample 95th Percentile Geometric mean 50th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 .120 (.107 - .135) .114 (.105 - .129) .167 (.148 - .203) .250 (.209 - .315) .333 (.280 - .357) 787 Mexican Americans - .138 (.128 - .149) .130 (.117 - .143) .182 (.159 - .203) .269 (.229 - .308) .338 (.308 - .429) 682 01 02 - 03 .086 (.076 - .098) .082 (

255 Urinary Antimony (creat inine corrected) (2011 2014) – onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 * .059 (.055 - .063) Total .092 (.085 - .100) .152 (.135 - .171) .223 (.181 - .261) 2502 11 - 14 .050 (.046 - .055) .047 (.044 - .051) .073 (.068 - .079) .114 (.103 - .127) .160 - .172) 2663 13 (.145 Age group 11 years - 11 - 12 .091 (.081 - .102) .091 (.078 - .100) .130 (.116 - .147) .206 (.153 - .283) .308 (.218 - .340) 398 6 - - .077 (.068 - .088) .076 (.067 - .084) .114 (.098 14 .133) .177 (.154 - .193) .225 (.191 - .238) 402 13 - 19 years 11 - 12 .062 (.055 - .069) .058 (.051 - .067) .085 (.070 - .106) .147 (.115 - .181) .222 (.122 - .373) 12 390 - 14 .046 (.041 - .053) .047 (.039 - .052) .064 (.057 - .071) .103 (.084 - .115) .144 (.109 - .172) 451 13 11 12 * .056 (

256 Urinary Total Arsenic (2003 – 2010) nd Geometric mean and selected percentiles of urine concentrations (in μg /L) for the U.S. population from the National Health a Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 8.30 (7.19 - 9.57) 7.70 (6.90 - Total 16.0 (14.1 18.7) 37.4 (31.6 - 43.5) 65.4 (48.7 - 83.3) 2557 03 - 04 8.90) 06 9.29 (8.05 - 10.7) 8.65 (7.48 - 9.99) 17.1 (14.9 - 20.6) 41.1 (33.3 - 49.7) 66.7 (53.7 - 87.0) 2576 05 - 08 8.10 (7.44 - 8.83) 7.49 (6.90 - 8.12) 14.9 (13.2 - 17.0) 33.3 (29.8 - 38.7) 50.8 (42.3 - 65.1) 2605 07 - - 10 9.28 - - 10.2) 8.15 (7.20 - 8.98) 18.0 (15.3 - 20.8) 44.6 (39.0 55.1) 85.6 (64.7 - 114) 2860 09 (8.47 Age group 11 years 6 03 - 04 7.08 (5.66 - 8.84) 6.80 (5.90 - 7.70) 10.9 (8.90 - 14.2) 24.6 (13.8 - 61.8) 46.9 (17.5 - 178) 290 - 05 06 7.19 (5.81 - 8.90) 6.96 (5.32 - 8.88) 11.5 (9.19 - 16.0) 19.6 (13.1 - 51.5) 34.1 (19.6 - 58.5) 355 - 12.3) - 6.85 (5.98 - 7.83) 6.40 (5.74 - 7.23) 10.8 (9.75 - 22.5 (16.9 - 34.7) 41.0 (21.1 - 52.8) 390 07 08 - 10 6.63 (5.74 - 7.66) 5.94 (5.14 - 7.19) 10.8 (9.37 - 12.5) 26.0 (18.2 - 33.4) 37.7 (27.8 - 65.6) 378 09 - 03 - 04 8.55 (7.34 - 9.97) 8.10 (6.80 - 9.40) 15.2 19 years (12.2 - 17.8) 30.5 (23.1 - 40.4) 46.1 (32.9 - 62.5) 725 12 05 - 06 8.19 (6.87 - 9.77) 7.92 (6.37 - 9.50) 14.0 (11.6 - 18.1) 28.2 (22.9 - 32.9) 41.9 (32.7 - 48.0) 701 - 08 7.09 (6.17 - 8.14) 6.87 (5.88 - 7.86) 11.4 (9.41 - 13.7) 20.4 (16.1 - 26.6) 38.2 (21.6 - 53.3) 373 07 09 - 6.45 (5.58 - 7.47) 6.11 (5.26 - 6.89) 10.8 (8.59 - 13.7) 25.9 (16.2 - 32.9) 38.8 (27.8 - 55.1) 454 10 19.7) 03 8.41 (7.25 - 9.77) 7.90 (7.00 - 9.10) 17.0 (15.0 - 04 40.5 (34.9 - 46.2) 66.2 (51.2 - 93.1) 1542 - 20 years and older - 06 9.76 (8.43 - 11.3) 9.12 (7.85 - 10.4) 18.9 (15.8 22.9) 44.2 (35.2 - 56.1) 71.4 (57.7 - 98.3) 1520 05 - 07 08 8.43 (7.70 - 9.22) 7.94 (7.09 - 8.67) 16.2 (14.5 - 18.6) 35.2 (30.4 - 42.3) 59.0 (44.2 - 75.6) 1842 - 09 - 10 10.2 (9.14 - 11.3) 8.75 (7.95 - 9.81) 20.4 (17.2 - 24.1) 52.1 (42.4 - 66.1) 93.1 (74.2 - 127) 2028 Gender - 04 9.50 (8.34 - 10.8) 8.90 (7.70 - 9.80) 17.6 (15.2 - 20.1) 41.6 (32.5 - 52.8) 65.8 (48.7 - 95.4) 1281 Males 03 05 - 06 10.1 (8.61 - 11.8) 8.95 (8.05 - 10.0) 18.3 (15.5 - 22.9) 40.8 (31.0 - 52.6) 63.7 (46.4 - 78.7) 1271 07 08 9.25 (8.28 - 10.3) 8.50 (7.37 - 9.53) 17.0 (14.6 - 19.4) 36.0 (32.1 - 44.2) 62.5 (44.3 - 84.6) 1318 - (16.1 10 10.1 (9.06 - 11.3) 8.80 (7.80 - 9.75) 20.4 - - 23.9) 47.4 (42.1 - 64.1) 89.1 (71.6 - 114) 1401 09 Females 03 - 04 7.30 (6.02 - 8.84) 6.90 (5.90 - 8.30) 15.0 (11.3 - 19.5) 33.4 (26.5 - 41.7) 60.5 (40.8 - 77.1) 1276 05 06 8.60 (7.38 - 10.0) 8.18 (6.64 - 9.97) 15.9 (13.7 - 19.9) 41.5 (32.2 - 53.7) 72.6 (54.8 - 122) 1305 - 07 - 7.14 (6.51 - 7.82) 6.54 (6.09 - 7.14) 12.7 (11.6 - 14.4) 30.1 (26.0 - 34.0) 49.1 (40.1 - 57.5) 1287 08 (31.7 - 8.55 09 (7.44 - 9.83) 7.63 (6.45 - 8.62) 15.8 (13.1 - 19.9) 41.5 10 - 55.5) 81.5 (54.3 - 132) 1459 Race/ethnicity 03 - 04 9.29 (8.12 - 10.6) 9.20 (8.10 - 10.3) 16.2 (13.5 - 19.9) 34.4 (24.0 - 60.5) 68.2 (41.3 - 111) 618 Mexican Americans 05 06 9.55 (8.54 - 10.7) 9.11 (7.99 - 10.3) 15.6 (14.0 - 17.1) 29.2 (21.4 - 56.8) 67.6 (41.7 - 81.4) 652 - - 07 8.98 (8.13 - 9.92) 8.84 (7.80 - 9.48) 15.4 (12.3 08 19.7) 35.2 (25.0 - 46.0) 53.0 (44.2 - 77.4) 510 - 09 - 10 8.47 (7.30 - 9.84) 7.96 (6.87 - 9.08) 13.9 (11.3 - 34.7 (25.0 - 53.2) 60.9 (49.3 - 78.7) 613 17.7) Non Hispanic blacks 03 - 04 11.6 (9.50 - 14.1) 10.4 (7.90 - 11.8) - (14.9 - 34.4) 43.5 (36.2 - 61.8) 78.0 (43.6 - 141) 722 21.5 05 - 06 11.0 (8.60 - 14.0) 9.55 (6.99 - 13.3) 21.9 (14.9 - 28.9) 44.9 (31.1 - 71.4) 82.3 (49.2 - 164) 692 07 08 10.5 (9.40 - 11.7) 9.21 (8.22 - 10.4) 18.4 (16.1 - 21.5) 42.4 (32.9 - 52.8) 65.6 (45.5 - 112) 585 - 09 24.2) 10 10.9 (9.46 - 12.5) 9.26 (7.70 - 11.4) 21.7 (17.6 - 49.1 (32.2 - 81.7) 84.8 (51.3 - 174) 546 - - 03 - 04 7.12 (6.13 - 8.27) 7.00 (6.10 - 7.90) 13.7 Non (11.3 - 15.8) 29.0 (22.6 - 35.9) 53.1 (38.4 - 65.6) 1074 Hispanic whites 05 - 06 8.66 (7.20 - 10.4) 8.05 (6.52 - 9.66) 16.3 (13.4 - 20.6) 40.8 (29.4 - 50.2) 58.5 (46.0 - 88.0) 1041 (11.3 08 6.98 (6.31 - 7.71) 6.46 (5.93 - 7.29) 12.4 - - 14.3) 28.3 (21.6 - 32.6) 42.1 (32.3 - 50.0) 1088 07 09 - 10 8.18 (7.46 - 8.96) 7.24 (6.46 - 8.21) 14.8 (12.7 - 17.4) 38.9 (31.7 - 44.4) 66.3 (49.3 - 88.7) 1224 Limit of detection (LOD, see Data Analysis section) for Survey years 03 - 04, 05 - 06, 07 - 08 and 09 - 10 are 0.74, 0.74, 0.74, and 0.74 respectively. Biomonitoring S ummary http://www.cdc.gov/biomonitoring/Arsenic_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Arsenic_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 237

257 Urinary Total Arsenic (2011 – 2014) trations (in μg As/L) for the U.S. population from the National Health and Geometric mean and selected percentiles of urine concen Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 6.85 (5.85 - 8.02) 6.09 (5.22 Total 7.12) 13.0 (10.9 - 16.6) 32.0 (25.9 - 39.0) 52.5 (41.9 - 66.2) 2504 11 - - 14 6.29 (5.58 - 7.08) 5.82 (5.10 - 6.69) 11.7 (10.5 - 13.2) 26.6 (23.7 - 30.1) (37.5 - 56.1) 2662 13 46.0 Age group 11 years - 11 - 12 6.02 (5.03 - 7.19) 5.50 (4.58 - 6.56) 10.5 (7.93 - 14.1) 30.1 (16.7 - 46.5) 53.0 (37.5 - 70.3) 399 6 - - 5.21 (4.57 - 5.95) 4.78 (4.27 - 5.57) 8.79 (7.52 14 10.3) 17.1 (12.4 - 25.3) 29.0 (17.9 - 47.7) 402 13 - 19 years 11 - 12 6.01 (4.45 - 8.11) 5.26 (3.95 - 7.47) 10.9 (7.74 - 16.9) 25.9 (16.6 - 44.0) 44.0 (25.9 - 153) 390 12 13 14 5.79 (4.96 - 6.75) 5.33 (4.83 - 5.91) 9.40 (8.44 - 11.8) 22.0 (17.4 - 28.1) 44.1 (27.0 - 90.8) 451 - 11 12 7.09 (6.03 - 8.33) 6.31 (5.32 - 7.45) 13.6 (11.3 - 18.3) 33.2 (26.7 - 39.5) 52.5 (41.9 - 77.3) 1715 20 years and older - - - 6.49 (5.72 - 7.36) 6.12 (5.22 - 7.06) 12.1 (10.9 14 14.2) 27.9 (24.1 - 32.1) 48.0 (37.5 - 57.5) 1809 13 Gender - - 12 7.69 (6.35 - 9.31) 6.84 (5.33 Males 8.59) 15.4 (11.7 - 19.7) 33.5 (27.7 - 41.9) 56.5 (42.2 - 78.0) 1262 11 13 (10.8 14 6.67 (5.97 - 7.46) 6.37 (5.68 - 7.12) 11.7 - 13.0) 27.0 (22.3 - 32.5) 48.5 (33.3 - 57.5) 1316 - (9.85 Females - 12 6.14 (5.22 - 7.22) 5.42 (4.79 - 6.25) 11.6 11 - 13.7) 29.0 (22.5 - 38.2) 50.6 (37.5 - 79.8) 1242 13 - 14 5.94 (5.18 - 6.80) 5.38 (4.68 - 6.28) 11.2 (9.49 - 13.7) 26.0 (21.8 - 31.1) 43.6 (36.0 - 55.8) 1346 Race/ethnicity 11 12 7.12 (5.73 - 8.84) 6.94 (5.34 - 8.70) 12.2 (9.84 - 16.5) 24.2 (18.4 - 35.7) 44.0 (23.8 - 70.3) 317 Mexican Americans - - - 5.73 (5.01 - 6.56) 5.64 (4.93 - 6.47) 9.19 (8.10 14 10.2) 17.5 (11.2 - 36.6) 36.6 (15.4 - 73.0) 453 13 - Hispanic blacks 11 - 12 9.31 (7.19 - 12.0) 8.18 (6.16 - 10.8) 17.9 Non - 25.3) 46.8 (28.8 - 76.5) 82.1 (53.1 - 107) 669 (13.1 - 14 8.17 (6.87 - 9.72) 6.99 (6.01 - 8.20) 14.9 (10.9 - 18.2) 30.7 (25.5 - 38.2) 59.8 (40.0 - 79.0) 579 13 - 11 - 12 5.89 (4.92 - 7.06) 5.08 (4.56 - 6.06) 10.8 Non (8.48 - 15.5) 26.3 (20.3 - 34.9) 43.2 (34.9 - 56.0) 820 Hispanic whites 13 - 14 5.67 (4.88 - 6.59) 5.30 (4.40 - 6.62) 11.0 (9.16 - 12.7) 22.4 (17.6 - 29.9) 39.0 (30.8 - 50.6) 985 All Hispanics - 12 7.62 (6.63 - 8.76) 7.32 (6.31 - 8.35) 13.7 (11.7 - 16.6) 25.8 (21.2 - 29.8) 45.6 (28.7 - 55.8) 573 11 (9.11 13 14 6.16 (5.24 - 7.22) 5.93 (5.02 - 6.82) 10.4 - - 11.9) 20.2 (14.2 - 30.1) 37.5 (24.1 - 57.9) 701 Asians 11 - 12 16.7 (14.7 - 18.9) 14.9 (12.8 - 19.0) 39.0 (33.2 - 44.8) 83.2 (61.4 - 108) 117 (88.4 - 145) 353 (23.2 14 12.1 (10.4 - 14.1) 11.5 (9.08 - 13.6) 30.8 - - 37.0) 70.7 (52.5 - 90.8) 126 (79.2 - 181) 292 13 Limit of detection (LOD, see Data Analysis section) for Survey year 11 - 12 and 13 - 14 are 1.25 and 0.26. Biomonitoring Summary http://www.cdc.gov/biomonitoring/ Arsenic_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Arsenic_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 238

258 Urinary Total Arsenic (creatinine corrected) (2003 – 2010) ional Geometric mean and selected percentiles of urine concentrations (in μg /g of creatinine) for the U.S. population from the Nat Health and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 8.24 (7.07 - 9.59) 7.04 (5.93 - 8.51) 14.1 (11.6 - 17.2) 30.4 (26.0 - 38.7) 50.4 (40.3 Total 64.5) 2557 03 - - 9.15 (7.93 - 10.6) 7.70 (6.55 - 8.98) 15.2 (11.7 - 06 35.1 (26.5 - 44.7) 62.8 (44.7 - 85.0) 2576 05 19.4) - 08 8.46 (7.78 - 9.21) 7.06 (6.56 - 7.74) 13.8 (12.5 - 15.2) 28.9 (24.2 - 36.7) (38.8 - 70.5) 2605 07 49.0 09 10 9.90 (9.06 - 10.8) 7.90 (6.98 - 8.97) 17.6 (15.4 - 20.2) 45.2 (36.6 - 53.3) 80.8 (60.5 - 94.4) 2860 - Age group 11 years 03 - 04 8.25 (6.58 - 10.3) 7.18 (5.93 - 9.45) 11.7 (9.10 - 16.3) 22.2 (12.0 - 69.5) 40.1 (14.7 - 6 290 - 188) 05 06 8.88 (7.05 - 11.2) 7.87 (6.19 - 9.42) 11.8 (9.32 - 18.9) 24.5 (13.0 - 62.8) 45.4 (22.9 - 80.9) 355 - 07 - 08 8.87 (8.06 - 9.77) 7.53 (6.73 - 7.88) 13.4 (10.2 - 16.0) 26.7 (19.9 - 34.0) 37.2 (28.6 - 71.4) 390 - 10 8.97 (7.93 - 10.2) 7.42 (6.70 - 8.32) 11.0 (9.90 - 14.0) 33.5 (17.0 - 54.6) 60.8 (36.6 - 84.9) 378 09 - 19 years 03 - 04 6.11 (5.23 - 7.13) 5.06 (4.47 - 6.04) 9.66 (7.44 - 11.2) 17.8 (12.0 - 26.0) 27.8 (20.7 - 35.9) 725 12 - - 6.30 (5.56 - 7.14) 5.19 (4.80 - 6.19) 9.62 (8.12 06 11.1) 19.4 (13.9 - 25.8) 28.0 (21.9 - 33.2) 701 05 07 - 08 5.50 (4.91 - 6.16) 4.96 (4.25 - 5.40) 7.69 (6.09 - 9.31) 16.8 (10.8 - 21.1) 22.5 (16.8 - 29.1) 373 09 10 6.06 (5.34 - 6.87) 4.95 (4.39 - 5.81) 9.18 (7.00 - 11.0) 19.2 (14.5 - 21.3) 28.4 (20.8 - 35.7) 454 - - 04 8.64 (7.38 - 10.1) 7.47 (6.20 - 9.01) 15.4 (12.7 - 18.8) 33.8 (27.3 - 41.2) 53.9 (45.4 - 64.5) 1542 20 years and older 03 05 - 06 9.75 (8.46 - 11.2) 8.22 (6.98 - 9.75) 17.0 - 21.3) 41.0 (29.6 - 52.5) 68.4 (52.8 - 89.7) 1520 (12.8 - 08 9.00 (8.20 - 9.88) 7.55 (6.79 - 8.53) 14.9 07 - 17.1) 32.5 (25.8 - 41.0) 59.4 (41.0 - 86.2) 1842 (13.1 09 - 10 10.8 (9.71 - 12.0) 8.73 (7.69 - 9.71) 20.1 (16.5 - 24.2) 50.8 (40.5 - 59.7) 87.3 (70.0 - 105) 2028 Gender 03 04 8.00 (6.81 - 9.40) 6.75 (5.66 - 8.35) 13.7 (11.0 - 18.0) 28.7 (25.1 - 36.4) 45.6 (35.3 - 62.1) 1281 Males - 18.0) - 8.26 (7.09 - 9.63) 7.16 (5.87 - 8.54) 12.9 (10.2 - 28.8 (22.9 - 36.3) 46.1 (35.1 - 66.5) 1271 05 06 - 08 8.30 (7.49 - 9.18) 6.79 (6.39 - 7.61) 13.2 (11.8 15.2) 28.9 (23.5 - 38.5) 47.7 (35.7 - 68.1) 1318 07 - 09 10 9.21 (8.55 - 9.93) 7.22 (6.43 - 8.67) 17.0 (14.9 - 18.6) 41.8 (35.4 - 47.9) 66.9 (52.0 - 81.5) 1401 - 03 - 04 8.47 (7.12 - 10.1) 7.33 (6.10 - 8.75) 14.4 (11.7 - 17.7) Females (24.2 - 46.6) 58.4 (42.8 - 75.0) 1276 32.3 - 06 10.1 (8.72 - 11.7) 8.29 (7.23 - 9.87) 17.4 (13.0 - 21.4) 43.8 (29.2 - 61.5) 74.1 (55.0 - 96.2) 1305 05 - 07 8.63 (7.91 - 9.41) 7.13 (6.53 - 8.33) 14.1 (12.3 08 16.9) 27.9 (24.1 - 37.0) 51.4 (39.7 - 83.3) 1287 - 09 - 10 10.6 (9.36 - 12.0) 8.38 (7.40 - 9.41) 18.6 (14.9 - 23.9) 50.8 (35.1 - 72.9) 87.8 (66.8 - 109) 1459 Race/ethnicity (10.2 - 04 8.61 (7.33 - 10.1) 7.76 (6.30 Mexican Americans 9.44) 12.6 03 - 15.9) 24.0 (17.7 - 34.8) 42.4 (24.8 - 62.4) 618 - 05 - 06 8.98 (7.89 - 10.2) 7.48 (6.72 - 8.87) 12.8 (11.0 - 16.3) 28.1 (21.1 - 35.5) 49.1 (31.0 - 108) 652 07 08 8.88 (7.71 - 10.2) 7.38 (6.51 - 8.63) 14.1 (10.6 - 17.8) 28.6 (22.5 - 35.3) 48.2 (31.1 - 75.7) 510 - - 09 8.88 (7.87 - 10.0) 7.62 (6.69 - 8.45) 13.2 (10.7 10 17.2) 31.4 (23.7 - 38.5) 49.8 (37.5 - 68.9) 613 - - Hispanic blacks 03 - 04 8.31 (6.99 - 9.88) 6.88 (5.66 - 8.41) 13.8 (11.5 - 17.0) 27.6 (17.9 - 56.0) 54.3 (27.5 - 120) 722 Non - 06 7.96 (6.40 - 9.92) 6.48 (5.21 - 8.30) 13.4 (10.0 - 18.6) 32.5 (18.7 - 66.5) 71.4 (35.6 - 98.8) 692 05 (11.5 07 08 7.72 (6.98 - 8.54) 6.60 (6.01 - 7.56) 13.4 - - 15.4) 25.7 (22.1 - 30.0) 42.7 (31.4 - 60.3) 585 09 - 10 8.67 (7.54 - 9.98) 7.26 (5.96 - 9.02) 15.6 (12.4 - 21.3) 38.7 (31.5 - 48.7) 63.9 (43.1 - 102) 546 Non 03 - 04 7.50 (6.25 - 9.01) 6.32 (5.28 - 7.96) 12.5 (9.86 - 17.1) 26.8 (21.8 - 32.0) 40.0 (31.3 - 53.9) 1074 Hispanic whites - - 06 9.01 (7.57 - 10.7) 7.68 (6.18 - 9.56) 14.3 05 - 20.8) 31.9 (24.1 - 46.1) 59.4 (37.9 - 96.2) 1041 (11.1 07 - 08 7.82 (7.05 - 8.68) 6.72 (6.00 - 7.54) 12.5 (11.1 - 13.9) 24.6 (19.6 - 32.3) 43.1 (29.1 - 64.0) 1088 (30.4 - 10 9.14 (8.35 - 10.0) 7.10 (6.43 - 8.06) 15.8 (13.7 - 18.4) 40.9 09 - 50.8) 66.4 (50.9 - 90.0) 1224 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Arsenic_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Arsenic_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 239

259 Urinary Total Arsenic (creatinine corrected) (2011 – 2014) ation al Geometric mean and selected percentiles of urine concentrations (in μg As/g of creatinine) for the U.S. population from the N Health and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 12 7.77 (6.85 - 8.81) 6.39 (5.57 Total 7.24) 13.7 (11.5 - 16.5) 30.8 (24.6 - 38.6) 50.4 (38.2 - 70.1) 2502 11 - - 14 7.27 (6.62 - 7.99) 6.10 (5.39 - 6.88) 11.9 (10.5 - 13.5) 27.6 (23.8 - 32.8) 52.0 (43.5 - 60.9) 2661 13 Age group 11 years - 11 - 12 8.63 (7.26 - 10.3) 6.87 (5.84 - 8.00) 12.3 (9.58 - 15.5) 27.7 (17.7 - 57.7) 91.2 (26.2 - 129) 398 6 - - 7.78 (7.08 - 8.54) 6.91 (5.91 - 7.65) 12.5 (10.3 14 13.6) 17.7 (16.1 - 21.1) 29.9 (20.4 - 52.1) 402 13 - 19 years 11 - 12 5.75 (4.49 - 7.36) 4.69 (3.70 - 5.73) 8.73 12 (6.26 - 13.3) 22.1 (11.5 - 52.6) 34.9 (21.1 - 159) 390 - 14 5.24 (4.53 - 6.06) 4.21 (3.61 - 4.61) 7.92 (5.75 - 10.3) 17.6 (12.6 - 23.0) 30.5 (20.3 - 54.1) 451 13 - 12 8.04 (7.07 - 9.14) 6.52 (5.88 - 7.69) 14.8 (12.1 - 18.8) 32.4 (25.2 - 39.8) 49.7 (38.2 - 70.1) 1714 20 years and older 11 13 - 14 7.58 (6.87 - 8.36) 6.39 (5.66 - 7.29) 12.4 (10.9 - 14.7) 31.0 (26.0 - 37.9) 54.0 (47.9 - 66.1) 1808 Gender 69.6) - 12 7.20 (6.15 - 8.43) 6.13 (5.18 - 7.23) 12.5 (10.5 - 15.2) 28.3 (20.2 - 34.9) 50.4 (33.3 - Males 1261 11 (9.50 13 14 6.69 (6.07 - 7.38) 5.55 (4.96 - 6.26) 10.9 - - 12.5) 26.0 (19.5 - 30.6) 47.9 (36.5 - 55.3) 1315 Females 11 - 12 8.35 (7.40 - 9.42) 6.64 (6.12 - 7.37) 15.0 (12.2 - 19.1) 33.1 (26.1 - 41.4) 50.7 (39.8 - 79.0) 1241 13 14 7.88 (7.03 - 8.82) 6.67 (5.82 - 7.78) 13.1 (10.9 - 15.6) 31.3 (24.9 - 39.4) 54.1 (46.3 - 68.3) 1346 - Race/ethnicity - 11 12 8.00 (6.85 - 9.36) 6.91 (6.07 - 11.9 (9.05 - 14.6) 26.1 (16.7 - 39.4) 40.8 (24.0 - 70.1) 317 Mexican Americans 7.98) 13 - 14 6.54 (5.70 - 7.51) 5.83 (5.08 - 6.54) 8.97 (7.32 - 11.6) 17.1 (12.6 - 20.8) 29.2 (15.1 - 72.2) 453 Non Hispanic blacks 11 - 12 7.24 (5.51 - 9.51) 5.83 (4.65 - 7.96) 13.5 (9.02 - 19.0) 28.8 (21.5 - 46.3) 55.4 (31.6 - 87.1) 669 - - 14 6.23 (5.25 - 7.39) 4.86 (4.24 - 6.22) 10.3 13 - 13.4) 22.7 (17.8 - 29.1) 37.4 (25.8 - 70.5) 579 (8.03 Non - Hispanic whites 11 - 12 7.13 (6.05 - 8.39) 5.72 (5.05 - 6.70) 12.4 (10.3 - 15.4) 28.4 (21.7 - 37.5) 46.5 (33.1 - 75.8) 818 13 14 7.01 (6.25 - 7.87) 5.87 (5.13 - 6.88) 11.6 (9.92 - 13.7) 27.5 (21.6 - 35.8) 49.5 (40.8 - 55.3) 984 - (11.2 All Hispanics - 12 8.53 (7.74 - 9.40) 7.60 (6.84 - 8.42) 12.8 11 - 14.1) 25.3 (20.8 - 30.8) 37.5 (28.2 - 50.6) 573 13 - 14 6.87 (6.08 - 7.76) 6.26 (5.36 - 6.89) 10.3 (8.75 - 11.9) 18.7 (14.3 - 24.0) 28.7 (18.9 - 50.7) 701 (32.2 Asians - 12 22.3 (19.1 - 26.1) 20.1 (16.3 - 25.2) 39.4 11 - 61.0) 100 (73.2 - 129) 162 (114 - 202) 353 13 - 14 19.0 (16.1 - 22.5) 15.2 (13.0 - 19.2) 41.9 (31.1 - 59.2) 95.0 (74.2 - 131) 137 (111 - 229) 292 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Arsenic_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Arsenic_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 240

260 Urinary Inorganic - – 2010) related Arsenic Species (2003 cid, and monomethylarsonic acid** Sum of arsenic acid, arsenous acid, dimethylarsinic a and Geometric mean and selected percentiles of urine concentrations (in μg As/L) for the U.S. population from the National Health Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 04 6.52 (6.03 - 7.04) 6.10 (5.50 - 6.40) 8.60 (8.00 - 9.50) Total (12.5 - 15.4) 19.1 (15.8 - 22.9) 2572 03 14.0 - 6.84 (6.35 - 7.38) 6.40 (5.88 - 6.85) 9.00 (8.19 - 06 13.9 (12.0 - 16.5) 18.5 (15.8 - 21.7) 2588 05 10.0) - 08 6.47 (6.20 - 6.76) 6.02 (5.74 - 6.26) 8.55 (8.03 - 9.22) 12.9 (11.8 - 16.8 (14.7 - 18.9) 2576 07 14.0) 09 10 6.56 (6.23 - 6.90) 5.87 (5.57 - 6.09) 8.80 (8.14 - 9.47) 14.6 (12.3 - 17.2) 20.8 (17.8 - 24.5) 2852 - Age group 11 years 03 - 04 6.46 (5.67 - 7.35) 6.10 (5.80 - 6.90) 8.50 (7.10 - 10.0) 12.1 (10.0 - 14.7) 15.0 (10.7 - 6 292 - 26.3) 05 06 6.71 (6.13 - 7.35) 6.27 (5.44 - 6.98) 8.46 (7.48 - 9.72) 13.5 (9.72 - 16.1) 16.1 (14.0 - 18.3) 354 - 07 - 08 6.70 (6.15 - 7.31) 6.08 (5.77 - 6.44) 8.78 (7.72 - 10.3) 13.9 (10.9 - 16.5) 18.3 (12.2 - 390 42.3) - 10 6.29 (5.85 - 6.75) 5.80 (5.11 - 6.32) 8.34 (7.67 - 9.07) 13.2 (10.7 - 14.6) 16.0 (14.0 - 17.9) 379 09 - 19 years 03 - 04 6.72 (6.08 - 7.42) 6.10 (5.90 - 7.00) 8.80 (7.70 - 10.4) 13.1 (10.6 - 16.6) 16.7 (14.5 - 20.3) 729 12 - - 6.82 (6.18 - 7.53) 6.38 (5.67 - 7.45) 8.78 (7.77 06 10.4) 13.1 (10.9 - 15.4) 16.4 (13.3 - 17.7) 703 05 07 - 08 6.42 (5.89 - 6.99) 6.34 (5.60 - 6.95) 8.15 (7.33 - 9.69) 11.8 (10.5 - 13.4) 14.6 (12.0 - 18.1) 366 09 10 5.84 (5.43 - 6.27) 5.31 (4.89 - 5.85) 7.67 (6.79 - 8.60) 11.4 (9.66 - 13.1) 13.9 (11.8 - 17.0) 453 - - 04 6.49 (6.02 - 7.00) 6.00 (5.30 - 6.20) 8.60 (8.10 - 9.40) 14.1 (12.7 - 15.6) 19.5 (16.8 - 24.9) 1550 20 years and older 03 05 - 06 6.86 (6.34 - 7.42) 6.43 (5.83 - 6.87) 9.10 - 10.2) 14.1 (12.0 - 17.3) 19.9 (15.8 - 24.0) 1531 (8.22 - 08 6.46 (6.17 - 6.76) 5.95 (5.71 - 6.18) 8.57 07 - 9.40) 13.0 (11.8 - 14.2) 17.2 (15.0 - 19.2) 1820 (8.00 09 - 10 6.70 (6.33 - 7.10) 5.95 (5.71 - 6.20) 9.12 (8.20 - 9.87) 15.4 (12.6 - 19.6) 23.2 (19.4 - 27.4) 2020 Gender 03 04 7.03 (6.38 - 7.74) 6.40 (6.00 - 7.10) 9.20 (8.30 - 10.5) 14.8 (12.7 - 18.1) 21.3 (16.0 - 28.1) 1283 Males - 10.5) - 7.10 (6.56 - 7.68) 6.59 (6.10 - 7.05) 9.37 (8.22 - 14.3 (11.6 - 17.7) 18.4 (14.9 - 23.1) 1276 05 06 - 08 6.94 (6.54 - 7.36) 6.44 (6.13 - 6.87) 9.22 (8.53 - 9.89) 13.5 (12.4 - 15.2) 18.3 (14.9 - 26.4) 1289 07 09 - 6.80 (6.30 - 7.34) 6.09 (5.71 - 6.54) 9.06 (8.27 - 9.89) 15.0 (12.0 - 20.4) 23.5 (16.3 - 29.4) 1396 10 - 04 6.08 (5.62 - 6.57) 5.50 (5.10 - 6.10) 8.10 (7.10 - 9.10) 12.7 (11.1 - 14.9) 17.3 (14.6 - 21.9) 1289 Females 03 05 - 06 (6.11 - 7.14) 6.14 (5.47 - 6.81) 8.77 (8.06 - 9.51) 13.3 (11.7 - 16.2) 18.6 (15.8 - 22.0) 1312 6.60 - 08 6.06 (5.81 - 6.33) 5.66 (5.42 - 5.84) 7.96 (7.35 - 8.59) 11.9 (10.7 - 13.7) 15.8 (14.0 - 16.8) 1287 07 - 09 6.33 (5.98 - 6.70) 5.64 (5.21 - 5.95) 8.36 (7.70 10 9.60) 14.2 (12.1 - 16.2) 19.6 (17.8 - 21.1) 1456 - Race/ethnicity - - 04 7.72 (7.09 - 8.41) 7.10 (6.50 Mexican Americans 8.00) 10.1 (9.10 - 11.8) 15.5 (12.8 - 20.5) 22.7 (16.5 - 29.4) 622 03 (9.21 05 06 7.27 (6.94 - 7.62) 7.05 (6.69 - 7.42) 9.83 - - 10.5) 12.5 (11.7 - 14.5) 16.1 (13.9 - 18.5) 651 07 - 08 7.22 (6.80 - 7.66) 7.02 (6.43 - 7.46) 9.89 (9.18 - 10.3) 12.7 (11.3 - 14.3) 15.3 (13.6 - 23.3) 513 09 10 6.76 (6.19 - 7.38) 6.31 (5.48 - 7.19) 9.12 (8.06 - 10.3) 14.1 (11.9 - 16.5) 19.8 (15.8 - 22.2) 618 - - 03 - 04 7.04 (6.42 - 7.73) 6.50 (6.10 - 7.30) 9.30 (8.70 - 10.3) 15.7 (12.3 - 18.1) 19.4 (17.1 - 21.4) 725 Non Hispanic blacks 05 06 7.05 (6.36 - 7.82) 6.48 (5.73 - 7.16) 8.85 (7.77 - 9.80) 14.0 (11.0 - 16.5) 17.9 (14.5 - 31.0) 695 - (8.55 08 7.06 (6.76 - 7.38) 6.45 (6.00 - 6.81) 9.43 - - 10.3) 14.5 (13.3 - 15.8) 18.5 (15.8 - 23.5) 586 07 09 - 10 7.03 (6.44 - 7.67) 6.28 (5.66 - 6.92) 9.84 (8.48 - 11.4) 16.0 (12.7 - 19.9) 22.2 (17.8 - 33.5) 543 Non 03 - 04 5.96 (5.54 - 6.41) 5.50 (5.10 - 6.10) 7.70 (7.10 - 8.50) 12.0 (9.80 - 13.7) 15.1 (12.8 - 18.1) 1081 Hispanic whites - - 06 6.55 (5.96 - 7.20) 6.10 (5.42 - 6.83) 8.50 05 - 9.73) 13.3 (11.1 - 16.2) 17.3 (14.1 - 21.4) 1050 (7.74 07 - 08 5.95 (5.69 - 6.23) 5.66 (5.35 - 5.96) 7.72 (7.26 - 8.25) 11.1 (10.3 - 12.2) 14.0 (12.5 - 16.1) 1063 13.3) - 10 5.96 (5.75 - 6.18) 5.46 (5.22 - 5.65) 7.89 (7.56 - 8.19) 11.5 (10.1 - 09 15.3 (13.3 - 18.8) 1210 **See Calculation of Inorganic related Arsenic Species for additional information . - Biomonitoring Summary http://www.cdc.gov/biomonitoring/Arsenic_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Arsenic_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 241

261 Urinary Inorganic - – 2014) related Arsenic Species (2011 senic acid, and methylarsonic acid** Sum of arsenic acid, arsenous acid, dimethylar and Geometric mean and selected percentiles of urine concentrations (in μg As/L) for the U.S. population from the National Health Nutrition Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 Total (5.24 - 5.96) 5.15 (4.73 - 5.56) 7.73 (7.09 - 8.57) 12.2 (11.1 - 13.9) 17.2 (14.6 - 19.9) 2517 11 5.59 - 14 4.80 (4.53 - 5.09) 4.53 (4.18 - 4.94) 7.22 (6.74 - 7.70) 11.2 (10.3 - 14.7 (13.5 - 16.8) 2654 13 12.0) Age group 11 years - 11 - 12 5.48 (5.05 - 5.95) 5.36 (4.50 - 5.98) 7.58 (7.08 - 8.34) 11.2 (9.93 - 12.1) 13.4 (11.6 - 16.2) 401 6 - - 4.91 (4.44 - 5.43) 4.59 (4.02 - 5.00) 7.21 (6.20 14 8.38) 11.3 (9.91 - 13.9) 14.2 (11.4 - 19.6) 397 13 - 19 years 11 - 12 5.37 (4.67 - 6.17) 5.09 (4.24 - 6.00) 12 7.28 (6.27 - 8.32) 11.1 (8.34 - 14.9) 15.6 (10.8 - 23.9) 392 - 14 5.09 (4.64 - 5.57) 5.02 (4.51 - 5.46) 7.29 (6.53 - 8.08) 11.9 (9.80 - 13.7) 14.5 (12.5 - 15.9) 450 13 - 12 5.64 (5.28 - 6.01) 5.15 (4.71 - 5.57) 7.83 (7.07 - 8.88) 12.5 (11.2 - 14.8) 17.6 (15.2 - 20.0) 1724 20 years and older 11 13 - 14 4.75 (4.46 - 5.05) 4.45 (4.08 - 4.91) 7.20 (6.63 - 7.72) 11.2 (10.3 - 11.8) 14.8 (12.9 - 17.1) 1807 Gender 20.8) - 12 6.00 (5.52 - 6.52) 5.63 (5.11 - 6.28) 8.31 (7.29 - 9.94) 13.4 (11.7 - 16.5) 18.8 (16.7 - Males 1264 11 (7.09 13 14 5.02 (4.78 - 5.28) 4.92 (4.45 - 5.32) 7.45 - - 7.94) 11.4 (10.3 - 12.1) 14.8 (13.5 - 16.1) 1308 Females 11 - 12 5.23 (4.90 - 5.58) 4.70 (4.36 - 5.05) 7.16 (6.47 - 8.01) 11.6 (10.1 - 12.9) 14.9 (12.3 - 20.5) 1253 13 14 4.59 (4.26 - 4.96) 4.29 (3.87 - 4.69) 6.94 (5.99 - 7.67) 10.8 (10.0 - 12.1) 14.7 (12.8 - 18.3) 1346 - Race/ethnicity - 11 12 5.76 (5.37 - 6.18) 5.26 (5.02 - 7.71 (7.37 - 8.54) 11.9 (10.1 - 13.8) 16.8 (12.1 - 19.9) 317 Mexican Americans 5.77) 13 - 14 5.01 (4.77 - 5.27) 5.14 (4.62 - 5.52) 7.21 (6.84 - 7.70) 10.3 (9.54 - 11.3) 12.4 (11.2 - 16.2) 455 Non Hispanic blacks 11 - 12 6.20 (5.52 - 6.97) 5.77 (5.09 - 6.42) 8.81 (7.43 - 10.6) 14.4 (12.1 - 18.0) 20.5 (16.5 - 25.4) 672 - - 14 5.58 (5.03 - 6.20) 5.28 (4.84 - 5.81) 7.81 13 - 9.63) 13.4 (10.6 - 15.7) 19.2 (13.5 - 25.0) 576 (6.82 Non - Hispanic whites 11 - 12 5.10 (4.79 - 5.43) 4.69 (4.35 - 5.11) 7.01 (6.36 - 7.72) 10.7 (8.90 - 12.1) 12.9 (11.9 - 16.0) 825 13 14 4.35 (4.02 - 4.71) 4.12 (3.67 - 4.47) 6.46 (5.79 - 7.21) 9.95 (8.65 - 10.9) 12.3 (10.9 - 14.0) 980 - (7.41 All Hispanics - 12 6.22 (5.52 - 7.01) 5.72 (5.08 - 6.51) 8.97 11 - 11.1) 14.5 (11.4 - 19.0) 19.9 (15.8 - 21.6) 574 13 - 14 5.31 (4.87 - 5.80) 5.34 (4.64 - 6.01) 7.92 (7.18 - 8.84) 11.7 (10.5 - 12.9) 14.8 (12.4 - 16.2) 703 (14.6 Asians - 12 10.1 (9.11 - 11.2) 9.53 (8.32 - 11.1) 17.8 11 - 19.9) 29.6 (24.5 - 34.2) 42.3 (33.0 - 46.4) 356 13 - 14 7.60 (7.10 - 8.14) 7.69 (6.65 - 8.90) 13.8 (11.0 - 14.9) 23.0 (18.3 - 24.3) 28.0 (23.1 - 39.4) 291 additional **See Calculation of Inorganic - related Arsenic Species for information. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Arsenic_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Arsenic_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 242

262 Urinary Inorganic - ated Arsenic Species (creatinine corrected) (2003 – 2010) rel ous acid, dimethylarsinic acid, and monomethylarsonic acid** Sum of arsenic acid, arsen ational Geometric mean and selected percentiles of urine concentrations (in μg As/g of creatinine) for the U.S. population from the N Health and Nutrition Examination Survey. Survey Sample 75th Percentile 90th Percentile 50th Percentile 95th Percentile Geometric mean Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 04 6.47 (5.84 - 7.16) 5.95 (5.40 - 6.62) 9.64 (8.25 - 11.4) 15.7 Total (13.3 - 18.5) 20.0 (17.4 - 23.9) 2569 03 - 6.72 (6.30 - 7.17) 6.21 (5.81 - 6.58) 9.75 (8.81 - 06 16.2 (14.2 - 18.0) 21.3 (18.7 - 24.3) 2588 05 11.0) - 08 6.75 (6.41 - 7.12) 6.42 (5.97 - 6.88) 9.77 (9.03 - 10.6) 15.5 (14.2 - 21.2 (18.1 - 23.3) 2576 07 17.0) 09 10 6.94 (6.55 - 7.36) 6.55 (6.04 - 7.00) 10.3 (9.58 - 11.0) 16.4 (14.9 - 17.9) 22.5 (19.0 - 26.5) 2851 - Age group 11 years 03 - 04 7.52 (6.45 - 8.77) 6.51 (6.05 - 8.30) 10.5 (8.06 - 13.5) 16.8 (12.4 - 19.7) 19.2 (14.3 - 6 292 - 41.3) 05 06 8.28 (7.20 - 9.52) 7.73 (6.44 - 8.96) 10.7 (8.86 - 14.1) 17.4 (13.6 - 22.1) 24.0 (18.8 - 26.2) 354 - 07 - 08 8.81 (7.92 - 9.80) 8.09 (7.23 - 9.44) 12.1 (10.8 - 13.9) 18.3 (15.5 - 23.4) 24.5 (18.4 - 390 37.9) - 10 8.47 (7.76 - 9.25) 7.92 (7.20 - 8.73) 10.7 (9.71 - 12.6) 17.0 (13.8 - 22.3) 24.9 (14.8 - 42.2) 378 09 - 19 years 03 - 04 4.79 (4.33 - 5.29) 4.46 (3.98 - 5.00) 6.31 (5.46 - 7.44) 8.96 (8.17 - 11.4) 12.8 (10.2 - 15.7) 728 12 - - 5.24 (4.95 - 5.55) 4.97 (4.61 - 5.44) 7.23 (6.71 06 7.72) 10.7 (9.48 - 11.6) 13.3 (11.5 - 15.5) 703 05 07 - 08 5.00 (4.64 - 5.39) 4.72 (4.47 - 5.13) 6.68 (5.85 - 7.49) 9.85 (7.88 - 11.8) 12.1 (10.2 - 14.8) 366 09 10 5.44 (4.97 - 5.95) 4.83 (4.46 - 5.50) 8.10 (6.54 - 9.23) 12.1 (10.4 - 15.1) 16.6 (13.6 - 20.5) 453 - - 04 6.67 (6.00 - 7.41) 6.12 (5.54 - 7.03) 10.2 (8.51 - 12.0) 15.9 (13.8 - 19.2) 21.2 (18.2 - 25.5) 1548 20 years and older 03 05 - 06 6.82 (6.39 - 7.28) 6.27 (5.80 - 6.79) 10.3 - 11.5) 16.7 (14.5 - 18.9) 22.2 (19.3 - 25.9) 1531 (9.07 - 08 6.87 (6.48 - 7.29) 6.54 (6.14 - 7.08) 9.90 07 - 11.1) 16.2 (14.2 - 18.0) 21.3 (18.2 - 24.3) 1820 (9.10 09 - 10 7.06 (6.61 - 7.53) 6.67 (6.13 - 7.09) 10.6 (9.71 - 11.4) 17.0 (15.0 - 18.9) 23.3 (19.5 - 27.5) 2020 Gender 03 04 5.93 (5.19 - 6.78) 5.43 (4.73 - 6.14) 8.57 (7.19 - 10.7) 13.7 (11.4 - 17.4) 19.4 (14.7 - 25.6) 1283 Males - 9.46) - 5.83 (5.41 - 6.28) 5.43 (5.00 - 5.90) 8.27 (7.26 - 12.9 (11.3 - 15.5) 18.0 (14.2 - 20.4) 1276 05 06 - 08 6.21 (5.91 - 6.53) 5.89 (5.47 - 6.27) 8.87 (8.27 - 9.71) 14.3 (12.7 - 16.6) 18.9 (17.0 - 21.3) 1289 07 09 - 6.17 (5.82 - 6.54) 5.70 (5.34 - 6.30) 8.95 (8.40 - 9.46) 14.3 (12.5 - 15.8) 18.1 (16.0 - 22.0) 1395 10 - 04 7.02 (6.45 - 7.64) 6.59 (5.94 - 7.20) 10.5 (8.95 - 12.4) 16.8 (14.9 - 19.1) 20.6 (18.0 - 25.4) 1285 Females 03 05 - 06 (7.22 - 8.21) 7.11 (6.54 - 7.73) 11.4 (10.3 - 13.1) 17.9 (16.2 - 20.0) 25.7 (22.1 - 28.5) 1312 7.70 - 08 7.30 (6.85 - 7.77) 7.00 (6.44 - 7.48) 10.4 (9.59 - 11.5) 16.2 (13.7 - 20.1) 22.7 (18.9 - 28.3) 1287 07 - 09 7.77 (7.27 - 8.31) 7.29 (6.80 - 7.91) 11.7 (10.9 10 12.5) 18.9 (16.3 - 22.0) 26.5 (20.4 - 34.0) 1456 - Race/ethnicity - - 04 7.16 (6.29 - 8.15) 6.78 (5.58 Mexican Americans 8.01) 10.4 (8.19 - 12.7) 15.6 (13.3 - 18.9) 20.0 (16.1 - 29.9) 621 03 (8.51 05 06 6.83 (6.38 - 7.32) 6.55 (5.94 - 7.34) 9.40 - - 10.6) 13.6 (11.6 - 15.9) 16.2 (14.3 - 20.0) 651 07 - 08 7.19 (6.39 - 8.10) 7.07 (6.17 - 7.76) 9.73 (8.28 - 11.4) 15.4 (12.9 - 19.2) 21.3 (17.8 - 24.3) 513 09 10 7.04 (6.44 - 7.69) 6.92 (6.15 - 7.70) 10.3 (9.19 - 10.9) 14.7 (13.3 - 16.2) 18.9 (16.9 - 20.6) 618 - - 03 - 04 5.08 (4.63 - 5.56) 4.72 (4.34 - 5.25) 7.04 (6.23 - 8.00) 10.7 (8.71 - 14.3) 15.0 (11.4 - 19.1) 725 Non Hispanic blacks 05 06 5.08 (4.63 - 5.57) 4.73 (4.33 - 5.21) 6.82 (6.13 - 7.61) 10.6 (8.32 - 13.5) 15.1 (11.2 - 25.0) 695 - (6.97 08 5.19 (4.86 - 5.55) 4.79 (4.41 - 5.39) 7.28 - - 7.97) 11.2 (10.2 - 12.2) 14.7 (12.2 - 18.9) 586 07 09 - 10 5.58 (5.10 - 6.10) 5.01 (4.58 - 5.42) 8.50 (6.94 - 10.4) 13.6 (12.6 - 15.5) 19.0 (14.6 - 23.1) 542 Non 03 - 04 6.28 (5.55 - 7.10) 5.82 (5.19 - 6.53) 9.10 (7.74 - 11.4) 14.8 (11.4 - 18.8) 19.4 (15.8 - 23.6) 1079 Hispanic whites - - 06 6.78 (6.30 - 7.31) 6.26 (5.79 - 6.78) 10.2 05 - 11.4) 16.2 (13.8 - 18.2) 20.8 (17.9 - 24.6) 1050 (8.85 07 - 08 6.66 (6.29 - 7.06) 6.37 (5.73 - 6.95) 9.64 (8.88 - 10.2) 14.8 (12.8 - 16.5) 20.0 (16.5 - 22.7) 1063 15.8) - 10 6.61 (6.20 - 7.05) 6.31 (5.76 - 6.81) 9.44 (8.75 - 10.0) 14.7 (13.6 - 09 18.9 (17.0 - 22.0) 1210 **See Calculation of Inorganic related Arsenic Species for additional information . - Biomonitoring Summary http://www.cdc.gov/biomonitoring/Arsenic_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Arsenic_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 243

263 Urinary Inorganic - – 2014) related Arsenic Species (creatinine corrected) (2011 , arsenous acid, dimethylarsenic acid, and methlyarsonic acid** Sum of arsenic acid ational Geometric mean and selected percentiles of urine concentrations (in μg As/g of creatinine) for the U.S. population from the N Health and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 12 6.31 Total (6.02 - 6.63) 6.00 (5.64 - 6.37) 9.46 (8.88 - 10.1) 15.1 (13.4 - 16.5) 19.6 (18.3 - 20.4) 2516 11 - 14 5.53 (5.24 - 5.83) 5.28 (4.91 - 5.61) 8.09 (7.61 - 8.62) 13.0 (11.9 - 17.4 (15.6 - 18.8) 2653 13 14.1) Age group 11 years - 11 - 12 7.77 (7.36 - 8.20) 7.33 (6.95 - 8.26) 10.6 (9.74 - 11.9) 15.9 (14.3 - 16.8) 20.2 (16.8 - 22.3) 401 6 - - 7.38 (6.78 - 8.04) 6.73 (5.99 - 8.30) 10.4 (9.30 14 12.3) 15.4 (14.1 - 16.8) 17.8 (15.5 - 19.4) 397 13 - 19 years 11 - 12 5.13 (4.48 - 5.88) 4.76 (4.40 - 5.11) 12 (5.86 - 8.81) 11.4 (8.17 - 16.8) 16.8 (11.4 - 28.7) 392 7.40 - 14 4.61 (4.14 - 5.15) 4.38 (3.92 - 4.81) 6.57 (5.55 - 7.69) 9.38 (8.11 - 11.1) 11.7 (9.46 - 16.7) 450 13 - 12 6.37 (6.08 - 6.67) 6.09 (5.72 - 6.52) 9.53 (8.98 - 10.2) 15.6 (13.6 - 17.0) 19.6 (18.3 - 20.4) 1723 20 years and older 11 13 - 14 5.51 (5.24 - 5.79) 5.29 (4.95 - 5.57) 7.95 (7.61 - 8.52) 12.9 (11.9 - 14.2) 17.7 (15.6 - 19.4) 1806 Gender 19.1) - 12 5.61 (5.24 - 6.01) 5.27 (4.81 - 5.87) 8.39 (7.73 - 9.04) 12.4 (10.6 - 13.9) 16.8 (13.6 - Males 1263 11 (6.66 13 14 5.02 (4.79 - 5.26) 4.72 (4.44 - 5.04) 7.04 - - 7.54) 11.4 (10.7 - 12.8) 17.0 (14.2 - 17.8) 1307 Females 11 - 12 7.06 (6.69 - 7.45) 6.77 (6.30 - 7.15) 11.0 (10.2 - 11.9) 16.8 (15.3 - 19.1) 21.5 (19.4 - 24.2) 1253 13 14 6.06 (5.62 - 6.54) 5.80 (5.33 - 6.46) 9.14 (8.21 - 10.1) 13.9 (12.5 - 15.5) 18.0 (15.9 - 19.5) 1346 - Race/ethnicity - 11 12 6.48 (6.05 - 6.94) 6.33 (5.77 - 9.18 (7.97 - 9.86) 12.4 (11.2 - 13.3) 16.0 (13.0 - 19.0) 317 Mexican Americans 6.82) 13 - 14 5.71 (5.39 - 6.06) 5.52 (5.15 - 5.87) 7.61 (6.97 - 8.52) 10.9 (9.87 - 12.4) 13.9 (12.2 - 15.8) 455 Non Hispanic blacks 11 - 12 4.83 (4.23 - 5.53) 4.53 (3.92 - 5.26) 7.30 (6.09 - 8.27) 10.9 (9.40 - 13.2) 16.2 (12.6 - 17.3) 672 - - 14 4.21 (3.77 - 4.72) 4.00 (3.42 - 4.75) 6.13 13 - 6.97) 8.70 (7.90 - 10.5) 12.2 (9.92 - 15.4) 576 (5.48 Non - Hispanic whites 11 - 12 6.13 (5.77 - 6.50) 5.81 (5.27 - 6.36) 9.09 (8.41 - 9.86) 14.3 (12.4 - 16.2) 18.6 (16.2 - 19.8) 824 13 14 5.36 (4.99 - 5.76) 5.14 (4.65 - 5.55) 7.69 (7.04 - 8.64) 12.5 (11.1 - 13.9) 16.0 (14.1 - 18.3) 979 - (9.30 All Hispanics - 12 6.96 (6.56 - 7.38) 6.90 (6.45 - 7.36) 9.80 11 - 10.5) 13.4 (12.0 - 15.9) 17.2 (14.7 - 20.3) 574 13 - 14 5.93 (5.59 - 6.28) 5.76 (5.43 - 6.09) 8.05 (7.53 - 8.71) 11.9 (10.5 - 13.0) 15.2 (12.4 - 19.0) 703 (16.5 Asians - 12 13.6 (11.9 - 15.4) 13.2 (11.4 - 14.6) 20.8 11 - 24.6) 33.9 (24.6 - 58.3) 58.8 (36.4 - 71.5) 356 13 - 14 11.8 (10.6 - 13.2) 11.2 (10.0 - 12.8) 18.6 (14.7 - 21.7) 30.3 (23.9 - 40.3) 44.5 (31.2 - 48.9) 291 additional **See Calculation of Inorganic - related Arsenic Species for information. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Arsenic_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Arsenic_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 244

264 Urinary Arsenic (V) acid (2003 – 2010) and Geometric mean and selected percentiles of urine concentrations (in μg As/L) for the U.S. population from the National Health Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 04 * < LOD < LOD < LOD 1.10 (

265 Urinary Arsenic (V) acid (2011 – 2014) for the U.S. population from the National Health and Geometric mean and selected percentiles of urine concentrations (in μg As/L) Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 12 * < LOD < LOD < LOD Total < LOD 2517 11 - * < LOD < LOD 14 < LOD 2654 13 < LOD Age group - 11 - 12 * < LOD < LOD < LOD < LOD 401 6 11 years - * < LOD < LOD 13 < LOD < LOD 397 14 < LOD 19 years 11 - 12 * < LOD - < LOD < LOD 392 12 13 - * < LOD < LOD < LOD < LOD 450 14 20 years and older 11 - 12 * < LOD < LOD < LOD < LOD 1724 13 - * < LOD < LOD < LOD < LOD 1807 14 Gender 11 12 < LOD < LOD - < LOD < LOD 1264 Males * 13 - 14 * < LOD < LOD < LOD 1308 < LOD Females 11 - 12 * < LOD < LOD < LOD < LOD 1253 13 14 * < LOD < LOD < LOD < LOD - 1346 Race/ethnicity Mexican Americans 11 - 12 * < LOD < LOD < LOD < LOD 317 13 14 * < LOD < LOD < LOD < LOD 455 - - Hispanic blacks 11 - 12 * < LOD < LOD < LOD < LOD 672 Non - * < LOD < LOD 14 < LOD < LOD 576 13 - Hispanic whites 11 - 12 * < LOD < LOD < LOD < LOD 825 Non 13 < LOD 14 * < LOD < LOD < LOD 980 - 12 * < LOD < LOD - < LOD < LOD 574 All Hispanics 11 13 - 14 * < LOD < LOD < LOD 703 < LOD Asians 11 - 12 * < LOD < LOD < LOD < LOD 356 13 - 14 * < LOD < LOD < LOD < LOD 291 11 Limit detection (LOD, see Data Analysis section) for Survey year of - 12 and 13 - 14 are 0.87 and 0.79, respectively. < LOD means less than the limit of detection, which may vary for some chemicals by year and by individual sample. high * Not calculated: proportion of results below limit of detection was too to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Arsenic_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Arsenic_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 246

266 Urinary Arsenic (V) acid (creatinine corrected) (2003 2010) – ational Geometric mean and selected percentiles of urine concentrations (in μg As/g of creatinine) for the U.S. population from the N Health and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD 3.04 (

267 Urinary Arsenic (V) acid (creatinine corrected) (2011 – 2014) ational Geometric mean and selected percentiles of urine concentrations (in μg As/g of creatinine) for the U.S. population from the N Health and Nutrition Examination Survey. Survey Sample 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size < LOD - 11 * < LOD < LOD 12 < LOD 2516 Total - 14 * < LOD < LOD < LOD 2653 13 < LOD Age group 11 years 11 - 12 * < LOD < LOD < LOD - < LOD 401 6 - * < LOD < LOD 14 < LOD < LOD 397 13 - 19 years 11 - 12 * 12 < LOD < LOD < LOD 392 < LOD - 14 * < LOD < LOD < LOD < LOD 450 13 11 12 * < LOD < LOD < LOD < LOD 1723 20 years and older - - * < LOD < LOD 14 < LOD < LOD 1806 13 Gender - 12 Males * < LOD < LOD < LOD < LOD 1263 11 13 < LOD 14 * < LOD < LOD < LOD 1307 - < LOD Females - 12 * < LOD 11 < LOD < LOD 1253 13 - 14 * < LOD < LOD < LOD < LOD 1346 Race/ethnicity 11 12 * < LOD < LOD < LOD < LOD 317 Mexican Americans - - * < LOD < LOD 14 < LOD < LOD 455 13 - Hispanic blacks 11 - 12 * < LOD < LOD < LOD < LOD 672 Non 13 14 * < LOD < LOD < LOD < LOD 576 - - 11 - 12 * < LOD Non < LOD < LOD < LOD 824 Hispanic whites - 14 * < LOD 13 < LOD < LOD 979 < LOD All Hispanics 11 - 12 * < LOD < LOD < LOD < LOD 574 13 14 * < LOD < LOD < LOD < LOD 703 - < LOD - 12 * < LOD Asians < LOD < LOD 356 11 < LOD 13 14 * < LOD - < LOD < LOD 291 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. high * Not calculated: proportion of results below limit of detection was too to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Arsenic_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Arsenic_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 248

268 Urinary Arsenobetaine (2003 – 2010) and Geometric mean and selected percentiles of urine concentrations (in μg As/L) for the U.S. population from the National Health Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size 04 1.55 (1.31 - 1.83) 1.00 (.800 - - 5.20 (4.00 - 6.50) 16.8 (12.7 - 22.3) 35.0 (27.6 - 44.6) 2568 03 Total 1.40) 06 1.86 (1.43 - 2.41) 1.53 (.980 - 2.26) 6.73 (4.80 - 8.91) 22.6 (16.5 - 30.3) 40.6 (30.7 - 59.4) 05 - 2588 - * .670 (.510 - .910) 4.26 (3.53 - 4.88) 16.6 (12.5 - 20.2) 29.5 (22.8 - 37.1) 2576 07 08 - 10 1.59 (1.38 - - .940 (.720 - 1.26) 6.18 (4.67 - 7.87) 23.5 (19.8 30.1) 50.4 (35.7 - 63.2) 2870 09 1.83) Age group 11 years 6 03 - 04 * < LOD 1.80 (.800 - 4.00) 8.80 (3.90 - 29.9) 29.9 (6.20 - 190) 292 - 05 06 * < LOD 2.22 (.620 - 5.35) 7.14 (2.34 - 29.9) 18.9 (5.46 - 45.0) 354 - (3.37 - * < LOD 1.24 (.780 - 2.42) 6.71 - 8.38) 13.0 (7.22 - 25.2) 390 07 08 - 10 * < LOD 1.20 (.590 - 3.12) 7.98 (5.20 - 15.7) 19.4 (9.25 - 47.9) 380 09 19 years 03 - 04 - * .600 (.400 - .800) 3.20 (2.00 - 4.70) 13.9 (7.20 - 25.1) 31.8 (17.2 - 35.8) 728 12 - * .550 (

269 Urinary Arsenobetaine (2011 – 2014) ation from the National Health and Geometric mean and selected percentiles of urine concentrations (in μg As/L) for the U.S. popul Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 * < LOD 4.62 (3.25 - 6.25) 18.0 (13.7 - 23.2) 36.5 (25.7 Total 51.9) 2517 11 - - * < LOD 3.70 (2.77 - 5.00) 15.1 14 - 19.6) 30.5 (24.2 - 39.7) 2654 13 (12.4 Age group - 11 - 12 * < LOD 1.58 (

270 Urinary Arsenobetaine (creatinine corrected) (2003 – 2010) ational Geometric mean and selected percentiles of urine concentrations (in μg As/g of creatinine) for the U.S. population from the N Health and Nutrition Examination Survey. Survey Sample 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 1.54 (1.30 - 1.82) 1.16 (.959 - 1.43) 5.00 (3.62 - 6.91) 16.2 (12.5 Total 20.3) 29.4 (24.0 - 36.4) 2568 03 - - 1.82 (1.40 - 2.37) 1.64 (1.10 - 2.41) 6.64 (4.48 - 06 20.3 (14.5 - 28.1) 37.0 (27.5 - 58.3) 2588 05 8.79) - 08 * 1.00 (.850 - 1.18) 4.07 (3.36 - 4.98) 14.7 (11.1 - 17.8) 27.7 (18.9 - 45.4) 2576 07 - 09 1.69 (1.45 - 1.97) 1.23 (.980 - 1.47) 6.48 (4.90 - 8.00) 23.6 (18.5 - 30.7) 49.6 (36.6 - 61.3) 2869 10 Age group 11 years 03 - 04 * < LOD 2.00 (1.15 - 4.83) 12.2 (4.13 - 39.7) 29.6 (6.80 - 153) 292 6 - - * < LOD 2.88 05 (1.04 - 6.25) 8.77 (2.88 - 40.5) 23.6 (6.86 - 74.8) 354 06 07 * < LOD 2.11 (1.27 - 3.79) 8.98 08 (4.76 - 14.8) 16.4 (8.98 - 23.8) 390 - 09 - 10 * < LOD 1.70 (1.21 - 3.02) 9.52 (5.08 - 24.9 (9.81 - 50.7) 379 20.7) 12 19 years 03 - 04 * .531 (.400 - .638) 2.14 (1.39 - 3.51) 9.29 (4.29 - 14.7) 17.3 (10.4 - 28.7) 728 - 05 - * .620 (

271 Urinary Arseno betaine (creatinine corrected) (2011 2014) – ational Geometric mean and selected percentiles of urine concentrations (in μg As/g of creatinine) for the U.S. population from the N Health and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 * < LOD 5.63 Total (4.42 - 7.22) 18.0 (13.8 - 26.1) 36.9 (26.9 - 45.6) 2516 11 - 14 * < LOD 4.91 (3.98 - 6.31) 16.3 (12.7 - 21.2) (33.3 - 46.8) 2653 13 38.7 Age group 11 years - 11 - 12 * < LOD 4.35 (

272 Urinary Arsenocholine (2003 – 2010) ions (in μg As/L) for the U.S. population from the National Health and Geometric mean and selected percentiles of urine concentrat Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD < LOD 2568 Total 03 06 * < LOD < LOD < LOD < LOD 2588 05 - < LOD - * < LOD < LOD < LOD 2576 07 08 - 10 * < LOD < LOD < LOD 2871 09 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 292 - 6 - 06 * < LOD < LOD < LOD < LOD 354 05 - * < LOD < LOD < LOD < LOD 390 07 08 09 * < LOD < LOD 10 < LOD < LOD 380 - - 19 years 03 - 04 * < LOD < LOD < LOD < LOD 12 728 - 06 * < LOD < LOD < LOD < LOD 703 05 07 - * < LOD < LOD < LOD < LOD 366 08 < LOD - * < LOD < LOD < LOD 456 09 10 03 - 04 * < LOD < LOD 20 years and older < LOD < LOD 1548 05 06 * < LOD < LOD - < LOD < LOD 1531 07 - 08 * < LOD < LOD < LOD < LOD 1820 09 * 10 < LOD < LOD < LOD < LOD 2035 - Gender 03 04 < LOD < LOD - < LOD < LOD 1284 Males * 05 - 06 * < LOD < LOD < LOD 1276 < LOD - 08 * < LOD < LOD < LOD < LOD 1289 07 < LOD 09 10 * < LOD - < LOD < LOD 1403 Females 03 - 04 * < LOD < LOD < LOD < LOD 1284 05 06 * < LOD < LOD < LOD < LOD 1312 - 07 - * < LOD < LOD < LOD < LOD 1287 08 < LOD - * < LOD < LOD < LOD 1468 09 10 Race/ethnicity 03 * 04 < LOD < LOD < LOD < LOD 621 Mexican Americans - - * < LOD < LOD 06 < LOD < LOD 651 05 07 - 08 * < LOD < LOD < LOD < LOD 513 - 10 * < LOD < LOD < LOD < LOD 618 09 < LOD - 03 - 04 * < LOD < LOD < LOD 725 Non Hispanic blacks 05 - 06 * < LOD < LOD < LOD < LOD 695 - 08 * < LOD < LOD < LOD < LOD 586 07 < LOD 09 10 * < LOD - < LOD < LOD 546 Non - Hispanic whites 03 - 04 * < LOD < LOD < LOD < LOD 1078 05 06 * < LOD < LOD < LOD < LOD 1050 - 07 < LOD 08 * < LOD < LOD < LOD 1063 - < LOD 10 * < LOD - < LOD < LOD 1226 09 Limit of detection (LOD, see Data Analysis section) for Survey years 03 - 04, 05 - 06, 07 - 08 and 09 - 10 are 0.6, 0.6, 0.6, and 0.6 respectively. vary < means less than the limit of detection, which may LOD for some chemicals by year and by individual sample. * Not calculated: proportion of results below limit of detection was too high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Arsenic_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Arsenic_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 253

273 Urinary Arsenocholine (2011 – 2014) ation from the National Health and Geometric mean and selected percentiles of urine concentrations (in μg As/L) for the U.S. popul Nutrition Examination Survey. Survey Sample 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size < LOD - 11 * < LOD < LOD 12 < LOD 2517 Total - 14 * < LOD < LOD .200 (.140 - .250) .320 (.290 - .350) 2654 13 Age group 11 years - 12 * < LOD < LOD 11 < LOD < LOD 401 - 6 - 14 * < LOD < LOD < LOD .260 (

274 Urinary Arsen ocholine (creatinine corrected) (2003 2010) – ational Geometric mean and selected percentiles of urine concentrations (in μg As/g of creatinine) for the U.S. population from the N Health and Nutrition Examination Survey. Survey Sample 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * Total < LOD < LOD < LOD < LOD 2568 03 - * < LOD < LOD 06 < LOD 2588 05 < LOD - 08 * < LOD < LOD < LOD < LOD 2576 07 - 09 * < LOD < LOD < LOD < LOD 2870 10 Age group 11 years 03 - 04 * < LOD < LOD < LOD < LOD 292 6 - - 05 * < LOD < LOD < LOD < LOD 354 06 07 * < LOD < LOD 08 < LOD < LOD 390 - 09 - 10 * < LOD < LOD < LOD < LOD 379 12 - 03 - 04 * < LOD < LOD < LOD < LOD 728 19 years 05 - * < LOD < LOD < LOD < LOD 703 06 < LOD - * < LOD < LOD < LOD 366 07 08 - 10 * < LOD < LOD < LOD 456 09 < LOD - 04 * < LOD 03 < LOD < LOD 1548 20 years and older < LOD 05 - 06 * < LOD < LOD < LOD < LOD 1531 - 08 * < LOD < LOD < LOD < LOD 1820 07 09 * < LOD < LOD 10 < LOD < LOD 2035 - Gender - 04 Males * < LOD < LOD < LOD < LOD 1284 03 < LOD 05 06 * < LOD - < LOD < LOD 1276 07 - 08 * < LOD < LOD < LOD < LOD 1289 09 10 * < LOD < LOD < LOD < LOD 1402 - 03 04 * < LOD < LOD < LOD < LOD 1284 Females - < LOD - * < LOD < LOD < LOD 1312 05 06 - 08 * < LOD < LOD < LOD < LOD 1287 07 09 10 * < LOD < LOD - < LOD < LOD 1468 Race/ethnicity * - 04 Mexican Americans < LOD < LOD < LOD < LOD 621 03 05 * < LOD < LOD 06 < LOD < LOD 651 - 07 - 08 * < LOD < LOD < LOD < LOD 513 09 - 10 * < LOD < LOD < LOD < LOD 618 - 03 - 04 * < LOD Non < LOD < LOD < LOD 725 Hispanic blacks 05 - 06 * < LOD < LOD < LOD < LOD 695 07 08 * < LOD < LOD < LOD < LOD 586 - 09 * < LOD < LOD 10 < LOD < LOD 545 - - Hispanic whites 03 - 04 * < LOD < LOD < LOD < LOD 1078 Non - 06 * < LOD < LOD < LOD < LOD 1050 05 < LOD 07 08 * < LOD - < LOD < LOD 1063 09 - 10 * < LOD < LOD < LOD < LOD 1226 for < means less than the limit of detection LOD the urine levels not corrected for creatinine. * Not calculated: proportion of results below limit of detection was too high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Arsenic_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Arsenic_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 255

275 Urinary Arseno choline (creatinine corrected) (2011 2014) – ational Geometric mean and selected percentiles of urine concentrations (in μg As/g of creatinine) for the U.S. population from the N Health and Nutrition Examination Survey. Survey Sample 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size < LOD - 11 * < LOD < LOD 12 < LOD 2516 Total - 14 * < LOD < LOD .333 (.296 - .381) .533 (.444 - .615) 2653 13 Age group 11 years - 12 * < LOD < LOD 11 < LOD < LOD 401 - 6 - 14 * < LOD < LOD < LOD .533 (

276 Urinary Arsenous (III) acid (2003 – 2010) and Geometric mean and selected percentiles of urine concentrations (in μg As/L) for the U.S. population from the National Health Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 04 * < LOD < LOD < LOD < LOD 2568 Total 03 06 * < LOD < LOD < LOD < LOD 2588 05 - < LOD - * < LOD < LOD < LOD 2576 07 08 - 10 * < LOD < LOD < LOD < LOD 2871 09 Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 292 - 6 - 06 * < LOD < LOD < LOD < LOD 354 05 - * < LOD < LOD < LOD < LOD 390 07 08 09 * < LOD < LOD 10 < LOD < LOD 380 - - 19 years 03 - 04 * < LOD < LOD < LOD 1.40 (

277 Urinary Arsenous (III) acid (2011 – 2014) S. population from the National Health and Geometric mean and selected percentiles of urine concentrations (in μg As/L) for the U. Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 * < LOD .520 (

278 Urina ry Arsenous (III) acid (creatinine corrected) (2003 2010) – ational Geometric mean and selected percentiles of urine concentrations (in μg As/g of creatinine) for the U.S. population from the N Health and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD < LOD 2568 Total 03 06 * < LOD < LOD < LOD < LOD 2588 05 - < LOD - * < LOD < LOD < LOD 2576 07 08 - 10 * < LOD < LOD < LOD 2870 09 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 292 - 6 - 06 * < LOD < LOD < LOD < LOD 354 05 - * < LOD < LOD < LOD < LOD 390 07 08 09 * < LOD < LOD 10 < LOD < LOD 379 - - 19 years 03 - 04 * < LOD < LOD < LOD 12 (

279 Urinar y Arsenous (III) acid (creatinine corrected) (2011 2014) – ational Geometric mean and selected percentiles of urine concentrations (in μg As/g of creatinine) for the U.S. population from the N Health and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 * < LOD .791 Total (

280 Urinary Dimethylarsinic acid (2003 – 2010) Metabolite of Arsenic and Geometric mean and selected percentiles of urine concentrations (in μg As/L) for the U.S. population from the National Health Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 04 3.71 (3.33 - 4.14) 3.90 (3.00 - 4.00) 6.00 (5.00 - 7.00) 11.0 (9.20 - 12.0) 16.0 (13.0 Total 17.8) 2568 03 - - 3.95 (3.59 - 4.35) 3.90 (3.46 - 4.31) 6.17 (5.53 - 06 10.3 (9.00 - 12.2) 15.0 (12.2 - 17.8) 2588 05 7.04) - 08 3.67 (3.44 - 3.91) 3.58 (3.44 - 3.84) 5.96 (5.44 - 6.57) 9.78 (8.72 - 11.2) 13.3 (11.8 - 15.3) 2576 07 09 10 3.67 (3.43 - 3.93) 3.50 (3.25 - 3.76) 6.16 (5.59 - 6.73) 11.5 (9.35 - 13.7) 17.4 (14.0 - 21.0) 2871 - Age group 11 years 03 - 04 3.73 (3.12 - 4.45) 4.00 (3.00 - 4.00) 6.00 (5.00 - 7.00) 9.00 (7.00 - 12.0) 12.0 (8.00 - 6 292 - 22.0) 05 06 3.96 (3.49 - 4.49) 3.94 (3.20 - 4.71) 5.94 (5.01 - 7.10) 10.5 (7.10 - 12.1) 13.0 (10.7 - 15.3) 354 - 07 - 08 3.86 (3.45 - 4.32) 3.76 (3.47 - 4.01) 6.10 (5.29 - 6.99) 10.4 (7.57 - 13.9) 15.2 (9.32 - 390 39.2) - 10 3.53 (3.17 - 3.92) 3.27 (2.81 - 3.87) 5.76 (5.07 - 6.53) 10.7 (7.84 - 11.9) 12.8 (11.0 - 14.4) 380 09 - 19 years 03 - 04 3.85 (3.34 - 4.42) 4.00 (3.00 - 4.00) 6.00 (5.00 - 7.10) 9.30 (7.70 - 12.0) 13.0 (10.0 - 16.0) 728 12 - - 3.97 (3.46 - 4.55) 3.97 (3.31 - 4.64) 5.74 (5.11 06 7.10) 9.43 (7.63 - 11.6) 12.0 (10.7 - 13.9) 703 05 07 - 08 3.60 (3.16 - 4.09) 3.66 (3.24 - 4.26) 5.53 (4.75 - 6.72) 8.90 (7.33 - 9.95) 10.7 (9.08 - 13.3) 366 09 10 3.08 (2.77 - 3.43) 2.89 (2.64 - 3.29) 5.05 (4.44 - 5.77) 7.89 (6.87 - 10.1) 11.3 (8.75 - 13.8) 456 - - 04 3.69 (3.31 - 4.11) 3.70 (3.00 - 4.00) 6.00 (5.00 - 7.00) 11.0 (10.0 - 12.0) 16.0 (13.0 - 19.0) 1548 20 years and older 03 05 - 06 3.95 (3.58 - 4.36) 3.87 (3.46 - 4.32) 6.30 - 7.28) 10.3 (9.25 - 13.3) 16.2 (12.5 - 19.4) 1531 (5.59 - 08 3.66 (3.43 - 3.91) 3.56 (3.41 - 3.80) 5.97 07 - 6.63) 9.89 (8.72 - 11.4) 13.8 (11.8 - 15.5) 1820 (5.44 09 - 10 3.79 (3.51 - 4.09) 3.60 (3.33 - 3.87) 6.40 (5.71 - 7.03) 12.1 (9.52 - 16.0) 18.2 (15.8 - 23.6) 2035 Gender 03 04 4.12 (3.60 - 4.71) 4.00 (3.70 - 4.30) 6.00 (5.60 - 7.70) 11.0 (9.00 - 15.0) 17.0 (12.1 - 22.0) 1284 Males - 7.61) - 4.17 (3.79 - 4.59) 4.04 (3.68 - 4.43) 6.32 (5.41 - 10.5 (8.68 - 13.3) 14.8 (11.8 - 19.2) 1276 05 06 - 08 4.05 (3.73 - 4.40) 3.96 (3.63 - 4.27) 6.53 (5.77 - 7.15) 10.3 (9.31 - 12.0) 14.6 (11.6 - 20.2) 1289 07 09 - 3.89 (3.50 - 4.32) 3.71 (3.35 - 4.11) 6.33 (5.80 - 7.02) 11.6 (8.80 - 17.3) 19.2 (13.0 - 24.7) 1403 10 - 04 3.37 (3.00 - 3.78) 3.00 (3.00 - 4.00) 5.50 (4.80 - 6.20) 10.0 (8.00 - 11.0) 14.0 (11.0 - 17.7) 1284 Females 03 05 - 06 (3.37 - 4.18) 3.70 (3.28 - 4.21) 6.03 (5.46 - 6.99) 9.95 (8.81 - 12.2) 15.5 (11.6 - 19.0) 1312 3.75 - 08 3.34 (3.13 - 3.57) 3.37 (3.15 - 3.53) 5.48 (5.00 - 6.05) 8.99 (7.97 - 10.4) 11.9 (10.7 - 13.9) 1287 07 - 09 3.48 (3.22 - 3.76) 3.28 (2.95 - 3.63) 5.85 (5.21 10 6.69) 11.5 (9.42 - 13.3) 16.1 (13.8 - 17.7) 1468 - Race/ethnicity - - 04 4.72 (4.27 - 5.22) 4.80 (4.00 Mexican Americans 5.00) 7.00 (6.00 - 9.00) 12.0 (10.0 - 16.0) 17.0 (12.0 - 25.0) 621 03 (6.38 05 06 4.43 (4.15 - 4.72) 4.66 (4.26 - 5.13) 6.93 - - 7.58) 9.51 (8.70 - 11.1) 13.1 (10.3 - 15.1) 651 07 - 08 4.36 (4.05 - 4.69) 4.62 (4.07 - 5.07) 7.14 (6.23 - 7.76) 9.67 (8.39 - 10.8) 11.7 (9.96 - 17.6) 513 09 10 3.90 (3.45 - 4.40) 3.98 (3.18 - 4.63) 6.53 (5.61 - 7.15) 10.7 (8.95 - 13.2) 16.2 (13.1 - 19.2) 618 - (6.00 - 03 - 04 4.27 (3.71 - 4.92) 4.00 (3.50 - 5.00) 7.00 - 8.00) 11.6 (9.00 - 15.0) 16.0 (14.0 - 18.7) 725 Non Hispanic blacks 05 - 06 4.28 (3.68 - 4.98) 4.02 (3.37 - 4.82) 6.42 (5.31 - 7.36) 10.9 (8.22 - 13.1) 15.2 (11.5 - 27.1) 695 - 08 4.19 (3.92 - 4.49) 3.98 (3.63 - 4.27) 6.69 (5.80 - 7.43) 11.2 (10.1 - 12.5) 14.7 (12.1 - 19.2) 586 07 (5.99 09 10 4.09 (3.63 - 4.61) 3.93 (3.31 - 4.36) 7.13 - - 8.63) 12.3 (10.1 - 17.0) 18.2 (13.7 - 27.8) 546 Non - Hispanic whites 03 - 04 3.27 (2.95 - 3.62) 3.00 (3.00 - 3.80) 5.00 (4.60 - 6.00) 9.00 (7.00 - 10.0) 12.0 (9.50 - 15.0) 1078 05 06 3.69 (3.28 - 4.15) 3.60 (3.19 - 4.08) 5.66 (5.10 - 6.70) 9.62 (8.11 - 11.8) 13.9 (10.6 - 17.8) 1050 - (4.77 08 3.23 (3.01 - 3.48) 3.34 (3.04 - 3.53) 5.14 - - 5.59) 8.27 (7.48 - 9.07) 10.5 (9.25 - 13.2) 1063 07 09 - 10 3.21 (3.07 - 3.37) 3.12 (2.91 - 3.29) 5.32 (5.00 - 5.66) 8.65 (7.23 - 10.1) 12.0 (10.1 - 14.4) 1226 Limit of detection (LOD, see Data Analysis section) for Survey years 03 - 04, 05 - 06, 07 - 08 and 09 - 10 are 1.7, 1.7, 1.7, and 1.7 respectively. Biomonitoring S ummary http://www.cdc.gov/biomonitoring/Arsenic_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Arsenic_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 261

281 Urinary Dimethylarsinic acid (2011 – 2014) Metabolite of Arsenic Geometric mean and select ed percentiles of urine concentrations (in μg As/L) for the U.S. population from the National Health and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 12 3.47 (3.18 - 3.78) 3.37 (3.06 Total 3.66) 5.81 (5.14 - 6.59) 9.55 (8.43 - 11.2) 14.0 (11.4 - 16.5) 2517 11 - - 14 3.20 (2.97 - 3.44) 3.08 (2.73 - 3.41) 5.15 (4.68 - 5.69) 8.60 (8.02 - 9.25) 11.8 (10.6 - 13.5) 2654 13 Age group 11 years - 11 - 12 3.43 (3.06 - 3.85) 3.53 (2.81 - 4.05) 5.81 (5.21 - 6.38) 8.60 (7.55 - 9.73) 11.4 (9.35 - 13.7) 401 6 - - 3.33 (2.95 - 3.75) 3.12 (2.68 - 3.56) 5.27 (4.31 14 6.14) 8.69 (7.44 - 10.8) 11.8 (8.62 - 18.5) 397 13 - 19 years 11 - 12 3.27 (2.71 - 3.94) 3.33 (2.49 - 4.20) 5.02 (4.33 - 6.05) 8.53 (6.29 - 11.1) 11.6 (8.74 - 17.9) 392 12 - 14 3.30 (2.99 - 3.63) 3.24 (2.86 - 3.66) 4.95 (4.53 - 5.66) 9.02 (6.97 - 10.6) 11.4 (10.0 - 13.1) 450 13 11 12 3.51 (3.22 - 3.82) 3.37 (3.05 - 3.67) 5.91 (5.20 - 6.83) 9.94 (8.57 - 11.5) 14.1 (12.2 - 16.4) 1724 20 years and older - - - 3.17 (2.93 - 3.43) 3.02 (2.66 - 3.41) 5.18 (4.68 14 5.78) 8.53 (7.82 - 9.21) 11.7 (10.3 - 14.2) 1807 13 Gender - - 12 3.79 (3.40 - 4.23) 3.71 (3.33 Males 4.29) 6.27 (5.36 - 7.61) 10.3 (8.75 - 12.5) 15.3 (12.5 - 16.7) 1264 11 13 (5.03 14 3.31 (3.12 - 3.51) 3.25 (3.02 - 3.56) 5.34 - 5.61) 8.56 (8.11 - 9.30) 11.6 (10.3 - 12.8) 1308 - (4.61 Females - 12 3.19 (2.92 - 3.48) 3.01 (2.73 - 3.30) 5.30 11 - 5.96) 8.96 (7.72 - 10.5) 12.2 (9.56 - 17.8) 1253 13 - 14 3.09 (2.81 - 3.40) 2.81 (2.53 - 3.23) 4.85 (4.27 - 5.82) 8.60 (7.56 - 9.54) 11.9 (10.6 - 14.6) 1346 Race/ethnicity 11 12 3.67 (3.33 - 4.04) 3.58 (3.27 - 4.18) 5.82 (5.24 - 6.47) 9.05 (7.91 - 10.0) 12.1 (9.61 - 17.4) 317 Mexican Americans - - - 3.32 (3.10 - 3.54) 3.45 (2.94 - 3.84) 5.19 (4.79 14 5.75) 7.74 (7.22 - 8.45) 9.94 (8.21 - 12.7) 455 13 - Hispanic blacks 11 - 12 4.05 (3.46 - 4.74) 4.05 (3.35 - 4.65) 6.78 Non - 8.21) 12.0 (10.0 - 14.2) 17.4 (14.2 - 19.8) 672 (5.46 - 14 3.83 (3.35 - 4.39) 3.62 (3.21 - 4.05) 5.84 (4.60 - 7.84) 10.2 (8.42 - 13.2) 15.7 (10.9 - 20.7) 576 13 - 11 - 12 3.06 (2.82 - 3.33) 2.97 (2.72 - 3.29) 4.95 Non (4.39 - 5.77) 7.98 (6.92 - 9.02) 10.5 (8.71 - 13.0) 825 Hispanic whites 13 - 14 2.86 (2.59 - 3.15) 2.69 (2.29 - 3.10) 4.56 (3.96 - 5.21) 7.52 (6.61 - 8.52) 9.62 (8.53 - 11.3) 980 All Hispanics - 12 4.02 (3.45 - 4.69) 3.96 (3.33 - 4.68) 6.73 (5.49 - 8.39) 11.1 (8.53 - 16.6) 16.8 (12.1 - 19.7) 574 11 (5.01 13 14 3.54 (3.16 - 3.97) 3.61 (3.07 - 4.11) 5.63 - - 6.88) 9.09 (7.80 - 10.3) 11.8 (9.98 - 12.9) 703 Asians 11 - 12 7.38 (6.50 - 8.37) 7.52 (6.45 - 8.74) 14.4 (11.7 - 17.2) 24.7 (20.3 - 31.3) 38.6 (28.5 - 40.5) 356 (9.01 14 5.59 (5.13 - 6.09) 5.62 (5.08 - 6.53) 11.3 - - 12.4) 19.9 (15.6 - 22.1) 23.6 (19.7 - 34.6) 291 13 Limit of detection (LOD, see Data Analysis section) for Survey year 11 - 12 and 13 - 14 are 1.8 and 1.91. Biomonitoring Summary http://www.cdc.gov/biomonitoring/ Arsenic_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Arsenic_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 262

282 Urinary Dimethylarsinic acid (creatinine corrected) (2003 – 2010) Metabolite of Arsenic Geometric mean and selected percentiles of urine concentrations (in μg As/g of creatinine) for the U.S. population from the N ational Health and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 04 3.69 (3.24 - 4.19) 3.37 (2.94 - 3.91) 5.71 (4.69 - 6.74) 9.09 (7.61 - 11.5) 13.0 (10.7 Total 16.0) 2568 03 - - 3.88 (3.57 - 4.22) 3.66 (3.39 - 3.93) 5.71 (5.10 - 06 9.57 (7.95 - 10.9) 12.3 (10.6 - 15.0) 2588 05 6.43) - 08 3.83 (3.60 - 4.07) 3.62 (3.37 - 3.93) 5.80 (5.33 - 6.32) 9.01 (8.00 - 9.97) 11.6 (9.97 - 14.4) 2576 07 09 10 3.90 (3.64 - 4.18) 3.53 (3.30 - 3.80) 6.03 (5.36 - 6.62) 10.2 (9.15 - 11.8) 14.9 (12.3 - 19.2) 2870 - Age group 11 years 03 - 04 4.34 (3.57 - 5.28) 4.03 (3.20 - 4.80) 6.32 (4.65 - 8.33) 10.3 (7.00 - 13.9) 13.9 (7.86 - 6 292 - 21.8) 05 06 4.89 (4.22 - 5.65) 4.31 (3.64 - 5.69) 6.85 (5.71 - 7.69) 10.0 (7.54 - 14.7) 14.7 (10.0 - 18.8) 354 - 07 - 08 5.07 (4.56 - 5.64) 4.54 (4.08 - 4.82) 6.90 (6.14 - 7.76) 12.0 (8.39 - 17.1) 20.9 (12.0 - 40.8) 390 - 10 4.77 (4.34 - 5.23) 4.48 (4.12 - 4.85) 6.41 (5.66 - 6.82) 10.0 (7.63 - 15.3) 16.5 (9.33 - 27.0) 379 09 - 19 years 03 - 04 2.74 (2.39 - 3.14) 2.55 (2.27 - 2.94) 3.77 (3.17 - 4.44) 5.88 (4.65 - 6.67) 7.18 (6.16 - 11.7) 728 12 - - 3.05 (2.78 - 3.34) 2.92 (2.55 - 3.29) 4.25 (3.87 06 4.84) 6.68 (5.49 - 8.06) 9.08 (7.11 - 10.6) 703 05 07 - 08 2.80 (2.54 - 3.09) 2.69 (2.37 - 2.93) 3.91 (3.46 - 4.56) 6.27 (4.72 - 8.21) 8.21 (5.77 - 10.1) 366 09 10 2.89 (2.61 - 3.20) 2.60 (2.36 - 2.86) 4.08 (3.43 - 4.80) 6.67 (5.71 - 8.57) 10.0 (7.61 - 12.6) 456 - - 04 3.79 (3.34 - 4.31) 3.48 (3.00 - 4.00) 5.95 (4.86 - 7.05) 9.45 (8.00 - 12.0) 13.5 (11.1 - 18.6) 1548 20 years and older 03 05 - 06 3.93 (3.62 - 4.27) 3.71 (3.42 - 4.02) 5.82 - 6.47) 9.74 (8.00 - 11.2) 12.6 (10.9 - 15.8) 1531 (5.22 - 08 3.89 (3.64 - 4.16) 3.69 (3.44 - 4.02) 5.96 07 - 6.58) 9.10 (8.00 - 10.0) 11.6 (9.74 - 14.5) 1820 (5.47 09 - 10 4.00 (3.70 - 4.32) 3.61 (3.33 - 3.90) 6.25 (5.57 - 6.88) 10.8 (9.23 - 12.9) 16.1 (12.6 - 22.2) 2035 Gender 03 04 3.48 (2.95 - 4.10) 3.16 (2.70 - 3.82) 5.46 (4.17 - 6.90) 8.59 (6.92 - 12.0) 12.3 (8.84 - 18.9) 1284 Males - 6.08) - 3.43 (3.13 - 3.75) 3.24 (2.91 - 3.63) 5.11 (4.25 - 7.90 (6.65 - 9.77) 11.0 (9.29 - 13.0) 1276 05 06 - 08 3.63 (3.41 - 3.85) 3.44 (3.22 - 3.68) 5.33 (5.00 5.82) 8.31 (7.21 - 10.1) 12.1 (9.73 - 14.9) 1289 07 - 09 10 3.54 (3.29 - 3.80) 3.20 (3.04 - 3.38) 5.31 (4.80 - 5.99) 9.24 (7.80 - 10.8) 13.3 (10.3 - 16.5) 1402 - 03 - 04 3.89 (3.49 - 4.34) 3.57 (3.13 - 4.06) 5.78 (4.95 - 6.67) Females (8.00 - 11.5) 13.7 (10.6 - 18.6) 1284 9.32 - 06 4.37 (4.03 - 4.75) 4.03 (3.72 - 4.51) 6.26 (5.71 - 6.84) 10.0 (8.50 - 12.6) 14.4 (11.2 - 19.3) 1312 05 - 07 4.02 (3.75 - 4.32) 3.80 (3.46 - 4.26) 6.15 (5.58 08 7.06) 9.23 (8.11 - 10.1) 10.9 (9.52 - 14.9) 1287 - 09 - 10 4.28 (3.96 - 4.63) 4.00 (3.62 - 4.32) 6.55 (5.98 - 7.14) 11.0 (9.64 - 13.2) 17.2 (13.2 - 24.4) 1468 Race/ethnicity (4.84 - 04 4.38 (3.80 - 5.05) 4.11 (3.29 Mexican Americans 4.90) 6.25 03 - 8.15) 10.3 (8.00 - 11.8) 12.9 (11.1 - 15.2) 621 - 05 - 06 4.16 (3.83 - 4.52) 4.00 (3.65 - 4.36) 5.94 (5.40 - 6.49) 8.69 (7.23 - 9.65) 10.2 (9.52 - 13.2) 651 07 08 4.34 (3.87 - 4.88) 4.19 (3.66 - 4.83) 6.23 (5.31 - 7.44) 9.14 (8.00 - 11.0) 12.1 (10.1 - 15.1) 513 - - 09 4.06 (3.63 - 4.54) 3.95 (3.33 - 4.44) 6.32 (5.36 10 7.10) 9.23 (8.10 - 10.6) 11.7 (10.2 - 14.8) 618 - - Hispanic blacks 03 - 04 3.08 (2.69 - 3.52) 2.86 (2.60 - 3.24) 4.34 (3.82 - 5.05) 7.81 (5.82 - 9.45) 10.4 (7.61 - 16.9) 725 Non - 06 3.08 (2.70 - 3.52) 2.91 (2.52 - 3.32) 4.21 (3.75 - 4.91) 7.33 (5.40 - 10.7) 11.6 (7.66 - 17.9) 695 05 (4.31 07 08 3.08 (2.87 - 3.31) 2.77 (2.56 - 3.13) 4.74 - - 5.22) 7.29 (6.58 - 8.26) 9.67 (8.26 - 11.0) 586 09 - 10 3.26 (2.90 - 3.66) 2.86 (2.47 - 3.34) 5.10 (4.43 - 6.06) 10.0 (7.39 - 11.7) 13.1 (11.1 - 15.2) 545 Non 03 - 04 3.44 (2.97 - 3.98) 3.17 (2.80 - 3.73) 5.16 (4.03 - 6.49) 8.00 (6.32 - 10.9) 11.1 (8.00 - 15.4) 1078 Hispanic whites - - 06 3.82 (3.47 - 4.21) 3.64 (3.30 - 3.93) 5.71 05 - 6.51) 9.23 (7.26 - 10.6) 11.6 (9.93 - 13.9) 1050 (4.90 07 - 08 3.62 (3.38 - 3.87) 3.48 (3.20 - 3.76) 5.38 (4.95 - 5.80) 8.00 (7.28 - 8.86) 10.0 (8.96 - 11.1) 1063 (7.06 - 10 3.58 (3.36 - 3.81) 3.31 (3.09 - 3.49) 5.30 (4.87 - 5.75) 8.12 09 - 9.21) 11.5 (9.43 - 14.3) 1226 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Arsenic_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Arsenic_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 263

283 Urinary Dimethylarsinic acid (creatinine corrected) (2011 – 2014) Metabolite of Arsenic Geometric mean and selected percentiles of urine concentrations (in μg As/g of creatinine) for the U.S. population from the National Health and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 12 3.92 (3.69 - 4.16) 3.65 (3.47 Total 3.91) 5.92 (5.40 - 6.49) 9.86 (8.68 - 11.3) 13.1 (11.5 - 15.2) 2516 11 - - 14 3.68 (3.46 - 3.92) 3.47 (3.17 - 3.79) 5.53 (5.11 - 5.97) 9.18 (8.11 - 10.2) 12.7 (11.4 - 13.6) 2653 13 Age group 11 years - 11 - 12 4.86 (4.54 - 5.21) 4.44 (4.10 - 4.70) 6.82 (6.15 - 7.69) 9.77 (8.65 - 11.5) 13.8 (10.3 - 15.0) 401 6 - - 5.00 (4.56 - 5.50) 4.59 (4.06 - 5.40) 7.50 (6.62 14 8.44) 10.8 (9.11 - 12.3) 13.3 (12.0 - 14.4) 397 13 - 19 years 11 - 12 3.13 (2.68 - 3.64) 3.02 (2.48 - 3.34) 12 (3.49 - 5.62) 7.03 (5.08 - 10.8) 10.8 (6.13 - 18.1) 392 4.51 - 14 2.99 (2.68 - 3.33) 2.74 (2.57 - 3.00) 4.32 (3.65 - 5.28) 6.80 (5.81 - 7.46) 9.30 (6.94 - 12.8) 450 13 - 12 3.96 (3.75 - 4.19) 3.73 (3.52 - 3.94) 6.05 (5.45 - 6.68) 10.1 (8.97 - 11.3) 13.1 (11.5 - 15.5) 1723 20 years and older 11 13 - 14 3.68 (3.46 - 3.91) 3.48 (3.21 - 3.75) 5.47 (5.12 - 5.89) 9.32 (8.24 - 10.3) 13.0 (11.3 - 14.7) 1806 Gender 14.1) - 12 3.55 (3.27 - 3.86) 3.34 (3.11 - 3.69) 5.32 (4.75 - 6.06) 8.47 (7.35 - 9.73) 11.0 (9.45 - Males 1263 11 (4.57 13 14 3.31 (3.12 - 3.51) 3.03 (2.92 - 3.29) 4.79 - - 5.05) 8.05 (7.51 - 9.13) 11.4 (10.3 - 12.8) 1307 Females 11 - 12 4.30 (4.06 - 4.56) 4.10 (3.85 - 4.35) 6.68 (5.93 - 7.36) 10.8 (9.77 - 12.4) 14.9 (12.4 - 17.0) 1253 13 14 4.08 (3.75 - 4.44) 3.94 (3.54 - 4.29) 6.16 (5.64 - 6.90) 9.84 (8.39 - 12.0) 13.4 (11.3 - 15.4) 1346 - Race/ethnicity - 11 12 4.12 (3.83 - 4.44) 4.10 (3.43 - 5.77 (5.29 - 6.37) 8.06 (7.49 - 9.54) 10.5 (8.70 - 14.8) 317 Mexican Americans 4.59) 13 - 14 3.78 (3.61 - 3.96) 3.72 (3.55 - 3.94) 5.11 (4.81 - 5.40) 7.29 (6.75 - 7.94) 9.73 (7.53 - 11.7) 455 Non Hispanic blacks 11 - 12 3.16 (2.66 - 3.74) 3.05 (2.41 - 3.67) 4.98 (4.01 - 6.08) 8.27 (6.68 - 9.70) 11.3 (8.87 - 13.7) 672 - - 14 2.89 (2.53 - 3.30) 2.68 (2.33 - 3.05) 4.40 13 - 5.00) 6.81 (5.84 - 8.72) 10.1 (7.41 - 12.5) 576 (3.70 Non - Hispanic whites 11 - 12 3.68 (3.44 - 3.93) 3.47 (3.31 - 3.63) 5.32 (5.04 - 5.93) 9.07 (7.47 - 10.3) 11.5 (9.87 - 13.1) 824 13 14 3.52 (3.22 - 3.84) 3.38 (2.94 - 3.75) 5.24 (4.70 - 5.87) 8.64 (7.50 - 10.1) 12.0 (9.54 - 13.5) 979 - (5.91 All Hispanics - 12 4.50 (4.14 - 4.89) 4.38 (4.20 - 4.82) 6.62 11 - 7.47) 9.46 (8.09 - 10.6) 13.0 (9.66 - 16.6) 574 13 - 14 3.95 (3.69 - 4.23) 3.84 (3.64 - 4.08) 5.56 (5.12 - 6.09) 7.92 (6.98 - 9.33) 11.0 (8.07 - 14.0) 703 (12.4 Asians - 12 9.89 (8.57 - 11.4) 9.72 (8.10 - 11.0) 15.6 11 - 20.5) 28.6 (20.1 - 41.1) 45.1 (34.3 - 57.2) 356 13 - 14 8.71 (7.85 - 9.67) 8.44 (7.33 - 9.33) 13.8 (12.2 - 17.0) 24.7 (18.7 - 34.4) 37.9 (27.5 - 44.4) 291 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Arsenic_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Arsenic_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 264

284 Urinary Monomethylarsonic acid (2003 – 2010) Metabolite of Arsenic and Geometric mean and selected percentiles of urine concentrations (in μg As/L) for the U.S. population from the National Health Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD 1.20 - - 1.30) 1.90 (1.60 2.10) 2.40 (2.00 - 2.80) 2567 03 Total (1.00 06 * < LOD 1.19 (1.05 - 1.34) 1.72 (1.51 - 1.94) 2.12 (1.79 - 2.70) 2588 05 - - * < LOD 1.11 (1.00 - 1.20) 1.61 08 - 1.69) 2.09 (1.91 - 2.26) 2576 07 (1.51 - 10 * < LOD 1.02 (.920 - 1.10) 1.64 (1.41 1.83) 2.01 (1.82 - 2.28) 2871 09 - Age group 11 years - 04 * < LOD 1.00 (

285 Urinary Monomethylarsonic acid (2011 – 2014) Metabolite of Arsenic Geometric mean and selected percentiles of urine concentration s (in μg As/L) for the U.S. population from the National Health and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 * < LOD < LOD 1.36 (1.17 - 1.55) 1.83 (1.57 - 2.07) 2517 Total 11 .870) 14 .411 (.372 - .454) .460 (.390 - .530) .810 (.750 - 1.22 (1.11 - 1.33) 1.53 (1.36 - 1.74) 2654 - 13 Age group - 11 - 12 * < LOD < LOD 1.21 (.970 - 1.40) 1.42 (1.24 - 1.54) 401 6 11 years - * .380 (

286 Urinary Monomethylarsonic acid (creatinine corrected) (2003 – 2010) Metabolite of Arsenic Geometric mean and selected percentiles of urine concentrations (in μg As/g of creatinine) for the U.S. population from the N ational Health and Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD 1.33 - - 1.54) 2.22 (1.82 2.57) 2.86 (2.40 - 3.53) 2567 03 Total (1.18 06 * < LOD 1.28 (1.14 - 1.52) 2.37 (1.94 - 2.78) 3.13 (2.67 - 3.76) 2588 05 - - * < LOD 1.31 (1.23 - 1.42) 2.24 08 - 2.56) 3.19 (2.78 - 3.58) 2576 07 (2.00 - 10 * < LOD 1.36 (1.25 - 1.45) 2.16 (2.00 2.29) 2.91 (2.67 - 3.15) 2870 09 - Age group 11 years - 04 * < LOD 1.63 (

287 Urinary Monomethylarsonic acid (creatinine corrected) (2011 – 2014) Metabolite of Arsenic Geometric mean and selected percentiles of urine concentrations (in μg As/g of creatinine) for the U.S. population from the N ational Health and Nutrition Examination Survey. Survey Sample 50th Percentile 90th Percentile 75th Percentile Geometric mean 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size 2.42) - * < LOD < LOD 2.21 (2.03 - 12 2.86 (2.63 - 3.32) 2516 11 Total - 14 .474 (.425 - .527) .489 (.424 - .556) .812 (.734 - .904) 1.27 (1.17 1.40) 1.61 (1.45 - 1.84) 2653 13 - Age group 11 years 11 - 12 * < LOD < LOD 2.55 (2.17 - 3.15) 3.32 (2.52 - 4.50) 401 - 6 - 13 * .543 (

288 Urinary Trimethylarsine oxide (2003 – 2010) oncentrations (in μg As/L) for the U.S. population from the National Health and Geometric mean and selected percentiles of urine c Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * < LOD < LOD < LOD < LOD 2568 Total 03 06 * < LOD < LOD < LOD < LOD 2588 05 - < LOD - * < LOD < LOD < LOD 2576 07 08 - 10 * < LOD < LOD < LOD 2871 09 < LOD Age group 11 years - 04 * < LOD < LOD 03 < LOD < LOD 292 - 6 - 06 * < LOD < LOD < LOD < LOD 354 05 - * < LOD < LOD < LOD < LOD 390 07 08 09 * < LOD < LOD 10 < LOD < LOD 380 - - 19 years 03 - 04 * < LOD < LOD < LOD < LOD 12 728 - 06 * < LOD < LOD < LOD < LOD 703 05 07 - * < LOD < LOD < LOD < LOD 366 08 < LOD - * < LOD < LOD < LOD 456 09 10 03 - 04 * < LOD < LOD 20 years and older < LOD < LOD 1548 05 06 * < LOD < LOD - < LOD < LOD 1531 07 - 08 * < LOD < LOD < LOD < LOD 1820 09 * 10 < LOD < LOD < LOD < LOD 2035 - Gender 03 04 < LOD < LOD - < LOD < LOD 1284 Males * 05 - 06 * < LOD < LOD < LOD 1276 < LOD - 08 * < LOD < LOD < LOD < LOD 1289 07 < LOD 09 10 * < LOD - < LOD < LOD 1403 Females 03 - 04 * < LOD < LOD < LOD < LOD 1284 05 06 * < LOD < LOD < LOD < LOD 1312 - 07 - * < LOD < LOD < LOD < LOD 1287 08 < LOD - * < LOD < LOD < LOD 1468 09 10 Race/ethnicity 03 * 04 < LOD < LOD < LOD < LOD 621 Mexican Americans - - * < LOD < LOD 06 < LOD < LOD 651 05 07 - 08 * < LOD < LOD < LOD < LOD 513 - 10 * < LOD < LOD < LOD < LOD 618 09 < LOD - 03 - 04 * < LOD < LOD < LOD 725 Non Hispanic blacks 05 - 06 * < LOD < LOD < LOD < LOD 695 - 08 * < LOD < LOD < LOD < LOD 586 07 < LOD 09 10 * < LOD - < LOD < LOD 546 Non - Hispanic whites 03 - 04 * < LOD < LOD < LOD < LOD 1078 05 06 * < LOD < LOD < LOD < LOD 1050 - 07 < LOD 08 * < LOD < LOD < LOD 1063 - < LOD 10 * < LOD - < LOD < LOD 1226 09 Limit of detection (LOD, see Data Analysis section) for Survey years 03 - 04, 05 - 06, 07 - 08 and 09 - 10 are 1.0, 1.0, 1.0, and 1.0 respectively. vary < means less than the limit of detection, which may LOD for some chemicals by year and by individual sample. * Not calculated: proportion of results below limit of detection was too high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Arsenic_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Arsenic_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 269

289 Urinary Trimethylarsine oxide (2011 – 2012)‡ and Geometric mean and selected percentiles of urine concentrations (in μg As/L) for the U.S. population from the National Health Nutrition Examination Survey. Sample Survey Geometric mean 50th Percentile 95th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 11 - 12 * < LOD < LOD Total < LOD < LOD 2517 Age group < LOD 11 years 11 - 12 * - < LOD < LOD .300 (

290 Urin ary Trimethylarsine oxide (creatinine corrected) (2003 2010) – ational Geometric mean and selected percentiles of urine concentrations (in μg As/g of creatinine) for the U.S. population from the N Health and Nutrition Examination Survey. Survey Sample 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 04 * Total < LOD < LOD < LOD < LOD 2568 03 - * < LOD < LOD 06 < LOD 2588 05 < LOD - 08 * < LOD < LOD < LOD < LOD 2576 07 - 09 * < LOD < LOD < LOD < LOD 2870 10 Age group 11 years 03 - 04 * < LOD < LOD < LOD < LOD 292 6 - - 05 * < LOD < LOD < LOD < LOD 354 06 07 * < LOD < LOD 08 < LOD < LOD 390 - 09 - 10 * < LOD < LOD < LOD < LOD 379 12 - 03 - 04 * < LOD < LOD < LOD < LOD 728 19 years 05 - * < LOD < LOD < LOD < LOD 703 06 < LOD - * < LOD < LOD < LOD 366 07 08 - 10 * < LOD < LOD < LOD 456 09 < LOD - 04 * < LOD 03 < LOD < LOD 1548 20 years and older < LOD 05 - 06 * < LOD < LOD < LOD < LOD 1531 - 08 * < LOD < LOD < LOD < LOD 1820 07 09 * < LOD < LOD 10 < LOD < LOD 2035 - Gender - 04 Males * < LOD < LOD < LOD < LOD 1284 03 < LOD 05 06 * < LOD - < LOD < LOD 1276 07 - 08 * < LOD < LOD < LOD < LOD 1289 09 10 * < LOD < LOD < LOD < LOD 1402 - 03 04 * < LOD < LOD < LOD < LOD 1284 Females - < LOD - * < LOD < LOD < LOD 1312 05 06 - 08 * < LOD < LOD < LOD < LOD 1287 07 09 10 * < LOD < LOD - < LOD < LOD 1468 Race/ethnicity * - 04 Mexican Americans < LOD < LOD < LOD < LOD 621 03 05 * < LOD < LOD 06 < LOD < LOD 651 - 07 - 08 * < LOD < LOD < LOD < LOD 513 09 - 10 * < LOD < LOD < LOD < LOD 618 - 03 - 04 * < LOD Non < LOD < LOD < LOD 725 Hispanic blacks 05 - 06 * < LOD < LOD < LOD < LOD 695 07 08 * < LOD < LOD < LOD < LOD 586 - 09 * < LOD < LOD 10 < LOD < LOD 545 - - Hispanic whites 03 - 04 * < LOD < LOD < LOD < LOD 1078 Non - 06 * < LOD < LOD < LOD < LOD 1050 05 < LOD 07 08 * < LOD - < LOD < LOD 1063 09 - 10 * < LOD < LOD < LOD < LOD 1226 for < means less than the limit of detection LOD the urine levels not corrected for creatinine. * Not calculated: proportion of results below limit of detection was too high to provide a valid result. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Arsenic_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Arsenic_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 271

291 Urinary Trimethylarsine oxide (creatinine corrected) (2011 – 2012)‡ ational Geometric mean and selected percentiles of urine concentrations (in μg As/g of creatinine) for the U.S. population from the N Health and Nutrition Examination Survey. Survey Sample 50th Percentile 90th Percentile 75th Percentile 95th Percentile Geometric mean Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size 11 12 * < LOD < LOD < LOD < LOD - 2516 Total Age group - 11 years 11 - 12 * < LOD < LOD < LOD 1.06 (

292 Urinary Barium (1999 – 2010) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 1.50 (1.35 - 1.66) 1.60 (1.50 - Total 3.10 (2.70 3.40) 5.40 (4.60 - 6.10) 6.90 (6.20 - 8.40) 2180 99 - 00 1.90) 02 1.52 (1.41 - 1.65) 1.63 (1.50 - 1.76) 3.12 (2.77 - 3.51) 5.24 (4.73 - 5.84) 7.48 (6.54 8.12) 2690 01 - - - 1.49 (1.36 - 1.64) 1.51 (1.35 - 1.72) 2.91 (2.64 - 3.28) 5.36 (4.86 - 5.71) 7.54 (6.93 - 8.63) 2558 03 04 3.41) 06 1.52 (1.39 - 1.66) 1.58 (1.44 - 1.70) 2.99 (2.63 - 5.34 (4.82 - 5.83) 7.10 (6.46 - 8.18) 2576 05 - - 08 1.56 (1.45 - 1.69) (1.49 - 1.80) 3.01 (2.72 - 3.34) 4.93 (4.39 - 5.69) 7.04 (6.07 - 8.20) 2627 07 1.64 09 10 1.47 (1.34 - 1.60) 1.48 (1.35 - 1.62) 2.81 (2.52 - 3.06) 4.66 (4.34 - 5.35) 6.78 (5.86 - 7.76) 2848 - Age group 11 years 99 - 00 2.15 (1.70 - 2.72) 2.20 (1.90 - 2.50) 4.00 (2.60 - 6.10) 6.40 (5.20 - 8.30) 8.30 (5.00 - 76.2) 297 6 - - - 1.80 (1.44 - 2.26) 2.09 (1.74 01 2.49) 3.63 (2.86 - 4.39) 5.37 (4.26 - 7.38) 6.88 (5.37 - 8.49) 368 02 - 03 2.21 (1.81 - 2.71) 2.50 (1.81 - 2.75) 4.76 (3.80 04 5.65) 8.63 (5.59 - 11.8) 11.8 (6.87 - 14.8) 290 - 05 - 06 1.73 (1.53 - 1.97) 1.87 (1.61 - 2.03) 3.55 (2.41 - 4.30) 6.21 (4.30 - 7.32) 7.72 (6.26 - 8.92) 355 - 08 1.75 (1.50 - 2.04) 1.86 (1.58 - 2.23) 3.41 (2.85 - 3.79) 5.57 (4.49 - 6.59) 7.32 (5.71 - 9.18) 394 07 09 - 1.49 (1.28 - 1.74) 1.50 (1.22 - 1.68) 2.72 (2.19 - 3.13) 4.63 (4.02 - 5.37) 6.59 (5.24 - 7.72) 378 10 19 years (3.10 99 - 00 1.97 (1.78 - 2.19) 2.00 (1.70 - 2.30) 3.50 - - 4.00) 5.90 (4.80 - 7.00) 9.70 (5.90 - 13.1) 621 12 - - 2.03 (1.76 - 2.34) 2.27 (1.96 - 2.53) 4.11 (3.48 02 4.72) 6.73 (5.55 - 7.87) 9.02 (7.25 - 11.4) 762 01 03 - 04 2.16 (1.93 - 2.41) 2.35 (2.06 - 2.63) 4.11 (3.48 - 4.71) 7.18 (6.00 - 8.29) 9.63 (8.15 - 11.4) 725 05 06 2.16 (1.92 - 2.42) 2.33 (1.99 - 2.56) 3.80 (3.60 - 4.21) 6.35 (5.48 - 7.49) 8.24 (6.06 - 10.5) 701 - - 07 2.18 (1.99 - 2.39) 2.31 (2.07 - 2.59) 3.62 (3.34 08 4.10) 6.19 (4.75 - 7.51) 8.20 (6.22 - 11.1) 376 - 09 - 10 1.79 (1.52 - 2.09) 1.90 (1.46 - 2.45) 3.25 (2.82 - 4.14) 5.43 (4.45 - 6.07) 6.87 (5.73 - 8.16) 451 20 years and older - 00 1.36 (1.24 - 1.51) 1.50 (1.30 - 1.70) 2.80 (2.60 - 3.20) 5.10 (4.30 - 5.50) 6.40 (5.70 - 8.40) 1262 99 (2.55 01 02 1.43 (1.32 - 1.54) 1.50 (1.39 - 1.65) 2.85 - - 3.27) 4.86 (4.53 - 5.47) 7.14 (6.08 - 8.12) 1560 03 - 04 1.34 (1.20 - 1.50) 1.39 (1.19 - 1.56) 2.54 (2.21 - 2.91) 4.61 (3.99 - 5.30) 6.61 (5.57 - 7.43) 1543 05 06 1.42 (1.28 - 1.57) 1.43 (1.28 - 1.63) 2.75 (2.47 - 3.11) 5.12 (4.45 - 5.81) 6.83 (6.14 - 7.90) 1520 - 07 - 1.46 (1.35 - 1.58) 1.51 (1.39 - 1.67) 2.79 (2.54 - 3.15) 4.61 (4.19 - 5.42) 6.80 (5.50 - 8.37) 1857 08 (4.22 - 1.42 09 (1.30 - 1.55) 1.43 (1.31 - 1.58) 2.67 (2.36 - 3.02) 4.58 10 - 5.14) 6.80 (5.70 - 8.63) 2019 Gender 99 - 00 1.70 (1.54 - 1.88) 1.90 (1.80 - 2.00) 3.20 (3.00 - 3.60) 5.50 (4.20 - 6.70) 7.50 (5.90 - 9.70) 1083 Males 01 - 02 1.64 (1.47 - 1.82) 1.80 (1.65 1.98) 3.15 (2.76 - 3.73) 5.52 (4.82 - 6.35) 7.87 (6.49 - 9.32) 1335 - - 03 1.62 (1.47 - 1.78) 1.69 (1.49 - 1.85) 3.09 (2.81 04 3.54) 5.65 (5.14 - 6.16) 8.56 (6.71 - 9.67) 1281 - 05 - 06 1.66 (1.48 - 1.85) 1.71 (1.50 - 1.94) 3.21 - 3.79) 5.48 (4.68 - 6.22) 7.10 (6.18 - 8.84) 1271 (2.76 - 08 1.62 (1.48 - 1.77) 1.80 (1.57 - 1.93) 3.14 07 - 3.42) 5.00 (4.31 - 5.70) 6.84 (5.83 - 7.72) 1327 (2.79 09 - 10 1.53 (1.35 - 1.74) 1.57 (1.36 - 1.82) 3.01 (2.53 - 3.36) 4.83 (4.25 - 5.77) 6.81 (5.77 - 8.76) 1398 Females - 00 1.33 (1.15 - 1.53) 1.50 (1.20 - 1.60) 2.80 (2.30 - 3.30) 5.20 (4.20 - 5.90) 6.80 (5.60 - 10.4) 1097 99 - 01 1.43 (1.30 - 1.56) 1.44 (1.29 - 1.63) 3.11 (2.74 02 3.43) 4.93 (4.44 - 5.88) 7.15 (6.32 - 7.86) 1355 - 03 - 04 1.38 (1.24 - 1.54) 1.39 (1.18 - 1.57) 2.71 - 3.15) 4.95 (4.29 - 5.51) 6.87 (5.65 - 8.10) 1277 (2.41 - 06 1.40 (1.27 - 1.54) 1.42 (1.30 - 1.63) 2.70 05 - 3.19) 5.21 (4.65 - 5.71) 7.09 (6.24 - 7.94) 1305 (2.39 07 - 08 1.51 (1.36 - 1.68) 1.54 (1.38 - 1.70) 2.84 (2.52 - 3.37) 4.87 (4.23 - 6.13) 7.18 (5.94 - 8.83) 1300 (2.41 10 1.40 (1.30 - 1.51) 1.38 (1.31 - 1.47) 2.61 - - 2.90) 4.58 (4.33 - 4.95) 6.59 (5.37 - 7.86) 1450 09 Limit of detection (LOD, see Data Analysis section) for Survey years 99 - 00, 01 - 02, 03 - 04, 05 - 06, 07 - 08, and 09 - 10 are 0.12, 0.12, 0.31, 0.12, 0.12, and 0.12 respectively. Biomonitoring S ummary http://www.cdc.gov/biomonitoring/Barium_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 273

293 Urinary Barium (1999 – 2010) n and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health and Geometric mea Nutrition Examination Survey. Survey Sample 95th Percentile Geometric mean 50th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 1.35 (1.25 - 1.46) 1.40 (1.20 - 1.50) 2.60 (2.30 - 2.90) 4.50 (4.10 - 5.30) 6.30 (5.50 - 6.80) 692 Mexican Americans - 1.21 (1.06 - 1.37) 1.25 (1.11 - 1.46) 2.56 (2.04 - 2.91) 4.35 (3.65 - 5.49) 6.43 (5.21 - 8.22) 683 01 02 - 03 1.40 (1.15 - 1.70) 1.45 (1.22 - 1.73) 2.62 (1.78 04 3.38) 4.07 (2.95 - 6.37) 6.01 (4.01 - 7.88) 618 - 05 - 06 1.33 (1.24 - 1.42) 1.36 (1.22 - 1.50) 2.63 (2.35 - 2.89) 4.47 (3.80 - 5.23) 6.21 (5.23 - 7.00) 652 - 08 1.33 (1.16 - 1.53) 1.37 (1.19 - 1.48) 2.60 (2.29 - 2.84) 4.21 (3.53 - 4.90) 5.79 (4.90 - 8.00) 515 07 - 09 1.24 (1.07 - 1.45) 1.18 (1.05 - 1.40) 2.25 (1.88 10 2.71) 4.15 (3.55 - 5.40) 6.35 (5.00 - 8.75) 613 - - Hispanic blacks 99 - 00 1.34 (1.12 - 1.62) 1.40 (1.20 - 1.60) 2.50 (2.30 - 2.90) 5.10 (3.70 - 6.60) 7.40 (5.40 - 13.9) 540 Non - 02 1.30 (1.14 - 1.48) 1.42 (1.22 - 1.62) 2.61 (2.31 - 2.82) 4.30 (3.70 - 5.18) 5.99 (4.87 - 7.26) 667 01 (2.05 03 04 1.27 (1.17 - 1.39) 1.38 (1.26 - 1.48) 2.34 - - 2.59) 3.77 (3.35 - 4.36) 5.86 (4.76 - 7.45) 723 05 - 06 1.25 (1.15 - 1.37) 1.31 (1.21 - 1.41) 2.40 (2.22 - 2.61) 4.24 (3.69 - 4.83) 6.19 (5.23 - 6.96) 692 07 08 1.17 (1.07 - 1.28) 1.23 (1.12 - 1.37) 2.14 (2.01 - 2.34) 3.70 (3.27 - 4.00) 5.00 (3.93 - 5.90) 589 - - 09 1.22 (1.08 - 1.38) 1.22 (1.07 - 1.38) 2.13 (1.91 10 2.51) 3.76 (3.09 - 4.88) 5.50 (4.06 - 7.32) 544 - - Hispanic whites 99 - 00 1.56 (1.36 - 1.80) 1.80 (1.60 - 2.00) 3.30 Non (2.80 - 3.70) 5.50 (4.50 - 6.30) 7.50 (6.20 - 8.80) 765 - 02 1.61 (1.46 - 1.77) 1.68 (1.54 - 1.85) 3.31 01 - 3.74) 5.66 (4.94 - 6.30) 7.73 (6.61 - 8.49) 1132 (2.87 03 - 04 1.56 (1.37 - 1.78) 1.61 (1.28 - 1.92) 3.12 (2.75 - 3.70) 5.57 (5.04 - 6.43) 8.08 (6.87 - 9.53) 1074 05 06 1.59 (1.42 - 1.78) 1.66 (1.50 - 1.86) 3.08 (2.63 - 3.79) 5.50 (4.90 - 6.08) 7.10 (6.46 - 8.24) 1041 - (2.91 08 1.71 (1.55 - 1.88) 1.82 (1.62 - 1.97) 3.36 - - 3.71) 5.38 (4.51 - 6.30) 7.18 (6.22 - 9.05) 1095 07 09 - 10 1.56 (1.42 - 1.73) 1.60 (1.40 - 1.76) 3.00 (2.64 - 3.36) 4.89 (4.48 - 5.84) 7.16 (6.12 - 9.31) 1225 07 Limit of detection (LOD, see Data Analysis section) for Survey years 99 - 00, 01 - 02, 03 - 04, 05 - 06, - 08, and 09 - 10 are 0.12, 0.12, 0.31, 0.12, 0.12, and 0.12 respectively. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Barium_BiomonitoringSu mmary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 274

294 Urinary Barium (2011 – 2014) in μg/L) for the U.S. population from the National Health and Geometric mean and selected percentiles of urine concentrations ( Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 1.19 (1.11 - 1.28) 1.23 (1.14 Total 1.33) 2.40 (2.24 - 2.54) 4.04 (3.76 - 4.35) 5.52 (4.92 - 5.95) 2504 11 - - 14 1.09 (1.03 - 1.16) 1.10 (.980 - 1.21) 2.17 (2.05 - 2.31) 4.01 (3.61 - 4.28) (5.29 - 6.09) 2664 13 5.67 Age group 11 years - 11 - 12 1.39 (1.24 - 1.55) 1.46 (1.21 - 1.62) 2.96 (2.33 - 3.52) 4.92 (4.52 - 5.29) 6.68 (5.25 - 7.92) 399 6 - - 1.13 (.962 - 1.33) 1.20 (.970 - 1.43) 2.06 (1.73 14 2.64) 3.48 (2.64 - 5.02) 5.02 (2.96 - 9.85) 402 13 - 19 years 11 - 12 1.52 (1.25 - 1.84) 1.61 (1.24 - 1.90) 2.98 (2.40 - 4.03) 5.37 (4.27 - 6.08) 6.63 (5.53 - 8.77) 390 12 13 14 1.43 (1.19 - 1.70) 1.49 (1.10 - 1.75) 2.78 (2.23 - 3.49) 5.67 (4.18 - 6.69) 6.92 (6.14 - 8.11) 451 - 11 12 1.13 (1.06 - 1.21) 1.19 (1.09 - 1.27) 2.24 (2.09 - 2.44) 3.74 (3.39 - 4.01) 5.05 (4.37 - 5.78) 1715 20 years and older - - - 1.05 (.989 - 1.11) 1.03 (.930 - 1.16) 2.13 (1.93 14 2.31) 3.88 (3.33 - 4.25) 5.60 (4.78 - 5.96) 1811 13 Gender - - 12 1.29 (1.20 - 1.38) 1.30 (1.24 Males 1.41) 2.52 (2.25 - 2.71) 4.29 (3.74 - 4.58) 5.96 (4.49 - 7.35) 1262 11 13 (2.09 14 1.20 (1.10 - 1.31) 1.24 (1.05 - 1.43) 2.38 - 2.68) 4.27 (3.76 - 4.95) 5.96 (5.60 - 6.69) 1318 - (2.06 Females - 12 1.11 (.989 - 1.25) 1.14 (1.00 - 1.35) 2.33 11 - 2.57) 3.90 (3.34 - 4.35) 5.13 (4.44 - 5.57) 1242 13 - 14 .998 (.940 - 1.06) .980 (.870 - 1.12) 2.03 (1.85 - 2.19) 3.66 (3.21 - 4.07) 5.19 (4.42 - 5.74) 1346 Race/ethnicity 11 12 1.08 (.961 - 1.22) 1.06 (.910 - 1.23) 2.10 (1.79 - 2.57) 3.95 (3.24 - 4.86) 5.58 (4.10 - 7.22) 317 Mexican Americans - - - .938 (.853 - 1.03) .870 (.760 - 1.02) 2.00 (1.61 14 2.25) 3.15 (2.84 - 3.53) 4.19 (3.48 - 4.95) 453 13 - Hispanic blacks 11 - 12 .997 (.891 - 1.12) 1.05 (.910 - 1.20) 2.08 Non - 2.29) 3.63 (3.09 - 4.08) 4.68 (4.02 - 5.19) 669 (1.79 - 14 .947 (.865 - 1.04) .940 (.860 - 1.06) 1.81 (1.59 - 2.08) 3.48 (2.94 - 4.01) 4.50 (3.92 - 5.95) 581 13 - 11 - 12 1.27 (1.17 - 1.38) 1.32 (1.22 - 1.43) 2.50 Non (2.25 - 2.71) 4.33 (3.63 - 4.81) 5.57 (4.87 - 6.35) 820 Hispanic whites 13 - 14 1.18 (1.10 - 1.26) 1.20 (1.05 - 1.35) 2.32 (2.16 - 2.53) 4.27 (3.74 - 4.94) 5.99 (5.57 - 6.44) 985 All Hispanics - 12 1.08 (.970 - 1.19) 1.07 (.940 - 1.23) 2.15 (1.86 - 2.47) 3.74 (2.99 - 4.34) 4.82 (3.96 - 5.98) 573 11 (1.72 13 14 .927 (.840 - 1.03) .890 (.760 - 1.05) 1.92 - - 2.14) 3.15 (2.84 - 3.53) 4.25 (3.60 - 4.82) 701 Asians 11 - 12 1.16 (1.03 - 1.30) 1.21 (1.02 - 1.35) 2.28 (1.94 - 2.67) 3.90 (3.20 - 4.47) 5.50 (4.01 - 6.40) 353 (1.47 14 .962 (.831 - 1.12) .920 (.790 - 1.13) 1.93 - - 2.33) 3.79 (2.95 - 4.75) 5.67 (4.19 - 6.61) 292 13 Limit of detection (LOD, see Data Analysis section) for Survey year 11 - 12 and 13 - 14 are 0.1 and 0.06. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Ba rium_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 275

295 Urinary Barium (creatinine corrected) (1999 – 2010) onal Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati Nutrition Examination Survey. Health and Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 00 1.40 (1 .26 - 1.56) 1.41 (1.28 - 1.54) 2.54 (2.20 - 2.91) 4.68 (3.85 - 5.47) 6.33 (5.47 Total 8.09) 2180 99 - - 1.44 (1.31 - 1.58) 1.49 (1.35 - 1.63) 2.76 (2.51 - 02 4.58 (4.15 - 4.96) 6.24 (5.28 - 7.27) 2689 01 3.03) - 04 1.48 (1.37 - 1.60) 1.41 (1.31 - 1.58) 2.68 (2.44 - 2.89) 4.92 (4.39 - 7.10 (6.29 - 7.77) 2558 03 5.45) 05 06 1.50 (1.40 - 1.61) 1.48 (1.37 - 1.61) 2.75 (2.50 - 3.03) 4.65 (4.09 - 5.10) 6.38 (5.62 - 7.56) 2576 - - 1.63 (1.51 - 1.75) 1.60 (1.51 - 1.72) 2.92 (2.72 - 3.16) 4.85 07 (4.40 - 5.57) 7.20 (5.94 - 8.59) 2627 08 (4.12 - 1.56 09 (1.45 - 1.68) 1.55 (1.42 - 1.64) 2.72 (2.54 - 2.97) 4.69 10 - 5.16) 6.24 (5.60 - 7.43) 2848 Age group - 11 years 99 - 00 2.37 (1.68 - 3.32) 2.38 (1.84 - 2.92) 4.47 (2.55 - 6.46) 10.2 (3.75 - 22.0) 11.4 (5.46 - 6 297 22.0) - 02 2.20 (1.91 - 2.52) 2.41 (2.19 - 2.83) 3.91 (3.29 - 4.51) 5.01 (4.58 - 6.00) 6.71 (5.20 - 8.47) 368 01 03 - 2.58 (2.22 - 2.99) 3.00 (2.35 - 3.29) 4.45 (3.57 - 5.54) 6.69 (5.59 - 7.70) 10.3 (6.53 - 21.0) 290 04 - - 2.14 (1.85 - 2.48) 2.15 (1.76 - 2.51) 3.83 (3.10 05 4.73) 6.19 (4.84 - 7.83) 10.0 (5.76 - 11.1) 355 06 - 07 2.28 (2.04 - 2.54) 2.41 (2.05 - 2.59) 4.43 (3.87 08 4.70) 6.58 (5.05 - 9.46) 9.89 (7.13 - 13.3) 394 - 09 - 10 2.03 (1.78 - 2.30) 2.00 (1.77 - 2.40) 3.33 (2.81 - 5.04 (4.17 - 7.39) 8.76 (5.93 - 10.8) 378 3.79) 12 19 years 99 - 00 1.51 (1.34 - 1.70) 1.40 (1.26 - 1.59) 2.48 (1.97 - 3.06) 4.36 (3.23 - 5.39) 7.62 (4.24 - 11.4) 621 - 01 2.89 02 1.45 (1.33 - 1.59) 1.56 (1.31 - 1.77) (2.68 - 3.12) 4.52 (3.84 - 5.20) 5.55 (4.81 - 6.10) 762 - (2.24 04 1.54 (1.36 - 1.75) 1.59 (1.39 - 1.87) 2.60 - - 3.48) 4.97 (4.34 - 5.58) 6.47 (5.38 - 7.77) 725 03 05 - 06 1.66 (1.50 - 1.84) 1.73 (1.52 - 1.93) 3.15 (2.76 - 3.42) 4.25 (3.88 - 4.56) 5.00 (4.46 - 6.68) 701 07 08 1.71 (1.52 - 1.92) 1.70 (1.48 - 1.96) 3.03 (2.51 - 3.65) 4.80 (3.96 - 5.47) 6.17 (4.80 - 8.12) 376 - 09 - 1.67 (1.48 - 1.88) 1.66 (1.54 - 1.84) 2.69 (2.24 - 3.18) 3.98 (3.40 - 5.29) 6.42 (4.61 - 9.33) 451 10 2.62) 99 1.30 (1.19 - 1.42) 1.33 (1.20 - 1.46) 2.32 (2.08 - 00 4.29 (3.63 - 4.96) 5.65 (5.28 - 6.33) 1262 - 20 years and older - 02 1.37 (1.24 - 1.50) 1.40 (1.24 - 1.52) 2.53 (2.23 2.84) 4.38 (4.02 - 5.00) 6.55 (5.00 - 7.64) 1559 01 - 03 04 1.38 (1.26 - 1.50) 1.32 (1.22 - 1.41) 2.39 (2.13 - 2.70) 4.39 (3.77 - 5.16) 7.00 (5.45 - 8.50) 1543 - 05 - 06 1.42 (1.30 - 1.54) 1.39 (1.26 - 1.55) 2.59 (2.33 - 2.82) 4.53 (3.65 - 5.40) 6.34 (5.37 - 7.67) 1520 - 08 1.56 (1.44 - 1.69) 1.55 (1.40 - 1.66) 2.80 (2.55 - 3.04) 4.64 (4.05 - 5.43) 7.20 (5.78 - 8.65) 1857 07 - 09 1.50 (1.40 - 1.61) 1.46 (1.38 - 1.55) 2.67 (2.42 10 2.92) 4.71 (4.07 - 5.23) 6.03 (5.53 - 7.34) 2019 - Gender - - 00 1.32 (1.22 - 1.42) 1.36 (1.23 Males 1.47) 2.39 (2.11 - 2.57) 4.24 (3.48 - 5.00) 5.61 (4.39 - 10.2) 1083 99 (2.14 01 02 1.30 (1.16 - 1.45) 1.34 (1.19 - 1.50) 2.46 - - 2.83) 4.51 (3.73 - 4.96) 5.42 (4.81 - 7.51) 1334 03 - 04 1.36 (1.26 - 1.47) 1.31 (1.19 - 1.43) 2.60 (2.37 - 2.75) 4.36 (3.97 - 4.72) 6.01 (5.45 - 6.96) 1281 05 06 1.36 (1.23 - 1.50) 1.38 (1.25 - 1.52) 2.36 (2.19 - 2.73) 4.24 (3.65 - 4.82) 5.69 (4.75 - 7.36) 1271 - - 07 1.45 (1.34 - 1.55) 1.50 (1.32 - 1.60) 2.59 (2.34 08 2.79) 4.30 (3.84 - 4.72) 5.56 (5.05 - 6.30) 1327 - 09 - 10 1.40 (1.28 - 1.52) 1.38 (1.29 - 1.50) 2.39 (2.13 2.68) 4.05 (3.52 - 4.71) 5.55 (4.89 - 6.77) 1398 - Females 99 - 00 1.49 (1.27 - 1.74) 1.48 (1.29 - 1.68) 2.65 (2.13 - 3.46) 4.91 (3.96 - 6.38) 7.36 (5.25 - 11.3) 1097 01 - 02 1.59 (1.45 - 1.75) 1.64 (1.48 - 1.79) 2.98 (2.75 - 3.30) 4.76 (4.38 - 5.31) 6.97 (5.86 - 7.52) 1355 03 04 1.60 (1.45 - 1.77) 1.55 (1.35 - 1.73) 2.78 (2.34 - 3.25) 5.50 (4.43 - 6.86) 7.88 (6.28 - 11.5) 1277 - (2.71 06 1.65 (1.54 - 1.76) 1.63 (1.45 - 1.83) 3.09 - - 3.38) 4.87 (4.48 - 5.65) 7.48 (6.04 - 10.0) 1305 05 07 - 08 1.83 (1.63 - 2.05) 1.74 (1.52 - 2.06) 3.22 (2.82 - 3.89) 5.94 (4.57 - 7.38) 8.15 (7.18 - 9.49) 1300 - 10 1.73 (1.60 - 1.87) 1.71 (1.62 - 1.86) 3.06 (2.72 - 3.41) 5.06 09 (4.59 - 5.74) 6.58 (5.88 - 8.19) 1450 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Barium_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 276

296 Urinary Barium (creatinine corrected) (1999 – 2010) r the U.S. population from the National Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) fo and Nutrition Examination Survey. Survey Sample 95th Percentile Geometric mean 50th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 1.21 (1.10 - 1.33) 1.18 (1.05 - 1.38) 2.39 (2.10 - 2.59) 4.00 (3.33 - 4.80) 5.31 (4.80 - 6.51) 692 Mexican Americans - 1.18 (1.03 - 1.34) 1.16 (1.00 - 1.38) 2.33 (1.90 - 2.61) 3.68 (3.29 - 4.10) 4.96 (4.24 - 6.80) 682 01 02 - 03 1.29 (1.08 - 1.55) 1.28 (1.03 - 1.53) 2.25 (1.73 04 2.97) 3.99 (2.79 - 5.03) 4.99 (4.24 - 6.56) 618 - 05 - 06 1.25 (1.17 - 1.33) 1.21 (1.09 - 1.33) (1.84 - 2.61) 3.66 (3.07 - 4.35) 5.11 (4.00 - 5.95) 652 2.27 - 08 1.33 (1.16 - 1.53) 1.28 (1.14 - 1.49) 2.40 (1.87 - 2.90) 4.23 (3.45 - 4.87) 6.18 (4.75 - 7.27) 515 07 - 09 1.30 (1.18 - 1.44) 1.26 (1.14 - 1.41) 2.33 (1.98 10 2.79) 3.55 (3.11 - 4.42) 5.50 (4.27 - 6.58) 613 - - Hispanic blacks 99 - 00 .881 (.703 - 1.11) .905 (.710 - 1.06) 1.64 Non (1.36 - 2.00) 3.27 (2.26 - 4.76) 4.84 (3.57 - 10.8) 540 - 02 .891 (.777 - 1.02) .921 (.754 - 1.11) 1.64 01 - 2.03) 2.86 (2.48 - 3.37) 4.02 (3.52 - 4.68) 667 (1.44 03 - 04 .915 (.832 - 1.01) .963 (.880 - 1.04) 1.51 (1.39 - 1.75) 2.62 (2.29 - 3.04) 3.76 (3.22 - 4.72) 723 05 06 .909 (.845 - .979) .880 (.820 - .970) 1.78 (1.56 - 1.97) 2.99 (2.63 - 3.14) 3.91 (3.39 - 4.73) 692 - - 07 .858 (.807 - .913) .850 (.790 - .920) 1.53 (1.34 08 1.61) 2.51 (2.01 - 3.03) 3.43 (2.83 - 5.05) 589 - 09 - 10 .965 (.853 - 1.09) .930 (.860 - 1.05) 1.63 (1.40 - 2.92 (2.33 - 3.34) 3.71 (3.24 - 4.69) 544 1.85) Non Hispanic whites 99 - 00 1.56 (1.38 - 1.77) 1.55 (1.36 - 1.74) - (2.27 - 3.24) 5.00 (3.81 - 6.02) 6.60 (5.52 - 10.2) 765 2.72 01 - 02 1.62 (1.49 - 1.76) 1.66 (1.49 - 1.82) 3.04 (2.76 - 3.32) 4.96 (4.55 - 5.41) 6.74 (5.57 - 7.64) 1132 03 04 1.64 (1.49 - 1.82) 1.60 (1.40 - 1.76) 2.88 (2.56 - 3.26) 5.38 (4.67 - 6.28) 7.57 (6.69 - 9.27) 1074 - (2.70 06 1.65 (1.52 - 1.80) 1.61 (1.46 - 1.83) 2.95 - - 3.26) 4.82 (4.32 - 5.65) 7.21 (5.69 - 8.51) 1041 05 07 - 08 1.91 (1.74 - 2.10) 1.85 (1.65 - 2.09) 3.22 (2.84 - 3.76) 5.42 (4.55 - 6.91) 7.81 (6.33 - 9.45) 1095 - 10 1.75 (1.59 - 1.92) 1.70 (1.58 - 1.86) 2.99 (2.67 - 3.33) 5.00 09 (4.14 - 5.69) 6.63 (5.69 - 8.50) 1225 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Barium_BiomonitoringSu mmary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 277

297 Urinary Barium (creatinine corrected) (2011 – 2014) onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati an d Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 1.35 (1.24 - 1.48) 1.38 (1.27 Total 1.47) 2.44 (2.10 - 2.84) 4.19 (3.72 - 4.85) 6.27 (5.20 - 6.66) 2502 11 - - 14 1.26 (1.19 - 1.34) 1.24 (1.13 - 1.38) 2.33 (2.18 - 2.50) 4.06 (3.75 - 4.26) (5.02 - 6.06) 2663 13 5.59 Age group 11 years - 11 - 12 1.99 (1.80 - 2.19) 2.18 (1.70 - 2.61) 3.72 (3.35 - 4.03) 5.82 (4.95 - 6.45) 6.78 (5.98 - 8.18) 398 6 - - 1.69 (1.39 - 2.05) 1.61 (1.24 - 2.20) 3.10 (2.29 14 3.80) 5.24 (3.54 - 7.57) 6.62 (5.03 - 9.83) 402 13 - 19 years 11 - 12 1.45 (1.24 - 1.70) 1.42 (1.24 - 1.78) 2.81 12 (1.96 - 3.19) 4.90 (3.82 - 5.69) 6.29 (4.90 - 6.57) 390 - 14 1.29 (1.18 - 1.42) 1.36 (1.20 - 1.59) 2.33 (2.12 - 2.64) 3.69 (3.24 - 4.20) 4.80 (4.09 - 5.05) 451 13 - 12 1.29 (1.17 - 1.41) 1.31 (1.20 - 1.43) 2.21 (1.95 - 2.63) 3.83 (3.50 - 4.31) 5.54 (4.38 - 6.84) 1714 20 years and older 11 13 - 14 1.22 (1.16 - 1.29) 1.18 (1.10 - 1.28) 2.23 (2.04 - 2.43) 4.00 (3.69 - 4.31) 5.59 (5.00 - 6.11) 1810 Gender 6.34) - 12 1.20 (1.10 - 1.32) 1.17 (1.08 - 1.33) 2.09 (1.85 - 2.53) 3.72 (3.37 - 4.22) 5.35 (4.11 - Males 1261 11 (1.97 13 14 1.20 (1.13 - 1.28) 1.16 (1.09 - 1.30) 2.26 - - 2.48) 3.80 (3.39 - 4.28) 4.79 (4.42 - 5.24) 1317 Females 11 - 12 1.51 (1.36 - 1.68) 1.51 (1.39 - 1.67) 2.73 (2.39 - 3.12) 4.83 (3.88 - 5.63) 6.52 (5.32 - 8.33) 1241 13 14 1.32 (1.23 - 1.43) 1.33 (1.17 - 1.52) 2.42 (2.18 - 2.72) 4.24 (3.96 - 4.60) 6.23 (5.29 - 8.04) 1346 - Race/ethnicity - 11 12 1.22 (1.09 - 1.36) 1.16 (1.02 - 2.20 (1.82 - 2.71) 4.00 (3.08 - 4.84) 5.74 (3.94 - 7.90) 317 Mexican Americans 1.31) 13 - 14 1.07 (.985 - 1.16) 1.02 (.943 - 1.13) 1.88 (1.68 - 2.19) 3.53 (2.78 - 4.32) 4.76 (4.28 - 5.62) 453 Non Hispanic blacks 11 - 12 .775 (.698 - .861) .744 (.664 - .918) 1.48 (1.32 - 1.64) 2.64 (2.24 - 3.06) 3.56 (3.21 - 3.86) 669 - - 14 .721 (.660 - .786) .717 (.657 - .790) 1.31 13 - 1.49) 2.42 (1.95 - 2.85) 3.26 (2.85 - 4.46) 581 (1.18 Non - Hispanic whites 11 - 12 1.54 (1.38 - 1.70) 1.53 (1.44 - 1.64) 2.71 (2.18 - 3.18) 4.71 (3.82 - 5.54) 6.45 (5.36 - 7.63) 818 13 14 1.45 (1.38 - 1.52) 1.46 (1.27 - 1.63) 2.59 (2.45 - 2.87) 4.31 (3.99 - 4.59) 6.06 (5.03 - 6.79) 984 - (1.81 All Hispanics - 12 1.21 (1.09 - 1.34) 1.19 (1.09 - 1.28) 2.20 11 - 2.70) 3.70 (3.10 - 4.66) 5.17 (3.73 - 6.49) 573 13 - 14 1.04 (.960 - 1.12) 1.01 (.935 - 1.10) 1.86 (1.68 - 2.00) 3.15 (2.78 - 3.64) 4.52 (3.76 - 5.32) 701 (2.34 Asians - 12 1.55 (1.40 - 1.71) 1.49 (1.35 - 1.73) 2.86 11 - 3.33) 5.03 (4.00 - 5.95) 7.26 (5.03 - 9.71) 353 13 - 14 1.51 (1.34 - 1.69) 1.56 (1.19 - 1.82) 2.79 (2.37 - 3.21) 4.42 (3.96 - 5.51) 6.27 (4.99 - 8.05) 292 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Barium_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 278

298 Urinary Beryllium (1999 – 2010)‡ d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Survey Sample 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 00 * < LOD < LOD < LOD < LOD Total 99 2465 - * < LOD < LOD < LOD < LOD 2690 01 02 < LOD 04 * < LOD < LOD < LOD 2558 03 - - 06 * < LOD < LOD < LOD < LOD 2576 05 - 07 * < LOD < LOD < LOD < LOD 2627 08 - * < LOD < LOD < LOD < LOD 2848 10 09 Age group 11 years 99 - 00 * < LOD < LOD < LOD 6 340 - < LOD 01 02 * < LOD < LOD < LOD < LOD 368 - - * < LOD < LOD 04 < LOD < LOD 290 03 05 - 06 * < LOD < LOD < LOD 355 < LOD - 08 * < LOD < LOD < LOD < LOD 394 07 09 - * < LOD < LOD < LOD < LOD 378 10 19 years - 00 * < LOD < LOD 99 < LOD < LOD 719 - 12 - 02 * < LOD < LOD .140 (

299 Urinary Beryllium (1999 – 2010)‡ d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Survey Sample 95th Percentile Geometric mean 50th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 * < LOD < LOD < LOD < LOD 884 Mexican Americans - 01 * < LOD < LOD < LOD .130 (

300 Urinary Beryllium (creatini ne corrected) (1999 2010)‡ – onal Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati Health and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 00 * < LOD < LOD < LOD < LOD 2465 Total 99 02 * < LOD < LOD < LOD < LOD 2689 01 - < LOD - * < LOD < LOD < LOD 2558 03 04 - 06 * < LOD < LOD < LOD 2576 05 < LOD 07 08 * < LOD < LOD < LOD < LOD 2627 - < LOD - * < LOD < LOD < LOD 2848 09 10 Age group 11 years 99 - 00 - * < LOD < LOD < LOD < LOD 340 6 - * < LOD < LOD 02 < LOD < LOD 368 01 03 - 04 * < LOD < LOD < LOD 290 < LOD - 06 * < LOD < LOD < LOD < LOD 355 05 07 - * < LOD < LOD < LOD < LOD 394 08 - * < LOD < LOD < LOD 09 < LOD 378 10 < LOD 19 years 99 - 00 * < LOD - < LOD < LOD 719 12 01 - 02 * < LOD < LOD < LOD .231 (

301 Urinary Beryllium (creatinine corrected) (1999 – 2010)‡ onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati an d Nutrition Examination Survey. Survey Sample 95th Percentile Geometric mean 50th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 * < LOD Mexican Americans < LOD < LOD 884 < LOD 01 02 * < LOD < LOD < LOD .346 (

302 Blood Cadmium (1999 – 2010) ood concentrations (in μg/L) for the U.S. population from the National Health and Geometric mean and selected percentiles of bl Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - .412 (.378 - .449) .400 (.300 - Total .600 (.500 .700) 1.00 (1.00 - 1.10) 1.40 (1.30 - 1.40) 7970 99 - 00 .400) 02 * .300 (.300 - .400) .500 (.500 - .600) 1.00 (.900 - 1.10) 1.40 (1.20 - 1.70) 8945 01 - - .304 (.289 - .320) .300 (.300 - .300) .500 (.500 - .600) 1.10 (1.00 - 1.20) 1.60 (1.50 - 1.60) 8372 03 04 .560) 06 .310 (.294 - .327) .270 (.250 - .280) .510 (.460 - 1.02 (.910 - 1.13) 1.53 (1.34 - 1.75) 8407 05 - - 08 .315 (.300 - .331) .270 (.260 - .280) .500 (.460 - .560) 1.00 (.900 - 1.13) 1.52 (1.30 - 1.77) 8266 07 09 10 .302 (.293 - .311) .260 (.250 - .270) .480 (.460 - .510) .960 (.880 - 1.01) 1.40 (1.29 - 1.53) 8793 - Age group - 00 * < LOD .300 5 years - .400) .400 99 (.300 - .400) .400 (.300 - .700) 723 - 1 (

303 Blood Cadmium (1999 – 2010) d Geometric mean and selected percentiles of blood concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity - 00 .395 (.367 - Mexican Americans .400 (.400 - .400) .500 (.500 - .600) .800 (.700 - 1.00) 1.20 (.900 - 1.30) 2742 99 .424) - 02 * < LOD .400 (.400 - .600 (.500 - .800) 1.00 (.700 - 1.30) 2268 01 .500) 03 04 .235 (.216 - .255) .200 (.200 - .300) .400 (.300 - .400) .600 (.500 - .800) 1.00 (.800 - 1.50) 2085 - 05 06 * .220 (.200 - .240) .350 (.300 - .400) - .580 (.510 - .680) .820 (.710 - 1.00) 2236 07 - 08 * .220 (.210 - .230) .350 (.320 - .570 (.510 - .660) .840 (.690 - 1.02) 1712 .370) - 10 * .220 (.200 - .230) .330 (.300 - .370) .580 (.500 - .670) .800 (.690 - .960) 1966 09 (.500 - 99 - 00 .393 (.361 - .427) .400 (.300 - .400) .600 - .600) 1.00 (.900 - 1.20) 1.40 (1.20 - 1.60) 1842 Non Hispanic blacks 01 - 02 * .300 (

304 Blood Cadmium (2011 – 2016) d Geometric mean and selected percentiles of blood concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - .279 (.267 - .292) .250 (.230 - Total .460 (.430 .490) .960 (.870 - 1.10) 1.50 (1.30 - 1.70) 7920 11 - 12 .260) 14 .235 (.224 - .247) .210 (.200 - .220) .410 (.370 - .450) .840 (.730 - .940) 1.22 (1.03 1.40) 5215 13 - - - .238 (.224 - .253) .220 (.200 - .230) .400 (.370 - .430) .810 (.700 - .920) 1.22 (1.07 - 1.37) 4988 15 16 Age group - - 12 * < LOD 5 years .190 (.160 11 .200) .210 (.190 - .240) 713 - 1 < LOD - 14 * < LOD .100 (

305 Urinary Cadmium (1999 – 2010) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - .193 (.169 - .220) .232 (.214 - Total .475 (.436 .519) .858 (.763 - .980) 1.20 (1.06 - 1.34) 2257 99 - 00** .249) 02** .210 (.189 - .235) .230 (.207 - .255) .458 (.423 - .482) .839 (.753 - .919) 1.20 (1.07 1.28) 2690 01 - - - .211 (.196 - .226) .210 (.200 - .230) .450 (.400 - .500) .800 (.730 - .880) 1.15 (.980 - 1.26) 2543 03 04 .460) 06 .191 (.170 - .216) .200 (.170 - .220) .400 (.360 - .780 (.700 - .860) 1.05 (.960 - 1.17) 2576 05 - - 08 .185 (.172 - .180 (.170 - .200) .380 (.360 - .400) .700 (.650 - .770) 1.00 (.920 - 1.12) 2627 07 .198) 09 10 .179 (.169 - .190) .180 (.170 - .200) .370 (.340 - .400) .690 (.630 - .770) 1.03 (.910 - 1.13) 2848 - Age group 11 years 99 - 00** * .078 (.061 - .101) .141 (.115 - .173) .219 (.178 - .233) .279 (.211 - .507) 310 6 - - .061 (

306 Urinary Cadmium (1999 – 2010) an and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health and Geometric me Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity - 00** .191 (.157 - Mexican Americans .202 (.167 - .221) .447 (.351 - .551) .813 (.686 - .977) 1.12 (.886 - 1.38) 780 99 .233) - 02** .160 (.135 - .189) .181 (.171 - .198) .322 - .362) .559 (.430 - .733) .766 (.633 - 1.15) 683 01 (.285 03 04 .175 (.151 - .203) .170 (.150 - .210) .350 (.290 - .430) .680 (.520 - .820) 1.04 (.820 - 1.20) 614 - - - .173 (.152 - .196) .180 (.160 - .200) .340 (.300 06 .380) .560 (.500 - .630) .780 (.660 - .900) 652 05 07 - 08 .159 (.139 - .181) .170 (.140 - .200) (.290 - .370) .570 (.510 - .620) .710 (.630 - .830) 515 .320 - 10 .153 (.136 - .173) .150 (.130 - .170) .300 (.240 - .360) .530 (.440 - .680) .790 (.610 - .840) 613 09 (.498 - 99 - 00** .283 (.208 - .387) .316 (.243 - .412) .633 - .806) 1.22 (.892 - 1.38) 1.48 (1.30 - 1.72) 546 Non Hispanic blacks 01 - 02** .277 (.229 - .336) .302 (.257 - .354) .589 (.476 - .713) 1.04 (.843 - 1.38) 1.51 (1.28 - 1.74) 667 - 04 .265 (.237 - .295) .270 (.220 - .320) .550 (.440 - .640) .960 (.810 - 1.17) 1.52 (1.06 - 1.82) 717 03 (.420 05 06 .236 (.218 - .254) .240 (.210 - .260) .480 - - .530) .830 (.670 - .930) 1.04 (.870 - 1.26) 692 07 - 08 .246 (.218 - .277) .260 (.220 - .300) .460 (.420 - .530) .840 (.690 - .980) 1.40 (.900 - 1.85) 589 09 10 .234 (.211 - .260) .240 (.220 - .270) .450 (.410 - .540) .910 (.750 - 1.06) 1.42 (.990 - 1.74) 544 - (.388 - 99 - 00** .175 (.148 - .206) .220 (.194 - .246) .455 - .510) .848 (.714 - 1.01) 1.17 (.963 - 1.47) 760 Non Hispanic whites 01 - 02** .204 (.179 - .231) .221 (.191 - .255) .445 (.394 - .479) .817 (.717 - .875) 1.17 (.989 - 1.24) 1132 - 04 .209 (.192 - .226) .200 (.190 - .220) .440 (.390 - .500) .790 (.700 - .860) 1.13 (.940 - 1.26) 1070 03 (.330 05 06 .185 (.159 - .216) .200 (.160 - .230) .400 - - .480) .780 (.670 - .920) 1.05 (.940 - 1.25) 1041 07 - 08 .177 (.161 - .195) .170 (.150 - .190) .370 (.320 - .400) .690 (.620 - .780) 1.00 (.880 - 1.13) 1095 (.320 10 .171 (.158 - .186) .180 (.150 - .200) .350 - - .390) .680 (.590 - .780) 1.05 (.880 - 1.18) 1225 09 Limit of detection (LOD, see Data Analysis section) for Survey years 99 - 00, 01 - 02, 03 - 04, 05 - 06, 07 - 08, and 09 - 10 are 0.06, 0.06, 0.06, 0.042, 0.042, and 0.042 respectively. vary < means less than the limit of detection, which may LOD for some chemicals by year and by individual sample. * Not calculated: proportion of results below limit of detection was too high to provide a valid result .**All results are corrected for molyb - MS method. denum oxide interference in the ICP Biomonitoring Summary http://www.cdc.gov/biomonitoring/Cadmium_Biomonitorin gSummary.html Factsheet http://www.cdc.gov/biomonitoring/Cadmium_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 287

307 Urinary Cadmium (2011 – 2014) om the National Health and Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population fr Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 .155 (.143 - .169) .153 (.134 Total .175) .310 (.281 - .352) .629 (.590 - .670) .874 (.806 - 1.08) 2504 11 - - 14 .124 (.116 - .133) .126 (.116 - .137) .273 (.243 - .576 (.519 - .621) .842 (.767 - .945) 2664 13 .302) Age group 11 years - 11 - 12 * < LOD .070 (.056 - .076) .107 (.088 - .128) .148 (.118 - .200) 399 6 - * < LOD .050 (.044 - .059) .087 14 (.077 - .101) .113 (.098 - .140) 402 13 - 19 years 11 - 12 * 12 .069 (

308 Urinary Cadmium (creatinine corrected) (1999 – 2010) onal Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati Health and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size (.391 ** .181 (.157 - .209) .219 (.199 Total .238) .423 - .446) .712 (.645 - .757) .941 (.826 - 1.07) 2257 99 - 00 - 02 ** .199 (.181 - .218) .212 (.194 - .232) .404 (.377 - .440) .690 (.630 - .754) .919 - .998) 2689 01 - (.813 - .210 (.201 - .219) .208 (.189 - .226) .412 (.381 - .438) .678 (.650 - .716) .940 (.833 - 1.04) 2543 03 04 .430) 06 .189 (.169 - .210) .180 (.160 - .200) .370 (.310 - .650 (.590 - .720) .910 (.770 - 1.08) 2576 05 - - 08 .193 (.177 - .190 (.180 - .210) .370 (.330 - .410) .660 (.580 - .740) .960 (.840 - 1.06) 2627 07 .210) 09 10 .191 (.184 - .199) .180 (.170 - .190) .370 (.340 - .400) .680 (.630 - .730) .910 (.840 - 1.00) 2848 - Age group 11 years 99 - 00 ** * .085 (.063 - .107) .148 (.123 - .182) .210 (.171 - .316) .316 (.184 - .607) 310 6 - - .112) ** .075 (

309 Urinary Cadmium (creatinine co rrected) (1999 2010) – onal Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati Health and Nutrition Examination Survey. Survey Sample 95th Percentile Geometric mean 50th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 ** .175 (.137 - .223) .181 (.144 - .225) .331 (.266 - .418) .622 (.441 - .828) .856 (.674 - 1.13) 780 Mexican Americans - ** .156 (.136 - .178) .170 (.150 - .184) .282 (.263 - .340) .501 (.388 - .614) .693 (.507 - .839) 682 01 02 - - .163 (.147 - .181) .159 (.140 - .183) .296 (.256 04 .311) .531 (.418 - .667) .718 (.562 - .950) 614 03 05 - 06 .162 (.146 - .181) .150 (.140 - .170) .280 (.220 - .340) .480 (.430 - .510) .570 (.520 - .640) 652 - 08 .159 (.141 - .178) .160 (.130 - .180) .270 (.220 - .330) .480 (.370 - .620) .720 (.520 - .950) 515 07 - 09 .161 (.149 - .173) .150 (.130 - .170) .280 (.240 10 .320) .510 (.410 - .630) .720 (.540 - .890) 613 - - Hispanic blacks 99 - 00 ** .183 (.140 - .240) .202 (.168 - .241) .414 (.343 - .472) .663 (.516 - .827) .873 (.722 - .962) 546 Non - 02 ** .190 (.156 - .232) .196 (.174 - .225) .387 (.336 - .449) .686 (.559 - .850) .917 (.725 - 1.08) 667 01 (.288 03 04 .190 (.173 - .210) .185 (.168 - .207) .338 - - .431) .700 (.500 - .818) .865 (.708 - 1.10) 717 05 - 06 .171 (.159 - .183) .160 (.140 - .180) .320 (.290 - .370) .550 (.500 - .580) .700 (.610 - .730) 692 07 08 .180 (.164 - .197) .170 (.160 - .190) .330 (.290 - .390) .600 (.470 - .700) .770 (.690 - .900) 589 - - 09 .186 (.170 - .203) .180 (.160 - .200) .360 (.310 10 .430) .680 (.570 - .760) .860 (.740 - 1.04) 544 - - Hispanic whites 99 - 00 ** .175 (.146 - .209) .219 (.191 - .250) .432 (.387 - .470) .729 (.666 - .783) 1.00 (.826 - 1.16) 760 Non - 02 ** .205 (.184 - .229) .224 (.208 - .242) .421 (.382 - .470) .719 (.668 - .784) .931 (.806 - 1.05) 1132 01 (.398 03 04 .220 (.207 - .235) .221 (.197 - .253) .434 - - .476) .687 (.647 - .767) 1.00 (.830 - 1.08) 1070 05 - 06 .193 (.169 - .221) .180 (.160 - .220) .390 (.310 - .480) .680 (.630 - .750) .930 (.800 - 1.07) 1041 07 08 .199 (.178 - .222) .200 (.180 - .230) .380 (.340 - .440) .700 (.630 - .810) 1.03 (.880 - 1.13) 1095 - (.340 10 .192 (.183 - .201) .180 (.170 - .200) .390 - - .420) .700 (.630 - .760) .910 (.840 - 1.02) 1225 09 < LOD means less than the limit of detection for the urine levels not corrected for creatinine. * Not calculated: proportion of results below limit of detection was too high to provide a valid result. **All results are corrected for m - MS method. olybdenum oxide interference in the ICP Biomonitoring Summary http://www.cdc.gov/biomonitoring/Cadmium_Biomonitorin gSummary.html Factsheet http://www.cdc.gov/biomonitoring/Cadmium_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 290

310 Urinary Cadmium (creatin ine corrected) (2011 2014) – onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 .176 (.165 - .187) .172 (.159 - .182) .346 (.313 - .378) .582 (.551 - .639) .907 (.772 Total .997) 2502 11 - - .144 (.136 - .152) .138 (.125 - .151) .288 (.263 - 14 .563 (.487 - .621) .800 (.712 - .859) 2663 13 .311) Age group - 11 - 12 * < LOD .118 (.107 - .129) .168 (.150 - .211) .235 (.180 - .300) 398 6 11 years - - * < LOD .086 (.076 - .096) .147 (.119 13 .167) .175 (.140 - .214) 402 14 .135) 19 years 11 - 12 * .071 (

311 Urinary Cesium (1999 – 2010) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 4.35 (4.00 - 4.74) 4.90 (4.40 - Total 7.10 (6.60 7.70) 9.60 (8.80 - 10.3) 11.5 (10.2 - 13.0) 2464 99 - 00 5.40) 02 4.81 (4.40 - 5.26) 5.49 (5.12 - 5.90) 7.91 (7.47 - 8.39) 10.4 (9.56 - 11.4) 12.6 (11.1 13.8) 2690 01 - - - 4.67 (4.39 - 4.97) 5.14 (4.84 - 5.49) 7.68 (7.20 - 8.21) 10.6 (9.55 - 11.4) 12.7 (11.5 - 13.9) 2558 03 04 8.09) 06 4.69 (4.41 - 4.98) 5.19 (4.91 - 5.43) 7.68 (7.21 - 10.1 (9.65 - 10.9) 12.6 (12.0 - 13.4) 2576 05 - - 08 4.42 (4.25 - 4.60) (4.64 - 5.12) 7.02 (6.79 - 7.38) 9.46 (9.04 - 9.86) 11.3 (10.5 - 11.8) 2627 07 4.90 09 10 4.06 (3.87 - 4.26) 4.47 (4.22 - 4.66) 6.54 (6.35 - 6.75) 8.98 (8.25 - 9.68) 11.0 (10.1 - 11.6) 2848 - Age group 11 years 99 - 00 4.87 (4.08 - 5.81) 5.70 (4.60 - 6.70) 7.30 (6.70 - 8.00) 9.00 (7.90 - 10.1) 9.70 (9.00 - 10.8) 340 6 - - - 4.87 (4.08 - 5.82) 5.64 (4.69 01 6.56) 7.96 (6.77 - 8.84) 9.88 (8.64 - 10.6) 11.1 (10.2 - 12.4) 368 02 - 03 5.21 (4.74 - 5.71) 5.50 (4.76 - 6.37) 8.08 (7.10 04 8.83) 11.5 (8.86 - 12.9) 12.9 (10.8 - 13.6) 290 - 05 - 06 4.74 (4.31 - 5.21) 5.38 (4.67 - 5.60) 7.00 (6.38 - 7.50) 9.30 (8.60 - 9.95) 11.2 (9.62 - 12.9) 355 - 08 4.58 (4.22 - 4.96) 5.10 (4.50 - 5.44) 6.91 (6.45 - 7.47) 8.25 (7.77 - 8.93) 9.88 (8.47 - 10.9) 394 07 09 - 4.21 (3.84 - 4.62) 4.58 (4.01 - 5.12) 6.68 (6.25 - 6.98) 8.28 (7.47 - 9.11) 9.56 (8.68 - 11.9) 378 10 19 years (6.10 99 - 00 4.55 (4.09 - 5.05) 5.20 (4.40 - 5.60) 6.90 - - 7.80) 8.80 (8.10 - 9.50) 10.7 (8.90 - 12.5) 718 12 - - 5.22 (4.57 - 5.95) 5.62 (5.16 - 6.12) 7.55 (7.13 02 8.04) 9.77 (9.12 - 11.1) 12.0 (10.0 - 15.0) 762 01 03 - 04 5.04 (4.59 - 5.54) 5.70 (5.16 - 6.07) 7.53 (6.91 - 8.37) 9.71 (8.80 - 10.4) 11.6 (9.92 - 13.2) 725 05 06 4.76 (4.24 - 5.34) 5.27 (4.80 - 5.74) 7.50 (6.71 - 8.04) 9.60 (8.52 - 10.5) 10.6 (9.68 - 11.8) 701 - - 07 4.58 (4.10 - 5.13) 5.14 (4.30 - 5.76) 6.93 (6.33 08 7.37) 9.20 (7.67 - 9.91) 10.6 (8.91 - 15.1) 376 - 09 - 10 3.70 (3.39 - 4.02) 4.11 (3.54 - 4.70) 6.17 (5.72 - 6.47) 8.20 (7.16 - 8.79) 9.52 (8.66 - 10.6) 451 20 years and older - 00 4.26 (3.94 - 4.62) 4.80 (4.40 - 5.30) 7.10 (6.50 - 7.60) 9.80 (8.90 - 10.7) 11.7 (10.2 - 13.4) 1406 99 (7.43 01 02 4.74 (4.32 - 5.20) 5.43 (5.05 - 5.87) 7.97 - - 8.52) 10.6 (9.73 - 11.5) 12.9 (11.2 - 14.2) 1560 03 - 04 4.56 (4.23 - 4.90) 5.03 (4.60 - 5.42) 7.66 (7.01 - 8.34) 10.7 (9.40 - 11.5) 12.9 (11.5 - 14.9) 1543 05 06 4.67 (4.38 - 4.99) 5.14 (4.84 - 5.44) 7.77 (7.32 - 8.30) 10.4 (9.72 - 11.5) 13.2 (12.4 - 13.9) 1520 - 07 - 4.38 (4.20 - 4.58) 4.79 (4.59 - 4.99) 7.12 (6.81 - 7.52) 9.69 (9.23 - 10.2) 11.4 (10.6 - 12.0) 1857 08 (8.37 - 4.10 09 (3.88 - 4.34) 4.49 (4.21 - 4.71) 6.57 (6.33 - 6.84) 9.26 10 - 10.1) 11.1 (10.3 - 11.9) 2019 Gender 99 - 00 4.84 (4.35 - 5.38) 5.50 (4.60 - 6.00) 7.50 (7.00 - 8.20) 9.70 (8.80 - 11.3) 11.7 (10.3 - 13.0) 1226 Males 01 - 02 5.34 (4.89 - 5.84) 6.13 (5.61 6.64) 8.27 (7.84 - 9.08) 10.8 (10.1 - 12.1) 12.8 (11.3 - 15.0) 1335 - - 03 5.03 (4.73 - 5.36) 5.59 (5.17 - 6.00) 7.98 (7.31 04 8.63) 11.0 (9.53 - 11.8) 12.9 (11.5 - 16.1) 1281 - 05 - 06 5.13 (4.78 - 5.51) 5.37 (5.03 - 5.71) 7.92 - 8.41) 10.9 (9.96 - 11.6) 13.2 (12.4 - 13.9) 1271 (7.61 - 08 4.77 (4.59 - 4.96) 5.26 (4.98 - 5.43) 7.18 07 - 7.54) 9.68 (8.93 - 10.6) 11.6 (10.6 - 12.6) 1327 (6.93 09 - 10 4.27 (4.00 - 4.55) 4.70 (4.46 - 5.00) 6.57 (6.39 - 6.81) 8.67 (7.91 - 9.57) 10.7 (9.66 - 11.3) 1398 Females - 00 3.95 (3.63 - 4.29) 4.50 (4.20 - 4.90) 6.70 (6.20 - 7.30) 9.10 (8.30 - 10.0) 11.2 (9.90 - 12.9) 1238 99 - 01 4.36 (3.95 - 4.81) 4.87 (4.45 - 5.25) 7.33 (6.71 02 8.01) 9.77 (9.07 - 11.0) 12.4 (10.4 - 13.8) 1355 - 03 - 04 4.35 (4.03 - 4.70) 4.79 (4.25 - 5.26) 7.30 - 7.81) 10.2 (9.40 - 11.0) 12.1 (11.2 - 13.6) 1277 (6.87 - 06 4.30 (3.98 - 4.65) 4.89 (4.58 - 5.25) 7.43 05 - 7.83) 9.79 (9.30 - 10.5) 12.1 (10.6 - 13.1) 1305 (6.99 07 - 08 4.12 (3.88 - 4.37) 4.40 (4.17 - 4.74) 6.84 (6.32 - 7.36) 9.31 (8.69 - 9.76) 10.5 (9.93 - 11.7) 1300 (5.95 10 3.88 (3.63 - 4.14) 4.13 (3.83 - 4.55) 6.46 - - 6.90) 9.29 (8.62 - 10.0) 11.2 (10.3 - 12.1) 1450 09 Limit of detection (LOD, see Data Analysis section) for Survey years 99 - 00, 01 - 02, 03 - 04, 05 - 06, 07 - 08, and 09 - 10 are 0.14, 0.14, 0.2, 0.066, 0.066, and 0.066 respectively. Biomonitoring S ummary http://www.cdc.gov/biomonitoring/Cesium_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 292

312 Urinary Cesium (1999 – 2010) ean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health and Geometric m Nutrition Examination Survey. Survey Sample 95th Percentile Geometric mean 50th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 4.32 (3.82 - 4.89) 4.80 (4.30 - 5.20) 6.70 (6.40 - 7.20) 9.10 (8.00 - 9.90) 11.1 (9.60 - 12.7) 884 Mexican Americans - 4.63 (4.10 - 5.24) 5.29 (4.59 - 5.89) 7.08 (6.42 - 7.99) 9.13 (7.86 - 11.3) 11.3 (8.81 - 14.9) 683 01 02 - 03 4.94 (4.64 - 5.27) 5.62 (5.01 - 6.09) 7.86 (7.15 04 8.46) 10.3 (8.99 - 11.3) 11.9 (10.7 - 14.7) 618 - 05 - 06 4.64 (4.41 - 4.88) 5.18 (4.91 - 5.55) 7.29 (6.74 - 7.73) 9.52 (8.76 - 9.98) 11.5 (9.88 - 11.9) 652 - 08 4.50 (4.06 - 4.99) 4.93 (4.40 - 5.56) 6.98 (6.38 - 7.49) 9.12 (8.25 - 9.82) 10.8 (9.45 - 12.1) 515 07 - 09 4.20 (3.95 - 4.48) 4.47 (4.16 - 4.87) 6.49 (6.00 10 7.01) 8.64 (7.81 - 9.40) 10.2 (9.15 - 11.4) 613 - - Hispanic blacks 99 - 00 4.94 (4.33 - 5.64) 5.40 (4.80 - 6.40) 7.50 (6.90 - 8.40) 9.80 (8.80 - 10.8) 11.6 (9.80 - 13.1) 568 Non - 02 4.93 (4.70 - 5.17) 5.33 (5.05 - 5.64) 7.36 (6.97 - 7.59) 9.44 (8.71 - 9.68) 10.7 (10.1 - 12.3) 667 01 (6.72 03 04 4.71 (4.47 - 4.97) 5.12 (4.71 - 5.49) 7.17 - - 7.60) 9.13 (8.52 - 9.99) 10.7 (9.99 - 11.4) 723 05 - 06 4.78 (4.42 - 5.18) 5.26 (5.03 - 5.44) 7.20 (6.63 - 7.66) 9.14 (8.26 - 10.6) 11.0 (9.63 - 13.7) 692 07 08 4.64 (4.29 - 5.01) 4.90 (4.48 - 5.31) 6.90 (6.35 - 7.42) 9.39 (8.29 - 10.3) 11.3 (9.59 - 12.6) 589 - - 09 4.07 (3.82 - 4.35) 4.68 (4.29 - 4.84) 6.56 (6.19 10 7.01) 8.98 (8.12 - 9.31) 9.97 (9.27 - 11.3) 544 - - Hispanic whites 99 - 00 4.25 (3.83 - 4.72) 4.80 (4.20 - 5.50) 7.20 Non (6.60 - 7.90) 9.70 (8.90 - 10.7) 11.8 (10.3 - 13.3) 821 - 02 4.77 (4.27 - 5.32) 5.49 (4.99 - 6.05) 7.98 01 - 8.61) 10.4 (9.54 - 11.4) 12.6 (11.0 - 13.8) 1132 (7.45 03 - 04 4.56 (4.22 - 4.94) 5.02 (4.59 - 5.42) 7.60 (7.00 - 8.23) 10.7 (9.26 - 11.8) 12.9 (11.5 - 14.7) 1074 05 06 4.64 (4.25 - 5.05) 5.19 (4.76 - 5.49) 7.77 (7.18 - 8.46) 10.3 (9.62 - 11.5) 13.1 (12.1 - 13.9) 1041 - (6.67 08 4.29 (4.07 - 4.53) 4.76 (4.48 - 5.08) 7.02 - - 7.49) 9.50 (8.91 - 9.93) 11.3 (10.3 - 12.2) 1095 07 09 - 10 3.96 (3.73 - 4.20) 4.38 (4.10 - 4.64) 6.43 (6.15 - 6.63) 8.62 (7.86 - 9.29) 10.5 (9.35 - 11.5) 1225 07 Limit of detection (LOD, see Data Analysis section) for Survey years 99 - 00, 01 - 02, 03 - 04, 05 - 06, - 08, and 09 - 10 are 0.14, 0.14, 0.2, 0.066, 0.066, and 0.066 respectively. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Cesium_BiomonitoringSu mmary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 293

313 Urinary Cesium (2011 – 2014) (in μg/L) for the U.S. population from the National Health and Geometric mean and selected percentiles of urine concentrations Nutrition Examination Survey. Survey Sample Geometric mean 50th Percentile 90th Percentile 75th Percentile 95th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 12 3.82 (3.58 - 4.08) 4.11 (3.90 Total 4.42) 6.31 (5.96 - 6.63) 8.81 (8.39 - 9.21) 10.5 (9.76 - 11.1) 2503 11 - - 14 3.94 (3.76 - 4.12) 4.21 (3.96 - 4.47) 6.63 (6.36 - 6.85) 9.31 (8.87 - 9.80) 11.3 (10.4 - 11.8) 2664 13 Age group 11 years - 11 - 12 3.91 (3.50 - 4.36) 4.52 (3.75 - 4.96) 6.71 (6.18 - 7.16) 8.61 (7.39 - 9.28) 10.2 (9.02 - 10.6) 399 6 - - 4.15 (3.80 - 4.52) 4.63 (4.05 - 5.12) 7.11 (6.58 14 7.54) 9.58 (8.49 - 10.0) 10.4 (9.92 - 11.1) 402 13 - 19 years 11 - 12 3.56 (3.08 - 4.13) 3.96 (3.45 - 4.56) 5.96 (5.19 - 6.73) 7.74 (7.17 - 8.99) 9.55 (7.81 - 10.6) 390 12 13 14 4.14 (3.72 - 4.61) 4.55 (4.12 - 5.08) 6.62 (6.09 - 7.29) 8.93 (8.19 - 9.86) 10.9 (9.40 - 11.8) 451 - 11 12 3.85 (3.61 - 4.10) 4.11 (3.85 - 4.43) 6.31 (5.94 - 6.67) 9.08 (8.51 - 9.44) 10.7 (9.81 - 11.2) 1714 20 years and older - - - 3.89 (3.70 - 4.09) 4.09 (3.85 - 4.36) 6.57 (6.32 14 6.82) 9.30 (8.67 - 9.90) 11.3 (10.4 - 12.2) 1811 13 Gender - - 12 4.20 (3.94 - 4.47) 4.49 (4.21 Males 4.98) 6.53 (6.15 - 6.95) 9.08 (8.43 - 9.55) 10.6 (9.80 - 11.1) 1261 11 13 (6.42 14 4.10 (3.84 - 4.38) 4.47 (4.10 - 4.88) 6.79 - 7.22) 9.30 (8.56 - 10.1) 11.1 (9.81 - 13.1) 1318 - (5.38 Females - 12 3.49 (3.16 - 3.85) 3.75 (3.48 - 3.99) 5.94 11 - 6.55) 8.58 (7.58 - 9.33) 10.3 (9.44 - 11.2) 1242 13 - 14 3.78 (3.57 - 4.02) 3.98 (3.60 - 4.28) 6.35 (5.98 - 6.75) 9.31 (8.50 - 9.88) 11.5 (10.1 - 12.4) 1346 Race/ethnicity 11 12 3.76 (3.43 - 4.12) 4.12 (3.61 - 4.54) 5.50 (5.21 - 6.21) 7.77 (7.32 - 8.75) 9.68 (8.07 - 10.4) 317 Mexican Americans - - - 3.99 (3.76 - 4.24) 4.25 (3.65 - 5.09) 6.53 (6.13 14 7.18) 9.01 (8.28 - 9.61) 10.2 (9.01 - 11.2) 453 13 - Hispanic blacks 11 - 12 3.97 (3.68 - 4.29) 4.49 (4.10 - 4.88) 6.49 Non - 6.88) 8.12 (7.56 - 9.21) 9.59 (8.61 - 11.0) 669 (5.98 - 14 4.41 (3.97 - 4.89) 4.83 (4.20 - 5.38) 6.82 (6.20 - 7.30) 8.93 (8.01 - 9.81) 10.7 (9.34 - 12.2) 581 13 - 11 - 12 3.78 (3.50 - 4.07) 4.01 (3.75 - 4.30) 6.30 Non (5.85 - 6.85) 9.08 (8.53 - 9.48) 10.6 (9.88 - 11.1) 820 Hispanic whites 13 - 14 3.81 (3.54 - 4.10) 4.09 (3.70 - 4.47) 6.62 (6.19 - 7.06) 9.38 (8.56 - 10.2) 11.5 (10.1 - 13.1) 985 All Hispanics - 12 3.80 (3.44 - 4.20) 4.13 (3.65 - 4.62) 5.87 (5.40 - 6.34) 7.77 (7.16 - 8.73) 9.52 (8.08 - 10.3) 573 11 (6.29 13 14 4.04 (3.79 - 4.30) 4.21 (3.70 - 4.77) 6.65 - - 7.17) 9.01 (8.43 - 9.61) 10.4 (9.30 - 11.6) 701 Asians 11 - 12 4.22 (3.88 - 4.60) 4.43 (4.00 - 5.02) 7.42 (6.58 - 7.92) 10.7 (9.27 - 11.4) 12.4 (11.1 - 15.6) 352 (5.87 14 3.92 (3.61 - 4.24) 4.10 (3.43 - 4.52) 6.41 - - 7.48) 9.81 (7.91 - 11.4) 11.4 (9.11 - 14.3) 292 13 Limit of detection (LOD, see Data Analysis section) for Survey year 11 - 12 and 13 - 14 are 0.12 and 0.086. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Ce sium_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 294

314 Urinary Cesium (creatinine corrected) (1999 – 2010) onal Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati Nutrition Examination Survey. Health and Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 00 4.10 (3 .96 - 4.25) 4.13 (3.97 - 4.27) 5.41 (5.21 - 5.70) 7.14 (6.83 - 7.50) 8.64 (8.00 Total 9.30) 2464 99 - - 4.54 (4.30 - 4.79) 4.44 (4.20 - 4.64) 6.06 (5.66 - 02 8.18 (7.62 - 8.95) 10.2 (8.84 - 11.7) 2689 01 6.47) - 04 4.64 (4.42 - 4.87) 4.42 (4.21 - 4.74) 6.11 (5.76 - 6.48) 8.51 (7.99 - 10.6 (9.75 - 11.0) 2558 03 9.15) 05 06 4.62 (4.37 - 4.88) 4.51 (4.20 - 4.76) 6.19 (5.90 - 6.55) 8.84 (8.14 - 9.24) 10.8 (9.71 - 12.1) 2576 - - 4.62 (4.42 - 4.82) 4.58 (4.36 - 4.79) 6.23 (5.96 - 6.61) 8.67 07 (7.79 - 9.52) 10.6 (9.78 - 11.2) 2627 08 (7.76 - 4.33 09 (4.17 - 4.49) 4.28 (4.12 - 4.45) 6.00 (5.70 - 6.23) 8.06 10 - 8.36) 9.75 (9.05 - 10.4) 2848 Age group - 11 years 99 - 00 5.34 (5.03 - 5.67) 5.42 (5.03 - 6.04) 6.63 (6.18 - 7.13) 8.23 (7.13 - 9.41) 9.90 (7.88 - 6 340 10.1) - 02 5.95 (5.48 - 6.46) 5.91 (5.43 - 6.53) 7.77 (7.00 - 8.28) 9.27 (8.35 - 11.9) 11.9 (9.38 - 12.3) 368 01 03 - 6.07 (5.63 - 6.53) 6.02 (5.45 - 6.49) 8.30 (7.16 - 8.99) 10.8 (9.15 - 11.8) 11.9 (10.3 - 15.8) 290 04 - - 5.85 (5.41 - 6.34) 5.74 (5.21 - 6.41) 7.65 (6.67 05 9.11) 10.1 (9.38 - 10.8) 11.6 (10.1 - 14.9) 355 06 - 07 5.96 (5.53 - 6.43) 6.12 (5.79 - 6.55) 7.88 (7.33 08 8.53) 10.7 (8.91 - 12.1) 12.5 (10.9 - 14.1) 394 - 09 - 10 5.74 (5.30 - 6.22) 5.58 (5.15 - 6.12) 7.16 (6.71 - 9.19 (8.13 - 10.4) 12.2 (8.69 - 14.8) 378 7.87) 12 19 years 99 - 00 3.43 (3.29 - 3.58) 3.54 (3.29 - 3.68) 4.35 (4.17 - 4.56) 5.31 (4.97 - 5.79) 6.67 (5.33 - 8.09) 718 - 01 4.74 02 3.73 (3.41 - 4.08) 3.55 (3.36 - 3.74) (4.40 - 5.14) 6.10 (5.35 - 7.63) 8.08 (6.44 - 9.82) 762 - (4.24 04 3.60 (3.37 - 3.85) 3.51 (3.33 - 3.72) 4.53 - - 4.87) 6.08 (5.14 - 6.94) 7.27 (6.13 - 9.07) 725 03 05 - 06 3.66 (3.40 - 3.93) 3.59 (3.40 - 3.83) 4.76 (4.30 - 5.20) 5.93 (5.62 - 6.62) 7.62 (6.03 - 8.07) 701 07 08 3.58 (3.31 - 3.88) 3.70 (3.22 - 3.96) 4.98 (4.60 - 5.17) 6.36 (5.38 - 7.28) 7.93 (6.06 - 9.76) 376 - 09 - 3.46 (3.27 - 3.65) 3.48 (3.23 - 3.74) 4.39 (4.16 - 4.70) 5.54 (5.01 - 6.32) 6.56 (5.95 - 7.35) 451 10 5.85) 99 4.08 (3.88 - 4.29) 4.06 (3.85 - 4.29) 5.39 (5.04 - 00 7.17 (6.84 - 7.58) 8.61 (7.91 - 9.30) 1406 - 20 years and older - 02 4.54 (4.30 - 4.78) 4.43 (4.20 - 4.59) 5.94 (5.64 6.40) 8.15 (7.46 - 8.97) 10.2 (8.74 - 11.7) 1559 01 - 03 04 4.68 (4.46 - 4.91) 4.47 (4.27 - 4.80) 6.11 (5.83 - 6.43) 8.47 (7.76 - 9.17) 10.5 (9.68 - 11.2) 1543 - 05 - 06 4.67 (4.42 - 4.93) 4.54 (4.25 - 4.78) 6.24 (5.93 - 6.66) 8.92 (8.29 - 9.31) 11.2 (9.71 - 12.7) 1520 - 08 4.67 (4.46 - 4.88) 4.58 (4.34 - 4.82) 6.19 (5.93 - 6.61) 8.65 (7.79 - 9.52) 10.6 (9.68 - 11.3) 1857 07 - 09 4.34 (4.17 - 4.53) 4.28 (4.10 - 4.49) 6.07 (5.70 10 6.33) 8.20 (7.81 - 8.65) 9.80 (9.05 - 11.1) 2019 - Gender - - 00 3.78 (3.65 - 3.91) 3.78 (3.61 Males 3.96) 4.96 (4.72 - 5.20) 6.50 (6.18 - 6.70) 7.71 (7.01 - 8.64) 1226 99 (5.27 01 02 4.22 (3.96 - 4.51) 4.10 (3.87 - 4.41) 5.60 - - 6.03) 7.67 (6.90 - 8.48) 9.46 (8.22 - 11.5) 1334 03 - 04 4.24 (3.99 - 4.50) 4.12 (3.89 - 4.37) 5.66 (5.19 - 6.06) 7.66 (6.90 - 8.40) 9.00 (8.36 - 10.3) 1281 05 06 4.21 (3.94 - 4.50) 4.11 (3.72 - 4.46) 5.75 (5.14 - 6.11) 7.68 (6.91 - 8.78) 9.33 (8.84 - 9.84) 1271 - - 07 4.27 (4.04 - 4.51) 4.19 (4.02 - 4.42) 5.81 (5.46 08 6.29) 7.84 (7.20 - 8.65) 9.61 (8.65 - 10.2) 1327 - 09 - 10 3.89 (3.70 - 4.09) 3.85 (3.60 - 4.06) 5.29 (4.89 5.69) 7.02 (6.76 - 7.42) 8.38 (7.87 - 9.18) 1398 - Females 99 - 00 4.43 (4.20 - 4.68) 4.45 (4.14 - 4.77) 5.92 (5.36 - 6.47) 7.70 (7.16 - 8.07) 9.41 (8.00 - 10.4) 1238 01 - 02 4.86 (4.58 - 5.16) 4.72 (4.50 - 5.06) 6.54 (5.93 - 7.00) 8.50 (7.84 - 9.79) 10.3 (8.95 - 12.2) 1355 03 04 5.05 (4.77 - 5.35) 4.77 (4.44 - 5.14) 6.58 (6.14 - 7.22) 9.43 (8.56 - 10.5) 11.3 (10.7 - 12.3) 1277 - (6.31 06 5.05 (4.78 - 5.33) 4.86 (4.57 - 5.17) 6.72 - - 7.23) 9.65 (9.23 - 10.3) 12.6 (11.0 - 13.3) 1305 05 07 - 08 4.98 (4.76 - 5.20) 4.90 (4.69 - 5.20) 6.72 (6.20 - 7.06) 9.50 (8.37 - 10.5) 11.3 (10.7 - 12.1) 1300 - 10 4.79 (4.63 - 4.97) 4.69 (4.50 - 4.93) 6.57 (6.34 - 6.85) 8.88 09 (8.36 - 9.33) 10.5 (9.56 - 12.0) 1450 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Cesium_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 295

315 Urinary Cesium (creatinine corrected) (1999 – 2010) r the U.S. population from the National Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) fo and Nutrition Examination Survey. Survey Sample 95th Percentile Geometric mean 50th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 3.99 (3.73 - 4.25) 3.95 (3.65 - 4.17) 5.09 (4.79 - 5.39) 6.65 (6.08 - 7.10) 7.98 (7.20 - 8.95) 884 Mexican Americans - 4.51 (4.00 - 5.08) 4.51 (3.82 - 4.95) 5.91 (5.31 - 6.64) 7.77 (6.60 - 10.0) 10.0 (7.60 - 20.5) 682 01 02 - 03 4.58 (4.16 - 5.05) 4.51 (4.10 - 4.92) 5.74 (5.42 04 6.09) 7.53 (6.59 - 8.91) 9.44 (8.24 - 10.6) 618 - 05 - 06 4.36 (4.10 - 4.64) 4.40 (3.97 - 4.73) (5.24 - 6.22) 7.23 (6.69 - 7.80) 8.14 (7.65 - 9.33) 652 5.69 - 08 4.50 (4.22 - 4.79) 4.39 (3.96 - 4.86) 6.07 (5.57 - 6.59) 7.63 (7.30 - 7.89) 9.06 (7.89 - 10.5) 515 07 - 09 4.41 (4.17 - 4.65) 4.38 (4.04 - 4.59) 5.70 (5.34 10 6.07) 7.68 (7.17 - 8.24) 8.89 (8.50 - 9.52) 613 - - Hispanic blacks 99 - 00 3.21 (2.90 - 3.56) 3.26 (3.05 - 3.44) 4.30 Non (4.00 - 4.55) 5.50 (5.00 - 5.98) 6.33 (5.91 - 7.04) 568 - 02 3.38 (3.19 - 3.57) 3.35 (3.05 - 3.60) 4.41 01 - 4.78) 5.87 (5.63 - 6.29) 6.75 (6.41 - 7.03) 667 (4.15 03 - 04 3.38 (3.21 - 3.56) 3.30 (3.08 - 3.50) 4.31 (4.02 - 4.62) 5.79 (5.12 - 6.47) 6.98 (6.38 - 7.18) 723 05 06 3.47 (3.34 - 3.60) 3.40 (3.21 - 3.60) 4.47 (4.25 - 4.68) 5.94 (5.52 - 6.31) 6.95 (6.20 - 7.51) 692 - - 07 3.39 (3.21 - 3.58) 3.33 (3.18 - 3.54) 4.50 (4.21 08 4.78) 5.84 (5.41 - 6.18) 6.87 (5.94 - 7.58) 589 - 09 - 10 3.23 (3.05 - 3.42) 3.20 (2.99 - 3.46) 4.31 (4.12 - 5.88 (5.30 - 6.28) 6.69 (6.32 - 7.89) 544 4.59) Non Hispanic whites 99 - 00 4.26 (4.07 - 4.47) 4.28 (4.05 - 4.50) - (5.26 - 6.05) 7.27 (6.84 - 7.83) 8.75 (7.93 - 9.38) 821 5.66 01 - 02 4.81 (4.55 - 5.08) 4.63 (4.42 - 4.96) 6.33 (5.91 - 6.68) 8.46 (7.84 - 9.39) 10.3 (9.04 - 11.8) 1132 03 04 4.81 (4.52 - 5.12) 4.56 (4.31 - 4.98) 6.28 (5.95 - 6.71) 8.63 (7.99 - 9.28) 10.6 (9.43 - 11.0) 1074 - (6.00 06 4.82 (4.50 - 5.17) 4.68 (4.32 - 5.04) 6.41 - - 6.81) 9.18 (8.67 - 9.53) 11.0 (9.71 - 12.7) 1041 05 07 - 08 4.81 (4.54 - 5.09) 4.73 (4.42 - 5.12) 6.43 (6.01 - 6.80) 9.24 (8.20 - 9.82) 11.0 (10.2 - 11.7) 1095 - 10 4.42 (4.23 - 4.63) 4.36 (4.15 - 4.54) 6.16 (5.82 - 6.51) 8.13 09 (7.68 - 8.65) 9.83 (8.79 - 11.4) 1225 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Cesium_BiomonitoringSu mmary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 296

316 Urinary Cesium (creatinine corrected) (2011 – 2014) onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati an d Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 4.33 (4.13 - 4.53) 4.27 (4.08 Total 4.50) 5.91 (5.63 - 6.33) 8.12 (7.43 - 8.63) 10.2 (8.93 - 10.7) 2501 11 - - 14 4.55 (4.40 - 4.70) 4.42 (4.24 - 4.64) 6.37 (6.16 - 6.58) 8.61 (8.32 - 8.86) (9.67 - 10.9) 2663 13 10.3 Age group 11 years - 11 - 12 5.56 (5.16 - 5.99) 5.47 (5.06 - 5.98) 7.15 (6.68 - 7.43) 9.42 (7.88 - 10.7) 10.7 (9.45 - 13.0) 398 6 - - 6.18 (5.90 - 6.48) 6.25 (5.82 - 6.83) 8.07 (7.58 14 8.75) 9.96 (9.24 - 11.1) 11.6 (9.88 - 13.4) 402 13 - 19 years 11 - 12 3.41 (3.16 - 3.67) 3.35 (3.05 - 3.82) 4.34 12 (3.95 - 4.93) 5.30 (5.07 - 6.17) 6.34 (5.66 - 6.64) 390 - 14 3.75 (3.49 - 4.03) 3.69 (3.45 - 3.95) 4.79 (4.36 - 5.37) 6.79 (5.47 - 7.52) 7.52 (6.17 - 9.30) 451 13 - 12 4.36 (4.15 - 4.59) 4.29 (4.10 - 4.54) 6.00 (5.65 - 6.45) 8.22 (7.64 - 8.78) 10.2 (9.47 - 11.2) 1713 20 years and older 11 13 - 14 4.53 (4.38 - 4.69) 4.40 (4.18 - 4.67) 6.29 (6.15 - 6.50) 8.61 (8.30 - 8.86) 10.3 (9.81 - 10.8) 1810 Gender 10.2) - 12 3.93 (3.73 - 4.14) 3.80 (3.63 - 4.10) 5.31 (4.87 - 5.91) 7.58 (6.78 - 8.26) 8.80 (8.28 - Males 1260 11 (5.10 13 14 4.10 (3.92 - 4.29) 4.04 (3.79 - 4.29) 5.39 - - 5.77) 7.55 (6.83 - 8.11) 8.92 (8.18 - 10.1) 1317 Females 11 - 12 4.74 (4.52 - 4.97) 4.73 (4.55 - 4.93) 6.43 (5.91 - 6.82) 8.55 (8.05 - 9.48) 11.2 (9.48 - 12.5) 1241 13 14 5.02 (4.86 - 5.19) 5.00 (4.71 - 5.23) 7.08 (6.80 - 7.39) 9.51 (8.67 - 10.1) 11.3 (10.5 - 12.3) 1346 - Race/ethnicity - 11 12 4.23 (3.96 - 4.51) 4.14 (3.72 - 5.63 (5.11 - 5.91) 7.06 (6.41 - 8.03) 8.78 (7.48 - 10.3) 317 Mexican Americans 4.53) 13 - 14 4.56 (4.37 - 4.74) 4.40 (4.16 - 4.78) 6.02 (5.61 - 6.35) 7.58 (6.91 - 7.94) 8.92 (7.94 - 10.0) 453 Non Hispanic blacks 11 - 12 3.09 (2.92 - 3.27) 3.12 (2.89 - 3.32) 4.13 (3.90 - 4.40) 5.31 (4.98 - 5.63) 6.29 (5.67 - 6.84) 669 - - 14 3.35 (3.20 - 3.52) 3.34 (3.14 - 3.54) 4.37 13 - 4.63) 5.82 (5.37 - 6.27) 7.18 (6.25 - 7.86) 581 (4.14 Non - Hispanic whites 11 - 12 4.56 (4.29 - 4.85) 4.50 (4.19 - 4.80) 6.34 (5.74 - 6.88) 8.26 (7.86 - 9.36) 10.3 (9.27 - 11.5) 818 13 14 4.70 (4.56 - 4.85) 4.56 (4.30 - 4.84) 6.63 (6.40 - 6.95) 8.91 (8.37 - 9.67) 10.5 (9.98 - 11.3) 984 - (5.35 All Hispanics - 12 4.25 (4.00 - 4.52) 4.25 (3.88 - 4.49) 5.69 11 - 5.91) 7.43 (6.61 - 8.23) 8.67 (8.12 - 9.70) 573 13 - 14 4.51 (4.34 - 4.69) 4.43 (4.25 - 4.64) 5.89 (5.61 - 6.21) 7.71 (7.12 - 8.15) 8.93 (8.29 - 9.52) 701 (6.84 Asians - 12 5.65 (5.13 - 6.22) 5.40 (5.12 - 5.95) 7.88 11 - 9.33) 12.0 (10.1 - 13.7) 14.7 (12.2 - 19.4) 352 13 - 14 6.14 (5.49 - 6.86) 6.12 (5.47 - 6.70) 8.31 (7.23 - 9.63) 11.5 (9.32 - 16.0) 16.0 (10.8 - 18.2) 292 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Cesium_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 297

317 Blood Chromium (2015 – 2016) d Geometric mean and selected percentiles of blood concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 15 - Total * < LOD < LOD .700 (.540 - .900) 1.08 (.750 - 1.49) 3442 16 Age group - 59 years 15 - 16 * < LOD < LOD .650 (.470 - .970) 1.07 (.710 - 1.57) 1719 40 60 years and older - 16 * < LOD < LOD .750 (.550 - .940) 1.13 (.790 - 1.49) 1723 15 Gender 15 - 16 * < LOD < LOD .620 (.460 - .880) 1.07 (.680 - 1.58) 1656 Males 1.08 Females - 16 * < LOD < LOD .740 (.580 - .940) 15 (.800 - 1.43) 1786 Race/ethnicity Mexican Americans 15 - 16 * < LOD < LOD .570 (.460 - .700) .750 (.550 - 1.34) 589 Non - 15 - 16 * < LOD < LOD .490 (

318 Blood Cobalt (2015 – 2016) d Geometric mean and selected percentiles of blood concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Survey Sample 90th Percentile Geometric mean 50th Percentile 95th Percentile 75th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years 15 - 16 .151 (.146 - .156) .130 (.130 - .140) .170 (.170 - .180) .280 (.250 - .300) Total (.370 - .450) 3454 .400 Age group (.150 59 years 15 - 16 .144 (.138 - .150) .130 (.120 - .130) .160 - .170) .260 (.220 - .290) .360 (.300 - .440) 1726 40 - 15 - 16 60 years and older (.155 - .168) .140 (.140 - .150) .190 (.180 - .200) .300 (.270 - .370) .450 (.390 - .520) 1728 .162 Gender - 16 .135 (.129 - .142) .120 (.120 - .130) .150 (.140 - .160) .210 (.190 - .240) .360 (.250 - .400) 1661 Males 15 15 - 16 Females .167 (.161 - .173) .150 (.140 - .150) .200 (.190 - .210) .320 (.280 - .360) .460 (.410 - .550) 1793 Race/ethnicity Mexican Americans 15 - 16 .151 (.146 - .157) .130 (.120 - .140) .170 (.160 - .190) .300 (.240 - .360) .440 (.350 - .610) 592 Non - 15 - 16 .148 (.138 - .159) .130 (.120 - .140) .180 (.160 - .190) .280 (.250 - .340) .440 (.390 - .500) 718 Hispanic blacks Non 15 - 16 .151 (.145 - .157) .130 (.130 - .140) .170 Hispanic whites (.160 - .190) .270 (.240 - .290) .390 (.330 - .450) 1198 - All Hispanics 15 - 16 .150 (.145 - .154) .130 (.120 - .140) .170 (.160 - .180) .300 (.240 - .360) .440 (.350 - .560) 1067 (.160 Asians - 16 .152 (.145 - .160) .140 (.130 - .150) .170 15 - .180) .290 (.210 - .370) .380 (.290 - .620) 368 Limit of detection (LOD, see Data Analysis section) for Survey year 15 - 16 is 0.06. < LOD means less than the limit of detection, which may vary for some chemicals by year and by individual sample. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 299

319 Urinary Cobalt (1999 – 2010) d Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - .375 (.336 - .419) .410 (.370 - Total .630 (.570 .680) .950 (.890 - 1.03) 1.32 (1.16 - 1.48) 2465 99 - 00 .450) 02 .379 (.355 - .404) .410 (.380 - .430) .610 (.570 - .660) .940 (.870 - 1.00) 1.28 (1.15 1.44) 2690 01 - - - .316 (.291 - .343) .330 (.300 - .350) .520 (.490 - .550) .820 (.750 - .890) 1.16 (1.08 - 1.26) 2558 03 04 .630) 06 .374 (.357 - .392) .390 (.370 - .410) .600 (.560 - .880 (.840 - .950) 1.33 (1.17 - 1.47) 2576 05 - - 08 .369 (.351 - .389) (.360 - .390) .580 (.550 - .600) .920 (.840 - 1.01) 1.32 (1.10 - 1.43) 2627 07 .380 09 10 .369 (.341 - .398) .380 (.350 - .400) .600 (.560 - .650) .960 (.870 - 1.06) 1.40 (1.20 - 1.58) 2848 - Age group 11 years 99 - 00 .499 (.427 - .583) .530 (.450 - .640) .750 (.610 - .900) 1.03 (.880 - 1.12) 1.22 (1.03 - 1.50) 340 6 - - - .452 (.377 - .543) .520 (.430 01 .610) .710 (.670 - .810) 1.07 (.940 - 1.21) 1.32 (1.17 - 1.53) 368 02 - 03 .454 (.393 - .523) .460 (.410 - .520) .750 (.590 04 .900) 1.24 (.910 - 1.47) 1.68 (1.26 - 1.81) 290 - 05 - 06 .424 (.383 - .468) .450 (.410 - .490) .660 (.580 - .710) .870 (.830 - 1.04) 1.16 (.910 - 1.39) 355 - 08 .433 (.367 - .509) .450 (.360 - .550) .700 (.560 - .810) .960 (.790 - 1.28) 1.40 (.880 - 1.82) 394 07 09 - .424 (.379 - .474) .440 (.400 - .490) .670 (.610 - .740) .960 (.850 - 1.10) 1.14 (1.01 - 1.69) 378 10 19 years (.670 99 - 00 .519 (.463 - .581) .520 (.490 - .570) .820 - - .890) 1.17 (1.01 - 1.47) 1.52 (1.26 - 2.56) 719 12 - - .515 (.469 - .564) .520 (.480 - .570) .750 (.690 02 .840) 1.24 (1.07 - 1.32) 1.59 (1.37 - 1.99) 762 01 03 - 04 .461 (.428 - .496) .480 (.450 - .520) .740 (.650 - .800) 1.03 (.940 - 1.23) 1.60 (1.14 - 1.92) 725 05 06 .510 (.451 - .577) .500 (.460 - .570) .820 (.690 - .980) 1.30 (1.08 - 1.40) 1.74 (1.39 - 2.08) 701 - - 07 .529 (.478 - .585) .510 (.450 - .570) .820 (.690 08 .960) 1.36 (1.09 - 1.53) 1.70 (1.40 - 1.78) 376 - 09 - 10 .465 (.406 - .533) .460 (.430 - .530) .830 (.710 - .920) 1.21 (1.05 - 1.51) 1.56 (1.19 - 2.11) 451 20 years and older - 00 .343 (.305 - .386) .370 (.330 - .420) .570 (.520 - .640) .880 (.810 - .980) 1.28 (1.07 - 1.39) 1406 99 (.520 01 02 .352 (.333 - .373) .380 (.350 - .410) .560 - - .590) .860 (.800 - .930) 1.15 (1.04 - 1.42) 1560 03 - 04 .285 (.259 - .313) .300 (.270 - .330) .460 (.410 - .510) .690 (.660 - .730) 1.06 (.890 - 1.14) 1543 05 06 .351 (.332 - .371) .370 (.350 - .390) .550 (.520 - .600) .810 (.760 - .880) 1.30 (1.05 - 1.47) 1520 - 07 - .343 (.326 - .362) .350 (.340 - .370) .530 (.500 - .560) .830 (.750 - .920) 1.20 (1.00 - 1.38) 1857 08 (.800 - .351 09 (.322 - .382) .350 (.330 - .380) .570 (.520 - .630) .890 10 - 1.02) 1.35 (1.12 - 1.58) 2019 Gender 99 - 00 .371 (.331 - .416) .410 (.370 - .450) .580 (.540 - .640) .820 (.740 - .900) 1.01 (.900 - 1.12) 1227 Males 01 - 02 .367 (.338 - .399) .390 (.360 .420) .550 (.520 - .600) .790 (.740 - .850) 1.05 (.960 - 1.14) 1335 - - 03 .294 (.270 - .319) .320 (.290 - .340) .480 (.440 04 .500) .670 (.620 - .710) .870 (.790 - .920) 1281 - 05 - 06 .369 (.354 - .383) .380 (.370 - .400) .540 - .570) .760 (.690 - .850) 1.06 (.910 - 1.27) 1271 (.510 - 08 .350 (.330 - .371) .370 (.350 - .390) .530 07 - .560) .750 (.690 - .820) 1.00 (.860 - 1.14) 1327 (.500 09 - 10 .336 (.307 - .368) .360 (.330 - .380) .530 (.480 - .570) .750 (.690 - .850) .960 (.850 - 1.12) 1398 Females - 00 .379 (.333 - .431) .410 (.340 - .460) .680 (.590 - .790) 1.17 (.930 - 1.36) 1.50 (1.28 - 2.05) 1238 99 - 01 .390 (.364 - .417) .430 (.400 - .450) .670 (.620 02 .700) 1.06 (.980 - 1.16) 1.46 (1.22 - 1.81) 1355 - 03 - 04 .339 (.308 - .372) .340 (.310 - .370) .580 - .610) 1.04 (.900 - 1.13) 1.47 (1.33 - 1.73) 1277 (.540 - 06 .379 (.351 - .409) .410 (.370 - .440) .660 05 - .700) 1.04 (.900 - 1.21) 1.54 (1.30 - 1.93) 1305 (.620 07 - 08 .389 (.367 - .411) .390 (.360 - .410) .650 (.590 - .690) 1.08 (.980 - 1.26) 1.43 (1.34 - 1.62) 1300 (.640 10 .403 (.364 - .447) .400 (.360 - .440) .700 - - .770) 1.19 (1.05 - 1.36) 1.68 (1.51 - 2.11) 1450 09 Limit of detection (LOD, see Data Analysis section) for Survey years 99 - 00, 01 - 02, 03 - 04, 05 - 06, 07 - 08, and 09 - 10 are 0.07, 0.07, 0.08, 0.041, 0.041, and 0.041 respectively. Biomonitoring S ummary http://www.cdc.gov/biomonitoring/Cobalt_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 300

320 Urinary Cobalt (1999 – 2010) mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health and Geometric Nutrition Examination Survey. Survey Sample 95th Percentile Geometric mean 50th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 .418 (.348 - .502) .470 (.370 - .530) .670 (.630 - .770) 1.05 (.950 - 1.19) 1.47 (1.25 - 1.67) 884 Mexican Americans - .398 (.373 - .424) .430 (.410 - .450) .650 (.600 - .710) .950 (.850 - 1.03) 1.20 (1.06 - 1.48) 683 01 02 - 03 .374 (.350 - .398) .350 (.340 - .390) .580 (.530 04 .620) 1.09 (.920 - 1.16) 1.33 (1.16 - 1.73) 618 - 05 - 06 .437 (.404 - .473) .450 (.420 - .500) .680 (.620 - .720) 1.11 (.940 - 1.30) 1.58 (1.33 - 1.79) 652 - 08 .396 (.349 - .450) .400 (.330 - .480) .610 (.560 - .710) .980 (.870 - 1.08) 1.26 (1.05 - 1.69) 515 07 - 09 .378 (.351 - .407) .380 (.360 - .410) .590 (.560 10 .640) .920 (.860 - 1.04) 1.24 (1.04 - 1.58) 613 - - Hispanic blacks 99 - 00 .434 (.405 - .465) .430 (.390 - .470) .680 (.620 - .760) 1.17 (1.04 - 1.26) 1.45 (1.23 - 2.04) 568 Non - 02 .435 (.388 - .487) .420 (.380 - .460) .650 (.540 - .810) 1.16 (.850 - 1.64) 1.75 (1.32 - 2.22) 667 01 (.540 03 04 .380 (.348 - .414) .380 (.360 - .410) .600 - - .680) 1.01 (.890 - 1.09) 1.28 (1.01 - 2.03) 723 05 - 06 .412 (.374 - .453) .410 (.360 - .440) .600 (.560 - .670) .930 (.830 - 1.11) 1.47 (1.12 - 2.00) 692 07 08 .403 (.367 - .443) .390 (.360 - .420) .620 (.560 - .740) 1.06 (.880 - 1.31) 1.57 (1.22 - 1.86) 589 - - 09 .368 (.335 - .403) .380 (.340 - .400) .590 (.520 10 .650) .990 (.870 - 1.15) 1.47 (1.20 - 1.58) 544 - - Hispanic whites 99 - 00 .369 (.316 - .431) .410 (.350 - .460) .630 Non (.550 - .700) .930 (.830 - 1.08) 1.29 (1.02 - 1.65) 822 - 02 .359 (.327 - .394) .390 (.360 - .430) .590 01 - .660) .870 (.800 - .950) 1.16 (1.04 - 1.32) 1132 (.520 03 - 04 .301 (.270 - .334) .310 (.280 - .340) .500 (.460 - .540) .760 (.690 - .850) 1.09 (.950 - 1.26) 1074 05 06 .361 (.340 - .384) .380 (.360 - .410) .580 (.530 - .630) .860 (.800 - .940) 1.30 (1.06 - 1.50) 1041 - (.520 08 .358 (.338 - .379) .370 (.350 - .390) .560 - - .600) .900 (.780 - 1.00) 1.32 (1.02 - 1.46) 1095 07 09 - 10 .369 (.335 - .408) .370 (.350 - .400) .600 (.540 - .660) .970 (.850 - 1.10) 1.40 (1.17 - 1.64) 1225 07 Limit of detection (LOD, see Data Analysis section) for Survey years 99 - 00, 01 - 02, 03 - 04, 05 - 06, - 08, and 09 - 10 are 0.07, 0.07, 0.08, 0.041, 0.041, and 0.041 respectively. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Cobalt_BiomonitoringSu mmary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 301

321 Urinary Cobalt (2011 – 2014) s (in μg/L) for the U.S. population from the National Health and Geometric mean and selected percentiles of urine concentration Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 .326 (.309 - .344) .323 (.306 Total .347) .543 (.510 - .577) .860 (.800 - .979) 1.27 (1.09 - 1.45) 2504 11 - - 14 .391 (.373 - .411) .408 (.382 - .435) .687 (.662 - .713) 1.04 (.976 - 1.09) (1.23 - 1.48) 2664 13 1.35 Age group 11 years - 11 - 12 .397 (.356 - .442) .452 (.361 - .510) .704 (.616 - .772) 1.00 (.846 - 1.38) 1.42 (1.00 - 1.78) 399 6 - - .447 (.411 - .487) .479 (.408 - .522) .789 (.718 14 .877) 1.05 (.991 - 1.33) 1.55 (1.14 - 1.84) 402 13 - 19 years 11 - 12 .416 (.358 - .484) .429 (.341 - .527) .700 (.622 - .806) 1.12 (.960 - 1.30) 1.56 (1.16 - 1.96) 390 12 13 14 .549 (.462 - .653) .602 (.491 - .701) .936 (.783 - 1.05) 1.43 (1.08 - 1.75) 1.76 (1.49 - 3.07) 451 - 11 12 .307 (.288 - .327) .308 (.289 - .328) .491 (.457 - .534) .800 (.695 - .940) 1.16 (.984 - 1.36) 1715 20 years and older - - - .367 (.349 - .386) .382 (.357 - .410) .647 (.614 14 .673) .930 (.882 - 1.04) 1.23 (1.17 - 1.34) 1811 13 Gender - - 12 .317 (.299 - .336) .316 (.293 Males .339) .496 (.452 - .547) .715 (.659 - .798) .963 (.858 - 1.03) 1262 11 13 (.604 14 .380 (.355 - .407) .414 (.374 - .452) .641 - .684) .883 (.820 - .951) 1.11 (1.04 - 1.26) 1318 - (.554 Females - 12 .335 (.310 - .361) .340 (.308 - .382) .591 11 - .643) 1.07 (.891 - 1.20) 1.49 (1.30 - 1.74) 1242 13 - 14 .402 (.374 - .432) .398 (.366 - .438) .741 (.701 - .789) 1.16 (1.06 - 1.23) 1.50 (1.36 - 1.75) 1346 Race/ethnicity 11 12 .350 (.322 - .381) .350 (.307 - .377) .550 (.490 - .598) .891 (.721 - 1.18) 1.41 (1.14 - 2.08) 317 Mexican Americans - - - .415 (.378 - .456) .439 (.400 - .482) .686 (.610 14 .766) .918 (.866 - 1.09) 1.15 (1.06 - 1.56) 453 13 - Hispanic blacks 11 - 12 .340 (.311 - .373) .333 (.304 - .358) .519 Non - .576) .909 (.790 - .986) 1.44 (1.06 - 1.60) 669 (.489 - 14 .468 (.410 - .535) .471 (.402 - .561) .796 (.691 - .877) 1.26 (1.03 - 1.39) 1.50 (1.35 - 1.67) 581 13 - 11 - 12 .320 (.295 - .348) .320 (.296 - .357) .543 Non (.485 - .591) .858 (.750 - .995) 1.20 (1.03 - 1.35) 820 Hispanic whites 13 - 14 .374 (.349 - .401) .387 (.345 - .429) .681 (.638 - .723) 1.02 (.930 - 1.10) 1.34 (1.21 - 1.56) 985 All Hispanics - 12 .338 (.321 - .357) .326 (.306 - .350) .530 (.490 - .583) .891 (.763 - 1.14) 1.41 (1.10 - 1.81) 573 11 (.631 13 14 .412 (.384 - .442) .442 (.409 - .481) .674 - - .731) .964 (.891 - 1.07) 1.20 (1.09 - 1.36) 701 Asians 11 - 12 .317 (.282 - .357) .323 (.300 - .355) .519 (.445 - .634) .968 (.723 - 1.58) 1.78 (.980 - 2.31) 353 (.578 14 .362 (.315 - .416) .354 (.312 - .434) .653 - - .789) 1.05 (.854 - 1.25) 1.57 (1.09 - 2.26) 292 13 Limit of detection (LOD, see Data Analysis section) for Survey year 11 - 12 and 13 - 14 are 0.048 and 0.023. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Co balt_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 302

322 Urinary Cobalt (creatinine corrected) (1999 – 2010) onal Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati Nutrition Examination Survey. Health and Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 00 .353 ( .319 - .391) .328 (.302 - .365) .515 (.457 - .581) .821 (.679 - .963) 1.16 (.938 Total 1.50) 2465 99 - - .358 (.333 - .384) .335 (.313 - .360) .523 (.487 - 02 .844 (.750 - .955) 1.16 (1.00 - 1.28) 2689 01 .562) - 04 .314 (.303 - .325) .290 (.278 - .306) .455 (.434 - .481) .737 (.703 - 1.02 (.911 - 1.10) 2558 03 .781) 05 06 .368 (.353 - .384) .340 (.320 - .360) .520 (.490 - .550) .810 (.750 - .920) 1.17 (.990 - 1.27) 2576 - - .385 (.366 - .406) .360 (.350 - .380) .560 (.520 - .590) .870 07 (.760 - .990) 1.22 (1.01 - 1.46) 2627 08 (.830 - .393 09 (.372 - .415) .370 (.350 - .390) .560 (.530 - .600) .890 10 - .940) 1.29 (1.08 - 1.49) 2848 Age group - 11 years 99 - 00 .547 (.467 - .640) .554 (.449 - .647) .774 (.626 - .938) 1.00 (.833 - 1.49) 1.25 (.895 - 6 340 1.50) - 02 .552 (.508 - .599) .548 (.503 - .609) .756 (.660 - .829) 1.00 (.900 - 1.27) 1.30 (1.03 - 1.73) 368 01 03 - .529 (.471 - .593) .500 (.463 - .543) .689 (.634 - .750) 1.04 (.760 - 1.29) 1.29 (1.04 - 1.36) 290 04 - - .523 (.494 - .554) .520 (.480 - .570) .720 (.660 05 .760) .900 (.840 - 1.04) 1.27 (.980 - 1.45) 355 06 - 07 .564 (.501 - .635) .580 (.500 - .630) .760 (.660 08 .910) 1.12 (.830 - 1.46) 1.39 (1.06 - 1.81) 394 - 09 - 10 .578 (.538 - .620) .570 (.530 - .620) .760 (.690 - 1.06 (.920 - 1.21) 1.26 (1.06 - 1.58) 378 .840) 12 19 years 99 - 00 .391 (.353 - .433) .378 (.329 - .407) .537 (.469 - .595) .824 (.638 - 1.17) 1.44 (.821 - 3.54) 719 - 01 .534 02 .368 (.343 - .396) .352 (.327 - .372) (.471 - .611) .851 (.673 - .949) 1.06 (.932 - 1.24) 762 - (.442 04 .329 (.304 - .355) .316 (.277 - .348) .495 - - .561) .738 (.630 - .847) .952 (.792 - 1.09) 725 03 05 - 06 .392 (.360 - .427) .360 (.330 - .400) .530 (.480 - .620) .810 (.720 - .920) 1.02 (.870 - 1.48) 701 07 08 .414 (.382 - .448) .390 (.340 - .450) .610 (.520 - .700) .880 (.750 - 1.13) 1.17 (.890 - 1.35) 376 - 09 - .435 (.398 - .476) .410 (.370 - .470) .610 (.550 - .700) .960 (.790 - 1.07) 1.30 (1.00 - 1.53) 451 10 .522) 99 .328 (.297 - .362) .306 (.280 - .328) .471 (.428 - 00 .727 (.632 - .905) 1.12 (.861 - 1.36) 1406 - 20 years and older - 02 .337 (.313 - .363) .313 (.294 - .337) .475 (.435 .513) .792 (.704 - .955) 1.15 (.963 - 1.33) 1559 01 - 03 04 .293 (.282 - .304) .271 (.257 - .286) .400 (.380 - .429) .691 (.616 - .744) .976 (.829 - 1.10) 1543 - 05 - 06 .350 (.334 - .367) .320 (.300 - .340) .490 (.450 - .520) .780 (.690 - .940) 1.17 (.970 - 1.31) 1520 - 08 .366 (.348 - .384) .340 (.330 - .360) .510 (.480 - .540) .830 (.720 - .960) 1.19 (.980 - 1.47) 1857 07 - 09 .371 (.350 - .394) .340 (.320 - .360) .520 (.490 10 .550) .840 (.750 - .930) 1.29 (1.02 - 1.52) 2019 - Gender - - 00 .290 (.259 - .324) .279 (.248 Males .301) .402 (.365 - .449) .608 (.534 - .728) .838 (.667 - 1.10) 1227 99 (.361 01 02 .290 (.272 - .310) .278 (.256 - .297) .392 - - .425) .644 (.574 - .707) .848 (.786 - .929) 1334 03 - 04 .247 (.237 - .259) .234 (.215 - .250) .333 (.313 - .352) .513 (.476 - .585) .700 (.630 - .753) 1281 05 06 .302 (.289 - .317) .290 (.270 - .300) .410 (.370 - .440) .610 (.580 - .640) .770 (.710 - .850) 1271 - - 07 .313 (.298 - .329) .300 (.280 - .310) .420 (.400 08 .440) .630 (.580 - .680) .830 (.680 - 1.02) 1327 - 09 - 10 .306 (.290 - .323) .290 (.280 - .300) .420 (.390 .450) .630 (.570 - .690) .810 (.720 - .920) 1398 - Females 99 - 00 .426 (.378 - .479) .407 (.362 - .457) .606 (.550 - .694) .960 (.781 - 1.29) 1.50 (1.11 - 1.83) 1238 01 - 02 .435 (.404 - .468) .408 (.382 - .438) .635 (.560 - .708) 1.00 (.879 - 1.19) 1.29 (1.12 - 1.60) 1355 03 04 .393 (.378 - .409) .361 (.342 - .381) .554 (.513 - .615) .937 (.850 - 1.00) 1.29 (1.10 - 1.33) 1277 - (.590 06 .445 (.423 - .468) .420 (.400 - .440) .630 - - .700) .990 (.900 - 1.17) 1.34 (1.18 - 1.60) 1305 05 07 - 08 .470 (.442 - .499) .450 (.430 - .480) .690 (.630 - .750) 1.09 (.930 - 1.27) 1.46 (1.26 - 1.69) 1300 - 10 .498 (.465 - .534) .460 (.450 - .480) .690 (.650 - .720) 1.09 09 (.990 - 1.33) 1.64 (1.34 - 2.15) 1450 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Cobalt_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 303

323 Urinary Cobalt (creatinine corrected) (1999 – 2010) r the U.S. population from the National Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) fo and Nutrition Examination Survey. Survey Sample 95th Percentile Geometric mean 50th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 .386 (.339 - .439) .376 (.333 - .419) .598 (.500 - .669) .898 (.826 - 1.00) 1.23 (1.11 - 1.35) 884 Mexican Americans - .388 (.361 - .417) .361 (.333 - .394) .591 (.500 - .662) .872 (.777 - .990) 1.10 (.990 - 1.27) 682 01 02 - 03 .346 (.326 - .368) .327 (.296 - .349) .542 (.487 04 .594) .850 (.753 - .963) 1.14 (.963 - 1.35) 618 - 05 - 06 .411 (.388 - .436) .380 (.360 - .400) (.520 - .650) .900 (.820 - 1.02) 1.19 (1.05 - 1.35) 652 .580 - 08 .396 (.348 - .450) .370 (.330 - .410) .560 (.470 - .690) .900 (.770 - 1.12) 1.17 (.990 - 1.54) 515 07 - 09 .396 (.367 - .427) .380 (.340 - .420) .590 (.530 10 .650) .930 (.820 - 1.03) 1.22 (1.04 - 1.30) 613 - - Hispanic blacks 99 - 00 .282 (.275 - .289) .257 (.243 - .279) .417 Non (.378 - .462) .723 (.600 - .785) .975 (.757 - 1.60) 568 - 02 .298 (.275 - .323) .268 (.251 - .296) .444 01 - .505) .728 (.582 - .917) 1.03 (.740 - 1.55) 667 (.393 03 - 04 .273 (.248 - .300) .259 (.239 - .281) .388 (.344 - .461) .700 (.563 - .842) .964 (.733 - 1.15) 723 05 06 .299 (.281 - .318) .280 (.240 - .300) .420 (.380 - .460) .700 (.570 - .780) .950 (.790 - 1.17) 692 - - 07 .295 (.277 - .314) .270 (.260 - .290) .420 (.390 08 .450) .710 (.570 - .860) 1.07 (.850 - 1.28) 589 - 09 - 10 .291 (.271 - .314) .280 (.240 - .310) .420 (.380 - .700 (.610 - .750) .840 (.750 - 1.06) 544 .480) Non Hispanic whites 99 - 00 .369 (.324 - .421) .352 (.313 - .387) - (.452 - .611) .861 (.667 - 1.16) 1.25 (.895 - 1.57) 822 .533 01 - 02 .362 (.331 - .396) .343 (.313 - .368) .523 (.479 - .562) .830 (.736 - .983) 1.16 (.983 - 1.33) 1132 03 04 .317 (.301 - .334) .291 (.274 - .309) .457 (.425 - .488) .738 (.683 - .804) 1.00 (.857 - 1.13) 1074 - (.490 06 .376 (.357 - .395) .350 (.330 - .370) .520 - - .580) .810 (.710 - .950) 1.18 (.950 - 1.43) 1041 05 07 - 08 .401 (.380 - .423) .380 (.360 - .400) .590 (.530 - .630) .890 (.760 - 1.06) 1.27 (.980 - 1.55) 1095 - 10 .413 (.388 - .440) .390 (.360 - .410) .580 (.530 - .620) .910 09 (.830 - .980) 1.33 (1.08 - 1.58) 1225 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Cobalt_BiomonitoringSu mmary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 304

324 Urinary Cobalt (creatinine corrected) (2011 – 2014) onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati an d Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 .370 (.349 - .391) .347 (.330 Total .371) .557 (.513 - .593) .880 (.768 - 1.03) 1.29 (1.12 - 1.46) 2502 11 - - 14 .452 (.437 - .466) .443 (.427 - .454) .656 (.625 - .688) .969 (.920 - 1.03) (1.18 - 1.47) 2663 13 1.31 Age group 11 years - 11 - 12 .567 (.535 - .602) .571 (.526 - .611) .778 (.713 - .834) 1.19 (.974 - 1.30) 1.38 (1.10 - 1.67) 398 6 - - .667 (.614 - .725) .646 (.593 - .704) .914 (.853 14 .986) 1.26 (1.09 - 1.40) 1.57 (1.24 - 2.13) 402 13 - 19 years 11 - 12 .398 (.349 - .455) .373 (.316 - .441) .585 12 (.454 - .700) .832 (.688 - 1.09) 1.26 (.830 - 2.77) 390 - 14 .497 (.463 - .534) .480 (.446 - .525) .692 (.597 - .769) .920 (.819 - 1.10) 1.30 (1.09 - 1.61) 451 13 - 12 .349 (.330 - .369) .327 (.300 - .341) .508 (.467 - .552) .803 (.711 - .982) 1.24 (1.10 - 1.50) 1714 20 years and older 11 13 - 14 .428 (.412 - .444) .417 (.390 - .441) .607 (.580 - .643) .929 (.853 - .994) 1.27 (1.10 - 1.46) 1810 Gender 1.17) - 12 .297 (.280 - .315) .276 (.254 - .294) .426 (.397 - .456) .637 (.564 - .750) .865 (.748 - Males 1261 11 (.493 13 14 .379 (.362 - .398) .368 (.344 - .390) .529 - - .560) .758 (.689 - .852) 1.02 (.871 - 1.29) 1317 Females 11 - 12 .455 (.418 - .496) .433 (.407 - .466) .660 (.600 - .729) 1.10 (.900 - 1.36) 1.54 (1.28 - 1.84) 1241 13 14 .534 (.515 - .553) .532 (.502 - .549) .774 (.733 - .816) 1.12 (.991 - 1.27) 1.48 (1.27 - 1.77) 1346 - Race/ethnicity - 11 12 .394 (.357 - .435) .374 (.322 - .576 (.531 - .637) 1.02 (.877 - 1.24) 1.50 (.988 - 2.02) 317 Mexican Americans .400) 13 - 14 .474 (.449 - .500) .448 (.425 - .473) .669 (.610 - .721) .971 (.888 - 1.03) 1.28 (1.03 - 1.51) 453 Non Hispanic blacks 11 - 12 .265 (.248 - .282) .244 (.222 - .267) .401 (.342 - .457) .645 (.559 - .816) 1.02 (.737 - 1.41) 669 - - 14 .356 (.332 - .382) .337 (.315 - .377) .545 13 - .624) .841 (.754 - .952) 1.08 (.930 - 1.22) 581 (.490 Non - Hispanic whites 11 - 12 .387 (.360 - .417) .365 (.336 - .400) .574 (.513 - .615) .860 (.749 - 1.09) 1.29 (1.04 - 1.57) 818 13 14 .461 (.442 - .480) .447 (.430 - .469) .669 (.613 - .703) .987 (.912 - 1.13) 1.32 (1.19 - 1.61) 984 - (.520 All Hispanics - 12 .379 (.351 - .409) .361 (.322 - .384) .572 11 - .626) .944 (.809 - 1.15) 1.33 (1.13 - 1.91) 573 13 - 14 .460 (.444 - .475) .448 (.429 - .464) .663 (.619 - .703) .952 (.888 - 1.00) 1.17 (1.03 - 1.35) 701 (.531 Asians - 12 .424 (.378 - .475) .386 (.329 - .457) .659 11 - .785) 1.18 (.907 - 1.51) 1.61 (1.14 - 2.72) 353 13 - 14 .567 (.516 - .624) .540 (.482 - .567) .814 (.670 - .931) 1.38 (1.07 - 1.97) 2.09 (1.39 - 3.78) 292 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Cobalt_BiomonitoringSummary.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 305

325 Serum Copper (2011 – 2014) nd Geometric mean and selected percentiles of serum concentrations (in μg/dL) for the U.S. population from the National Health a Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 114 (111 - 116) 112 (109 Total 114) 130 (127 - 134) 152 (145 - 162) 169 (161 - 183) 2329 11 - - 14 115 (112 - 118) 114 (110 - 117) 132 (129 - 135) 155 (150 - 160) (165 - 180) 2520 13 171 Age group 11 years - 11 - 12 120 (117 - 124) 121 (115 - 126) 135 (130 - 140) 154 (141 - 161) 164 (154 - 175) 316 6 - - 119 (114 - 123) 119 (114 - 123) 132 (127 14 141) 148 (143 - 155) 157 (148 - 175) 339 13 - 19 years 11 - 12 106 (103 - 110) 103 (99.7 - 106) 120 12 (115 - 125) 143 (130 - 161) 169 (141 - 199) 366 - 14 106 (103 - 108) 104 (101 - 106) 120 (116 - 125) 141 (132 - 147) 164 (146 - 181) 418 13 - 12 114 (111 - 117) 112 (109 - 115) 131 (127 - 136) 153 (145 - 164) 171 (162 - 184) 1647 20 years and older 11 13 - 14 116 (113 - 119) 114 (111 - 118) 134 (131 - 136) 157 (150 - 164) 175 (165 - 183) 1763 Gender 155) - 12 103 (101 - 106) 103 (101 - 105) 116 (114 - 119) 132 (126 - 139) 143 (135 - Males 1162 11 (113 13 14 103 (99.8 - 107) 103 (101 - 106) 117 - - 122) 131 (125 - 137) 141 (134 - 148) 1235 Females 11 - 12 124 (121 - 127) 123 (119 - 125) 142 (137 - 147) 165 (160 - 172) 187 (173 - 207) 1167 13 14 127 (124 - 130) 124 (122 - 128) 145 (142 - 149) 168 (162 - 176) 191 (175 - 214) 1285 - Race/ethnicity - 11 12 111 (107 - 116) 109 (105 - 125 (122 - 131) 144 (137 - 152) 156 (148 - 164) 285 Mexican Americans 115) 13 - 14 116 (113 - 120) 116 (110 - 119) 135 (128 - 142) 157 (147 - 164) 174 (162 - 182) 431 Non Hispanic blacks 11 - 12 126 (122 - 130) 127 (121 - 130) 147 (142 - 151) 168 (161 - 180) 191 (176 - 214) 620 - - 14 125 (121 - 129) 124 (120 - 128) 147 13 - 151) 165 (159 - 170) 176 (169 - 188) 516 (143 Non - Hispanic whites 11 - 12 113 (110 - 115) 111 (109 - 113) 128 (125 - 132) 150 (141 - 163) 169 (155 - 192) 780 13 14 113 (110 - 116) 111 (109 - 114) 130 (125 - 133) 150 (144 - 158) 168 (158 - 188) 975 - (124 - 12 112 (108 - 115) 109 (106 - 115) 128 All Hispanics - 132) 145 (139 - 152) 158 (151 - 164) 525 11 (129 13 14 117 (113 - 121) 116 (111 - 120) 136 - - 142) 157 (148 - 164) 171 (162 - 182) 666 Asians 11 - 12 105 (102 - 109) 101 (96.2 - 107) 120 (114 - 125) 143 (132 - 151) 166 (150 - 198) 323 (116 14 107 (104 - 111) 104 (99.8 - 108) 125 - - 130) 146 (132 - 162) 162 (145 - 186) 267 13 Limit of detection (LOD, see Data Analysis section) for Survey year 11 - 12 and 13 - 14 are 2.5 and 2.5, respectively. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 306

326 Blood Lead (1999 – 2010) ric mean and selected percentiles of blood concentrations (in μg/dL) for the U.S. population from the National Health and Geomet Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 1.66 (1.60 - 1.72) 1.60 (1.60 - Total 2.50 (2.40 2.60) 3.80 (3.60 - 4.00) 5.00 (4.70 - 5.50) 7970 99 - 00 1.70) 02 1.45 (1.39 - 1.51) 1.40 (1.40 - 1.50) 2.20 (2.10 - 2.30) 3.40 (3.20 - 3.60) 4.50 (4.20 4.70) 8945 01 - - - 1.43 (1.36 - 1.50) 1.40 (1.30 - 1.50) 2.10 (2.10 - 2.20) 3.20 (3.10 - 3.30) 4.20 (3.90 - 4.40) 8373 03 04 2.11) 06 1.29 (1.23 - 1.36) 1.27 (1.20 - 1.34) 2.01 (1.91 - 3.05 (2.86 - 3.22) 3.91 (3.64 - 4.18) 8407 05 - - 08 1.27 (1.21 - 1.34) (1.18 - 1.30) 1.90 (1.80 - 2.00) 2.80 (2.67 - 2.96) 3.70 (3.50 - 3.90) 8266 07 1.22 09 10 1.12 (1.08 - 1.16) 1.07 (1.03 - 1.12) 1.70 (1.62 - 1.77) 2.58 (2.45 - 2.71) 3.34 (3.14 - 3.57) 8793 - Age group 5 years 99 - 00 2.23 (1.96 - 2.53) 2.20 (1.90 - 2.50) 3.40 (2.80 - 3.90) 4.90 (4.00 - 6.60) 7.00 (6.10 - 8.30) 723 1 - - - 1.70 (1.55 - 1.87) 1.60 (1.50 01 1.80) 2.50 (2.20 - 2.90) 4.20 (3.50 - 5.20) 5.80 (4.70 - 6.90) 898 02 - 03 1.77 (1.60 - 1.95) 1.70 (1.50 - 1.90) 2.50 (2.30 04 2.80) 3.90 (3.30 - 4.60) 5.10 (4.10 - 6.60) 911 - 05 - 06 1.46 (1.36 - 1.57) 1.43 (1.34 - 1.55) (1.97 - 2.20) 2.98 (2.72 - 3.32) 3.80 (3.49 - 4.54) 968 2.10 - 08 1.51 (1.37 - 1.66) 1.43 (1.30 - 1.60) 2.20 (1.98 - 2.31) 3.20 (2.65 - 3.85) 4.10 (3.40 - 5.19) 817 07 09 - 1.17 (1.08 - 1.26) 1.15 (1.03 - 1.27) 1.70 (1.50 - 1.87) 2.39 (2.08 - 2.65) 3.37 (2.63 - 4.11) 836 10 - 11 years - 00 1.51 (1.36 - 1.66) 1.40 (1.30 - 1.60) 2.10 (1.80 99 2.50) 3.30 (2.80 - 3.80) 4.50 (3.40 - 6.20) 905 - 6 - 02 1.25 (1.14 - 1.36) 1.20 (1.00 - 1.30) 1.70 - 2.00) 2.80 (2.50 - 3.10) 3.70 (3.00 - 4.70) 1044 01 (1.60 03 04 1.25 (1.12 - 1.39) 1.20 (1.10 - 1.40) 1.80 (1.50 - 2.10) 2.60 (2.10 - 3.10) 3.30 (2.50 - 4.60) 856 - 05 - 06 1.02 (.948 - 1.10) .970 (.890 - 1.01) 1.40 - 1.55) 2.06 (1.80 - 2.72) 3.00 (2.26 - 3.81) 934 (1.28 - 08 .988 (.914 - 1.07) .960 (.880 - 1.07) 1.31 (1.22 - 1.49) 1.90 (1.70 - 2.11) 2.50 (2.10 - 2.88) 1011 07 - 09 .838 (.792 - .887) .810 (.740 - .840) 1.13 (1.06 10 1.21) 1.64 (1.45 - 1.84) 2.01 (1.88 - 2.25) 1009 - - 19 years 99 - 00 1.10 (1.04 - 1.17) 1.10 (1.00 - 1.20) 1.50 12 (1.40 - 1.70) 2.30 (2.10 - 2.40) 2.90 (2.70 - 3.00) 2135 - 02 .942 (.899 - .986) .900 (.900 - 1.00) 1.30 01 - 1.40) 2.00 (1.90 - 2.10) 2.70 (2.40 - 2.90) 2231 (1.20 03 - 04 .946 (.878 - 1.02) .900 (.800 - 1.00) 1.30 (1.20 - 1.40) 1.90 (1.70 - 2.10) 2.60 (2.20 - 3.00) 2081 05 06 .797 (.746 - .852) .740 (.690 - .790) 1.08 (.990 - 1.20) 1.69 (1.50 - 1.85) 2.23 (1.98 - 2.46) 1996 - 07 - .800 (.744 - .859) .760 (.720 - .820) 1.04 (.980 - 1.16) 1.50 (1.35 - 1.70) 1.90 (1.70 - 2.32) 1074 08 .990) - .680 (.636 - .727) .660 (.590 - .700) .910 (.840 - 1.29 (1.19 - 1.43) 1.72 (1.52 - 1.86) 1183 09 10 99 - 00 1.75 (1.68 - 1.81) 1.70 (1.60 - 1.80) 2.60 (2.50 20 years and older 2.70) 3.90 (3.70 - 4.10) 5.20 (4.80 - 5.60) 4207 - 01 02 1.56 (1.49 - 1.62) 1.60 (1.50 - 1.60) 2.30 (2.30 - 2.40) 3.60 (3.40 - 3.70) 4.60 (4.30 - 5.00) 4772 - 03 - 04 1.52 (1.45 - 1.60) 1.50 (1.40 - 1.60) 2.30 (2.20 - 2.40) 3.30 (3.20 - 3.50) 4.30 (4.00 - 4.60) 4525 05 1.41 06 (1.34 - 1.48) 1.41 (1.33 - 1.48) 2.17 (2.04 - 2.31) 3.22 (3.05 - 3.43) 4.12 (3.82 - 4.38) 4509 - - 07 1.38 (1.31 - 1.46) 1.34 (1.26 - 1.42) 2.06 (1.94 08 2.18) 3.00 (2.80 - 3.14) 3.90 (3.68 - 4.23) 5364 - 09 - 10 1.23 (1.19 - 1.28) 1.20 (1.14 - 1.25) 1.85 (1.78 - 1.93) 2.77 (2.60 - 2.93) 3.57 (3.29 - 3.84) 5765 Gender 6.50) - 00 2.01 (1.93 - 2.09) 1.90 (1.90 - 2.00) 2.90 (2.80 - 3.00) 4.50 (4.10 - 4.80) 6.00 (5.50 - Males 3913 99 (2.50 01 02 1.78 (1.71 - 1.86) 1.80 (1.70 - 1.80) 2.70 - - 2.80) 3.90 (3.80 - 4.10) 5.40 (5.00 - 5.50) 4339 03 - 04 1.69 (1.62 - 1.75) 1.60 (1.50 - 1.70) 2.50 (2.40 - 2.60) 3.70 (3.40 - 3.90) 4.80 (4.50 - 5.20) 4132 05 06 1.52 (1.42 - 1.62) 1.49 (1.41 - 1.58) 2.30 (2.12 - 2.51) 3.48 (3.20 - 3.75) 4.36 (4.04 - 4.76) 4092 - - 07 1.47 (1.39 - 1.56) 1.40 (1.32 - 1.50) 2.17 (2.00 08 2.30) 3.21 (3.01 - 3.53) 4.41 (4.10 - 4.88) 4147 - 09 - 10 1.31 (1.25 - 1.36) 1.26 (1.20 - 1.32) 1.96 (1.89 - 2.03) 2.93 (2.72 - 3.15) 3.84 (3.54 - 4.39) 4366 Females - 00 1.37 (1.32 - 1.43) 1.30 (1.30 - 1.40) 2.00 (1.90 - 2.10) 3.10 (2.90 - 3.30) 4.00 (3.80 - 4.20) 4057 99 (1.70 01 02 1.19 (1.14 - 1.25) 1.20 (1.10 - 1.20) 1.80 - - 1.90) 2.60 (2.50 - 2.80) 3.60 (3.10 - 4.00) 4606 03 - 04 1.22 (1.14 - 1.31) 1.20 (1.10 - 1.30) 1.80 (1.70 - 2.00) 2.70 (2.50 - 3.00) 3.50 (3.10 - 3.80) 4241 05 06 1.11 (1.05 - 1.17) 1.06 (.980 - 1.15) 1.73 (1.61 - 1.84) 2.59 (2.44 - 2.74) 3.25 (3.12 - 3.44) 4315 - (1.54 08 1.11 (1.06 - 1.16) 1.09 (1.00 - 1.14) 1.64 - - 1.74) 2.41 (2.35 - 2.50) 3.00 (2.81 - 3.20) 4119 07 09 - 10 .966 (.929 - 1.01) .940 (.890 - .970) 1.43 (1.36 - 1.53) 2.18 (2.08 - 2.30) 2.81 (2.63 - 2.93) 4427 - Limit of detection (LOD, see Data Analysis section) for Survey years 99 - 00, 01 - 02, 03 - 04, 05 - 06, 07 08, and 09 - 10 are 0.3, 0.3, 0.28, 0.25, 0.25, and 0.25 respectively. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Lead_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Lead_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 307

327 Blood Lead (1999 – 2010) nd Geometric mean and selected percentiles of blood concentrations (in μg/dL) for the U.S. population from the National Health a Nutrition Examination Survey. Survey Sample 95th Percentile Geometric mean 50th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 1.83 (1.75 - 1.91) 1.80 (1.70 - 1.90) 2.80 (2.60 - 2.90) 4.20 (3.90 - 4.60) 5.80 (5.10 - 6.60) 2742 Mexican Americans - 1.46 (1.34 - 1.60) 1.50 (1.30 - 1.60) 2.30 (2.10 - 2.60) 3.60 (3.40 - 4.20) 5.40 (4.40 - 6.70) 2268 01 02 - 03 1.55 (1.43 - 1.69) 1.50 (1.40 - 1.60) 2.30 (2.10 04 2.50) 3.50 (2.90 - 4.20) 4.90 (3.90 - 6.40) 2085 - 05 - 06 1.29 (1.21 - 1.38) 1.26 (1.15 - 1.36) 2.00 (1.87 - 2.20) 3.16 (2.79 - 3.58) 4.22 (3.47 - 5.36) 2236 - 08 1.25 (1.15 - 1.36) 1.20 (1.10 - 1.31) 1.88 (1.70 - 2.06) 2.81 (2.60 - 3.20) 3.92 (3.20 - 5.00) 1712 07 - 09 1.14 (1.03 - 1.28) 1.04 (.940 - 1.18) 1.76 (1.52 10 1.99) 2.93 (2.63 - 3.30) 3.92 (3.60 - 4.69) 1966 - - Hispanic blacks 99 - 00 1.87 (1.75 - 2.00) 1.80 (1.70 - 2.00) 2.80 (2.60 - 3.00) 4.30 (4.00 - 4.60) 5.70 (5.20 - 6.10) 1842 Non - 02 1.65 (1.52 - 1.80) 1.60 (1.40 - 1.70) 2.60 (2.30 - 2.90) 4.20 (3.80 - 4.70) 5.80 (5.30 - 6.50) 2219 01 (2.20 03 04 1.69 (1.52 - 1.89) 1.60 (1.40 - 1.80) 2.60 - - 3.00) 4.10 (3.50 - 4.70) 5.30 (4.60 - 6.60) 2293 05 - 06 1.39 (1.26 - 1.53) 1.31 (1.19 - 1.45) 2.16 (1.95 - 2.42) 3.48 (3.19 - 3.80) 4.65 (4.21 - 5.14) 2193 07 08 1.39 (1.30 - 1.48) 1.30 (1.20 - 1.42) 2.10 (2.00 - 2.20) 3.22 (3.08 - 3.50) 4.50 (4.00 - 4.80) 1746 - - 09 1.24 (1.18 - 1.30) 1.19 (1.12 - 1.25) 1.87 (1.76 10 1.99) 2.90 (2.68 - 3.18) 3.86 (3.57 - 4.29) 1593 - - Hispanic whites 99 - 00 1.62 (1.55 - 1.69) 1.60 (1.50 - 1.70) 2.40 (2.30 - 2.50) 3.60 (3.40 - 3.90) 5.00 (4.40 - 5.70) 2716 Non - 02 1.43 (1.37 - 1.48) 1.40 (1.30 - 1.50) 2.20 (2.10 - 2.20) 3.20 (3.10 - 3.40) 4.20 (3.90 - 4.50) 3806 01 (2.00 03 04 1.37 (1.32 - 1.43) 1.30 (1.30 - 1.40) 2.10 - - 2.10) 3.00 (2.80 - 3.20) 3.90 (3.60 - 4.30) 3478 05 - 06 1.28 (1.19 - 1.37) 1.27 (1.17 - 1.38) 1.97 (1.86 - 2.14) 2.99 (2.73 - 3.25) 3.82 (3.41 - 4.20) 3310 07 08 1.24 (1.16 - 1.33) 1.20 (1.10 - 1.30) 1.86 (1.72 - 2.00) 2.70 (2.54 - 2.90) 3.50 (3.20 - 3.89) 3461 - (1.59 10 1.10 (1.04 - 1.16) 1.07 (1.00 - 1.15) 1.67 - - 1.76) 2.49 (2.35 - 2.63) 3.14 (2.99 - 3.36) 3760 09 Limit of detection (LOD, see Data Analysis section) for Survey years 99 - 00, 01 - 02, 03 - 04, 05 - 06, 07 - 08, and 09 - 10 are 0.3, 0.3, 0.28, 0.25, 0.25, and 0.25 respectively. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Lead_BiomonitoringSummary.ht ml Factsheet http://www.cdc.gov/biomonitoring/Lead_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 308

328 Blood Lead (2011 – 2016) nd Geometric mean and selected percentiles of blood concentrations (in μg/dL) for the U.S. population from the National Health a Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - .973 (.916 - 1.04) .930 (.880 - Total 1.52 (1.41 1.61) 2.38 (2.17 - 2.61) 3.16 (2.77 - 3.68) 7920 11 - 12 .980) 14 .858 (.813 - .906) .830 (.780 - .870) 1.32 (1.24 - 1.42) 2.10 (1.96 - 2.30) 2.81 (2.49 - 3.14) 5215 13 - - .820 (.772 - .872) .780 (.740 - .840) 1.32 (1.21 - 1.42) 2.14 16 - 2.24) 2.75 (2.50 - 2.98) 4988 15 (2.02 Age group 5 years 11 - 12 .970 (.877 - 1.07) .950 (.870 - 1.04) 1.34 (1.20 - 1.65) 2.26 (1.88 - 2.65) 2.91 (2.41 - 3.83) 713 1 - - .782 (.705 - .869) .740 (.680 - .800) 1.08 (.940 - 1.24) 1.58 (1.33 - 1.90) 2.24 (1.68 - 2.64) 818 13 14 1.32) - .758 (.675 - .850) .690 (.610 - .790) 1.10 (.950 - 1.86 (1.50 - 2.65) 2.76 (1.94 - 3.81) 790 15 16 11 years 11 - 12 .681 (.623 - .744) .640 (.600 - .700) .930 (.820 - 1.05) 1.34 (1.14 - 1.60) 1.89 (1.36 - 2.94) 1048 6 - - .567 (.529 - .607) .530 (.500 - .570) .760 (.700 - .820) 1.13 (1.01 - 1.23) 1.42 (1.21 - 1.83) 1075 13 14 - 15 .571 (.523 - .623) .550 (.510 - .600) .780 (.720 16 .830) 1.18 (.970 - 1.44) 1.59 (1.24 - 2.24) 1023 - - 19 years 11 - 12 .554 (.511 - .601) .530 (.490 - .570) 12 (.660 - .830) 1.09 (.960 - 1.19) 1.31 (1.16 - 1.65) 1129 .740 - 14 .506 (.464 - .551) .460 (.420 - .500) .670 (.600 - .750) 1.13 (.870 - 1.53) 1.69 (1.27 - 2.06) 627 13 15 - .467 (.433 - .504) .450 (.410 - .490) .680 (.610 - .730) .930 (.820 - 1.03) 1.17 (.990 - 1.36) 565 16 1.79) 11 1.09 (1.03 - 1.16) 1.05 (1.00 - 1.12) 1.67 (1.56 - 12 2.56 (2.33 - 2.77) 3.36 (2.98 - 3.93) 5030 - 20 years and older - 14 .967 (.921 - 1.02) .940 (.900 - .980) 1.45 (1.37 1.55) 2.26 (2.09 - 2.49) 3.03 (2.65 - 3.55) 2695 13 - 15 16 .920 (.862 - .982) .880 (.810 - .960) 1.46 (1.35 - 1.59) 2.30 (2.15 - 2.44) 2.89 (2.65 - 3.07) 2610 - Gender - - 12 1.13 (1.06 - 1.21) 1.07 (1.01 Males 1.14) 1.74 (1.63 - 1.88) 2.73 (2.48 - 3.01) 3.68 (3.18 - 4.22) 3968 11 - 13 .994 (.919 - 1.08) .940 (.890 - 1.00) 1.48 (1.35 14 1.61) 2.41 (2.07 - 2.90) 3.47 (2.89 - 4.32) 2587 - 15 - 16 .921 (.864 - .981) .860 (.800 - .930) 1.46 (1.33 - 1.60) 2.41 (2.18 - 2.62) 2.93 (2.75 - 3.26) 2488 Females - 12 .842 (.796 - .890) .820 (.780 - .860) 1.30 (1.22 - 1.39) 1.98 (1.83 - 2.22) 2.59 (2.32 - 2.94) 3952 11 (1.11 13 14 .746 (.715 - .777) .730 (.700 - .760) 1.19 - - 1.28) 1.86 (1.69 - 2.02) 2.33 (2.24 - 2.42) 2628 15 - 16 .735 (.679 - .795) .720 (.650 - .770) 1.16 (1.04 - 1.31) 1.88 (1.66 - 2.13) 2.39 (2.21 - 2.65) 2500 Race/ethnicity 11 12 .838 (.767 - .916) .780 (.690 - .880) 1.27 (1.15 - 1.40) 2.05 (1.81 - 2.36) 3.06 (2.34 - 3.59) 1077 Mexican Americans - - - .746 (.685 - .813) .690 (.650 - .750) 1.17 (1.10 13 1.28) 1.88 (1.61 - 2.04) 2.38 (2.03 - 2.74) 969 14 - 15 .704 (.659 - .752) .680 (.610 - .730) 1.10 (.970 16 1.22) 1.77 (1.67 - 1.96) 2.39 (2.01 - 3.10) 994 - - Hispanic blacks 11 - 12 .998 (.947 - 1.05) .910 (.850 - .990) 1.53 (1.45 - 1.60) 2.58 (2.31 - 2.91) 3.72 (3.04 - 4.58) 2195 Non 13 14 .871 (.787 - .963) .830 (.720 - .940) 1.39 (1.27 - 1.48) 2.17 (2.00 - 2.38) 3.03 (2.48 - 4.00) 1119 - - 15 .856 (.763 - .962) .790 (.700 - .890) 1.32 (1.11 16 1.60) 2.19 (1.86 - 2.80) 3.11 (2.76 - 3.39) 1070 - - Hispanic whites 11 - 12 .993 (.914 - 1.08) .960 (.880 - 1.03) 1.56 Non (1.40 - 1.73) 2.43 (2.11 - 2.74) 3.14 (2.67 - 3.85) 2493 - 14 .882 (.820 - .950) .870 (.800 - .920) 1.34 13 - 1.48) 2.20 (1.94 - 2.48) 2.97 (2.43 - 3.58) 1848 (1.24 15 - 16 .835 (.774 - .900) .790 (.750 - .860) 1.35 (1.23 - 1.49) 2.21 (2.03 - 2.36) 2.72 (2.39 - 2.98) 1511 All Hispanics - 12 .855 (.793 - .922) .820 (.750 - .880) 1.27 (1.18 - 1.39) 2.00 (1.86 - 2.23) 2.84 (2.41 - 3.34) 1931 11 13 (1.08 14 .742 (.695 - .793) .690 (.660 - .730) 1.14 - 1.24) 1.80 (1.62 - 1.99) 2.36 (2.03 - 2.72) 1481 - (1.01 16 .703 (.658 - .750) .670 (.620 - .720) 1.10 - - 1.18) 1.73 (1.56 - 2.00) 2.39 (2.00 - 2.97) 1664 15 Asians 11 - 12 1.15 (1.06 - 1.24) 1.14 (1.02 - 1.26) 1.70 (1.56 - 1.86) 2.56 (2.36 - 2.72) 3.28 (2.80 - 3.65) 1005 (1.35 14 1.01 (.923 - 1.11) 1.02 (.900 - 1.19) 1.48 - - 1.66) 2.25 (2.06 - 2.39) 2.67 (2.37 - 2.86) 510 13 15 - 16 1.07 (.976 - 1.18) 1.08 (.920 - 1.20) 1.65 (1.47 - 1.96) 2.62 (2.11 - 2.92) 3.07 (2.76 - 3.49) 479 and Limit of detection (LOD, see Data Analysis section) for Survey years 11 - 12, 13 - 14, 15 - 16 are 0.25, 0.07, and 0.07 respectively. Biomonitoring S ummary http://www.cdc.gov/biomonitoring/Lead_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Lead_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 309

329 Urinary Lead (1999 – 2010) ric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health and Geomet Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - .766 (.708 - .828) .800 (.800 - Total 1.40 (1.30 1.50) 2.20 (2.00 - 2.30) 2.90 (2.60 - 3.30) 2465 99 - 00 .900) 02 .677 (.637 - .718) .700 (.700 - .800) 1.20 (1.20 - 1.30) 2.00 (1.90 - 2.20) 2.70 (2.50 2.80) 2690 01 - - - .636 (.595 - .680) .640 (.580 - .690) 1.04 (.960 - 1.12) 1.73 (1.52 - 1.86) 2.29 (2.03 - 2.62) 2558 03 04 1.05) 06 .554 (.523 - .587) .570 (.540 - .600) .990 (.910 - 1.58 (1.44 - 1.73) 2.14 (1.94 - 2.45) 2576 05 - - 08 .493 (.467 - .520) (.470 - .530) .850 (.790 - .910) 1.38 (1.23 - 1.58) 1.97 (1.75 - 2.17) 2627 07 .500 09 10 .458 (.441 - .476) .470 (.450 - .480) .790 (.750 - .830) 1.24 (1.11 - 1.38) 1.65 (1.46 - 1.84) 2848 - Age group 11 years 99 - 00 1.07 (.955 - 1.20) 1.10 (.900 - 1.30) 1.50 (1.40 - 1.70) 2.40 (1.80 - 3.10) 3.40 (2.40 - 5.00) 340 6 - - - .753 (.661 - .857) .800 (.600 01 .900) 1.20 (1.10 - 1.40) 2.10 (1.60 - 2.40) 2.60 (2.10 - 3.70) 368 02 - 03 .795 (.671 - .941) .790 (.640 - .900) 1.35 (.970 04 1.86) 2.27 (1.62 - 4.09) 3.33 (2.23 - 4.41) 290 - 05 - 06 .508 (.447 - .579) .510 (.440 - .560) .740 (.620 - .980) 1.33 (1.00 - 1.86) 1.90 (1.33 - 2.60) 355 - 08 .494 (.411 - .593) .520 (.410 - .590) .790 (.660 - .900) 1.23 (.980 - 1.73) 1.90 (1.51 - 2.18) 394 07 09 - .443 (.399 - .493) .460 (.430 - .490) .710 (.630 - .820) 1.09 (.880 - 1.33) 1.40 (1.06 - 1.82) 378 10 19 years (.900 99 - 00 .659 (.579 - .749) .700 (.600 - .800) 1.10 - - 1.30) 1.80 (1.40 - 2.20) 2.20 (1.90 - 2.80) 719 12 - - .564 (.526 - .605) .600 (.500 - .600) 1.00 (.800 02 1.10) 1.60 (1.40 - 1.70) 2.00 (1.80 - 2.40) 762 01 03 - 04 .604 (.553 - .660) .630 (.570 - .680) .920 (.810 - 1.02) 1.32 (1.14 - 1.80) 1.86 (1.44 - 2.29) 725 05 06 .472 (.421 - .530) .490 (.450 - .540) .780 (.710 - .830) 1.19 (1.10 - 1.45) 1.65 (1.34 - 1.80) 701 - - 07 .386 (.346 - .431) .380 (.350 - .410) .640 (.560 08 .720) 1.03 (.870 - 1.24) 1.38 (1.09 - 1.91) 376 - 09 - 10 .320 (.283 - .361) .320 (.270 - .370) .530 (.460 - .630) .830 (.710 - 1.10) 1.16 (.860 - 1.37) 451 20 years and older - 00 .752 (.691 - .818) .800 (.700 - .900) 1.40 (1.30 - 1.50) 2.20 (2.00 - 2.40) 2.90 (2.60 - 3.30) 1406 99 (1.20 01 02 .688 (.641 - .738) .700 (.700 - .800) 1.20 - - 1.30) 2.00 (1.90 - 2.30) 2.80 (2.50 - 2.90) 1560 03 - 04 .625 (.579 - .674) .620 (.560 - .700) 1.04 (.960 - 1.11) 1.70 (1.52 - 1.80) 2.21 (2.04 - 2.49) 1543 05 06 .574 (.539 - .612) .600 (.560 - .640) 1.02 (.970 - 1.13) 1.65 (1.53 - 1.81) 2.21 (1.99 - 2.57) 1520 - 07 - .512 (.485 - .540) .530 (.490 - .560) .900 (.820 - .950) 1.49 (1.29 - 1.64) 2.01 (1.78 - 2.33) 1857 08 (1.16 - .486 09 (.465 - .507) .490 (.470 - .520) .830 (.780 - .880) 1.32 10 - 1.46) 1.71 (1.52 - 2.03) 2019 Gender 99 - 00 .923 (.822 - 1.04) .900 (.900 - 1.00) 1.60 (1.40 - 1.80) 2.50 (2.20 - 2.90) 3.40 (2.90 - 3.80) 1227 Males 01 - 02 .808 (.757 - .862) .800 (.800 .900) 1.40 (1.30 - 1.50) 2.50 (2.20 - 2.70) 3.20 (2.90 - 3.50) 1335 - - 03 .731 (.680 - .785) .730 (.680 - .800) 1.17 (1.07 04 1.27) 2.03 (1.78 - 2.22) 2.66 (2.33 - 2.91) 1281 - 05 - 06 .672 (.638 - .707) .690 (.620 - .760) 1.16 - 1.28) 1.78 (1.60 - 2.00) 2.45 (2.00 - 2.97) 1271 (1.04 - 08 .560 (.518 - .606) .570 (.530 - .620) .930 07 - 1.02) 1.63 (1.36 - 1.97) 2.30 (1.97 - 3.07) 1327 (.840 09 - 10 .527 (.491 - .566) .540 (.480 - .580) .880 (.820 - .960) 1.41 (1.25 - 1.58) 1.83 (1.62 - 2.21) 1398 Females - 00 .642 (.589 - .701) .700 (.600 - .800) 1.20 (1.10 - 1.30) 1.90 (1.60 - 2.20) 2.40 (2.10 - 3.00) 1238 99 - 01 .573 (.535 - .613) .600 (.600 - .600) 1.10 (1.00 02 1.10) 1.60 (1.50 - 1.80) 2.20 (1.90 - 2.40) 1355 - 03 - 04 .558 (.506 - .616) .540 (.480 - .620) .920 - 1.04) 1.49 (1.24 - 1.75) 1.82 (1.59 - 2.30) 1277 (.820 - 06 .461 (.425 - .499) .460 (.430 - .510) .810 05 - .880) 1.27 (1.17 - 1.46) 1.86 (1.54 - 2.17) 1305 (.730 07 - 08 .436 (.412 - .461) .430 (.400 - .480) .760 (.690 - .830) 1.22 (1.05 - 1.34) 1.67 (1.44 - 1.81) 1300 (.660 10 .400 (.378 - .424) .420 (.390 - .440) .690 - - .740) 1.05 (.990 - 1.13) 1.42 (1.26 - 1.59) 1450 09 Limit of detection (LOD, see Data Analysis section) for Survey years 99 - 00, 01 - 02, 03 - 04, 05 - 06, 07 - 08, and 09 - 10 are 0.1, 0.1, 0.33, 0.1, 0.1, and 0.1 respectively. Biomonitoring S ummary http://www.cdc.gov/biomonitoring/Lead_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Lead_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 310

330 Urinary Lead (1999 – 2010) ted percentiles of urine concentrations (in μg/L) for the U.S. population from the National Health and Geometric mean and selec Nutrition Examination Survey. Survey Sample 95th Percentile Geometric mean 50th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 1.02 (.915 - 1.13) 1.10 (.900 - 1.20) 1.80 (1.60 - 1.90) 2.90 (2.50 - 3.40) 4.30 (3.10 - 5.40) 884 Mexican Americans - .833 (.745 - .931) .900 (.700 - 1.00) 1.50 (1.20 - 1.70) 2.50 (2.00 - 2.90) 3.30 (2.70 - 3.80) 683 01 02 - 03 .815 (.710 - .935) .840 (.700 - .990) 1.31 (1.18 04 1.59) 2.19 (1.86 - 2.50) 2.66 (2.13 - 3.97) 618 - 05 - 06 .729 (.653 - .815) .770 (.680 - .860) 1.32 (1.15 - 1.59) 2.22 (1.81 - 2.64) 3.08 (2.50 - 4.03) 652 - 08 .607 (.528 - .698) .610 (.530 - .690) .990 (.890 - 1.21) 1.76 (1.37 - 2.17) 2.29 (1.82 - 2.80) 515 07 - 09 .546 (.483 - .618) .520 (.460 - .580) .930 (.800 10 1.09) 1.66 (1.34 - 1.89) 2.16 (1.80 - 2.87) 613 - - Hispanic blacks 99 - 00 1.11 (1.00 - 1.23) 1.10 (1.00 - 1.20) 1.90 (1.50 - 2.10) 3.00 (2.40 - 3.50) 4.20 (3.30 - 5.70) 568 Non - 02 .940 (.833 - 1.06) .900 (.800 - 1.00) 1.60 (1.30 - 1.80) 2.70 (2.10 - 3.40) 3.70 (2.90 - 4.80) 667 01 (1.10 03 04 .848 (.729 - .986) .850 (.710 - 1.00) 1.40 - - 1.72) 2.14 (1.78 - 2.64) 2.82 (2.31 - 3.89) 723 05 - 06 .666 (.604 - .734) .660 (.590 - .760) 1.09 (.980 - 1.18) 1.62 (1.42 - 1.85) 2.24 (1.65 - 2.90) 692 07 08 .618 (.558 - .685) .620 (.560 - .690) 1.01 (.920 - 1.13) 1.56 (1.38 - 1.90) 2.06 (1.88 - 2.60) 589 - - 09 .560 (.522 - .601) .550 (.490 - .600) .910 (.830 10 1.01) 1.53 (1.26 - 1.71) 1.96 (1.68 - 2.80) 544 - - Hispanic whites 99 - 00 .695 (.625 - .773) .700 (.700 - .900) 1.30 (1.10 - 1.40) 2.00 (1.80 - 2.40) 2.70 (2.30 - 3.10) 822 Non - 02 .610 (.572 - .651) .700 (.600 - .700) 1.10 (1.10 - 1.20) 1.90 (1.70 - 2.00) 2.40 (2.30 - 2.60) 1132 01 (.910 03 04 .591 (.556 - .628) .590 (.540 - .650) .960 - - .990) 1.52 (1.40 - 1.75) 2.14 (1.78 - 2.51) 1074 05 - 06 .520 (.477 - .566) .540 (.490 - .580) .950 (.820 - 1.05) 1.53 (1.30 - 1.76) 2.07 (1.78 - 2.45) 1041 07 08 .452 (.422 - .485) .460 (.430 - .490) .780 (.700 - .880) 1.23 (1.03 - 1.50) 1.79 (1.58 - 1.97) 1095 - (.690 10 .431 (.406 - .458) .450 (.410 - .480) .750 - - .820) 1.11 (1.05 - 1.24) 1.51 (1.39 - 1.67) 1225 09 Limit of detection (LOD, see Data Analysis section) for Survey years 99 - 00, 01 - 02, 03 - 04, 05 - 06, 07 - 08, and 09 - 10 are 0.1, 0.1, 0.33, 0.1, 0.1, and 0.1 respectively. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Lead_BiomonitoringSummary.ht ml Factsheet http://www.cdc.gov/biomonitoring/Lead_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 311

331 Urinary Lead (2011 – 2014) n μg/L) for the U.S. population from the National Health and Geometric mean and selected percentiles of urine concentrations (i Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 .360 (.328 - .396) .370 (.340 Total .400) .650 (.580 - .720) 1.05 (.980 - 1.17) 1.49 (1.26 - 1.75) 2504 11 - - 14 .277 (.257 - .298) .290 (.270 - .300) .500 (.480 - .530) .840 (.780 - .900) (1.01 - 1.41) 2664 13 1.17 Age group 11 years - 11 - 12 .346 (.292 - .410) .370 (.300 - .440) .610 (.540 - .770) 1.12 (.830 - 1.51) 1.54 (1.28 - 1.85) 399 6 - - .222 (.192 - .258) .240 (.200 - .270) .390 (.330 14 .450) .630 (.560 - .810) .870 (.710 - 1.09) 402 13 - 19 years 11 - 12 .259 (.219 - .305) .260 (.220 - .340) .470 (.380 - .530) .720 (.540 - .900) .970 (.720 - 1.17) 390 12 13 14 .201 (.166 - .245) .220 (.190 - .260) .360 (.290 - .440) .550 (.450 - .700) .750 (.570 - .880) 451 - 11 12 .381 (.348 - .416) .390 (.360 - .420) .680 (.640 - .730) 1.11 (1.01 - 1.21) 1.58 (1.28 - 1.90) 1715 20 years and older - - - .297 (.280 - .315) .300 (.290 - .320) .540 (.510 14 .580) .900 (.820 - .980) 1.27 (1.08 - 1.55) 1811 13 Gender - - 12 .414 (.367 - .466) .420 (.380 Males .460) .730 (.640 - .800) 1.16 (.990 - 1.47) 1.73 (1.33 - 2.18) 1262 11 13 (.520 14 .315 (.295 - .337) .320 (.290 - .340) .580 - .620) .940 (.840 - 1.08) 1.48 (1.15 - 1.92) 1318 - (.500 Females - 12 .316 (.282 - .355) .320 (.290 - .360) .580 11 - .660) .970 (.830 - 1.14) 1.31 (1.15 - 1.41) 1242 13 - 14 .245 (.222 - .269) .260 (.240 - .280) .460 (.430 - .480) .720 (.670 - .790) 1.00 (.870 - 1.16) 1346 Race/ethnicity 11 12 .372 (.320 - .431) .380 (.320 - .480) .670 (.550 - .780) 1.17 (.820 - 1.58) 1.67 (1.17 - 2.18) 317 Mexican Americans - - - .277 (.240 - .319) .290 (.250 - .320) .480 (.440 14 .580) .890 (.690 - 1.15) 1.21 (.930 - 1.97) 453 13 - Hispanic blacks 11 - 12 .431 (.385 - .483) .440 (.370 - .520) .730 Non - .830) 1.15 (1.00 - 1.39) 1.64 (1.39 - 1.87) 669 (.660 - 14 .371 (.320 - .429) .380 (.310 - .440) .620 (.530 - .730) 1.09 (.830 - 1.34) 1.45 (1.24 - 1.72) 581 13 - 11 - 12 .346 (.311 - .385) .360 (.330 - .390) .610 Non (.540 - .700) 1.02 (.920 - 1.16) 1.38 (1.14 - 1.85) 820 Hispanic whites 13 - 14 .267 (.245 - .290) .280 (.260 - .300) .500 (.450 - .540) .820 (.730 - .920) 1.16 (.950 - 1.60) 985 All Hispanics - 12 .372 (.327 - .423) .370 (.320 - .420) .670 (.590 - .750) 1.15 (.950 - 1.31) 1.51 (1.18 - 2.13) 573 11 (.440 13 14 .270 (.239 - .305) .280 (.240 - .320) .480 - - .540) .820 (.690 - .930) 1.17 (.940 - 1.47) 701 Asians 11 - 12 .383 (.341 - .429) .380 (.350 - .460) .690 (.620 - .790) 1.15 (.950 - 1.32) 1.38 (1.21 - 1.72) 353 (.410 14 .257 (.230 - .287) .290 (.240 - .350) .470 - - .510) .710 (.560 - .790) .890 (.750 - .980) 292 13 Limit of detection (LOD, see Data Analysis section) for Survey year 11 - 12 and 13 - 14 are 0.08 and 0.03. Biomonitoring Summary http://www.cdc.gov/biomonitoring/Lead_Bio monitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Lead_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 312

332 Urinary Lead (creatinine corrected) (1999 – 2010) onal Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati Health and N utrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 00 .721 (.70 0 - .742) .701 (.677 - .725) 1.11 (1.05 - 1.15) 1.70 (1.62 - 1.85) 2.38 (2.22 Total 2.79) 2465 99 - - .639 (.603 - .677) .635 (.588 - .676) 1.03 (.963 - 02 1.52 (1.43 - 1.61) 2.03 (1.89 - 2.22) 2689 01 1.08) - 04 .632 (.603 - .662) .622 (.594 - .655) .979 (.920 - 1.03) 1.49 (1.33 - 1.97 (1.73 - 2.26) 2558 03 1.64) 05 06 .546 (.520 - .573) .530 (.510 - .560) .860 (.810 - .900) 1.27 (1.15 - 1.37) 1.71 (1.50 - 1.89) 2576 - - .514 (.482 - .548) .500 (.460 - .530) .800 (.720 - .880) 1.30 07 (1.23 - 1.42) 1.85 (1.73 - 1.96) 2627 08 (1.08 - .488 09 (.466 - .512) .470 (.440 - .500) .760 (.710 - .810) 1.16 10 - 1.28) 1.53 (1.41 - 1.62) 2848 Age group - 11 years 99 - 00 1.17 (.975 - 1.41) 1.06 (.918 - 1.22) 1.55 (1.22 - 1.97) 2.71 (1.67 - 4.66) 4.66 (1.97 - 6 340 18.0) - 02 .918 (.841 - 1.00) .870 (.800 - .933) 1.27 (1.12 - 1.43) 2.33 (1.59 - 3.64) 3.64 (1.89 - 5.56) 368 01 03 - .926 (.812 - 1.06) .914 (.781 - 1.03) 1.45 (1.17 - 1.72) 2.14 (1.62 - 3.47) 3.47 (2.19 - 5.31) 290 04 - - .628 (.563 - .701) .590 (.530 - .680) .870 (.770 05 .940) 1.29 (1.03 - 1.82) 1.96 (1.32 - 2.42) 355 06 - 07 .643 (.543 - .763) .630 (.530 - .730) 1.02 (.770 08 1.24) 1.50 (1.24 - 2.02) 2.04 (1.70 - 2.58) 394 - 09 - 10 .604 (.551 - .662) .580 (.520 - .650) .870 (.780 - 1.32 (1.09 - 1.51) 1.60 (1.38 - 1.75) 378 1.00) 12 19 years 99 - 00 .496 (.460 - .535) .469 (.408 - .508) .709 (.655 - .828) 1.11 (.981 - 1.28) 1.65 (1.15 - 2.79) 719 - 01 .603 02 .404 (.380 - .428) .375 (.342 - .400) (.541 - .702) .990 (.882 - 1.18) 1.41 (1.07 - 1.63) 762 - (.551 04 .432 (.404 - .461) .404 (.383 - .436) .623 - - .730) .938 (.828 - 1.06) 1.23 (1.09 - 1.35) 725 03 05 - 06 .363 (.333 - .395) .340 (.310 - .360) .510 (.460 - .600) .800 (.690 - .930) 1.07 (.940 - 1.23) 701 07 08 .302 (.270 - .337) .290 (.250 - .340) .430 (.400 - .490) .670 (.550 - .790) .900 (.700 - 1.09) 376 - 09 - .299 (.273 - .328) .290 (.260 - .320) .420 (.370 - .490) .620 (.550 - .760) .880 (.740 - 1.01) 451 10 1.18) 99 .720 (.683 - .758) .712 (.667 - .739) 1.10 (1.02 - 00 1.69 (1.53 - 1.87) 2.31 (2.15 - 2.62) 1406 - 20 years and older - 02 .658 (.617 - .703) .652 (.608 - .702) 1.05 (.992 1.11) 1.51 (1.40 - 1.61) 2.00 (1.85 - 2.19) 1559 01 - 03 04 .641 (.606 - .679) .633 (.605 - .670) .988 (.917 - 1.04) 1.47 (1.28 - 1.63) 1.94 (1.72 - 2.12) 1543 - 05 - 06 .573 (.548 - .600) .570 (.530 - .600) .890 (.850 - .960) 1.32 (1.22 - 1.41) 1.77 (1.53 - 1.94) 1520 - 08 .545 (.513 - .579) .530 (.490 - .570) .840 (.760 - .910) 1.36 (1.27 - 1.49) 1.92 (1.78 - 2.08) 1857 07 - 09 .514 (.489 - .539) .500 (.460 - .530) .790 (.730 10 .840) 1.22 (1.10 - 1.35) 1.57 (1.46 - 1.71) 2019 - Gender - - 00 .720 (.679 - .763) .693 (.645 Males .734) 1.10 (.992 - 1.22) 1.68 (1.50 - 2.09) 2.43 (2.15 - 3.03) 1227 99 (.957 01 02 .639 (.607 - .673) .638 (.586 - .686) 1.01 - - 1.08) 1.55 (1.41 - 1.61) 2.06 (1.88 - 2.43) 1334 03 - 04 .615 (.588 - .644) .593 (.561 - .639) .914 (.862 - .977) 1.44 (1.25 - 1.53) 2.00 (1.71 - 2.28) 1281 05 06 .551 (.522 - .582) .530 (.510 - .580) .830 (.770 - .910) 1.25 (1.13 - 1.39) 1.77 (1.42 - 2.20) 1271 - - 07 .501 (.471 - .534) .490 (.450 - .530) .750 (.700 08 .810) 1.29 (1.15 - 1.49) 1.88 (1.71 - 1.98) 1327 - 09 - 10 .481 (.458 - .505) .450 (.430 - .490) .740 (.690 .800) 1.15 (1.04 - 1.29) 1.56 (1.37 - 1.70) 1398 - Females 99 - 00 .722 (.681 - .765) .707 (.667 - .746) 1.11 (1.05 - 1.18) 1.74 (1.50 - 2.02) 2.38 (2.03 - 2.88) 1238 01 - 02 .639 (.594 - .688) .625 (.571 - .682) 1.03 (.946 - 1.11) 1.50 (1.39 - 1.61) 1.98 (1.85 - 2.15) 1355 03 04 .648 (.601 - .698) .649 (.604 - .718) 1.03 (.938 - 1.10) 1.56 (1.34 - 1.73) 1.96 (1.72 - 2.20) 1277 - (.820 06 .541 (.507 - .577) .530 (.500 - .580) .880 - - .940) 1.28 (1.12 - 1.41) 1.64 (1.38 - 1.91) 1305 05 07 - 08 .527 (.489 - .568) .500 (.470 - .550) .840 (.740 - .960) 1.34 (1.23 - 1.47) 1.79 (1.56 - 2.08) 1300 (1.08 - 10 .495 (.466 - .526) .480 (.450 - .520) .780 (.710 - .830) 1.20 09 - 1.32) 1.52 (1.39 - 1.62) 1450 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Lead_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Lead_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 313

333 Urinary Lead (creatinine corrected) (1999 – 2010) U.S. population from the National Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the and Nutrition Examination Survey. Survey Sample 95th Percentile Geometric mean 50th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 99 - 00 .940 (.876 - 1.01) .887 (.796 - 1.03) 1.43 (1.37 - 1.58) 2.38 (2.08 - 2.77) 3.46 (2.78 - 4.18) 884 Mexican Americans - .810 (.731 - .898) .774 (.702 - .893) 1.29 (1.09 - 1.44) 2.05 (1.75 - 2.50) 2.78 (2.56 - 3.33) 682 01 02 - 03 .755 (.681 - .838) .708 (.612 - .851) 1.18 (1.09 04 1.31) 1.86 (1.50 - 2.26) 2.31 (1.98 - 2.92) 618 - 05 - 06 .686 (.638 - .737) .680 (.620 - .740) (.930 - 1.13) 1.63 (1.39 - 1.88) 2.20 (1.77 - 3.20) 652 1.00 - 08 .607 (.514 - .717) .590 (.500 - .690) .970 (.770 - 1.19) 1.56 (1.25 - 2.07) 2.20 (1.78 - 2.46) 515 07 - 09 .573 (.526 - .623) .540 (.470 - .610) .950 (.780 10 1.06) 1.59 (1.41 - 1.82) 2.02 (1.82 - 2.40) 613 - - Hispanic blacks 99 - 00 .722 (.659 - .790) .671 (.583 - .753) 1.11 Non (.988 - 1.20) 2.00 (1.56 - 2.51) 2.83 (2.20 - 3.88) 568 - 02 .644 (.559 - .742) .608 (.510 - .710) .962 01 - 1.20) 1.79 (1.36 - 2.33) 2.75 (2.04 - 3.98) 667 (.853 03 - 04 .609 (.529 - .701) .569 (.492 - .698) .900 (.793 - 1.03) 1.48 (1.11 - 1.97) 2.24 (1.65 - 2.88) 723 05 06 .483 (.459 - .508) .470 (.440 - .490) .740 (.670 - .820) 1.18 (1.06 - 1.29) 1.60 (1.37 - 1.85) 692 - - 07 .452 (.414 - .492) .440 (.400 - .490) .710 (.610 08 .780) 1.13 (.930 - 1.33) 1.57 (1.21 - 1.88) 589 - 09 - 10 .444 (.417 - .473) .420 (.390 - .470) .680 (.600 - 1.07 (.940 - 1.18) 1.51 (1.18 - 1.65) 544 .740) Non Hispanic whites 99 - 00 .696 (.668 - .725) .677 (.645 - .718) - (.997 - 1.14) 1.66 (1.50 - 1.83) 2.31 (1.94 - 2.82) 822 1.07 01 - 02 .615 (.579 - .654) .621 (.571 - .667) 1.00 (.933 - 1.07) 1.46 (1.37 - 1.52) 1.88 (1.62 - 2.03) 1132 03 04 .623 (.592 - .655) .618 (.587 - .657) .971 (.914 - 1.03) 1.44 (1.25 - 1.61) 1.85 (1.64 - 2.10) 1074 - (.790 06 .541 (.500 - .585) .530 (.490 - .580) .850 - - .920) 1.24 (1.12 - 1.37) 1.62 (1.37 - 1.94) 1041 05 07 - 08 .506 (.466 - .550) .490 (.460 - .540) .790 (.700 - .880) 1.27 (1.15 - 1.42) 1.81 (1.59 - 1.96) 1095 (1.01 - 10 .482 (.448 - .518) .460 (.430 - .500) .740 (.690 - .820) 1.15 09 - 1.30) 1.46 (1.32 - 1.59) 1225 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Lead_BiomonitoringSummary. html Factsheet http://www.cdc.gov/biomonitoring/Lead_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 314

334 Urinary Lead (creatinine corrected) (2011 – 2014) onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 .409 (.380 - .440) .396 (.374 Total .418) .634 (.583 - .675) 1.00 (.878 - 1.16) 1.51 (1.24 - 1.71) 2502 11 - - 14 .320 (.302 - .339) .313 (.294 - .331) .519 (.491 - .554) .823 (.756 - .907) (1.00 - 1.30) 2663 13 1.16 Age group 11 years - 11 - 12 .494 (.430 - .567) .459 (.414 - .529) .708 (.559 - .930) 1.18 (.884 - 1.56) 1.56 (1.12 - 2.22) 398 6 - - .331 (.297 - .370) .313 (.273 - .370) .500 (.452 14 .571) .833 (.667 - .938) 1.07 (.905 - 1.34) 402 13 - 19 years 11 - 12 .247 (.218 - .281) .224 (.206 - .264) .385 12 (.317 - .429) .541 (.440 - .667) .667 (.513 - 1.03) 390 - 14 .182 (.160 - .208) .169 (.142 - .194) .276 (.225 - .330) .457 (.339 - .640) .640 (.438 - .908) 451 13 - 12 .433 (.402 - .466) .414 (.389 - .437) .660 (.619 - .712) 1.05 (.929 - 1.22) 1.61 (1.28 - 1.87) 1714 20 years and older 11 13 - 14 .346 (.331 - .363) .337 (.321 - .353) .554 (.505 - .592) .861 (.789 - .935) 1.23 (1.04 - 1.46) 1810 Gender 1.89) - 12 .388 (.346 - .436) .377 (.338 - .418) .590 (.524 - .658) .987 (.833 - 1.17) 1.51 (1.16 - Males 1261 11 (.440 13 14 .315 (.293 - .339) .303 (.278 - .327) .486 - - .541) .758 (.692 - .913) 1.16 (.956 - 1.58) 1317 Females 11 - 12 .430 (.405 - .457) .416 (.385 - .444) .667 (.626 - .709) 1.03 (.905 - 1.21) 1.49 (1.21 - 1.71) 1241 13 14 .325 (.303 - .348) .325 (.308 - .336) .545 (.500 - .580) .864 (.785 - .929) 1.18 (.970 - 1.33) 1346 - Race/ethnicity - 11 12 .418 (.370 - .471) .409 (.356 - .667 (.598 - .716) 1.05 (.822 - 1.25) 1.32 (1.16 - 1.54) 317 Mexican Americans .462) 13 - 14 .316 (.283 - .352) .319 (.278 - .336) .500 (.450 - .589) .845 (.720 - 1.04) 1.16 (.908 - 1.36) 453 Non Hispanic blacks 11 - 12 .335 (.301 - .374) .316 (.269 - .357) .529 (.464 - .598) .906 (.770 - 1.07) 1.34 (1.06 - 1.55) 669 - - 14 .282 (.251 - .317) .275 (.237 - .316) .455 13 - .515) .750 (.611 - .920) .977 (.836 - 1.21) 581 (.398 Non - Hispanic whites 11 - 12 .419 (.378 - .465) .404 (.369 - .439) .642 (.559 - .722) .966 (.826 - 1.22) 1.62 (1.16 - 2.00) 818 13 14 .329 (.306 - .353) .317 (.293 - .344) .541 (.486 - .589) .860 (.750 - .933) 1.23 (.983 - 1.60) 984 - (.561 All Hispanics - 12 .416 (.377 - .460) .401 (.366 - .442) .641 11 - .694) 1.02 (.851 - 1.24) 1.40 (1.16 - 1.65) 573 13 - 14 .301 (.276 - .328) .307 (.269 - .327) .473 (.438 - .508) .795 (.667 - .882) 1.07 (.882 - 1.24) 701 (.706 Asians - 12 .511 (.453 - .577) .512 (.440 - .588) .829 11 - .980) 1.28 (1.05 - 1.57) 1.61 (1.40 - 2.22) 353 13 - 14 .403 (.360 - .451) .417 (.342 - .503) .619 (.549 - .708) .929 (.767 - 1.03) 1.12 (.955 - 1.33) 292 Biomonitoring Summary http://www.cdc.gov/biomonitoring/Lead_BiomonitoringSummary.html Factsheet http://www.cdc.gov/biomonitoring/Lead_FactSheet.html _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 315

335 Blood Manganese (2011 – 2016) d Geometric mean and selected percentiles of blood concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 9.35 (9.19 - 9.51) 9.22 (9.04 - Total 11.5 (11.3 11.7) 14.4 (14.2 - 14.6) 16.7 (16.2 - 17.3) 7920 11 - 12 9.40) 14 9.52 (9.35 - 9.70) 9.41 (9.23 - 9.62) 11.8 (11.5 - 12.1) 14.6 (14.2 - 15.0) 16.7 (15.9 - 17.3) 5215 13 - - 9.59 (9.36 - 9.82) 9.52 (9.23 - 9.73) 12.0 (11.6 - 12.3) 14.8 16 - 15.1) 16.4 (15.9 - 17.3) 4987 15 (14.5 Age group 5 years 11 - 12 10.7 (10.2 - 11.2) 10.6 (10.1 - 11.2) 13.2 (12.6 - 13.5) 15.3 (14.5 - 16.8) 18.2 (15.3 - 19.7) 713 1 - - 10.9 (10.6 - 11.1) 10.7 (10.5 - 11.0) 13.2 (12.6 - 13.6) 16.1 (14.8 - 16.9) 18.3 (16.9 - 19.0) 818 13 14 13.7) - 10.8 (10.3 - 11.3) 10.8 (10.4 - 11.3) 12.9 (12.4 - 15.6 (14.6 - 17.2) 18.3 (16.5 - 19.3) 790 15 16 11 years 11 - 12 10.3 (9.98 - 10.6) 10.2 (9.83 - 10.4) 12.6 (12.2 - 12.8) 14.9 (14.2 - 15.5) 16.5 (16.0 - 17.6) 1048 6 - - 10.2 (9.87 - 10.6) 10.2 (9.95 - 10.6) 12.4 (12.0 - 13.0) 14.8 (14.2 - 15.6) 16.4 (15.5 - 17.1) 1075 13 14 - 15 10.4 (10.1 - 10.7) 10.4 (10.1 - 10.6) 12.6 (12.3 16 13.1) 15.2 (14.3 - 16.2) 17.1 (15.6 - 18.3) 1023 - - 19 years 11 - 12 10.1 (9.67 - 10.5) 9.90 (9.42 - 10.8) 12 (11.7 - 13.2) 14.8 (14.1 - 15.4) 16.6 (15.3 - 17.9) 1129 12.5 - 14 10.4 (10.0 - 10.8) 10.1 (9.55 - 10.6) 13.4 (12.5 - 13.9) 16.1 (15.0 - 17.4) 17.9 (16.1 - 20.3) 627 13 15 - 10.5 (10.1 - 10.9) 10.4 (9.81 - 10.9) 13.1 (12.1 - 13.9) 15.6 (14.9 - 16.2) 17.3 (16.4 - 18.3) 565 16 11.3) 11 9.09 (8.94 - 9.24) 8.96 (8.83 - 9.11) 11.1 (10.9 - 12 14.1 (13.7 - 14.5) 16.7 (16.1 - 17.3) 5030 - 20 years and older - 14 9.27 (9.11 - 9.43) 9.22 (9.01 - 9.39) 11.4 (11.2 11.7) 14.1 (13.9 - 14.6) 16.2 (15.5 - 17.0) 2695 13 - 15 16 9.34 (9.11 - 9.58) 9.20 (8.92 - 9.51) 11.6 (11.4 - 11.8) 14.7 (14.1 - 15.1) 16.1 (15.6 - 16.9) 2609 - Gender - - 12 8.74 (8.58 - 8.91) 8.78 (8.65 Males 8.91) 10.6 (10.3 - 10.9) 13.0 (12.7 - 13.4) 14.9 (14.4 - 15.3) 3968 11 - 13 8.92 (8.76 - 9.09) 8.96 (8.70 - 9.19) 10.9 (10.6 14 11.1) 13.3 (12.9 - 13.6) 14.7 (14.2 - 15.2) 2587 - 15 - 16 8.99 (8.74 - 9.25) 8.82 (8.59 - 9.17) 11.2 (10.8 - 11.6) 13.4 (13.1 - 14.0) 15.1 (14.5 - 15.5) 2488 Females - 12 9.96 (9.75 - 10.2) 9.72 (9.52 - 10.0) 12.4 (12.0 - 12.9) 15.5 (15.2 - 15.9) 17.8 (17.4 - 18.4) 3952 11 (12.3 13 14 10.1 (9.86 - 10.4) 9.93 (9.57 - 10.4) 12.6 - - 13.0) 15.7 (15.1 - 16.4) 17.9 (17.0 - 19.2) 2628 15 - 16 10.2 (9.95 - 10.4) 10.1 (9.83 - 10.3) 12.7 (12.3 - 13.2) 15.7 (15.2 - 16.2) 17.9 (17.0 - 18.4) 2499 Race/ethnicity 11 12 10.7 (10.4 - 11.0) 10.7 (10.3 - 11.0) 13.2 (12.9 - 13.5) 16.4 (15.2 - 17.1) 19.1 (17.7 - 20.3) 1077 Mexican Americans - - - 10.9 (10.6 - 11.3) 11.0 (10.6 - 11.3) 13.6 (13.1 13 14.0) 16.4 (15.2 - 17.4) 18.0 (17.1 - 19.9) 969 14 - 15 11.1 (10.8 - 11.4) 11.1 (10.7 - 11.4) 13.6 (13.2 16 14.1) 16.7 (15.9 - 17.2) 18.6 (17.9 - 19.8) 994 - - Hispanic blacks 11 - 12 8.34 (8.19 - 8.49) 8.18 (8.04 - 8.33) 10.1 (9.81 - 10.4) 12.7 (12.0 - 13.3) 15.5 (14.5 - 16.5) 2195 Non 13 14 8.23 (8.04 - 8.43) 8.17 (7.87 - 8.47) 10.0 (9.72 - 10.4) 12.5 (12.1 - 12.8) 14.0 (13.4 - 15.1) 1119 - - 15 8.46 (8.18 - 8.75) 8.53 (8.17 - 8.81) 10.2 (9.84 16 10.6) 12.5 (12.0 - 13.4) 14.5 (13.2 - 16.1) 1070 - - Hispanic whites 11 - 12 9.08 (8.91 - 9.26) 9.01 (8.79 - 9.21) 11.1 Non (10.9 - 11.3) 13.7 (13.3 - 14.2) 15.9 (15.2 - 16.4) 2493 - 14 9.27 (9.07 - 9.48) 9.18 (8.96 - 9.38) 11.2 13 - 11.5) 14.0 (13.0 - 14.5) 15.7 (14.7 - 17.0) 1848 (10.9 15 - 16 9.37 (9.08 - 9.67) 9.26 (8.91 - 9.65) 11.6 (11.2 - 11.9) 14.5 (13.4 - 14.9) 15.7 (15.1 - 16.4) 1510 All Hispanics - 12 10.4 (10.1 - 10.8) 10.3 (9.95 - 10.7) 12.8 (12.3 - 13.3) 15.7 (14.9 - 16.7) 18.3 (17.3 - 19.2) 1931 11 - 13 10.6 (10.3 - 10.9) 10.6 (10.4 - 10.8) 13.2 (12.9 14 13.5) 16.1 (15.2 - 16.7) 17.8 (17.1 - 18.7) 1481 - 15 - 16 10.8 (10.5 - 11.1) 10.7 (10.4 - 11.1) 13.4 (12.9 13.8) 16.3 (15.6 - 16.9) 18.1 (17.5 - 18.7) 1664 - Asians 11 - 12 11.9 (11.5 - 12.4) 11.8 (11.4 - 12.3) 14.7 (14.1 - 15.3) 17.6 (16.8 - 18.4) 19.8 (19.0 - 21.1) 1005 13 - 14 12.4 (12.0 - 12.8) 12.6 (12.0 - 13.0) 15.0 (14.7 - 15.5) 17.5 (16.8 - 18.4) 19.4 (18.4 - 20.4) 510 (14.1 16 12.1 (11.5 - 12.8) 12.0 (11.3 - 13.0) 14.9 - - 15.6) 17.9 (16.3 - 19.2) 19.8 (18.3 - 21.3) 479 15 Limit of detection (LOD, see Data Analysis section) for Survey years 11 - 12, 13 - 14, and 15 - 16 are 1.06, 0.99, and 0.99 respectively. < LOD means less than the limit of detection, which may vary for some chemicals by year and by individual sample. _________________________________________________________________________________________________ Fourth National Report on Human Exposure to Environmental Chemicals, Updated Tables, March 2018 Volume One Page 316

336 Urinary Manganese (2011 – 2014) om the National Health and Geometric mean and selected percentiles of urine concentrations (in μg/L) for the U.S. population fr Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 .123 (.112 - .136) .120 (.100 - .140) .200 (.180 - .230) .300 (.270 - .310) .370 (.320 - Total 2504 11 .450) - * < LOD .130 (

337 Urinary Manganese (cre atinine corrected) (2011 2014) – onal Health Geometric mean and selected percentiles of urine concentrations (in μg/g of creatinine) for the U.S. population from the Nati and Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 .140 (.126 - .155) .139 (.119 Total .154) .233 (.206 - .273) .389 (.354 - .444) .548 (.500 - .625) 2502 11 - - 14 * < LOD .219 (

338 Blood Total Mercury (2003 – 2010) d Geometric mean and selected percentiles of blood concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - .797 (.703 - .903) .800 (.700 - Total 1.70 (1.50 1.90) 3.30 (2.90 - 3.90) 4.90 (4.30 - 5.50) 8373 03 - 04 .900) 06 .863 (.787 - .946) .830 (.760 - .920) 1.66 (1.48 - 1.93) 3.20 (2.87 - 3.54) 4.64 (4.17 - 5.25) 8407 05 - 08 .769 (.689 - .859) .740 (.660 - .830) 1.48 (1.29 - 1.69) 2.95 (2.46 - 3.59) 4.64 (3.74 - 5.79) 8266 07 - - 10 .863 - - .941) .790 (.730 - .880) 1.68 (1.49 - 1.91) 3.43 (3.07 3.84) 5.13 (4.57 - 5.67) 8793 09 (.792 Age group 5 years 03 - 04 1 (.285 - .372) .300 (.300 - .300) .500 (.500 - .700) 1.00 (.800 - 1.60) 1.80 (1.30 - 2.50) 911 - .326 05 06 * < LOD .500 (.470 - .550) .940 (.820 - 1.24) 1.43 (1.25 - 1.59) 968 - (.620 - * < LOD .440 (.380 - .540) .830 - 1.12) 1.32 (.960 - 2.40) 817 07 08 - 10 * < LOD .490 (.430 - .590) .890 (.740 - 1.08) 1.30 (1.08 - 1.52) 836 09 856 11 years 03 - 04 .419 - (.363 - .484) .400 (.400 - .500) .700 (.700 - .900) 1.30 (1.00 - 1.60) 1.90 (1.40 - 3.50) 6 05 06 * .410 (.330 - .460) .740 (.630 - 1.00) - 1.43 (1.21 - 1.87) 2.34 (1.53 - 3.42) 934 07 - 08 * .380 (.340 - .700 (.600 - .790) 1.21 (.970 - 1.36) 1.56 (1.34 - 1.80) 1011 .440) - 10 * .360 (

339 Blood Total Mercury (2011 – 2016) d Geometric mean and selected percentiles of blood concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - .703 (.617 - .801) .640 (.580 - Total 1.38 (1.14 1.72) 2.87 (2.39 - 3.62) 4.40 (3.50 - 5.71) 7920 11 - 12 .730) 14 .683 (.621 - .751) .620 (.540 - .690) 1.29 (1.14 - 1.46) 2.65 (2.32 - 3.08) 4.36 (3.65 - 4.97) 5215 13 - 16 15 .678 (.619 - .743) .600 (.540 - .690) 1.26 (1.07 - 1.47) 2.55 (2.17 - 3.10) 4.25 (3.44 - 4.94) 4988 - Age group 11 - 12 .262 (.237 - .291) .250 (.220 - 1 .390 (.340 - .450) .680 (.540 - .880) .990 (.790 - 1.21) 713 - 5 years .270) - 14 * < LOD .410 (.370 - .450) .810 (.710 - .990) 1.21 (1.05 - 1.48) 818 13 15 16 * < LOD .380 (.340 - .430) .690 (.540 - .830) 1.06 (.840 - 1.36) 790 - - 11 years - 12 .330 (.287 - .379) .320 (.280 - .360) .530 (.480 11 .600) .930 (.780 - 1.20) 1.40 (1.02 - 2.17) 1048 - 6 - 14 * .300 (

340 Blood Inorganic Mercury – 2010) (2003 selected percentiles of blood μg/L) for the U.S. population from the National Health and Geometric mean and concentrations (in Survey. Nutrition Examination Survey Sample 75th Percentile 90th Percentile 50th Percentile 95th Percentile Geometric mean Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years - 04 * < LOD < LOD .600 Total (.500 - .600) .700 (.700 - .700) 8147 03 06 < LOD < LOD .540 (.500 - .580) * (.620 - .710) 8371 - 05 .660 08 * < LOD .350 07 - .370) .520 (.500 - .540) .650 (.620 - .690) 8162 - (

341 Blood Inorganic Mercury (2003 – 2010) d Geometric mean and selected percentiles of blood concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Survey Sample 95th Percentile Geometric mean 50th Percentile 75th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) size years Race/ethnicity 03 - 04 * < LOD < LOD .500 (.500 - .600) .700 Mexican Americans - .800) 2007 (.600 05 06 * < LOD < LOD .530 (.470 - .580) .670 (.560 - .830) 2224 - - - * < LOD < LOD .430 (.400 08 .480) .560 (.520 - .610) 1685 07 09 - * < LOD < LOD < LOD .470 (.390 - .530) 1947 10 Non Hispanic blacks 03 - 04 * < LOD < LOD .600 (.500 - .600) .700 (.600 - .800) 2240 - 05 06 * < LOD < LOD .530 (.470 - .600) .670 (.600 - .760) 2183 - 07 (.450 08 * < LOD < LOD .490 - .530) .610 (.560 - .650) 1729 - (.350 10 * < LOD < LOD .370 - - .390) .480 (.410 - .530) 1580 09 Non - Hispanic whites 03 - 04 * < LOD < LOD .600 (.500 - .600) .700 (.600 - .700) 3406 05 06 * < LOD < LOD .540 (.500 - .580) .650 (.610 - .710) 3298 - 07 08 * < LOD .360 (

342 Blood Inorganic Mercury (2011 – 2014) d Geometric mean and selected percentiles of blood concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 * < LOD < LOD .440 (.390 - .480) .600 (.520 - .680) 7841 Total 11 - 14 * < LOD < LOD .410 (.380 - .440) .530 (.490 .570) 5175 13 - Age group 1 11 - 12 * < LOD < LOD < LOD .280 (

343 Blood Ethyl Mercury (2011 – 2014) d Geometric mean and selected percentiles of blood concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 * < LOD < LOD < LOD Total < LOD 7841 11 - * < LOD < LOD 14 < LOD 5175 13 < LOD Age group - 11 - 12 * < LOD < LOD < LOD < LOD 657 1 5 years - * < LOD < LOD 13 < LOD < LOD 779 14 < LOD 11 years 11 - 12 * < LOD - < LOD < LOD 1044 6 13 - 14 * < LOD < LOD < LOD < LOD 1074 - 12 11 - 12 * < LOD < LOD < LOD < LOD 1121 19 years 13 - * < LOD < LOD < LOD < LOD 627 14 11 12 * < LOD < LOD < LOD < LOD 5019 20 years and older - - * < LOD < LOD 14 < LOD < LOD 2695 13 Gender - 12 Males * < LOD < LOD < LOD < LOD 3925 11 13 * < LOD < LOD 14 < LOD < LOD 2570 - 11 - 12 * < LOD Females < LOD < LOD 3916 < LOD - 14 * < LOD 13 < LOD < LOD 2605 < LOD Race/ethnicity Mexican Americans - 12 * < LOD < LOD < LOD < LOD 1058 11 13 - * < LOD < LOD < LOD < LOD 958 14 Hispanic blacks < LOD 11 - 12 * < LOD - < LOD < LOD 2170 Non - * < LOD < LOD 14 < LOD < LOD 1110 13 - Hispanic whites 11 - 12 * Non < LOD < LOD < LOD 2477 < LOD - 14 * < LOD < LOD < LOD < LOD 1835 13 - 12 * < LOD All Hispanics < LOD < LOD < LOD 1902 11 < LOD 13 14 * < LOD - < LOD < LOD 1467 Asians 11 - 12 * < LOD < LOD < LOD .160 (

344 Blood Methyl Mercury (2011 – 2014) d Geometric mean and selected percentiles of blood concentrations (in μg/L) for the U.S. population from the National Health an Nutrition Examination Survey. Sample Survey 50th Percentile Geometric mean 75th Percentile 95th Percentile 90th Percentile Categories (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) (95% conf. interval) years size - 12 .498 (.423 - .587) .480 (.400 - .570) 1.25 (.950 - 1.61) 2.81 (2.29 - 3.55) 4.43 (3.46 - 5.49) 7841 Total 11 - 14 .434 (.381 - .495) .420 (.340 - .510) 1.09 (.940 - 1.27) 2.62 (2.18 3.04) 4.28 (3.74 - 4.93) 5175 13 - Age group 5 years 11 - 12 * .140 (.120 - 1 .270 (.220 - .350) .540 (.420 - .780) .970 (.590 - 1.14) 657 - .170) 13 14 * < LOD .260 (.230 - .310) .660 (.550 - .810) 1.11 (.960 - 1.48) 779 - 1044 11 years 11 - 12 .209 (.182 - .241) .180 (.150 - .220) .400 (.330 - .490) .820 (.630 - 1.06) 1.34 (.940 - 1.84) 6 - 13 14 * .150 (